ATE269858T1 - Kristallines oder kristallisiertes säureadditionssalz von losartan und verfahren zur reinigung von losartan - Google Patents
Kristallines oder kristallisiertes säureadditionssalz von losartan und verfahren zur reinigung von losartanInfo
- Publication number
- ATE269858T1 ATE269858T1 AT00126032T AT00126032T ATE269858T1 AT E269858 T1 ATE269858 T1 AT E269858T1 AT 00126032 T AT00126032 T AT 00126032T AT 00126032 T AT00126032 T AT 00126032T AT E269858 T1 ATE269858 T1 AT E269858T1
- Authority
- AT
- Austria
- Prior art keywords
- losartan
- crystalline
- acid addition
- addition salt
- purifying
- Prior art date
Links
- 239000002083 C09CA01 - Losartan Substances 0.000 title abstract 5
- KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 title abstract 5
- 229960004773 losartan Drugs 0.000 title abstract 5
- 239000002253 acid Substances 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34682999 | 1999-12-06 | ||
| JP2000282853A JP2001226372A (ja) | 1999-12-06 | 2000-09-19 | ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE269858T1 true ATE269858T1 (de) | 2004-07-15 |
Family
ID=26578371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00126032T ATE269858T1 (de) | 1999-12-06 | 2000-11-29 | Kristallines oder kristallisiertes säureadditionssalz von losartan und verfahren zur reinigung von losartan |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6350880B1 (de) |
| EP (1) | EP1106611B1 (de) |
| JP (1) | JP2001226372A (de) |
| AT (1) | ATE269858T1 (de) |
| DE (1) | DE60011739T2 (de) |
| ES (1) | ES2218051T3 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60304175T2 (de) * | 2002-04-29 | 2007-03-15 | Teva Pharmaceutical Industries Ltd. | Verfahren zur herstellung von losartan und losartan-kaliumsalz |
| RU2305092C2 (ru) * | 2002-05-09 | 2007-08-27 | Инститьют Оф Материя Медика, Чайниз Экедеми Оф Медикал Сайенсез | НОВЫЕ 2-(α-ГИДРОКСИПЕНТИЛ)БЕНЗОАТЫ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ |
| SI1589966T1 (sl) * | 2003-01-30 | 2011-06-30 | Lek Pharmaceuticals D.D. | Postopek čiščenja losartana |
| WO2006064945A1 (ja) * | 2004-12-14 | 2006-06-22 | Kyorin Pharmaceutical Co., Ltd. | ムスカリン受容体拮抗作用薬の製造方法及びその中間体 |
| TWI347942B (en) * | 2005-06-22 | 2011-09-01 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
| JP2010535743A (ja) * | 2007-08-08 | 2010-11-25 | レツク・フアーマシユーテイカルズ・デー・デー | オルメサルタンメドキソミルの調製のための方法 |
| WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| ZA875052B (en) * | 1986-07-11 | 1989-03-29 | Du Pont | Angiotensin ii receptor blocking imidazoles |
| DK0643704T3 (da) | 1991-11-18 | 2004-01-19 | Merck & Co Inc | Tetrazolylphenylboronsyremellemprodukter til syntese af All-receptor antagonister |
| US5464854A (en) * | 1993-11-11 | 1995-11-07 | Depadova; Anathony S. | Method of modifying ovarian hormone-regulated AT1 receptor activity as treatment of incapacitating symptom(s) of P.M.S. |
| AU685898B2 (en) | 1993-12-23 | 1998-01-29 | Du Pont Merck Pharmaceutical Company, The | Polymorphs of losartan and the process for the preparation of form II of losartan |
| PT937068E (pt) | 1996-10-29 | 2002-07-31 | Merck & Co Inc | Processo para a cristalizacao de losartan |
| IT1301759B1 (it) | 1998-06-19 | 2000-07-07 | Nicox Sa | Sali nitrati di farmaci antiipertensivi |
-
2000
- 2000-09-19 JP JP2000282853A patent/JP2001226372A/ja active Pending
- 2000-11-16 US US09/714,339 patent/US6350880B1/en not_active Expired - Fee Related
- 2000-11-29 DE DE60011739T patent/DE60011739T2/de not_active Expired - Lifetime
- 2000-11-29 AT AT00126032T patent/ATE269858T1/de not_active IP Right Cessation
- 2000-11-29 EP EP00126032A patent/EP1106611B1/de not_active Expired - Lifetime
- 2000-11-29 ES ES00126032T patent/ES2218051T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6350880B1 (en) | 2002-02-26 |
| EP1106611A1 (de) | 2001-06-13 |
| DE60011739D1 (de) | 2004-07-29 |
| ES2218051T3 (es) | 2004-11-16 |
| EP1106611B1 (de) | 2004-06-23 |
| JP2001226372A (ja) | 2001-08-21 |
| DE60011739T2 (de) | 2005-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |