ATE264290T1 - Verfahren zur herstellung von 5-hydroxy-3-oxo- pentansäure-derivaten - Google Patents
Verfahren zur herstellung von 5-hydroxy-3-oxo- pentansäure-derivatenInfo
- Publication number
- ATE264290T1 ATE264290T1 AT00935526T AT00935526T ATE264290T1 AT E264290 T1 ATE264290 T1 AT E264290T1 AT 00935526 T AT00935526 T AT 00935526T AT 00935526 T AT00935526 T AT 00935526T AT E264290 T1 ATE264290 T1 AT E264290T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxy
- acid derivatives
- oxo
- producing
- mixture
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- ANTBRXMMNBUYMS-UHFFFAOYSA-N 5-hydroxy-3-oxopentanoic acid Chemical class OCCC(=O)CC(O)=O ANTBRXMMNBUYMS-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- ALRHLSYJTWAHJZ-UHFFFAOYSA-N 3-hydroxypropionic acid Chemical class OCCC(O)=O ALRHLSYJTWAHJZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000002168 ethanoic acid esters Chemical class 0.000 abstract 2
- AFRJJFRNGGLMDW-UHFFFAOYSA-N lithium amide Chemical compound [Li+].[NH2-] AFRJJFRNGGLMDW-UHFFFAOYSA-N 0.000 abstract 2
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/18—Preparation of carboxylic acid esters by conversion of a group containing nitrogen into an ester group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15803399 | 1999-06-04 | ||
| JP2000023804 | 2000-02-01 | ||
| PCT/JP2000/003574 WO2000075099A1 (en) | 1999-06-04 | 2000-06-02 | Processes for the preparation of 5-hydroxy-3-oxopentanoic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE264290T1 true ATE264290T1 (de) | 2004-04-15 |
Family
ID=26485289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00935526T ATE264290T1 (de) | 1999-06-04 | 2000-06-02 | Verfahren zur herstellung von 5-hydroxy-3-oxo- pentansäure-derivaten |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6340767B1 (de) |
| EP (1) | EP1104750B1 (de) |
| JP (1) | JP4659309B2 (de) |
| KR (1) | KR20010072175A (de) |
| AT (1) | ATE264290T1 (de) |
| AU (1) | AU5104300A (de) |
| CA (1) | CA2339357A1 (de) |
| DE (1) | DE60009836T2 (de) |
| ES (1) | ES2219345T3 (de) |
| HU (1) | HUP0103788A3 (de) |
| WO (1) | WO2000075099A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0011120D0 (en) * | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
| NL1015744C2 (nl) * | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
| KR100402047B1 (ko) * | 2001-05-25 | 2003-10-17 | 삼성정밀화학 주식회사 | 광학적으로 순수한 δ-히드록시-β-케토에스테르 유도체의제조방법 |
| EP1375493A1 (de) * | 2002-06-17 | 2004-01-02 | Dsm N.V. | Verfahren zur Herstellung von Dioxanessigsäureester |
| US20040067492A1 (en) * | 2002-10-04 | 2004-04-08 | Allan Peng | Reverse transcription on microarrays |
| JP4252037B2 (ja) * | 2003-01-16 | 2009-04-08 | エルジー・ライフ・サイエンシーズ・リミテッド | ５−ヒドロキシ−３−オキソ−ヘキサン酸誘導体の新規な製造方法 |
| AU2003272080A1 (en) * | 2003-09-18 | 2005-04-06 | Biocon Limited | Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate |
| GB2474687A (en) | 2009-10-23 | 2011-04-27 | Phoenix Chemicals Ltd | A continuous process for the production of (R)-6-cyano-5-hydroxy-3-oxo-hexanoic acid tert-butyl ester (and derivatives) |
| US9944586B2 (en) | 2013-10-17 | 2018-04-17 | Cargill, Incorporated | Methods for producing alkyl hydroxyalkanoates |
| US10239819B2 (en) | 2014-10-17 | 2019-03-26 | Cargill, Incorporated | Methods for producing an ester of an alpha, beta-unsaturated carboxylic acid |
| SG11202003762VA (en) | 2017-11-01 | 2020-05-28 | Melinta Therapeutics Inc | Synthesis of boronate ester derivatives and uses thereof |
| CN109912417A (zh) * | 2018-12-29 | 2019-06-21 | 京博农化科技有限公司 | 一种2-（2-甲基苯氧甲基）-苯甲酰甲酸甲酯的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3741509A1 (de) | 1987-12-08 | 1989-06-22 | Hoechst Ag | Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte |
| JP2619136B2 (ja) * | 1990-11-02 | 1997-06-11 | 鐘淵化学工業株式会社 | ５，６―ジヒドロキシ―３―オキソヘキサン酸エステル誘導体の製造法 |
| JPH04173757A (ja) * | 1990-11-06 | 1992-06-22 | Daicel Chem Ind Ltd | α―アルキルアクロレインの製造方法 |
| US5155251A (en) * | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
| US5278313A (en) * | 1992-03-27 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors |
| PT1619191E (pt) | 1998-08-05 | 2010-12-21 | Kaneka Corp | Processo de produção de derivados opticamente activos do ácido 2-[6-(hidroximetil)-1,3-dioxan-4-il]acético |
-
2000
- 2000-06-02 DE DE60009836T patent/DE60009836T2/de not_active Expired - Lifetime
- 2000-06-02 EP EP00935526A patent/EP1104750B1/de not_active Expired - Lifetime
- 2000-06-02 JP JP2001501581A patent/JP4659309B2/ja not_active Expired - Fee Related
- 2000-06-02 KR KR1020017001390A patent/KR20010072175A/ko not_active Abandoned
- 2000-06-02 US US09/762,215 patent/US6340767B1/en not_active Ceased
- 2000-06-02 AT AT00935526T patent/ATE264290T1/de not_active IP Right Cessation
- 2000-06-02 ES ES00935526T patent/ES2219345T3/es not_active Expired - Lifetime
- 2000-06-02 HU HU0103788A patent/HUP0103788A3/hu unknown
- 2000-06-02 CA CA002339357A patent/CA2339357A1/en not_active Abandoned
- 2000-06-02 AU AU51043/00A patent/AU5104300A/en not_active Abandoned
- 2000-06-02 US US10/705,665 patent/USRE39333E1/en not_active Expired - Lifetime
- 2000-06-02 WO PCT/JP2000/003574 patent/WO2000075099A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| USRE39333E1 (en) | 2006-10-10 |
| DE60009836D1 (de) | 2004-05-19 |
| JP4659309B2 (ja) | 2011-03-30 |
| DE60009836T2 (de) | 2005-04-21 |
| KR20010072175A (ko) | 2001-07-31 |
| WO2000075099A1 (en) | 2000-12-14 |
| US6340767B1 (en) | 2002-01-22 |
| HUP0103788A2 (hu) | 2002-02-28 |
| EP1104750A4 (de) | 2002-04-10 |
| CA2339357A1 (en) | 2000-12-14 |
| ES2219345T3 (es) | 2004-12-01 |
| EP1104750B1 (de) | 2004-04-14 |
| EP1104750A1 (de) | 2001-06-06 |
| HUP0103788A3 (en) | 2003-05-28 |
| AU5104300A (en) | 2000-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |