IS5356A - Viss bensóþíasíndíoxíð-mótlyf gegn endóþelíni og ferli til að smíða þau - Google Patents

Viss bensóþíasíndíoxíð-mótlyf gegn endóþelíni og ferli til að smíða þau

Info

Publication number: IS5356A
Authority: IS; Iceland
Prior art keywords: making; certain; antagonists against; against endothelin; benzothiazine dioxide
Prior art date: 1997-09-05

Application number

IS5356A

Other languages

English (en)

Inventor

Mae Bunker Amy

Cheng Xue-Min

Marian Doherty Annette

Lee Chitase

Thomas Repine Joseph

Skeean Richard

John Edmunds Jeremy

David Kanter Gerald

Original Assignee

Warner-Lambert Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-05

Filing date

2000-01-21

Publication date

2000-01-21

2000-01-21 Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company

2000-01-21 Publication of IS5356A publication Critical patent/IS5356A/is

Links

GHNLJDPNIAIWOQ-UHFFFAOYSA-N 2h-1$l^{6},2-benzothiazine 1,1-dioxide Chemical compound C1=CC=C2S(=O)(=O)NC=CC2=C1 GHNLJDPNIAIWOQ-UHFFFAOYSA-N 0.000 title 1
102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

IS5356A 1997-09-05 2000-01-21 Viss bensóþíasíndíoxíð-mótlyf gegn endóþelíni og ferli til að smíða þau IS5356A (is)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US5811197P	1997-09-05	1997-09-05
US9232698P	1998-07-09	1998-07-09
PCT/US1998/016856 WO1999012916A1 (en)	1997-09-05	1998-08-13	Certain benzothiazine dioxide endothelin antagonists and processes for their preparation

Publications (1)

Publication Number	Publication Date
IS5356A true IS5356A (is)	2000-01-21

Family

ID=26737251

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS5356A IS5356A (is)	1997-09-05	2000-01-21	Viss bensóþíasíndíoxíð-mótlyf gegn endóþelíni og ferli til að smíða þau

Country Status (24)

Country	Link
US (5)	US6265399B1 (is)
EP (1)	EP1009743B1 (is)
JP (1)	JP2001515893A (is)
KR (1)	KR20010023686A (is)
AR (1)	AR017056A1 (is)
AT (1)	ATE270281T1 (is)
AU (1)	AU759169B2 (is)
BR (1)	BR9812431A (is)
CA (1)	CA2296358A1 (is)
CO (1)	CO4970725A1 (is)
DE (1)	DE69824863T2 (is)
ES (1)	ES2221191T3 (is)
HU (1)	HUP0003689A3 (is)
IL (1)	IL134057A0 (is)
IS (1)	IS5356A (is)
MY (1)	MY116277A (is)
NO (1)	NO20001078L (is)
NZ (1)	NZ502670A (is)
PE (1)	PE116699A1 (is)
PL (1)	PL338983A1 (is)
PT (1)	PT1009743E (is)
TW (1)	TW508355B (is)
UY (1)	UY25168A1 (is)
WO (1)	WO1999012916A1 (is)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL338983A1 (en)	1997-09-05	2000-12-04	Warner Lambert Co	Some dioxides of benzothiazine as antagonists of endothelin and methods of obtaining them
AU4882101A (en) *	2000-04-28	2001-11-12	Shionogi & Co., Ltd.	Mmp-12 inhibitors
EP1289558A2 (en) *	2000-05-31	2003-03-12	Warner-Lambert Company Llc	Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic
US20020115661A1 (en) *	2000-12-07	2002-08-22	Keller Laurence Harvey	Method for treating chronic obstructive pulmonary disease
EP2428516A1 (en)	2003-11-19	2012-03-14	Metabasis Therapeutics, Inc.	Novel phosphorus-containing thyromimetics
FR2874011B1 (fr) *	2004-08-03	2007-06-15	Sanofi Synthelabo	Derives de sulfonamides, leur preparation et leur application en therapeutique
DE102008026894A1 (de) *	2008-06-05	2009-12-10	Evonik Degussa Gmbh	Ink Jet Tinte
CA2969756A1 (en) *	2014-12-05	2016-06-09	Aquinnah Pharmaceuticals, Inc.	Sulfonamide derivatives, compositions and methods of use in the treatment of neurodegenerative diseases
CN108727176B (zh) *	2018-07-26	2021-05-18	荆楚理工学院	一种制备5-卤-2,3-二羟基苯甲醛的方法
CN113214299A (zh) *	2021-03-01	2021-08-06	重庆西南制药二厂有限责任公司	γ-联苯双酯中间体及合成方法及γ-联苯双酯合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3960856A (en) *	1975-06-20	1976-06-01	Warner-Lambert Company	Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide
IN159273B (is) *	1981-10-05	1987-04-25	Pfizer
JPH0495057A (ja) *	1990-08-08	1992-03-27	Taisho Pharmaceut Co Ltd	Ｎ―置換スルホンアニリド化合物
DK0714897T3 (da) *	1993-08-18	2001-03-19	Banyu Pharma Co Ltd	Ring-kondenseret heteroaromatisk cyclopentenderivat med endothelinantagonist-aktivitet
US5389620A (en)	1993-08-18	1995-02-14	Banyu Pharmaceutical Co., Ltd.	Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
ATE246682T1 (de)	1993-12-24	2003-08-15	Daiichi Suntory Pharma Co Ltd	Benzothiazinderivate
JPH0912562A (ja)	1995-06-22	1997-01-14	Suntory Ltd	置換ベンゾチアジン誘導体
US5482960A (en)	1994-11-14	1996-01-09	Warner-Lambert Company	Nonpeptide endothelin antagonists
US5599811A (en) *	1995-02-21	1997-02-04	Warner-Lambert Company	Benzothiazine dioxides as endothelin antagonists
CA2190708A1 (en)	1995-12-08	1997-06-09	Johannes Aebi	Aminoalkyl substituted benzo-heterocyclic compounds
PL338983A1 (en)	1997-09-05	2000-12-04	Warner Lambert Co	Some dioxides of benzothiazine as antagonists of endothelin and methods of obtaining them

1998
- 1998-08-13 PL PL98338983A patent/PL338983A1/xx unknown
- 1998-08-13 JP JP2000510724A patent/JP2001515893A/ja not_active Abandoned
- 1998-08-13 NZ NZ502670A patent/NZ502670A/xx unknown
- 1998-08-13 CA CA002296358A patent/CA2296358A1/en not_active Abandoned
- 1998-08-13 HU HU0003689A patent/HUP0003689A3/hu unknown
- 1998-08-13 AU AU90196/98A patent/AU759169B2/en not_active Ceased
- 1998-08-13 BR BR9812431-5A patent/BR9812431A/pt not_active Application Discontinuation
- 1998-08-13 US US09/445,504 patent/US6265399B1/en not_active Expired - Fee Related
- 1998-08-13 AT AT98942061T patent/ATE270281T1/de not_active IP Right Cessation
- 1998-08-13 ES ES98942061T patent/ES2221191T3/es not_active Expired - Lifetime
- 1998-08-13 DE DE69824863T patent/DE69824863T2/de not_active Expired - Fee Related
- 1998-08-13 WO PCT/US1998/016856 patent/WO1999012916A1/en not_active Ceased
- 1998-08-13 KR KR1020007002339A patent/KR20010023686A/ko not_active Withdrawn
- 1998-08-13 EP EP98942061A patent/EP1009743B1/en not_active Expired - Lifetime
- 1998-08-13 PT PT98942061T patent/PT1009743E/pt unknown
- 1998-08-13 IL IL13405798A patent/IL134057A0/xx unknown
- 1998-09-03 MY MYPI98004024A patent/MY116277A/en unknown
- 1998-09-04 PE PE1998000822A patent/PE116699A1/es not_active Application Discontinuation
- 1998-09-04 CO CO98050781A patent/CO4970725A1/es unknown
- 1998-09-04 AR ARP980104414A patent/AR017056A1/es unknown
- 1998-09-04 UY UY25168A patent/UY25168A1/es not_active IP Right Cessation
- 1998-10-28 TW TW087114760A patent/TW508355B/zh not_active IP Right Cessation
2000
- 2000-01-21 IS IS5356A patent/IS5356A/is unknown
- 2000-03-02 NO NO20001078A patent/NO20001078L/no unknown
- 2000-08-07 US US09/633,720 patent/US6252070B1/en not_active Expired - Fee Related
2001
- 2001-03-27 US US09/818,394 patent/US6440962B2/en not_active Expired - Fee Related
- 2001-12-05 US US10/006,589 patent/US6545150B2/en not_active Expired - Fee Related
2002
- 2002-06-03 US US10/161,569 patent/US20030073684A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20030073684A1 (en)	2003-04-17
PE116699A1 (es)	1999-12-19
US20010036944A1 (en)	2001-11-01
HUP0003689A3 (en)	2003-05-28
HUP0003689A2 (hu)	2001-09-28
DE69824863T2 (de)	2005-06-30
MY116277A (en)	2003-12-31
EP1009743A1 (en)	2000-06-21
ATE270281T1 (de)	2004-07-15
EP1009743B1 (en)	2004-06-30
US6440962B2 (en)	2002-08-27
KR20010023686A (ko)	2001-03-26
IL134057A0 (en)	2001-04-30
NO20001078D0 (no)	2000-03-02
ES2221191T3 (es)	2004-12-16
PL338983A1 (en)	2000-12-04
US20020094980A1 (en)	2002-07-18
UY25168A1 (es)	1999-05-14
AR017056A1 (es)	2001-08-22
WO1999012916A1 (en)	1999-03-18
CA2296358A1 (en)	1999-03-18
JP2001515893A (ja)	2001-09-25
DE69824863D1 (de)	2004-08-05
US6265399B1 (en)	2001-07-24
TW508355B (en)	2002-11-01
PT1009743E (pt)	2004-09-30
NZ502670A (en)	2003-01-31
NO20001078L (no)	2000-03-02
CO4970725A1 (es)	2000-11-07
US6545150B2 (en)	2003-04-08
US6252070B1 (en)	2001-06-26
BR9812431A (pt)	2000-09-19
AU759169B2 (en)	2003-04-10
AU9019698A (en)	1999-03-29

Publication	Publication Date	Title
ID19385A (id)	1998-07-09	Adesif termosetting dan metoda pembuatannya
DE59712267D1 (de)	2005-05-19	Optoelektronischer Wandler und dessen Herstellungsverfahren
IS8717A (is)	2008-03-03	Ísókínólín og framleiðsla þeirra
DK0915880T3 (da)	2008-02-11	Azolotriaziner og pyrimidiner
NO180145C (no)	1997-02-26	Tannbörste og tildannelse av samme
DE69424436D1 (de)	2000-06-15	Asymmetrischer würfeleckiger gegenstand und herstellungsverfahren
NO2010022I2 (no)	2015-03-30	Denosumab
NO972625L (no)	1997-08-06	Fibrin-tetningsapplikator
MA26668A1 (fr)	2004-12-20	ACTIVATEURS DE hPPARy ET hPPARa
DK0815861T3 (da)	2002-01-21	Sulfonamider og anvendelse deraf
DK0791190T3 (da)	2000-03-13	Signaleringsgenstande og fremgangsmåde til fremstilling af samme
ID23985A (id)	2000-06-14	Baterai dan metode pembuatannya
DE69826975D1 (de)	2004-11-18	Thermoelektrisches element und herstellungsverfahren dafür
DK1094733T3 (da)	2003-08-04	Fremgangsmåde til fremstilling af børstehårsvarer og børstehårsvarer fremstillet herefter
NO973519L (no)	1997-10-03	Fleravtapnings- bore- og produksjonsinnretning
DE69702805D1 (de)	2000-09-21	Vielseitige Massstabsveränderung von Zeichnungen
NO980987D0 (no)	1998-03-06	Bore- og produksjonsskip
NO20001078D0 (no)	2000-03-02	Visse benzotiazindioksid endothelin-antagonister og fremgangsmõte for fremstilling av disse
DK199801303A (da)	1999-04-16	Modtager og fremgangsmåde til fremstilling af samme
FR2751795B1 (fr)	1998-08-28	Cavite microlaser et microlaser a selection de mode, et procedes de fabrication
DE69842206D1 (de)	2011-05-12	Echounterdrücker und echounterdrückungsverfahren
ITBZ950045A0 (it)	1995-08-11	Gioiello e procedimento per la realizzazione dello stesso.
ID19103A (id)	1998-06-11	Montasi tombol putaran
FI963955A0 (fi)	1996-10-03	Markeringsboll och dess monteringsfoerfarande foer hoegspaenningsledningar
ATA185596A (de)	1998-06-15	Schmuckstück