ATE260665T1 - Derivate des erythromycins, des clarithromycins, des roxithromycins oder des azithromycin mit antibiotischer und mucolytischer wirkung - Google Patents

Derivate des erythromycins, des clarithromycins, des roxithromycins oder des azithromycin mit antibiotischer und mucolytischer wirkung

Info

Publication number: ATE260665T1
Authority: AT; Austria
Prior art keywords: antibiotic; mucolytic; roxithromycin; clarithromycin; azithromycin
Prior art date: 1998-10-20

Application number

AT99947823T

Other languages

English (en)

Inventor

Helmut Schickaneder

Aggelos Nikolopoulos

Gesine Hermann

Original Assignee

Russinsky Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-20

Filing date

1999-10-15

Publication date

2004-03-15

1999-10-15 Application filed by Russinsky Ltd filed Critical Russinsky Ltd

2004-03-15 Application granted granted Critical

2004-03-15 Publication of ATE260665T1 publication Critical patent/ATE260665T1/de

Links

230000003115 biocidal effect Effects 0.000 title abstract 4
230000000510 mucolytic effect Effects 0.000 title abstract 4
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 3
RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 title abstract 2
229960004099 azithromycin Drugs 0.000 title abstract 2
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 title abstract 2
229960002626 clarithromycin Drugs 0.000 title abstract 2
AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 title abstract 2
229960005224 roxithromycin Drugs 0.000 title abstract 2
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
YTGJWQPHMWSCST-UHFFFAOYSA-N Tiopronin Chemical compound CC(S)C(=O)NCC(O)=O YTGJWQPHMWSCST-UHFFFAOYSA-N 0.000 abstract 1
108010058907 Tiopronin Proteins 0.000 abstract 1
229960004308 acetylcysteine Drugs 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
ZNEWHQLOPFWXOF-UHFFFAOYSA-N coenzyme M Chemical compound OS(=O)(=O)CCS ZNEWHQLOPFWXOF-UHFFFAOYSA-N 0.000 abstract 1
229960004100 dirithromycin Drugs 0.000 abstract 1
WLOHNSSYAXHWNR-NXPDYKKBSA-N dirithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H]2O[C@H](COCCOC)N[C@H]([C@@H]2C)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 WLOHNSSYAXHWNR-NXPDYKKBSA-N 0.000 abstract 1
229960003276 erythromycin Drugs 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229960001913 mecysteine Drugs 0.000 abstract 1
229960004635 mesna Drugs 0.000 abstract 1
MCYHPZGUONZRGO-VKHMYHEASA-N methyl L-cysteinate Chemical compound COC(=O)[C@@H](N)CS MCYHPZGUONZRGO-VKHMYHEASA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
150000003573 thiols Chemical class 0.000 abstract 1
229960004402 tiopronin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT99947823T 1998-10-20 1999-10-15 Derivate des erythromycins, des clarithromycins, des roxithromycins oder des azithromycin mit antibiotischer und mucolytischer wirkung ATE260665T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IE980869		1998-10-20
IE981062		1998-12-17
PCT/IE1999/000106 WO2000023081A1 (en)	1998-10-20	1999-10-15	Derivatives of erythromycin, clarithromycin, roxithromycin or azithromycin with antibiotic and mucolytic activity

Publications (1)

Publication Number	Publication Date
ATE260665T1 true ATE260665T1 (de)	2004-03-15

Family

ID=26320218

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99947823T ATE260665T1 (de)	1998-10-20	1999-10-15	Derivate des erythromycins, des clarithromycins, des roxithromycins oder des azithromycin mit antibiotischer und mucolytischer wirkung

Country Status (7)

Country	Link
US (1)	US6599885B2 (de)
EP (1)	EP1121134B1 (de)
AT (1)	ATE260665T1 (de)
AU (1)	AU760884B2 (de)
CA (1)	CA2346870A1 (de)
DE (1)	DE69915327T2 (de)
WO (1)	WO2000023081A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001263812B2 (en) *	2000-03-28	2004-09-23	Sandoz Ag	Granulated particles with masked taste
JP2009500356A (ja) *	2005-07-07	2009-01-08	エランファーマインターナショナルリミテッド	ナノ粒子クラリスロマイシン製剤
US20100022652A1 (en) *	2008-07-28	2010-01-28	Tyco Healthcare Group Lp	Antimicrobial and Anticoagulant Compositions and Methods
CA2784494C (en) *	2009-12-18	2019-03-12	North-West University	Composition comprising an amorphous non-crystalline glass form of roxithromycin
CN104177457A (zh) *	2013-05-23	2014-12-03	长春海悦药业有限公司	一种阿奇霉素药物原料及其制剂和用途
US11744859B2 (en)	2017-07-07	2023-09-05	Epicentrx, Inc.	Compositions and methods for parenteral administration of therapeutic agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2824443A1 (de)	1978-06-03	1979-12-13	Basf Ag	Lagerstabile und fliessfaehige silikatsuspensionen
IT1134458B (it) *	1980-11-26	1986-08-13	Real Sas Di Alberto Reiner	Derivato della n-acetil-cisteina ad attivita' terapeutica,procedimento per la sua preparazione e relative composizioni farmaceutiche
IT1134457B (it) *	1980-11-26	1986-08-13	Real Sas Di Alberto Reiner	Derivato dell'alfa-mercapto propionilglicina ad attivita' terapeutica,procedimento per la sua preparazione e relative composizioni farmaceutiche
FR2502627A1 (fr)	1981-02-02	1982-10-01	Refarmed Sa	Derives thioliques de l'erythromycine a activite therapeutique, procede de preparation et produits pharmaceutiques dans lesquels ils apparaissent
FR2519988B1 (fr) *	1982-01-20	1985-06-14	Refarmed Sa	Derives thioliques de l'erythromycine a activite therapeutique, procede de preparation et produits pharmaceutiques dans lesquels ils apparaissent
IT1189285B (it) *	1982-05-28	1988-02-04	Nuovo Consor Sanitar Nazionale	Sali dell'antibiotico eritromicina e del suo estere propionico con acidi ad attivita' terapeutica coadiuvante
AU4399396A (en) *	1994-12-19	1996-07-10	Russinsky Limited	Compounds
CA2255124A1 (en) *	1996-08-07	1998-02-12	Helmut Schickaneder	A process for the production of pharmaceuticals

1999
- 1999-10-15 AT AT99947823T patent/ATE260665T1/de not_active IP Right Cessation
- 1999-10-15 EP EP99947823A patent/EP1121134B1/de not_active Expired - Lifetime
- 1999-10-15 DE DE69915327T patent/DE69915327T2/de not_active Expired - Fee Related
- 1999-10-15 CA CA002346870A patent/CA2346870A1/en not_active Abandoned
- 1999-10-15 AU AU61185/99A patent/AU760884B2/en not_active Ceased
- 1999-10-15 WO PCT/IE1999/000106 patent/WO2000023081A1/en not_active Ceased
2001
- 2001-04-19 US US09/837,416 patent/US6599885B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU6118599A (en)	2000-05-08
WO2000023081A1 (en)	2000-04-27
US20010031736A1 (en)	2001-10-18
CA2346870A1 (en)	2000-04-27
DE69915327D1 (de)	2004-04-08
EP1121134A1 (de)	2001-08-08
DE69915327T2 (de)	2005-02-10
EP1121134B1 (de)	2004-03-03
US6599885B2 (en)	2003-07-29
AU760884B2 (en)	2003-05-22

Legal Events

Date	Code	Title	Description
2004-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
Čulić et al.	2001	Anti-inflammatory effects of macrolide antibiotics
FR11C0037I2 (fr)	2012-06-22	Antibiotiques macrolides et traitement de la pasteurellose
WO2003004509A3 (en)	2003-05-15	C12 modified erythromycin macrolides and ketolides having antibacterial activity
PT952835E (pt)	2004-08-31	Metodo de tratamento de doenca cardiaca causada por chlamidia pneumoniae
BR9502016A (pt)	1995-12-12	Derivado de propiofenona processo para a preparação do mesmo composição farmacêutica agente antidiabete e uso do dito derivado
ATE509938T1 (de)	2011-06-15	Makrolidverbindungen mit antiinflammatorischer wirkung
ATE260665T1 (de)	2004-03-15	Derivate des erythromycins, des clarithromycins, des roxithromycins oder des azithromycin mit antibiotischer und mucolytischer wirkung
ATE319729T1 (de)	2006-03-15	9a-azalide mit entzündungshemmender wirkung
DK1025114T3 (da)	2004-07-05	3'-N-modificerede 6-O-substituerede erythromycin-ketolidderivater med antibakteriel aktivitet
WO1996000576A3 (de)	1996-05-23	Neue klinische anwendungen von polyen-makroliden
BR9805318A (pt)	2000-04-11	Método para tratamento de infecções dos olhos com azitromicina.
EP1232171A4 (de)	2002-10-31	Verfahren zur herstellung von clarithromycin
KR930702369A (ko)	1993-09-08	에리쓰로마이신 또는 그의 유도체의 2'위치 수식 화합물
DE69915487D1 (de)	2004-04-15	Erythromycin-derivate mit antibiotischer wirkung
WO2002042315A3 (en)	2002-10-31	Macrolide solvates
EP1167375A4 (de)	2002-10-30	Erythromycin-derivate
EP0708770A1 (de)	1996-05-01	Amid-derivate von 16-gliedrige heterocyclen als antibiotische macrolide
TR200402446T4 (tr)	2004-12-21	Servik aşınmanın tedavisi için sükralfatın kullanımı.
BR0317539A (pt)	2005-11-22	Métodos e composições para o tratamento de infecções por vìrus da herpes usando inibidores seletivos da ou ciclooxigenase-2 ou inibidores da ciclooxigenase-2 em combinação com agentes antivirais
ATE289609T1 (de)	2005-03-15	Makrolid-lhrh-antagonisten
AR011105A1 (es)	2000-08-02	Formulacion de liposoma parenteral que reduce el dolor
林茂勇 et al.	2006	In vitro susceptibility of avian mycoplasma isolated in 1987 and 1999 in Taiwan and standard strains against 47 antimicrobials
NO950143L (no)	1995-01-13	Derivater av antibiotiske makrolider med 16-leddet ring
FI20011446A0 (fi)	2001-07-03	Farmaseuttinen, brivudiinia sisältävä, kerran päivässä käytettävä koostumus
ATE254625T1 (de)	2003-12-15	Eythromycinderivat mit antibiotischer aktvität