ATE262523T1 - Verfahren zur herstellung 5-substituierter pyrazole unter verwendung von dithietane - Google Patents
Verfahren zur herstellung 5-substituierter pyrazole unter verwendung von dithietaneInfo
- Publication number
- ATE262523T1 ATE262523T1 AT99961578T AT99961578T ATE262523T1 AT E262523 T1 ATE262523 T1 AT E262523T1 AT 99961578 T AT99961578 T AT 99961578T AT 99961578 T AT99961578 T AT 99961578T AT E262523 T1 ATE262523 T1 AT E262523T1
- Authority
- AT
- Austria
- Prior art keywords
- dithietane
- producing
- substituted pyrazoles
- substituted
- pyrazoles
- Prior art date
Links
- UPNNXUSUOSTIIM-UHFFFAOYSA-N 1,2-dithietane Chemical compound C1CSS1 UPNNXUSUOSTIIM-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003217 pyrazoles Chemical class 0.000 title 1
- -1 5-substituted pyrazoles Chemical class 0.000 abstract 1
- 229940111134 coxibs Drugs 0.000 abstract 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 abstract 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10917798P | 1998-11-20 | 1998-11-20 | |
| PCT/US1999/026011 WO2000031072A1 (en) | 1998-11-20 | 1999-11-18 | Process for making 5-substituted pyrazoles using dithietanes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE262523T1 true ATE262523T1 (de) | 2004-04-15 |
Family
ID=22326224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99961578T ATE262523T1 (de) | 1998-11-20 | 1999-11-18 | Verfahren zur herstellung 5-substituierter pyrazole unter verwendung von dithietane |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US6143892A (de) |
| EP (1) | EP1131318B1 (de) |
| JP (1) | JP2002530404A (de) |
| AT (1) | ATE262523T1 (de) |
| AU (1) | AU758811B2 (de) |
| CA (1) | CA2350081A1 (de) |
| DE (1) | DE69915862T2 (de) |
| DK (1) | DK1131318T3 (de) |
| ES (1) | ES2219092T3 (de) |
| IL (1) | IL142999A0 (de) |
| NZ (1) | NZ511594A (de) |
| PT (1) | PT1131318E (de) |
| WO (1) | WO2000031072A1 (de) |
| ZA (1) | ZA200103759B (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
| US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| ES2221426T3 (es) | 1998-08-20 | 2004-12-16 | Smithkline Beecham Corporation | Nuevos compuestos de triazol sustituidos. |
| US6548503B1 (en) | 1998-11-04 | 2003-04-15 | Smithkline Beecham Corporation | Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines |
| EP1131318B1 (de) | 1998-11-20 | 2004-03-24 | G.D. Searle LLC | Verfahren zur herstellung 5-substituierter pyrazole unter verwendung von dithietane |
| US7122666B2 (en) | 1999-07-21 | 2006-10-17 | Sankyo Company, Limited | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses |
| ES2230171T3 (es) | 1999-11-23 | 2005-05-01 | Smithkline Beecham Corporation | Compuestos 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de csbp/p38 quinasa. |
| US6759410B1 (en) * | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
| DE60023025T2 (de) | 1999-11-23 | 2006-07-13 | Smithkline Beecham Corp. | 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren |
| JP2003514900A (ja) | 1999-11-23 | 2003-04-22 | スミスクライン・ビーチャム・コーポレイション | ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４−ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物 |
| CO5261556A1 (es) | 1999-12-08 | 2003-03-31 | Pharmacia Corp | Composiciones inhibidoras de ciclooxigenasa-2 que tiene rapido acceso de efecto terapeutico |
| US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| US7057049B2 (en) | 2001-09-25 | 2006-06-06 | Pharmacia Corporation | Process for making substituted pyrazoles |
| YU30504A (sh) | 2001-09-25 | 2006-08-17 | Pharmacia Corporation | Postupak za dobijanje supstituisanih pirazola |
| ES2281633T3 (es) * | 2002-02-19 | 2007-10-01 | Pfizer Italia S.R.L. | Derivados triciclicos de pirazol, procedimiento para su preparacion y su uso como agentes antitumorales. |
| TW200400960A (en) * | 2002-06-05 | 2004-01-16 | Pharmacia Corp | Novel pyrazoles and their use as P38 kinase inhibitors |
| AU2003245989A1 (en) | 2002-07-09 | 2004-01-23 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
| TW200413351A (en) | 2002-08-21 | 2004-08-01 | Astrazeneca Ab | Chemical compounds |
| BR0317430A (pt) * | 2002-12-20 | 2005-10-25 | Pharmacia Corp | Compostos inibidores de quinase-2 de proteìna ativada por quinase de proteìna ativada por mitógeno |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| WO2007021966A1 (en) * | 2005-08-12 | 2007-02-22 | Synta Pharmaceuticals Corp. | Pyrazole compounds that modulate hsp90 activity |
| EP1992344A1 (de) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind |
| CA2687931C (en) * | 2007-05-31 | 2016-05-24 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists and uses thereof |
| ES2551557T3 (es) | 2008-12-19 | 2015-11-19 | Boehringer Ingelheim International Gmbh | Pirimidin-4-carboxamidas cíclicas como antagonistas del receptor CCR2 para el tratamiento de inflamaciones, asma y EPOC |
| EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| PL2513093T3 (pl) | 2009-12-17 | 2015-03-31 | Centrexion Therapeutics Corp | Nowi antagoniści receptora CCR2 i ich zastosowanie |
| WO2011141474A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| EP2569295B1 (de) | 2010-05-12 | 2014-11-19 | Boehringer Ingelheim International GmbH | Neue ccr2-rezeptorantagnonisten, herstellungsverfahren dafür und verwendung davon als medikamente |
| EP2571870B1 (de) | 2010-05-17 | 2015-01-21 | Boehringer Ingelheim International GmbH | Ccr2-antagonisten und verwendungen dafür |
| US9018212B2 (en) | 2010-05-25 | 2015-04-28 | Boehringer Ingelheim International Gmbh | Pyridazine carboxamides as CCR2 receptor antagonists |
| JP5721242B2 (ja) | 2010-06-01 | 2015-05-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ｃｃｒ２アンタゴニスト |
| JP5786258B2 (ja) | 2011-07-15 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規かつ選択的なｃｃｒ２拮抗薬 |
| UA114490C2 (uk) | 2011-10-06 | 2017-06-26 | Байєр Інтеллектуал Проперті Гмбх | Гетероциклілпіри(mі)динілпіразоли як фунгіциди |
| BR122020001830B1 (pt) | 2015-05-18 | 2023-02-28 | Shenyang Sinochem Agrochemicals R&D Co., LTD | Compostos pirazol substituídos contendo pirimidinila, preparação e aplicação dos mesmos |
| MX383744B (es) | 2015-07-02 | 2025-03-14 | Centrexion Therapeutics Corp | Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidin-1-il) (5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2h-piran-2-il) metilamino) pirimidin-4-il) metanona. |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| CN111004180A (zh) * | 2019-09-11 | 2020-04-14 | 浙江埃森化学有限公司 | 一种制备氟虫腈的方法 |
| CN115124471B (zh) * | 2021-03-24 | 2024-02-13 | 中国工程物理研究院化工材料研究所 | 一类具有高能和低熔点特性的吡唑环类炸药及其合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63119468A (ja) * | 1986-11-05 | 1988-05-24 | Takeda Chem Ind Ltd | ピラゾ−ル誘導体の製造法 |
| EP1131318B1 (de) | 1998-11-20 | 2004-03-24 | G.D. Searle LLC | Verfahren zur herstellung 5-substituierter pyrazole unter verwendung von dithietane |
-
1999
- 1999-11-18 EP EP19990961578 patent/EP1131318B1/de not_active Expired - Lifetime
- 1999-11-18 IL IL14299999A patent/IL142999A0/xx unknown
- 1999-11-18 ES ES99961578T patent/ES2219092T3/es not_active Expired - Lifetime
- 1999-11-18 JP JP2000583900A patent/JP2002530404A/ja active Pending
- 1999-11-18 US US09/442,971 patent/US6143892A/en not_active Expired - Fee Related
- 1999-11-18 DE DE69915862T patent/DE69915862T2/de not_active Expired - Fee Related
- 1999-11-18 NZ NZ511594A patent/NZ511594A/xx unknown
- 1999-11-18 DK DK99961578T patent/DK1131318T3/da active
- 1999-11-18 AU AU18126/00A patent/AU758811B2/en not_active Ceased
- 1999-11-18 CA CA002350081A patent/CA2350081A1/en not_active Abandoned
- 1999-11-18 WO PCT/US1999/026011 patent/WO2000031072A1/en not_active Ceased
- 1999-11-18 AT AT99961578T patent/ATE262523T1/de not_active IP Right Cessation
- 1999-11-18 PT PT99961578T patent/PT1131318E/pt unknown
-
2000
- 2000-08-07 US US09/633,726 patent/US6242612B1/en not_active Expired - Fee Related
-
2001
- 2001-01-30 US US09/772,743 patent/US6342608B1/en not_active Expired - Fee Related
- 2001-05-09 ZA ZA200103759A patent/ZA200103759B/xx unknown
- 2001-08-06 US US09/922,819 patent/US6482955B2/en not_active Expired - Fee Related
-
2002
- 2002-10-10 US US10/268,818 patent/US6750338B2/en not_active Expired - Fee Related
-
2004
- 2004-02-14 US US10/778,432 patent/US20040220232A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200103759B (en) | 2002-11-27 |
| JP2002530404A (ja) | 2002-09-17 |
| US6143892A (en) | 2000-11-07 |
| AU758811B2 (en) | 2003-04-03 |
| DE69915862D1 (de) | 2004-04-29 |
| NZ511594A (en) | 2003-01-31 |
| AU1812600A (en) | 2000-06-13 |
| WO2000031072A1 (en) | 2000-06-02 |
| PT1131318E (pt) | 2004-07-30 |
| ES2219092T3 (es) | 2004-11-16 |
| DK1131318T3 (da) | 2004-06-01 |
| US20030135057A1 (en) | 2003-07-17 |
| IL142999A0 (en) | 2002-04-21 |
| CA2350081A1 (en) | 2000-06-02 |
| US6242612B1 (en) | 2001-06-05 |
| US6750338B2 (en) | 2004-06-15 |
| US6342608B1 (en) | 2002-01-29 |
| US20020115868A1 (en) | 2002-08-22 |
| DE69915862T2 (de) | 2004-08-05 |
| EP1131318B1 (de) | 2004-03-24 |
| EP1131318A1 (de) | 2001-09-12 |
| US20040220232A1 (en) | 2004-11-04 |
| US6482955B2 (en) | 2002-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1131318 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |