ATE263161T1 - Verfahren zur herstellung des alpha-tocopherol acetats - Google Patents

Verfahren zur herstellung des alpha-tocopherol acetats

Info

Publication number: ATE263161T1
Authority: AT; Austria
Prior art keywords: tocopherol acetate; producing alpha; novel method; alpha; producing
Prior art date: 1998-09-18

Application number

AT99942978T

Other languages

English (en)

Inventor

Jildaz Dhainaut

Thierry Durand

Original Assignee

Aventis Animal Nutrition Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-18

Filing date

1999-09-15

Publication date

2004-04-15

1999-09-15 Application filed by Aventis Animal Nutrition Sa filed Critical Aventis Animal Nutrition Sa

2004-04-15 Application granted granted Critical

2004-04-15 Publication of ATE263161T1 publication Critical patent/ATE263161T1/de

Links

ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 title 1
ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
229940042585 tocopherol acetate Drugs 0.000 title 1
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
AUFZRCJENRSRLY-UHFFFAOYSA-N 2,3,5-trimethylhydroquinone Chemical compound CC1=CC(O)=C(C)C(C)=C1O AUFZRCJENRSRLY-UHFFFAOYSA-N 0.000 abstract 1
KEVYVLWNCKMXJX-ZCNNSNEGSA-N Isophytol Natural products CC(C)CCC[C@H](C)CCC[C@@H](C)CCC[C@@](C)(O)C=C KEVYVLWNCKMXJX-ZCNNSNEGSA-N 0.000 abstract 1
229930003427 Vitamin E Natural products 0.000 abstract 1
230000005494 condensation Effects 0.000 abstract 1
238000009833 condensation Methods 0.000 abstract 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract 1
229940046009 vitamin E Drugs 0.000 abstract 1
235000019165 vitamin E Nutrition 0.000 abstract 1
239000011709 vitamin E Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Steroid Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT99942978T 1998-09-18 1999-09-15 Verfahren zur herstellung des alpha-tocopherol acetats ATE263161T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9811679A FR2784104B1 (fr)	1998-09-18	1998-09-18	Procede de preparation de la vitamine e
PCT/FR1999/002196 WO2000017185A1 (fr)	1998-09-18	1999-09-15	Procede de preparation de la vitamine e

Publications (1)

Publication Number	Publication Date
ATE263161T1 true ATE263161T1 (de)	2004-04-15

Family

ID=9530589

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99942978T ATE263161T1 (de)	1998-09-18	1999-09-15	Verfahren zur herstellung des alpha-tocopherol acetats

Country Status (9)

Country	Link
US (2)	US6518439B1 (de)
EP (1)	EP1114041B1 (de)
JP (1)	JP2002526489A (de)
CN (1)	CN1141304C (de)
AT (1)	ATE263161T1 (de)
AU (1)	AU5628699A (de)
DE (1)	DE69916090T2 (de)
FR (1)	FR2784104B1 (de)
WO (1)	WO2000017185A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1186337C (zh) *	2000-10-23	2005-01-26	Sk株式会社	以高产率制备DL－α－生育酚的方法
ATE411307T1 (de) *	2003-12-05	2008-10-15	Dsm Ip Assets Bv	Verfahren zur herstellung von alkenylierten hydroxylierten aromatischen verbindungen, von chromanverbindungen und deren acylierten derivaten
CN1332666C (zh) *	2004-05-26	2007-08-22	中国科学院生物物理研究所	一种抗老年痴呆症复合制剂
CN1332667C (zh) *	2004-05-26	2007-08-22	中国科学院生物物理研究所	一种抗帕金森症（pd）复合制剂
WO2006018310A2 (en) *	2004-08-19	2006-02-23	Dsm Ip Assets B.V.	Process for the working-up of a vitamin e- and vitamin e-acetate and rectification colum suitable therefore
CN100564372C (zh) *	2004-08-19	2009-12-02	帝斯曼知识产权资产管理有限公司	用于精馏高沸点的对空气和/或温度敏感的有用产品的混合物的方法
CN102294240B (zh) *	2011-05-07	2013-02-13	浙江师范大学	一种用于TMBQ加氢生产TMHQ的Pd/C催化剂及制备方法
CN102295536B (zh) *	2011-07-14	2013-07-24	福建省福抗药业股份有限公司	一种高含量三甲基氢醌的制备方法
CN102336732A (zh) *	2011-07-14	2012-02-01	福建省福抗药业股份有限公司	一锅法制备维生素e乙酸酯的生产方法
JP2013063912A (ja) *	2011-08-31	2013-04-11	Eisai R & D Management Co Ltd	α−トコフェロールおよび酢酸α−トコフェロールの製造方法
CN102351831A (zh) *	2011-09-09	2012-02-15	重庆大学	一种制备D,L-α-生育酚乙酸酯的方法
CN102276572B (zh) *	2011-09-14	2013-03-27	重庆大学	一种制备维生素e乙酸酯的方法
CN111253218A (zh) *	2019-12-30	2020-06-09	上虞新和成生物化工有限公司	一种2,3,5-三甲基氢醌的合成方法和装置

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3708505A (en)	1971-02-25	1973-01-02	Diamond Shamrock Corp	Process for preparation of d,l-alpha tocopherol
JPS5180859A (en) *	1975-01-11	1976-07-15	Teijin Ltd	Arufua tokofuerooruruino seizoho
DE3203487A1 (de) *	1982-02-03	1983-08-11	Basf Ag, 6700 Ludwigshafen	Verfahren zur herstellung von tocopherylacetat oder tocopherylpropionat
FR2523494A1 (fr) *	1982-03-22	1983-09-23	Ferraz & Cie Lucien	Machine a rectifier les collecteurs electriques et analogues
JPS59190987A (ja) *	1983-04-11	1984-10-29	Mitsui Toatsu Chem Inc	ｄｌ−α−トコフエロ−ルの製造方法
JPS6054380A (ja) *	1983-09-05	1985-03-28	Sumitomo Chem Co Ltd	α−トコフエロ−ルの製造法
JPH0772184B2 (ja) *	1986-03-28	1995-08-02	エーザイ株式会社	ｄ▲ｌ▼−α−トコフエロ−ルの製造方法
US4966914A (en) *	1988-12-15	1990-10-30	E. I. Du Pont De Nemours And Company	Oculoselective beta-blockers as antiglaucoma agents
US5411969A (en) *	1993-04-16	1995-05-02	Bristol-Myers Squibb Company	Antihyperlipidemic/antioxidant dihydroquinolines
JPH09188673A (ja) *	1994-07-27	1997-07-22	Eisai Co Ltd	α−トコフェロールの製造方法
US5663376A (en)	1994-07-27	1997-09-02	Eisai Co., Ltd.	Process for the preparation of α-tocopherol
US6020505A (en) *	1994-07-27	2000-02-01	Eisai Co., Ltd.	Process for the preparation of α-tocopherol
ES2191078T3 (es)	1996-01-05	2003-09-01	Hoffmann La Roche	Procedimiento de obtencion de d,1-alfa-tocoferol en presencia de un catalizador de acido perfluoroalquilensulfonico.
US5908939A (en) *	1996-11-11	1999-06-01	Roche Vitamins Inc.	Method of making D,L-A-tocopherol
US6005122A (en) *	1996-12-23	1999-12-21	Basf Aktiengesellschaft	Preparation of α-tocopherol or α-tocopheryl acetate by reacting trimethylhydroquinone and phytol or isophytol, with recycling of the zinc halide condensation catalyst
DE19757124A1 (de) *	1997-12-20	1999-06-24	Degussa	Verfahren zur Herstellung von alpha-Tocopherolestern

1998
- 1998-09-18 FR FR9811679A patent/FR2784104B1/fr not_active Expired - Fee Related
1999
- 1999-09-15 DE DE69916090T patent/DE69916090T2/de not_active Expired - Lifetime
- 1999-09-15 AU AU56286/99A patent/AU5628699A/en not_active Abandoned
- 1999-09-15 US US09/787,264 patent/US6518439B1/en not_active Expired - Fee Related
- 1999-09-15 AT AT99942978T patent/ATE263161T1/de not_active IP Right Cessation
- 1999-09-15 JP JP2000574095A patent/JP2002526489A/ja not_active Ceased
- 1999-09-15 CN CNB998110434A patent/CN1141304C/zh not_active Expired - Fee Related
- 1999-09-15 EP EP99942978A patent/EP1114041B1/de not_active Expired - Lifetime
- 1999-09-15 WO PCT/FR1999/002196 patent/WO2000017185A1/fr not_active Ceased
2002
- 2002-12-19 US US10/323,273 patent/US6790967B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69916090T2 (de)	2005-02-17
EP1114041A1 (de)	2001-07-11
AU5628699A (en)	2000-04-10
FR2784104B1 (fr)	2002-12-27
EP1114041B1 (de)	2004-03-31
CN1318064A (zh)	2001-10-17
US6790967B2 (en)	2004-09-14
CN1141304C (zh)	2004-03-10
FR2784104A1 (fr)	2000-04-07
JP2002526489A (ja)	2002-08-20
DE69916090D1 (de)	2004-05-06
US6518439B1 (en)	2003-02-11
WO2000017185A1 (fr)	2000-03-30
US20030153772A1 (en)	2003-08-14

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Legal Events

Date	Code	Title	Description
2004-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties