ATE266018T1 - 1,3-dioxolanen mit hustenhemmender wirkung - Google Patents

1,3-dioxolanen mit hustenhemmender wirkung

Info

Publication number: ATE266018T1
Authority: AT; Austria
Prior art keywords: dioxolanes; cough; inhibiting effect; preparation; acetals
Prior art date: 2000-07-28

Application number

AT01967203T

Other languages

English (en)

Inventor

Marcello Allegretti

Maria Candida Cesta

Roberto Curti

Luigi Pellegrini

Gabriella Melillo

Original Assignee

Dompe Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-28

Filing date

2001-07-18

Publication date

2004-05-15

2001-07-18 Application filed by Dompe Spa filed Critical Dompe Spa

2004-05-15 Application granted granted Critical

2004-05-15 Publication of ATE266018T1 publication Critical patent/ATE266018T1/de

Links

206010011224 Cough Diseases 0.000 title 1
-1 (S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol cyclic acetals Chemical class 0.000 abstract 1
150000001241 acetals Chemical class 0.000 abstract 1
239000003434 antitussive agent Substances 0.000 abstract 1
229940124584 antitussives Drugs 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
PTVWPYVOOKLBCG-ZDUSSCGKSA-N levodropropizine Chemical compound C1CN(C[C@H](O)CO)CCN1C1=CC=CC=C1 PTVWPYVOOKLBCG-ZDUSSCGKSA-N 0.000 abstract 1
229960002265 levodropropizine Drugs 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Pulmonology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Glass Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

AT01967203T 2000-07-28 2001-07-18 1,3-dioxolanen mit hustenhemmender wirkung ATE266018T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2000MI001734A IT1318650B1 (it)	2000-07-28	2000-07-28	1,3-diossolani ad attivita' antitosse.
PCT/EP2001/008304 WO2002010149A1 (en)	2000-07-28	2001-07-18	1,3-dioxolanes with antitussive activity

Publications (1)

Publication Number	Publication Date
ATE266018T1 true ATE266018T1 (de)	2004-05-15

Family

ID=11445591

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01967203T ATE266018T1 (de)	2000-07-28	2001-07-18	1,3-dioxolanen mit hustenhemmender wirkung

Country Status (26)

Country	Link
US (1)	US6835734B2 (de)
EP (1)	EP1307441B1 (de)
JP (1)	JP5107497B2 (de)
KR (1)	KR100781403B1 (de)
CN (1)	CN1204135C (de)
AT (1)	ATE266018T1 (de)
AU (1)	AU2001287638A1 (de)
BR (1)	BR0112765A (de)
CZ (1)	CZ301087B6 (de)
DE (1)	DE60103164T2 (de)
DK (1)	DK1307441T3 (de)
EE (1)	EE05178B1 (de)
ES (1)	ES2219562T3 (de)
HU (1)	HUP0301497A3 (de)
IL (2)	IL153515A0 (de)
IT (1)	IT1318650B1 (de)
MX (1)	MXPA02012920A (de)
PL (1)	PL206307B1 (de)
PT (1)	PT1307441E (de)
RS (1)	RS50861B (de)
RU (1)	RU2276149C2 (de)
SI (1)	SI21040A (de)
SK (1)	SK286794B6 (de)
TR (1)	TR200401315T4 (de)
UA (1)	UA73789C2 (de)
WO (1)	WO2002010149A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1318651B1 (it) *	2000-07-28	2003-08-27	Dompe Spa	Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.
TWI496776B (zh) *	2007-11-15	2015-08-21	Astrazeneca Ab	製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法
EP2070915A1 (de) *	2007-12-03	2009-06-17	A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A.	Neues Verfahren zur Synthese von Moguistein

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4049660A (en) *	1971-06-18	1977-09-20	Delalande S.A.	N-substituted derivatives of 4 (N-piperazinylmethyl) spiro dibenzocycloheptadi- (or tri-) ene-5, 2-dioxolane (1,3) their method of preparation and their application in therapeutics
IT1203721B (it) *	1983-12-29	1989-02-23	Dompe Farmaceutici Spa	Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono
NL8801622A (nl) *	1988-06-25	1990-01-16	Stamicarbon	Bereiding van enantiomeren van dropropizine.
IT1226570B (it) *	1988-08-01	1991-01-24	Bidachem Spa	Procedimento di preparazione della levo- e destro-dropropizina
DE4041482A1 (de) *	1990-12-22	1992-06-25	Boehringer Ingelheim Kg	Neue pharmazeutische verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine
IT1254452B (it) *	1992-02-14	1995-09-25	Dompe Farmaceutici Spa	N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli
IT1254993B (it) *	1992-06-24	1995-10-11		Procedimento per la preparazione degli enantiomeri della dropropizina
IL111730A (en) *	1993-11-29	1998-12-06	Fujisawa Pharmaceutical Co	Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
IT1318651B1 (it) *	2000-07-28	2003-08-27	Dompe Spa	Sintesi di (+-)1,3-diossolani e loro risoluzione ottica.

2000
- 2000-07-28 IT IT2000MI001734A patent/IT1318650B1/it active
2001
- 2001-07-18 ES ES01967203T patent/ES2219562T3/es not_active Expired - Lifetime
- 2001-07-18 JP JP2002515880A patent/JP5107497B2/ja not_active Expired - Fee Related
- 2001-07-18 CZ CZ20030268A patent/CZ301087B6/cs not_active IP Right Cessation
- 2001-07-18 PT PT01967203T patent/PT1307441E/pt unknown
- 2001-07-18 HU HU0301497A patent/HUP0301497A3/hu unknown
- 2001-07-18 AU AU2001287638A patent/AU2001287638A1/en not_active Abandoned
- 2001-07-18 US US10/333,979 patent/US6835734B2/en not_active Expired - Fee Related
- 2001-07-18 DK DK01967203T patent/DK1307441T3/da active
- 2001-07-18 RU RU2003105691/04A patent/RU2276149C2/ru not_active IP Right Cessation
- 2001-07-18 PL PL361172A patent/PL206307B1/pl not_active IP Right Cessation
- 2001-07-18 EE EEP200300036A patent/EE05178B1/xx not_active IP Right Cessation
- 2001-07-18 AT AT01967203T patent/ATE266018T1/de active
- 2001-07-18 IL IL15351501A patent/IL153515A0/xx active IP Right Grant
- 2001-07-18 KR KR1020037000945A patent/KR100781403B1/ko not_active Expired - Fee Related
- 2001-07-18 WO PCT/EP2001/008304 patent/WO2002010149A1/en not_active Ceased
- 2001-07-18 UA UA2003021767A patent/UA73789C2/uk unknown
- 2001-07-18 SK SK89-2003A patent/SK286794B6/sk not_active IP Right Cessation
- 2001-07-18 EP EP01967203A patent/EP1307441B1/de not_active Expired - Lifetime
- 2001-07-18 BR BR0112765-9A patent/BR0112765A/pt not_active Application Discontinuation
- 2001-07-18 DE DE60103164T patent/DE60103164T2/de not_active Expired - Lifetime
- 2001-07-18 SI SI200120036A patent/SI21040A/sl not_active IP Right Cessation
- 2001-07-18 RS YUP-30/03A patent/RS50861B/sr unknown
- 2001-07-18 TR TR2004/01315T patent/TR200401315T4/xx unknown
- 2001-07-18 MX MXPA02012920A patent/MXPA02012920A/es active IP Right Grant
- 2001-07-18 CN CNB018134564A patent/CN1204135C/zh not_active Expired - Fee Related
2002
- 2002-12-18 IL IL153515A patent/IL153515A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT1307441E (pt)	2004-09-30
RS50861B (sr)	2010-08-31
HUP0301497A2 (hu)	2003-09-29
TR200401315T4 (tr)	2004-07-21
UA73789C2 (en)	2005-09-15
US20040038989A1 (en)	2004-02-26
YU3003A (sh)	2006-05-25
HK1058797A1 (en)	2004-06-04
EE200300036A (et)	2004-10-15
SI21040A (sl)	2003-04-30
HUP0301497A3 (en)	2005-08-29
EE05178B1 (et)	2009-06-15
EP1307441A1 (de)	2003-05-07
AU2001287638A1 (en)	2002-02-13
BR0112765A (pt)	2004-01-13
MXPA02012920A (es)	2004-04-20
DK1307441T3 (da)	2004-08-09
JP2004505073A (ja)	2004-02-19
CZ2003268A3 (cs)	2003-06-18
CN1204135C (zh)	2005-06-01
WO2002010149A1 (en)	2002-02-07
IL153515A0 (en)	2003-07-06
IL153515A (en)	2006-12-10
JP5107497B2 (ja)	2012-12-26
US6835734B2 (en)	2004-12-28
RU2276149C2 (ru)	2006-05-10
CZ301087B6 (cs)	2009-11-04
DE60103164T2 (de)	2005-05-04
KR100781403B1 (ko)	2007-12-03
ITMI20001734A0 (it)	2000-07-28
ITMI20001734A1 (it)	2002-01-28
SK892003A3 (en)	2003-09-11
DE60103164D1 (de)	2004-06-09
EP1307441B1 (de)	2004-05-06
ES2219562T3 (es)	2004-12-01
PL206307B1 (pl)	2010-07-30
CN1444578A (zh)	2003-09-24
PL361172A1 (en)	2004-09-20
SK286794B6 (sk)	2009-05-07
KR20030016425A (ko)	2003-02-26
IT1318650B1 (it)	2003-08-27

Legal Events

Date

Code

Title

Description

2004-11-15

UEP

Publication of translation of european patent specification

Ref document number: 1307441

Country of ref document: EP

2007-08-15

EEIH

Change in the person of patent owner

Publication	Publication Date	Title
DE69015650D1 (de)	1995-02-16	Herstellung von diamantverbundbeschichteten Schneidwerkzeugen.
PA8514401A1 (es)	2002-02-21	Nuevos derivados de piperazina
DE69022075D1 (de)	1995-10-05	Handwerkzeugmaschine zur Herstellung von kreisabschnittförmigen Nuten.
EA200300429A1 (ru)	2003-10-30	Способ получения порошковых композиций
EA200100826A1 (ru)	2002-02-28	16-галогенопроизводные эпотилона, способ их получения и их применение в фармацевтике
FI964565A0 (fi)	1996-11-14	Menetelmiä antihistamiinisten piperidiinijohdosten vedettömien ja hydratoituneiden muotojen, niiden polymorfien ja pseudomorfien, valmistamiseksi
ES2170735A1 (es)	2002-08-01	Metodo para la preparacion de citalopram.
ATE288414T1 (de)	2005-02-15	Herstellung von 2-amino-2(2-(4- alkylphenyl)äthyl)propan-1,3-diolen
SE9804002D0 (sv)	1998-11-23	New manufacturing process
IS6679A (is)	2003-01-14	Ný form (R)-N-[5-metýl-8-(4-metýlpíperasín-1-ýl)-1,2,3,4-tetrahýdró-2-naftýl]-4-morfólínóbensamíðs
DE60103164D1 (de)	2004-06-09	1,3-dioxolanen mit hustenhemmender wirkung
ATE275149T1 (de)	2004-09-15	Verfahren zur herstellung von taxanderivaten
FI916018A7 (fi)	1992-06-21	1,3-dioksolaanijohdannaisia kolesterolia alentavina aineina
BR0104738A (pt)	2002-06-25	Beta-hidroxialquilamidas, processo para sua produção e seu uso
IL153502A0 (en)	2003-07-06	2,2-disubstituted 1,3-dioxolanes as antitussive agents
AR027349A1 (es)	2003-03-26	Derivados de amidas heterociclicas
EA200100864A1 (ru)	2002-02-28	Способ получения 1,4,7,10-тетраазациклододекана
EA200001212A1 (ru)	2001-04-23	Усовершенствованный способ получения производных норбензоморфана с ценными фармацевтическими свойствами
UY26638A1 (es)	2001-10-25	Nuevos derivados de piperazina
DE59002266D1 (de)	1993-09-16	Verwendung von 4-(hydroxydi-phenylmethyl)-1-piperidyl-phenylalkan-derivaten zur herstellung eines antihistaminikums.
ATE71367T1 (de)	1992-01-15	Verfahren zur herstellung von indolinen.
DK1307440T3 (da)	2005-07-04	2,2-disubstituerede 1,3-dioxolaner som antihostemidler