ATE259796T1 - Respiratorisches syncytialvirus replikation inhibitoren - Google Patents

Respiratorisches syncytialvirus replikation inhibitoren

Info

Publication number
ATE259796T1
ATE259796T1 AT00936899T AT00936899T ATE259796T1 AT E259796 T1 ATE259796 T1 AT E259796T1 AT 00936899 T AT00936899 T AT 00936899T AT 00936899 T AT00936899 T AT 00936899T AT E259796 T1 ATE259796 T1 AT E259796T1
Authority
AT
Austria
Prior art keywords
replication inhibitors
syncytialvirus
respiratory
respiratory syncytialvirus
replication
Prior art date
Application number
AT00936899T
Other languages
English (en)
Inventor
Frans Eduard Janssens
Jean Fernand Armand Lacrampe
Jerome Emile G Jans Guillemont
Marc Gaston Venet
Koenraad Jozef Lodewij Andries
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE259796T1 publication Critical patent/ATE259796T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT00936899T 1999-06-28 2000-06-20 Respiratorisches syncytialvirus replikation inhibitoren ATE259796T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99202089 1999-06-28
PCT/EP2000/005677 WO2001000615A1 (en) 1999-06-28 2000-06-20 Respiratory syncytial virus replication inhibitors

Publications (1)

Publication Number Publication Date
ATE259796T1 true ATE259796T1 (de) 2004-03-15

Family

ID=8240374

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00936899T ATE259796T1 (de) 1999-06-28 2000-06-20 Respiratorisches syncytialvirus replikation inhibitoren
AT03102464T ATE356121T1 (de) 1999-06-28 2000-06-20 Hemmer des respiratorischen syncytial virus

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT03102464T ATE356121T1 (de) 1999-06-28 2000-06-20 Hemmer des respiratorischen syncytial virus

Country Status (34)

Country Link
US (2) US7071192B1 (de)
EP (2) EP1196410B1 (de)
JP (1) JP2003503403A (de)
KR (1) KR100731273B1 (de)
CN (1) CN1171887C (de)
AR (1) AR024495A1 (de)
AT (2) ATE259796T1 (de)
AU (1) AU774829B2 (de)
BG (1) BG65373B1 (de)
BR (1) BR0011997A (de)
CA (1) CA2376785A1 (de)
CZ (1) CZ20014573A3 (de)
DE (2) DE60008382T2 (de)
DK (1) DK1196410T3 (de)
EA (1) EA004746B1 (de)
EE (1) EE04592B1 (de)
ES (2) ES2283716T3 (de)
HK (1) HK1045998B (de)
HR (2) HRP20010934A2 (de)
HU (1) HUP0201789A3 (de)
IL (2) IL147328A0 (de)
MX (1) MXPA02000117A (de)
MY (1) MY129810A (de)
NO (1) NO321599B1 (de)
NZ (1) NZ515392A (de)
PL (1) PL200694B1 (de)
PT (1) PT1196410E (de)
SI (1) SI1196410T1 (de)
SK (1) SK18952001A3 (de)
TR (2) TR200103805T2 (de)
TW (1) TWI267513B (de)
UA (1) UA75866C2 (de)
WO (1) WO2001000615A1 (de)
ZA (1) ZA200110473B (de)

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ES2245380T3 (es) 2000-12-15 2006-01-01 Glaxo Group Limited Pirazolopiridinas.
US6774134B2 (en) 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
US7153855B2 (en) 2001-03-08 2006-12-26 Smithkline Beecham Corporation Pyrazolopyridinyl pyrimidine therapeutic compounds
EP1372643A1 (de) 2001-03-30 2004-01-02 Smithkline Beecham Corporation Pyrazolopyridine, verfahren zu ihrer herstellung und verwendung als therapeutika
JP4219171B2 (ja) 2001-04-10 2009-02-04 スミスクライン ビーチャム コーポレーション 抗ウイルス性ピラゾロピリジン化合物
AU2002305143A1 (en) 2001-04-27 2002-11-11 Smithkline Beecham Corporation Pyrazolo'1,5-a!pyridine derivatives
US7030150B2 (en) * 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
KR20040018281A (ko) 2001-06-21 2004-03-02 스미스클라인 비참 코포레이션 포진 바이러스 감염의 예방 및 치료를 위한 이미다조[1，２－α]피리딘 유도체
US7244740B2 (en) 2001-10-05 2007-07-17 Smithkline Beecham Corporation Imidazo-pyridine derivatives for use in the treatment of herpes viral infection
US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
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US7244847B2 (en) * 2002-02-06 2007-07-17 Isis Pharmaceuticals, Inc. Benzimidazole compounds
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WO2004033454A1 (en) 2002-10-03 2004-04-22 Smithkline Beecham Corporation Therapeutic compounds based on pyrazolopyridine derivatives
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TWI349007B (en) 2003-12-18 2011-09-21 Tibotec Pharm Ltd Piperidine-amino-benzimidazole derivatives as inhibitors of respiratory syncytial virus replication
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
AR046972A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Derivados de los amino-bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
MXPA06007110A (es) * 2003-12-18 2006-08-23 Tibotec Pharm Ltd Derivados de los amino-bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio.
ATE435222T1 (de) * 2003-12-18 2009-07-15 Tibotec Pharm Ltd Aminobenzimidazole und benzimidazole als inhibitoren der replikation von respiratory syncytial virus
AR046770A1 (es) * 2003-12-18 2005-12-21 Tibotec Pharm Ltd Derivados bencimidazol 5- o 6-substituidos como inhibidores de la replicacion del virus sincitial respiratorio
RU2410382C2 (ru) * 2005-03-17 2011-01-27 Тиботек Фармасьютикалз Лтд 1, 3-дигидробензимидазол-2-илиденовые амины в качестве ингибиторов репликации респираторного синцитиального вируса
AU2006260969B2 (en) * 2005-06-20 2011-11-17 Janssen Sciences Ireland Uc 1- ( 2-amino-3- (substituted alkyl)-3H-benzimidazolylmethyl) -3-substituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus
MX2007016311A (es) * 2005-06-20 2008-03-07 Tibotec Pharm Ltd Bencimidazoles sustituidos con heterociclilaminoalquilo.
PL1896450T3 (pl) * 2005-06-20 2013-01-31 Janssen Sciences Ireland Uc 2-podstawione benzimidazole
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WO2010045276A2 (en) * 2008-10-16 2010-04-22 Cara Therapeutics, Inc. Azabenzimidazolones
JP5487692B2 (ja) 2009-04-10 2014-05-07 国立大学法人京都大学 複素環骨格を有する化合物および該化合物を不斉触媒として用いる光学活性化合物の製造方法
US8993604B2 (en) 2009-06-30 2015-03-31 Siga Technologies, Inc. Treatment and prevention of dengue virus infections
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Also Published As

Publication number Publication date
NO321599B1 (no) 2006-06-06
DE60008382T2 (de) 2004-12-02
US7071192B1 (en) 2006-07-04
PL200694B1 (pl) 2009-01-30
IL147328A (en) 2007-06-03
HUP0201789A3 (en) 2003-12-29
TR200500707T2 (tr) 2005-04-21
ZA200110473B (en) 2003-03-20
BG106288A (en) 2002-10-31
AR024495A1 (es) 2002-10-02
NO20016370D0 (no) 2001-12-27
EP1196410A1 (de) 2002-04-17
CN1358182A (zh) 2002-07-10
HK1045998B (zh) 2005-06-03
BG65373B1 (bg) 2008-04-30
ES2215670T3 (es) 2004-10-16
EP1400519B1 (de) 2007-03-07
EE200100694A (et) 2003-02-17
CN1171887C (zh) 2004-10-20
KR20020000815A (ko) 2002-01-05
HUP0201789A2 (hu) 2002-11-28
BR0011997A (pt) 2002-03-05
SI1196410T1 (en) 2004-08-31
WO2001000615A1 (en) 2001-01-04
IL147328A0 (en) 2002-08-14
DE60008382D1 (en) 2004-03-25
EP1400519A1 (de) 2004-03-24
UA75866C2 (en) 2006-06-15
EP1196410B1 (de) 2004-02-18
KR100731273B1 (ko) 2007-06-21
MXPA02000117A (es) 2002-07-02
NZ515392A (en) 2004-03-26
DE60033859D1 (de) 2007-04-19
HRP20010934A2 (en) 2003-06-30
AU774829B2 (en) 2004-07-08
SK18952001A3 (sk) 2002-11-06
US7407969B2 (en) 2008-08-05
ES2283716T3 (es) 2007-11-01
DK1196410T3 (da) 2004-06-28
US20060058309A1 (en) 2006-03-16
TR200103805T2 (tr) 2002-06-21
PT1196410E (pt) 2004-07-30
WO2001000615A8 (en) 2002-01-10
EA200200086A1 (ru) 2002-06-27
JP2003503403A (ja) 2003-01-28
MY129810A (en) 2007-05-31
CA2376785A1 (en) 2001-01-04
DE60033859T2 (de) 2007-11-08
AU5222200A (en) 2001-01-31
CZ20014573A3 (cs) 2002-05-15
TWI267513B (en) 2006-12-01
PL352385A1 (en) 2003-08-25
HK1045998A1 (en) 2002-12-20
HRP20080390A2 (en) 2008-12-31
EA004746B1 (ru) 2004-08-26
EE04592B1 (et) 2006-02-15
NO20016370L (no) 2001-12-27
ATE356121T1 (de) 2007-03-15

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