ATE261452T1 - Neue kristallformen einer antiviralen benzimidazolverbindung - Google Patents

Neue kristallformen einer antiviralen benzimidazolverbindung

Info

Publication number
ATE261452T1
ATE261452T1 AT99917935T AT99917935T ATE261452T1 AT E261452 T1 ATE261452 T1 AT E261452T1 AT 99917935 T AT99917935 T AT 99917935T AT 99917935 T AT99917935 T AT 99917935T AT E261452 T1 ATE261452 T1 AT E261452T1
Authority
AT
Austria
Prior art keywords
crystal forms
new crystal
benzimidazole compound
antiviral
antiviral benzimidazole
Prior art date
Application number
AT99917935T
Other languages
English (en)
Inventor
Barry Carter
Bobby Neal Glover
Lian Huang
Robert William Lancaster
Stacey Todd Long
Michele Catherine Rizzolio
Eric Allen Schmitt
Barry Sickles
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE261452T1 publication Critical patent/ATE261452T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT99917935T 1998-04-07 1999-04-01 Neue kristallformen einer antiviralen benzimidazolverbindung ATE261452T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9807354.7A GB9807354D0 (en) 1998-04-07 1998-04-07 Antiviral compound
PCT/EP1999/002214 WO1999051618A1 (en) 1998-04-07 1999-04-01 Novel crystalline forms of an antiviral benzimidazole compound

Publications (1)

Publication Number Publication Date
ATE261452T1 true ATE261452T1 (de) 2004-03-15

Family

ID=10829932

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99917935T ATE261452T1 (de) 1998-04-07 1999-04-01 Neue kristallformen einer antiviralen benzimidazolverbindung

Country Status (28)

Country Link
US (9) US6469160B1 (de)
EP (1) EP1071693B1 (de)
JP (1) JP2002510703A (de)
KR (1) KR20010074472A (de)
CN (1) CN1303390A (de)
AP (1) AP2000001947A0 (de)
AT (1) ATE261452T1 (de)
AU (1) AU752877B2 (de)
BR (1) BR9909474A (de)
CA (1) CA2327494C (de)
DE (1) DE69915461T2 (de)
EA (1) EA002970B1 (de)
EE (1) EE04120B1 (de)
ES (1) ES2216503T3 (de)
GB (1) GB9807354D0 (de)
HR (1) HRP20000669A2 (de)
HU (1) HUP0101669A3 (de)
ID (1) ID27109A (de)
IL (1) IL138697A0 (de)
IS (1) IS5640A (de)
NO (1) NO20005005L (de)
NZ (1) NZ507173A (de)
PL (1) PL343397A1 (de)
SK (1) SK14832000A3 (de)
TR (1) TR200002860T2 (de)
WO (1) WO1999051618A1 (de)
YU (1) YU60900A (de)
ZA (1) ZA200005153B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9807355D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807354D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
ES2498370T5 (es) 2002-05-16 2021-11-24 Janssen Sciences Ireland Unlimited Co Formas pseudopolimórficas de un inhibidor de la proteasa de VIH
JP2008501657A (ja) * 2004-06-02 2008-01-24 サンド・アクチエンゲゼルシヤフト 結晶形態のメロペネム中間体
US7750153B2 (en) * 2005-07-05 2010-07-06 Hetero Drugs Limited Process for the preparation of didanosine using novel intermediates
US9198862B2 (en) * 2005-07-22 2015-12-01 Rubicon Research Private Limited Dispersible tablet composition
CN101287706A (zh) * 2005-09-21 2008-10-15 尼科梅德有限责任公司 作为组蛋白脱乙酰基酶抑制剂的磺酰基吡咯盐酸盐
US7728129B2 (en) * 2005-10-31 2010-06-01 Janssen Pharmaceutica Nv Processes for the preparation of piperazinyl and diazapanyl benzamide derivatives
AU2007260356B2 (en) * 2006-06-16 2013-01-24 H. Lundbeck A/S Crystalline forms of 4- [2- (4-methylphenylsulfanyl) -phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain
US7919598B2 (en) * 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
NZ598071A (en) * 2006-10-27 2013-08-30 Signal Pharm Llc Uses of and pharmaceutical compositions comprising 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol compounds
EP2085397A1 (de) * 2008-01-21 2009-08-05 Esteve Quimica, S.A. Kristalline Form von Abacavir
US7935817B2 (en) * 2008-03-31 2011-05-03 Apotex Pharmachem Inc. Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
AR071318A1 (es) * 2008-04-15 2010-06-09 Basilea Pharmaceutica Ag Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
KR101043794B1 (ko) * 2009-04-13 2011-06-27 청우산업 주식회사 황토판재로 제공되는 기능성 황토방
PT2544679T (pt) 2010-03-12 2019-07-11 Omeros Corp Inibidores de pde-10 e composições e métodos relacionados
JP2013536859A (ja) * 2010-09-01 2013-09-26 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストの非吸湿性塩
US8541391B2 (en) 2010-10-28 2013-09-24 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
US8940707B2 (en) 2010-10-28 2015-01-27 Viropharma Incorporated Maribavir isomers, compositions, methods of making and methods of using
JP2014530805A (ja) * 2011-09-30 2014-11-20 スンシネ ルアケ プハルマ カンパニー リミテッド アジルサルタンの結晶形並びにその製造及び使用
NZ630803A (en) * 2014-04-28 2016-03-31 Omeros Corp Optically active pde10 inhibitor
NZ716494A (en) 2014-04-28 2017-07-28 Omeros Corp Processes and intermediates for the preparation of a pde10 inhibitor
US9879002B2 (en) 2015-04-24 2018-01-30 Omeros Corporation PDE10 inhibitors and related compositions and methods
US9920045B2 (en) 2015-11-04 2018-03-20 Omeros Corporation Solid state forms of a PDE10 inhibitor
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
CN111303230B (zh) * 2020-03-09 2021-07-13 中国食品药品检定研究院 一种黄体酮共晶物及其制备方法和用途
CN119136799A (zh) * 2022-10-12 2024-12-13 武田药品工业株式会社 制备马立巴韦的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3399987A (en) * 1965-08-02 1968-09-03 United States Borax Chem 2-alkylaminobenzimidazoles as herbicides
CH443777A (de) * 1965-08-06 1968-02-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3655901A (en) * 1970-07-30 1972-04-11 Merck & Co Inc Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
WO1994008456A1 (en) * 1992-10-21 1994-04-28 The Regents Of The University Of Michigan Polysubstituted benzimidazoles as antiviral agents
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
GB9600143D0 (en) 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
GB9807354D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807355D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound

Also Published As

Publication number Publication date
US20110118203A1 (en) 2011-05-19
ID27109A (id) 2001-03-01
IL138697A0 (en) 2001-10-31
HUP0101669A2 (hu) 2001-10-28
US20170002035A1 (en) 2017-01-05
AU3603499A (en) 1999-10-25
NO20005005D0 (no) 2000-10-04
DE69915461T2 (de) 2005-03-03
KR20010074472A (ko) 2001-08-04
SK14832000A3 (sk) 2001-07-10
US20160030460A1 (en) 2016-02-04
TR200002860T2 (tr) 2000-12-21
ES2216503T3 (es) 2004-10-16
US9163052B2 (en) 2015-10-20
US20020177703A1 (en) 2002-11-28
ZA200005153B (en) 2001-09-26
EP1071693A1 (de) 2001-01-31
NZ507173A (en) 2003-07-25
EA002970B1 (ru) 2002-12-26
WO1999051618A1 (en) 1999-10-14
AU752877B2 (en) 2002-10-03
HUP0101669A3 (en) 2003-07-28
US20180044366A1 (en) 2018-02-15
US20130261294A1 (en) 2013-10-03
NO20005005L (no) 2000-12-06
IS5640A (is) 2000-09-26
CA2327494A1 (en) 1999-10-14
US6469160B1 (en) 2002-10-22
AP2000001947A0 (en) 2000-12-31
US20100179101A1 (en) 2010-07-15
DE69915461D1 (de) 2004-04-15
EA200000911A1 (ru) 2001-04-23
HRP20000669A2 (en) 2001-08-31
JP2002510703A (ja) 2002-04-09
YU60900A (sh) 2003-07-07
US20080103186A1 (en) 2008-05-01
US7714123B2 (en) 2010-05-11
CA2327494C (en) 2010-10-26
CN1303390A (zh) 2001-07-11
EE200000584A (et) 2002-04-15
US7297683B2 (en) 2007-11-20
BR9909474A (pt) 2000-12-19
PL343397A1 (en) 2001-08-13
GB9807354D0 (en) 1998-06-03
EP1071693B1 (de) 2004-03-10
EE04120B1 (et) 2003-08-15

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Legal Events

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