BRPI0409592A - compostos imidazopiridina tendo atividade agonìstica do receptor 5-ht4 e atividade antagonìstica do receptor 5-ht3 - Google Patents
compostos imidazopiridina tendo atividade agonìstica do receptor 5-ht4 e atividade antagonìstica do receptor 5-ht3Info
- Publication number
- BRPI0409592A BRPI0409592A BRPI0409592-8A BRPI0409592A BRPI0409592A BR PI0409592 A BRPI0409592 A BR PI0409592A BR PI0409592 A BRPI0409592 A BR PI0409592A BR PI0409592 A BRPI0409592 A BR PI0409592A
- Authority
- BR
- Brazil
- Prior art keywords
- receptor
- activity
- compounds
- antagonistic activity
- agonistic activity
- Prior art date
Links
- 230000001270 agonistic effect Effects 0.000 title abstract 3
- 230000003042 antagnostic effect Effects 0.000 title abstract 3
- 108091005477 5-HT3 receptors Proteins 0.000 title 1
- 102000035037 5-HT3 receptors Human genes 0.000 title 1
- 108091005482 5-HT4 receptors Proteins 0.000 title 1
- 125000004857 imidazopyridinyl group Chemical class N1C(=NC2=C1C=CC=N2)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000006549 dyspepsia Diseases 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000005232 imidazopyridines Chemical class 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"COMPOSTOS IMIDAZOPIRIDINA TENDO ATIVIDADE AGONìSTICA DO RECEPTOR 5-HT~ 4~ E ATIVIDADE ANTAGONìSTICA DO RECEPTOR 5-HT~ 3~". A presente invenção refere-se a um composto com a fórmula (I): em que R¬ 1¬ representa um átomo de hidrogênio ou um átomo de halogênio; R¬ 2¬ representa um grupo metila ou um grupo etila; ou seus sais farmaceuticamente aceitáveis. Estes compostos têm atividade agonística do receptor 5-HT~ 4~ e atividade antagonística do receptor 5-HT~ 3~, e por conseguinte são úteis para o tratamento de doença de refluxo gastroesofágico, dispepsia sem úlcera, dispepsia funcional, síndrome do intestino irritável, diabetes ou semelhantes em mamíferos, especialmente humanos. A presente invenção também se relaciona com uma composição farmacêutica, um método de tratamento e utilização, compreendendo os compostos acima.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46426303P | 2003-04-21 | 2003-04-21 | |
| PCT/IB2004/001269 WO2004094418A1 (en) | 2003-04-21 | 2004-04-13 | Imidazopyridine compounds having 5-ht4 receptor agonistic activity and 5-ht3 receptor antagonistic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0409592A true BRPI0409592A (pt) | 2006-05-02 |
Family
ID=33310862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0409592-8A BRPI0409592A (pt) | 2003-04-21 | 2004-04-13 | compostos imidazopiridina tendo atividade agonìstica do receptor 5-ht4 e atividade antagonìstica do receptor 5-ht3 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20040266814A1 (pt) |
| EP (1) | EP1620435A1 (pt) |
| BR (1) | BRPI0409592A (pt) |
| CA (1) | CA2523077A1 (pt) |
| MX (1) | MXPA05011270A (pt) |
| WO (1) | WO2004094418A1 (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| TWI351282B (en) * | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| US20090170899A1 (en) * | 2004-09-14 | 2009-07-02 | Guy Debonnel | Stimulators of 5-HT4 receptors and uses thereof |
| ATE441646T1 (de) * | 2004-11-05 | 2009-09-15 | Theravance Inc | 5-ht4-rezeptoragonistenverbindungen |
| EP1807423B1 (en) * | 2004-11-05 | 2009-05-20 | Theravance, Inc. | Quinolinone-carboxamide compounds |
| ATE469897T1 (de) * | 2004-12-22 | 2010-06-15 | Theravance Inc | Indazolcarbonsäureamidverbindungen |
| NZ560828A (en) * | 2005-03-02 | 2011-01-28 | Theravance Inc | Quinolinone compounds as 5-HT4 receptor agonists |
| US8642772B2 (en) | 2008-10-14 | 2014-02-04 | Sk Biopharmaceuticals Co., Ltd. | Piperidine compounds, pharmaceutical composition comprising the same and its use |
| US8232315B2 (en) | 2009-06-26 | 2012-07-31 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating drug addiction and improving addiction-related behavior |
| MX350745B (es) | 2009-11-06 | 2017-09-14 | Sk Biopharmaceuticals Co Ltd * | El uso de un compuesto de carbamoilo para el tratamiento del sindrome de fibromialgia. |
| US8895609B2 (en) | 2009-11-06 | 2014-11-25 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating attention-deficit/hyperactivity disorder |
| US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
| US9610274B2 (en) | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
| MX368017B (es) | 2013-12-16 | 2019-09-13 | Suven Life Sciences Ltd | Compuestos de indazol como agonistas del receptor de 5-ht4. |
| EP4406616A3 (en) | 2014-11-06 | 2024-11-06 | Bial-R&D Investments, S.A. | Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders |
| US20170333435A1 (en) | 2014-11-06 | 2017-11-23 | Lysosomal Therapeutics Inc. | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
| US20180185368A1 (en) | 2014-11-06 | 2018-07-05 | Lysosomal Therapeutics Inc. | Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders |
| EP3440081A4 (en) | 2016-04-06 | 2019-09-18 | Lysosomal Therapeutics Inc. | PYRROLO [1,2-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER |
| CA3020305A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| AU2017246455B2 (en) | 2016-04-06 | 2021-09-30 | Bial - R&D Investments, S.A. | Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| WO2017192931A1 (en) * | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| KR102530515B1 (ko) | 2016-05-05 | 2023-05-09 | 비알 - 알&디 인베스트먼츠, 에스.에이. | 치환된 이미다조[1,2-b]피리다진, 치환된 이미다조[1,5-b]피리다진, 관련 화합물, 및 의학적 장애의 치료에서의 그의 용도 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9221468D0 (en) * | 1992-10-13 | 1992-11-25 | Smithkline Beecham Plc | Pharmaceuticals |
| US6069152A (en) * | 1997-10-07 | 2000-05-30 | Eli Lilly And Company | 5-HT4 agonists and antagonists |
| IT1303123B1 (it) * | 1998-10-13 | 2000-10-30 | Rotta Research Lab | Derivati basici di benz(e)isoindol-1-oni e pirrolo(3,4-c)chinolin-1-oni ad attivita' 5ht3 antagonista, loro preparazione ed |
| US6624162B2 (en) * | 2001-10-22 | 2003-09-23 | Pfizer Inc. | Imidazopyridine compounds as 5-HT4 receptor modulators |
| WO2003035649A1 (en) * | 2001-10-22 | 2003-05-01 | Pfizer Japan Inc. | Imidazopyridine compounds as 5-ht4 receptor modulators |
| JP2006502180A (ja) * | 2002-09-20 | 2006-01-19 | ファイザー株式会社 | ５−ｈｔ４レセプターモジュレーターとしてのｎ−置換されたピペリジニル−イミダゾピリジン化合物 |
| DOP2003000703A (es) * | 2002-09-20 | 2004-03-31 | Pfizer | Compuestos de imidazopiradina como agonistas del receptor 5-ht4 |
-
2004
- 2004-04-13 BR BRPI0409592-8A patent/BRPI0409592A/pt not_active Application Discontinuation
- 2004-04-13 WO PCT/IB2004/001269 patent/WO2004094418A1/en not_active Ceased
- 2004-04-13 CA CA002523077A patent/CA2523077A1/en not_active Abandoned
- 2004-04-13 EP EP04727067A patent/EP1620435A1/en not_active Withdrawn
- 2004-04-13 MX MXPA05011270A patent/MXPA05011270A/es unknown
- 2004-04-20 US US10/827,701 patent/US20040266814A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004094418A1 (en) | 2004-11-04 |
| MXPA05011270A (es) | 2006-01-24 |
| EP1620435A1 (en) | 2006-02-01 |
| CA2523077A1 (en) | 2004-11-04 |
| US20040266814A1 (en) | 2004-12-30 |
| WO2004094418A8 (en) | 2005-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |