ATE266655T1 - Dibenzopyrane als glucocorticoid-rezeptor- antagonisten für die behandlung von zuckerkrankheit - Google Patents
Dibenzopyrane als glucocorticoid-rezeptor- antagonisten für die behandlung von zuckerkrankheitInfo
- Publication number
- ATE266655T1 ATE266655T1 AT00959835T AT00959835T ATE266655T1 AT E266655 T1 ATE266655 T1 AT E266655T1 AT 00959835 T AT00959835 T AT 00959835T AT 00959835 T AT00959835 T AT 00959835T AT E266655 T1 ATE266655 T1 AT E266655T1
- Authority
- AT
- Austria
- Prior art keywords
- dibenzopyrane
- treatment
- receptor antagonists
- glucocorticoid receptor
- subject disease
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003850 glucocorticoid receptor antagonist Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38825199A | 1999-09-01 | 1999-09-01 | |
| PCT/US2000/024234 WO2001016128A1 (en) | 1999-09-01 | 2000-09-01 | Dibenzopyrans as glucocorticoid receptor antagonists for treatment of diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE266655T1 true ATE266655T1 (de) | 2004-05-15 |
Family
ID=23533319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00959835T ATE266655T1 (de) | 1999-09-01 | 2000-09-01 | Dibenzopyrane als glucocorticoid-rezeptor- antagonisten für die behandlung von zuckerkrankheit |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1208095B1 (de) |
| JP (1) | JP2003508393A (de) |
| AR (1) | AR034096A1 (de) |
| AT (1) | ATE266655T1 (de) |
| AU (1) | AU7109000A (de) |
| BR (1) | BR0009320A (de) |
| CA (1) | CA2381239A1 (de) |
| CO (1) | CO5180649A1 (de) |
| DE (1) | DE60010722T2 (de) |
| DK (1) | DK1208095T3 (de) |
| ES (1) | ES2220529T3 (de) |
| HK (1) | HK1047580B (de) |
| MX (1) | MXPA02002110A (de) |
| PT (1) | PT1208095E (de) |
| WO (1) | WO2001016128A1 (de) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6593480B2 (en) | 1999-09-01 | 2003-07-15 | Abbott Laboratories | Glucocorticoid receptor antagonists for treatment of diabetes |
| US7235662B2 (en) | 2003-06-11 | 2007-06-26 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
| GB0316290D0 (en) | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Novel compounds |
| PE20060272A1 (es) | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
| TWI307630B (en) | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
| EP1841780B1 (de) | 2005-01-10 | 2011-07-27 | Glaxo Group Limited | Androstan-17-alpha-carbonat-derivate zur verwendung bei der behandlung allergischer und entzündlicher zustände |
| MY145343A (en) | 2005-03-25 | 2012-01-31 | Glaxo Group Ltd | Novel compounds |
| PE20061193A1 (es) | 2005-03-25 | 2006-12-02 | Glaxo Group Ltd | DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38 |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| PE20071068A1 (es) | 2005-12-20 | 2007-12-13 | Glaxo Group Ltd | Acido 3-(4-{[4-(4-{[3-(3,3-dimetil-1-piperidinil)propil]oxi}fenil)-1-piperidinil]carbonil}-1-naftalenil)propanoico o propenoico, sales de los mismos, como antagonistas de los receptores h1 y h3 |
| MX2008013411A (es) | 2006-04-20 | 2008-11-04 | Glaxo Group Ltd | Nuevos compuestos. |
| GB0611587D0 (en) | 2006-06-12 | 2006-07-19 | Glaxo Group Ltd | Novel compounds |
| TW200820977A (en) | 2006-08-08 | 2008-05-16 | Organon Nv | Use of glucocorticoid receptor antagonists for treatment of infectious conditions |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| MX2010012814A (es) | 2008-05-23 | 2010-12-20 | Amira Pharmaceuticals Inc | Inhibidor de proteina activadora de 5-lipoxigenasa. |
| US8163743B2 (en) | 2008-06-05 | 2012-04-24 | GlaxoGroupLimited | 4-carboxamide indazole derivatives useful as inhibitors of PI3-kinases |
| ES2383246T3 (es) | 2008-06-05 | 2012-06-19 | Glaxo Group Limited | 4-amino-indazoles |
| US9216221B2 (en) | 2008-11-07 | 2015-12-22 | University Of Sheffield | Medicament and method of diagnosis for treating subclinical Cushing's syndrome |
| WO2010094643A1 (en) | 2009-02-17 | 2010-08-26 | Glaxo Group Limited | Quinoline derivatives and their uses for rhinitis and urticaria |
| JP5656880B2 (ja) | 2009-03-09 | 2015-01-21 | グラクソ グループ リミテッドGlaxo Group Limited | Pi3キナーゼの阻害剤としての4−オキサジアゾール−2−イル−インダゾール |
| WO2010102968A1 (en) | 2009-03-10 | 2010-09-16 | Glaxo Group Limited | Indole derivatives as ikk2 inhibitors |
| EP2408769A1 (de) | 2009-03-17 | 2012-01-25 | Glaxo Group Limited | Als itk-inhibitoren verwendete pyrimidinderivate |
| JP2012520684A (ja) | 2009-03-19 | 2012-09-10 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸(siNA)を用いたBTBandCNCHomology1(塩基性ロイシンジッパー転写因子1)(Bach1)遺伝子発現のRNA干渉媒介性阻害 |
| EP2408916A2 (de) | 2009-03-19 | 2012-01-25 | Merck Sharp&Dohme Corp. | Rna-interferenz-vermittelte hemmung der genexpression von ctgf (connective tissue growth factor) unter verwendung von sina (short interfering nucleic acid) |
| EP2408458A1 (de) | 2009-03-19 | 2012-01-25 | Merck Sharp&Dohme Corp. | Rna-schnittstellen-vermittelte unterdrückung der signal transducer and activator of transcription 6 (stat6) genexpression mit short interfering nucleic acid (sina) |
| US20120029054A1 (en) | 2009-03-19 | 2012-02-02 | Merck Sharp & Dohme Corp. | RNA Interference Mediated Inhibition of GATA Binding Protein 3 (GATA3) Gene Expression Using Short Intefering Nucleic Acid (siNA) |
| WO2010111497A2 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF THE INTERCELLULAR ADHESION MOLECULE 1 (ICAM-1)GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| EP2411520A2 (de) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | Rna-interferenz-vermittelte hemmung der genexpression von tslp (thymic stromal lymphopoietin) unter verwendung von sina (short interfering nucleic acid) |
| EP2411018A2 (de) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | Rna-interferenz-vermittelte hemmung der nervenwachstumsfaktor-betaketten (ngf9-gen-expression mittels sina (short interfering nucleic acid) |
| WO2010111471A2 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 (STAT1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| JP2012521760A (ja) | 2009-03-27 | 2012-09-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸(siNA)を用いたアポトーシスシグナル調節キナーゼ1(ASK1)遺伝子発現のRNA干渉媒介性阻害 |
| EP2421834A1 (de) | 2009-04-24 | 2012-02-29 | Glaxo Group Limited | Pyrazol- und triazolcarbonsäureamide als inhibitoren des crac-kanals |
| AR076373A1 (es) | 2009-04-24 | 2011-06-08 | Glaxo Group Ltd | N-pirazolil carboxamidas como inhibidores de canales de calcio |
| LT2899191T (lt) | 2009-04-30 | 2017-10-25 | Glaxo Group Limited | Oksazolo pakeistieji indazolai kaip pi3-kinazės inhibitoriai |
| WO2011067365A1 (en) | 2009-12-03 | 2011-06-09 | Glaxo Group Limited | Benzpyrazole derivatives as inhibitors of p13 kinases |
| WO2011067364A1 (en) | 2009-12-03 | 2011-06-09 | Glaxo Group Limited | Novel compounds |
| JP2013512880A (ja) | 2009-12-03 | 2013-04-18 | グラクソ グループ リミテッド | Pi3−キナーゼ阻害剤としてのインダゾール誘導体 |
| EP3020393B1 (de) | 2009-12-16 | 2020-10-07 | 3M Innovative Properties Company | Formulierungen und verfahren zur steuerung der mdi-partikelgrössenfreisetzung |
| WO2011110575A1 (en) | 2010-03-11 | 2011-09-15 | Glaxo Group Limited | Derivatives of 2-[2-(benzo- or pyrido-) thiazolylamino]-6-aminopyridine, useful in the treatment of respiratoric, allergic or inflammatory diseases |
| GB201007203D0 (en) | 2010-04-29 | 2010-06-16 | Glaxo Group Ltd | Novel compounds |
| RS54286B1 (sr) | 2010-09-08 | 2016-02-29 | Glaxosmithkline Intellectual Property Development Limited | Polimorfi i soli n-[5-[4-(5-{[(2r,6s)-2,6-dimetil-4-morfolinil]metil}-1,3-oksazol-2-il)-1h-indazol-6-il]-2(metiloksi)-3-piridinil]-metansulfonamida |
| US9326987B2 (en) | 2010-09-08 | 2016-05-03 | Glaxo Group Limited | Indazole derivatives for use in the treatment of influenza virus infection |
| WO2012035055A1 (en) | 2010-09-17 | 2012-03-22 | Glaxo Group Limited | Novel compounds |
| EP2630127A1 (de) | 2010-10-21 | 2013-08-28 | Glaxo Group Limited | Pyrazolverbindungen, gegen allergie-, entzündungs- und immunerkrankungen |
| US9156791B2 (en) | 2010-10-21 | 2015-10-13 | Glaxo Group Limited | Pyrazole compounds acting against allergic, immune and inflammatory conditions |
| GB201018124D0 (en) | 2010-10-27 | 2010-12-08 | Glaxo Group Ltd | Polymorphs and salts |
| EP2683716A1 (de) | 2011-03-11 | 2014-01-15 | Glaxo Group Limited | Pyrido[3,4-b]pyrazinderivate als syk-hemmer |
| GB201104153D0 (en) | 2011-03-11 | 2011-04-27 | Glaxo Group Ltd | Novel compounds |
| KR20160060100A (ko) | 2013-09-22 | 2016-05-27 | 칼리토르 사이언시즈, 엘엘씨 | 치환된 아미노피리미딘 화합물 및 이용 방법 |
| WO2015055691A1 (en) | 2013-10-17 | 2015-04-23 | Glaxosmithkline Intellectual Property Development Limited | Pi3k inhibitor for treatment of respiratory disease |
| RU2016112268A (ru) | 2013-10-17 | 2017-11-22 | Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Ингибитор PI3K для лечения респираторного заболевания |
| WO2015148867A1 (en) | 2014-03-28 | 2015-10-01 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| US20170100385A1 (en) | 2014-05-12 | 2017-04-13 | Glaxosmithkline Intellectual Property (No. 2) Limited | Pharmaceutical compositions comprising danirixin for treating infectious diseases |
| JP2018527362A (ja) | 2015-09-11 | 2018-09-20 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドSunshine Lake Pharma Co.,Ltd. | 置換されたヘテロアリール化合物および使用方法 |
| GB201602527D0 (en) | 2016-02-12 | 2016-03-30 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| US20190161480A1 (en) | 2016-08-08 | 2019-05-30 | Glaxosmithkline Intellectual Property Development Limited | Chemical Compounds |
| GB201706102D0 (en) | 2017-04-18 | 2017-05-31 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| GB201712081D0 (en) | 2017-07-27 | 2017-09-13 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| WO2019099311A1 (en) | 2017-11-19 | 2019-05-23 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use |
| WO2021191875A1 (en) | 2020-03-26 | 2021-09-30 | Glaxosmithkline Intellectual Property Development Limited | Cathepsin inhibitors for preventing or treating viral infections |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2091721B (en) * | 1980-10-20 | 1984-02-15 | Erba Farmitalia | 6-substituted 6h-dibezo(b,d)pyran derivatives and process for their preparation |
| BR9907788A (pt) * | 1998-02-13 | 2001-10-30 | Abbott Lab | Agentes antiinflamatórios seletivos paraglicocorticóides |
-
2000
- 2000-08-30 CO CO00065017A patent/CO5180649A1/es not_active Application Discontinuation
- 2000-08-31 AR ARP000104550A patent/AR034096A1/es not_active Application Discontinuation
- 2000-09-01 MX MXPA02002110A patent/MXPA02002110A/es not_active Application Discontinuation
- 2000-09-01 PT PT00959835T patent/PT1208095E/pt unknown
- 2000-09-01 HK HK02107584.5A patent/HK1047580B/en not_active IP Right Cessation
- 2000-09-01 DE DE60010722T patent/DE60010722T2/de not_active Expired - Lifetime
- 2000-09-01 JP JP2001519695A patent/JP2003508393A/ja not_active Withdrawn
- 2000-09-01 ES ES00959835T patent/ES2220529T3/es not_active Expired - Lifetime
- 2000-09-01 DK DK00959835T patent/DK1208095T3/da active
- 2000-09-01 AU AU71090/00A patent/AU7109000A/en not_active Abandoned
- 2000-09-01 AT AT00959835T patent/ATE266655T1/de not_active IP Right Cessation
- 2000-09-01 WO PCT/US2000/024234 patent/WO2001016128A1/en not_active Ceased
- 2000-09-01 EP EP00959835A patent/EP1208095B1/de not_active Expired - Lifetime
- 2000-09-01 CA CA002381239A patent/CA2381239A1/en not_active Abandoned
- 2000-09-01 BR BR0009320-3A patent/BR0009320A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02002110A (es) | 2002-11-07 |
| HK1047580A1 (en) | 2003-02-28 |
| AR034096A1 (es) | 2004-02-04 |
| DK1208095T3 (da) | 2004-09-20 |
| DE60010722D1 (de) | 2004-06-17 |
| PT1208095E (pt) | 2004-09-30 |
| BR0009320A (pt) | 2002-02-05 |
| EP1208095B1 (de) | 2004-05-12 |
| DE60010722T2 (de) | 2005-05-12 |
| JP2003508393A (ja) | 2003-03-04 |
| HK1047580B (en) | 2005-04-01 |
| WO2001016128A1 (en) | 2001-03-08 |
| ES2220529T3 (es) | 2004-12-16 |
| AU7109000A (en) | 2001-03-26 |
| CA2381239A1 (en) | 2001-03-08 |
| CO5180649A1 (es) | 2002-07-30 |
| EP1208095A1 (de) | 2002-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1208095 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |