ATE264922T1 - Verfahren zur erkennung von klonalen populationen von transformierten zellen in einer genomisch heterogenen zellulären probe - Google Patents

Verfahren zur erkennung von klonalen populationen von transformierten zellen in einer genomisch heterogenen zellulären probe

Info

Publication number
ATE264922T1
ATE264922T1 AT96944531T AT96944531T ATE264922T1 AT E264922 T1 ATE264922 T1 AT E264922T1 AT 96944531 T AT96944531 T AT 96944531T AT 96944531 T AT96944531 T AT 96944531T AT E264922 T1 ATE264922 T1 AT E264922T1
Authority
AT
Austria
Prior art keywords
transformed cells
cellular sample
clonal populations
heterogeneous cellular
detecting
Prior art date
Application number
AT96944531T
Other languages
English (en)
Inventor
Stanley N Lapidus
Anthony P Shuber
Kevin M Ulmer
Original Assignee
Exact Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26679107&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE264922(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/700,583 external-priority patent/US5670325A/en
Application filed by Exact Sciences Corp filed Critical Exact Sciences Corp
Application granted granted Critical
Publication of ATE264922T1 publication Critical patent/ATE264922T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT96944531T 1995-12-22 1996-12-20 Verfahren zur erkennung von klonalen populationen von transformierten zellen in einer genomisch heterogenen zellulären probe ATE264922T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US913795P 1995-12-22 1995-12-22
US08/700,583 US5670325A (en) 1996-08-14 1996-08-14 Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
PCT/US1996/020627 WO1997023651A1 (en) 1995-12-22 1996-12-20 Methods for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample

Publications (1)

Publication Number Publication Date
ATE264922T1 true ATE264922T1 (de) 2004-05-15

Family

ID=26679107

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96944531T ATE264922T1 (de) 1995-12-22 1996-12-20 Verfahren zur erkennung von klonalen populationen von transformierten zellen in einer genomisch heterogenen zellulären probe

Country Status (7)

Country Link
EP (1) EP0815263B1 (de)
AT (1) ATE264922T1 (de)
AU (1) AU711754B2 (de)
CA (1) CA2211702C (de)
DE (1) DE69632252T2 (de)
ES (1) ES2220997T3 (de)
WO (1) WO1997023651A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6203993B1 (en) 1996-08-14 2001-03-20 Exact Science Corp. Methods for the detection of nucleic acids
US6300077B1 (en) 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
US6100029A (en) * 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
US6566101B1 (en) 1997-06-16 2003-05-20 Anthony P. Shuber Primer extension methods for detecting nucleic acids
JP4502502B2 (ja) * 1997-10-28 2010-07-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア フローサイトメトリーを用いるｄｎａ多型の同定方法
WO1999066077A2 (en) * 1998-06-16 1999-12-23 Exact Laboratories, Inc. Methods for the detection of nucleic acids
US20020001800A1 (en) * 1998-08-14 2002-01-03 Stanley N. Lapidus Diagnostic methods using serial testing of polymorphic loci
WO2000011215A2 (en) * 1998-08-14 2000-03-02 Exact Laboratories, Inc. Method for diagnostic screening
WO2000032820A1 (en) * 1998-11-23 2000-06-08 Exact Laboratories, Inc. Method for detecting target sequences in small proportions in heterogeneous samples
WO2000031298A1 (en) * 1998-11-23 2000-06-02 Exact Laboratories, Inc. Methods for detecting lower-frequency molecules
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
EP1169479B1 (de) 1999-04-09 2006-06-28 EXACT Sciences Corporation Verfahren zur detektion von nukleinsäuren, welche auf krebs hinweisen
AU6733800A (en) * 1999-08-30 2001-03-26 Japan Science And Technology Corporation Highly sensitive method of detecting gene mutation
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
CA2394921A1 (en) 1999-12-07 2001-06-14 Anthony P. Shuber Supracolonic aerodigestive neoplasm detection
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
US7776524B2 (en) 2002-02-15 2010-08-17 Genzyme Corporation Methods for analysis of molecular events
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
US9777314B2 (en) 2005-04-21 2017-10-03 Esoterix Genetic Laboratories, Llc Analysis of heterogeneous nucleic acid samples

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302509A (en) * 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
EP1134293A3 (de) * 1992-03-04 2004-01-07 The Regents of The University of California Vergleichende Genomhybridisierung
US6214542B1 (en) * 1992-10-20 2001-04-10 The United States Of America As Represented By The Department Of Health And Human Services Quantification of indicators of fibrosis
US5436142A (en) * 1992-11-12 1995-07-25 Cold Spring Harbor Laboratory Methods for producing probes capable of distingushing variant genomic sequences
WO1995002068A1 (en) * 1993-07-09 1995-01-19 Wakunaga Seiyaku Kabushiki Kaisha Method of discriminating nucleic acid and testing set for discriminating nucleic acid
US5472842A (en) * 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions

Also Published As

Publication number Publication date
WO1997023651A1 (en) 1997-07-03
CA2211702A1 (en) 1997-07-03
JP3325270B2 (ja) 2002-09-17
JPH10503384A (ja) 1998-03-31
EP0815263B1 (de) 2004-04-21
EP0815263A1 (de) 1998-01-07
AU1430797A (en) 1997-07-17
AU711754B2 (en) 1999-10-21
DE69632252T2 (de) 2005-04-14
CA2211702C (en) 1999-05-25
ES2220997T3 (es) 2004-12-16
DE69632252D1 (de) 2004-05-27

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