ATE270281T1 - Benzothiazindioxid-endothelin antagonisten und verfahren zu ihrer herstellung - Google Patents

Benzothiazindioxid-endothelin antagonisten und verfahren zu ihrer herstellung

Info

Publication number
ATE270281T1
ATE270281T1 AT98942061T AT98942061T ATE270281T1 AT E270281 T1 ATE270281 T1 AT E270281T1 AT 98942061 T AT98942061 T AT 98942061T AT 98942061 T AT98942061 T AT 98942061T AT E270281 T1 ATE270281 T1 AT E270281T1
Authority
AT
Austria
Prior art keywords
production
endothelin antagonists
benzothiazine dioxide
benzothiazine
dioxide
Prior art date
Application number
AT98942061T
Other languages
English (en)
Inventor
Amy Mae Bunker
Xue-Min Cheng
Annette Marian Doherty
Chitase Lee
Joseph Thomas Repine
Richard Skeean
Jeremy John Edmunds
Gerald David Kanter
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE270281T1 publication Critical patent/ATE270281T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT98942061T 1997-09-05 1998-08-13 Benzothiazindioxid-endothelin antagonisten und verfahren zu ihrer herstellung ATE270281T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5811197P 1997-09-05 1997-09-05
US9232698P 1998-07-09 1998-07-09
PCT/US1998/016856 WO1999012916A1 (en) 1997-09-05 1998-08-13 Certain benzothiazine dioxide endothelin antagonists and processes for their preparation

Publications (1)

Publication Number Publication Date
ATE270281T1 true ATE270281T1 (de) 2004-07-15

Family

ID=26737251

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98942061T ATE270281T1 (de) 1997-09-05 1998-08-13 Benzothiazindioxid-endothelin antagonisten und verfahren zu ihrer herstellung

Country Status (24)

Country Link
US (5) US6265399B1 (de)
EP (1) EP1009743B1 (de)
JP (1) JP2001515893A (de)
KR (1) KR20010023686A (de)
AR (1) AR017056A1 (de)
AT (1) ATE270281T1 (de)
AU (1) AU759169B2 (de)
BR (1) BR9812431A (de)
CA (1) CA2296358A1 (de)
CO (1) CO4970725A1 (de)
DE (1) DE69824863T2 (de)
ES (1) ES2221191T3 (de)
HU (1) HUP0003689A3 (de)
IL (1) IL134057A0 (de)
IS (1) IS5356A (de)
MY (1) MY116277A (de)
NO (1) NO20001078D0 (de)
NZ (1) NZ502670A (de)
PE (1) PE116699A1 (de)
PL (1) PL338983A1 (de)
PT (1) PT1009743E (de)
TW (1) TW508355B (de)
UY (1) UY25168A1 (de)
WO (1) WO1999012916A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1009743E (pt) 1997-09-05 2004-09-30 Warner Lambert Co Certos antagonistas da endotelina a base de dioxido de benzotiazina e processos para a sua preparacao
EP1288199A4 (de) * 2000-04-28 2005-10-12 Shionogi & Co Mnp-12 inhibitoren
MXPA02010764A (es) * 2000-05-31 2003-03-10 Warner Lambert Co Combinaciones de un antagonista del receptor endotelina y un compuesto antiepileptico que tiene propiedades para aliviar el dolor o analgesico.
US20020115661A1 (en) * 2000-12-07 2002-08-22 Keller Laurence Harvey Method for treating chronic obstructive pulmonary disease
US7829552B2 (en) 2003-11-19 2010-11-09 Metabasis Therapeutics, Inc. Phosphorus-containing thyromimetics
FR2874011B1 (fr) * 2004-08-03 2007-06-15 Sanofi Synthelabo Derives de sulfonamides, leur preparation et leur application en therapeutique
DE102008026894A1 (de) * 2008-06-05 2009-12-10 Evonik Degussa Gmbh Ink Jet Tinte
WO2016090317A1 (en) * 2014-12-05 2016-06-09 Aquinnah Pharmaceuticals, Inc. Sulfonamide derivatives, compositions and methods of use in the treatment of neurodegenerative diseases
CN108727176B (zh) * 2018-07-26 2021-05-18 荆楚理工学院 一种制备5-卤-2,3-二羟基苯甲醛的方法
CN113214299A (zh) * 2021-03-01 2021-08-06 重庆西南制药二厂有限责任公司 γ-联苯双酯中间体及合成方法及γ-联苯双酯合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960856A (en) * 1975-06-20 1976-06-01 Warner-Lambert Company Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide
IN159273B (de) * 1981-10-05 1987-04-25 Pfizer
JPH0495057A (ja) * 1990-08-08 1992-03-27 Taisho Pharmaceut Co Ltd Ｎ―置換スルホンアニリド化合物
US5389620A (en) 1993-08-18 1995-02-14 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
AU675870B2 (en) * 1993-08-18 1997-02-20 Msd K.K. Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
JPH0912562A (ja) 1995-06-22 1997-01-14 Suntory Ltd 置換ベンゾチアジン誘導体
DE69433005T2 (de) 1993-12-24 2004-06-09 Daiichi Suntory Pharma Co., Ltd. Benzothiazinderivate
US5482960A (en) 1994-11-14 1996-01-09 Warner-Lambert Company Nonpeptide endothelin antagonists
US5599811A (en) * 1995-02-21 1997-02-04 Warner-Lambert Company Benzothiazine dioxides as endothelin antagonists
CA2190708A1 (en) 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
PT1009743E (pt) 1997-09-05 2004-09-30 Warner Lambert Co Certos antagonistas da endotelina a base de dioxido de benzotiazina e processos para a sua preparacao

Also Published As

Publication number Publication date
UY25168A1 (es) 1999-05-14
PE116699A1 (es) 1999-12-19
PT1009743E (pt) 2004-09-30
EP1009743A1 (de) 2000-06-21
US20030073684A1 (en) 2003-04-17
IL134057A0 (en) 2001-04-30
CO4970725A1 (es) 2000-11-07
BR9812431A (pt) 2000-09-19
US6440962B2 (en) 2002-08-27
AU759169B2 (en) 2003-04-10
US6545150B2 (en) 2003-04-08
CA2296358A1 (en) 1999-03-18
IS5356A (is) 2000-01-21
TW508355B (en) 2002-11-01
NO20001078L (no) 2000-03-02
ES2221191T3 (es) 2004-12-16
US6252070B1 (en) 2001-06-26
NO20001078D0 (no) 2000-03-02
US20010036944A1 (en) 2001-11-01
MY116277A (en) 2003-12-31
AU9019698A (en) 1999-03-29
US6265399B1 (en) 2001-07-24
NZ502670A (en) 2003-01-31
DE69824863D1 (de) 2004-08-05
DE69824863T2 (de) 2005-06-30
HUP0003689A3 (en) 2003-05-28
AR017056A1 (es) 2001-08-22
US20020094980A1 (en) 2002-07-18
WO1999012916A1 (en) 1999-03-18
HUP0003689A2 (hu) 2001-09-28
EP1009743B1 (de) 2004-06-30
KR20010023686A (ko) 2001-03-26
JP2001515893A (ja) 2001-09-25
PL338983A1 (en) 2000-12-04

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