ATE272654T1 - Neue vernetzte derivate der hyaluronsäure. - Google Patents

Neue vernetzte derivate der hyaluronsäure.

Info

Publication number
ATE272654T1
ATE272654T1 AT01982230T AT01982230T ATE272654T1 AT E272654 T1 ATE272654 T1 AT E272654T1 AT 01982230 T AT01982230 T AT 01982230T AT 01982230 T AT01982230 T AT 01982230T AT E272654 T1 ATE272654 T1 AT E272654T1
Authority
AT
Austria
Prior art keywords
derivatives
hyaluronic acid
linked derivatives
cross
preparation
Prior art date
Application number
AT01982230T
Other languages
English (en)
Inventor
Davide Renier
Vittorio Crescenzi
Andrea Francescangeli
Original Assignee
Fidia Farmaceutici
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Farmaceutici filed Critical Fidia Farmaceutici
Application granted granted Critical
Publication of ATE272654T1 publication Critical patent/ATE272654T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Dental Preparations (AREA)
AT01982230T 2000-08-31 2001-08-31 Neue vernetzte derivate der hyaluronsäure. ATE272654T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000PD000207A IT1317358B1 (it) 2000-08-31 2000-08-31 Derivati cross-linkati dell'acido ialuronico.
PCT/EP2001/010063 WO2002018450A1 (en) 2000-08-31 2001-08-31 New cross-linked derivatives of hyaluronic acid

Publications (1)

Publication Number Publication Date
ATE272654T1 true ATE272654T1 (de) 2004-08-15

Family

ID=11452055

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01982230T ATE272654T1 (de) 2000-08-31 2001-08-31 Neue vernetzte derivate der hyaluronsäure.

Country Status (10)

Country Link
US (1) US7125860B1 (de)
EP (1) EP1313772B1 (de)
JP (1) JP2004507588A (de)
AT (1) ATE272654T1 (de)
AU (2) AU1387002A (de)
CA (1) CA2423384C (de)
DE (1) DE60104703T2 (de)
ES (1) ES2227297T3 (de)
IT (1) IT1317358B1 (de)
WO (1) WO2002018450A1 (de)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60218375D1 (de) 2001-03-30 2007-04-12 Chisso Corp Pharmazeutische Zusammensetzung zur Behandlung gynäkologischer Erkrankungen
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
ITPD20020003A1 (it) * 2002-01-11 2003-07-11 Fidia Advanced Biopolymers Srl Biomateriali a base di acido ialuronico come terapia anti-angiogenicanella cura dei tumori.
CA2496121C (en) * 2002-08-16 2010-03-30 Yoshiaki Miyata Stable formulations of hyaluronic acid for use in the therapeutic treatment of arthropathy
ITPD20020271A1 (it) 2002-10-18 2004-04-19 Fidia Farmaceutici Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati.
CA2509914A1 (en) 2002-12-11 2004-06-24 Ferrosan A/S Gelatine-based materials as swabs
WO2004060404A1 (ja) * 2002-12-27 2004-07-22 Chugai Seiyaku Kabushiki Kaisha 薬物担体
US8138265B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8137688B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US6982298B2 (en) * 2003-01-10 2006-01-03 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
JP4459543B2 (ja) * 2003-03-17 2010-04-28 株式会社メドジェル 徐放性ハイドロゲル製剤
AR054637A1 (es) 2004-01-30 2007-07-11 Ferrosan As Aerosoles y composiciones hemostaticas
ITPD20040053A1 (it) * 2004-02-27 2004-05-27 Fidia Advanced Biopolymers Srl Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi
CN101001649B (zh) 2004-07-09 2011-08-31 弗罗桑医疗设备公司 包括透明质酸的止血组合物及其制备方法
CA2572804C (en) * 2004-07-09 2013-04-02 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
ITPD20050242A1 (it) 2005-08-03 2007-02-04 Fidia Farmaceutici Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico
KR20080080481A (ko) * 2005-09-02 2008-09-04 콜바르 라이프사이언스 리미티드 교차-결합된 다당류 및 단백질 매트릭스 및 그의 제조 방법
ES2747978T3 (es) 2005-10-03 2020-03-12 Mark A Pinsky Liposomas no fosfolipídicos que comprenden ácido hialurónico
CN100348621C (zh) * 2005-12-02 2007-11-14 凌沛学 透明质酸铋及其制备方法和应用
CN101501075B (zh) * 2006-08-04 2013-07-10 诺维信生物制药丹麦公司 支化透明质酸和制造方法
ITMI20061726A1 (it) * 2006-09-11 2008-03-12 Fidia Farmaceutici Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
ITMI20071267A1 (it) 2007-06-22 2008-12-23 Fidia Farmaceutici Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative
ITMI20071724A1 (it) 2007-09-05 2009-03-06 Fidia Farmaceutici Formulazioni topiche antivirali in forma di gel bioadesivo
GB0722507D0 (en) * 2007-11-19 2007-12-27 Zhao Xiaobin Hyaluronic acid personal lubricant
RU2366666C1 (ru) * 2007-12-20 2009-09-10 Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН Способ получения сшитых солей гиалуроновой кислоты в водной среде
ES2585483T3 (es) 2008-02-13 2016-10-06 The Cleveland Clinic Foundation Mejora molecular de la matriz extracelular y métodos de uso
CN102014973A (zh) 2008-02-29 2011-04-13 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的装置
CA2722145A1 (en) 2008-04-24 2009-10-29 Medtronic, Inc. Rehydratable thiolated polysaccharide particles and sponge
EP2296637B1 (de) 2008-04-24 2014-04-02 Medtronic, Inc Chitosan enthaltende schutz-zusammensetzung
CA2721937C (en) 2008-04-24 2016-07-12 Medtronic, Inc. Protective gel based on chitosan and oxidized polysaccharide
US8653319B2 (en) 2008-04-24 2014-02-18 Medtronic, Inc. Cold ionizing radiation sterilization
US8410180B2 (en) 2008-04-30 2013-04-02 The Cleveland Clinic Foundation Methods to treat urinary incontinence
CA2735173C (en) 2008-09-02 2017-01-10 Tautona Group Lp Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
KR101092301B1 (ko) 2009-06-04 2011-12-13 포항공과대학교 산학협력단 히알루로난 하이드로겔의 ｘ-선 절삭법
IT1399351B1 (it) 2009-06-16 2013-04-16 Fidia Farmaceutici Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
IT1395392B1 (it) 2009-08-27 2012-09-14 Fidia Farmaceutici Geli viscoelastici come nuovi filler
CZ302503B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace
CZ2009836A3 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace
CN101831005B (zh) * 2010-04-27 2012-08-15 中国药科大学 pH敏感型壳聚糖衍生物及其在药剂学中的应用
ES2385239B1 (es) 2010-09-30 2013-06-19 Proteos Biotech S.L.U. Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno.
CZ304072B6 (cs) * 2011-04-26 2013-09-25 Contipro Biotech S.R.O. Amfoterní materiál na bázi sítované kyseliny hyaluronové, zpusob jeho prípravy, materiály obsahující aktivní cinidla uzavrené v síti hyaluronanu, zpusob jejich prípravy a jejich pouzití
CZ303879B6 (cs) 2012-02-28 2013-06-05 Contipro Biotech S.R.O. Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití
WO2013131520A2 (en) 2012-03-06 2013-09-12 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
CZ2012282A3 (cs) * 2012-04-25 2013-11-06 Contipro Biotech S.R.O. Zesítovaný derivát hyaluronanu, zpusob jeho prípravy, hydrogel a mikrovlákna na jeho bázi
RU2636240C2 (ru) 2012-06-12 2017-11-21 Ферросан Медикал Дивайсиз А/С Сухая гемостатическая композиция
KR101443673B1 (ko) * 2012-08-07 2014-09-26 주식회사 제네웰 히알루론산 유도체 스펀지의 제조방법 및 그에 의하여 제조된 히알루론산 유도체 스펀지
CZ304512B6 (cs) 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
CZ304654B6 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
EP3010419B1 (de) 2013-06-21 2020-05-20 Ferrosan Medical Devices A/S Vakuumerweiterte trockenzusammensetzung und spritze zum zurückhalten davon
JP6489485B2 (ja) 2013-12-11 2019-03-27 フェロサン メディカル デバイシーズ エイ／エス 押し出し増強因子を含んでいる乾燥組成物
CZ2014150A3 (cs) 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití
CN106716233B (zh) * 2014-05-09 2019-11-05 茵洛有限公司 具有润湿性表面的水凝胶隐形镜片及其制备方法
CA2950535C (en) 2014-06-15 2023-03-28 Yeda Research And Development Co. Ltd. Surface treatment by water-soluble polymers and lipids/liposomes
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
CA2960309A1 (en) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
RU2705905C2 (ru) 2014-12-24 2019-11-12 Ферросан Медикал Дивайсиз А/С Шприц для удерживания и смешивания первого и второго веществ
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
CZ2015398A3 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
US20160367705A1 (en) * 2015-06-16 2016-12-22 New York University Nanoparticles comprised of shells associated with charged entities and formed from monomers and methods of making and using nanoparticles
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
AU2016290433B2 (en) 2015-07-03 2018-05-24 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
KR101784863B1 (ko) 2015-09-03 2017-10-13 (주)진우바이오 히알루론산염이 코팅된 고 기능성 봉합사의 제조방법 및 이로부터 제조된 고 기능성 봉합사
EP3252082A1 (de) * 2016-05-31 2017-12-06 Galderma S.A. Verfahren zur deacetylierung von biopolymeren
ES2962687T3 (es) 2015-12-29 2024-03-20 Galderma Holding SA Reticulación de carbohidratos
EP3252080A1 (de) * 2016-05-31 2017-12-06 Galderma S.A. Verfahren zur herstellung von acylierten vernetzten glykosaminoglykanen
EP3252081A1 (de) * 2016-05-31 2017-12-06 Galderma S.A. Hydrolyse von esterbindungen in amid-kreuzverbundenen glykosaminoglykanen
ITUB20169882A1 (it) * 2016-01-08 2017-07-08 Flame S R L Vitamina E per l’uso nel trattamento e nella prevenzione delle infezioni da biofilm.
AU2017257956B2 (en) 2016-04-27 2019-11-07 Anika Therapeutics, Inc. Compositions for use in treating tendon degeneration
PT3623390T (pt) 2016-05-31 2023-10-27 Galderma Sa Reticulador de hidrato de carbono
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
US10590257B2 (en) 2016-09-26 2020-03-17 The Board Of Trustees Of The Leland Stanford Junior University Biomimetic, moldable, self-assembled cellulose silica-based trimeric hydrogels and their use as viscosity modifying carriers in industrial applications
IL250852B (en) * 2017-02-28 2018-02-28 Prudentix Ltd Periodontal preparation
JP7216006B2 (ja) 2017-03-22 2023-01-31 ジェネンテック， インコーポレイテッド ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法
US11969526B2 (en) 2017-04-03 2024-04-30 The Board Of Trustees Of The Leland Stanford Junior University Adhesion prevention with shear-thinning polymeric hydrogels
US11975123B2 (en) 2018-04-02 2024-05-07 The Board Of Trustees Of The Leland Stanford Junior University Adhesion prevention with shear-thinning polymeric hydrogels
US12599706B2 (en) 2017-04-03 2026-04-14 The Board Of Trustees Of The Leland Stanford Junior University Adhesion prevention with shear-thinning polymeric hydrogels
CN109956727B (zh) * 2017-12-14 2020-04-10 北新集团建材股份有限公司 一种除甲醛的纸面石膏板及其制备方法
US11413023B2 (en) 2018-01-10 2022-08-16 The Provost, Fellows, Scholars And Other Members Of Board Of Trinity College Dublin System and methods for sealing a channel in tissue
WO2020144372A1 (en) 2019-01-10 2020-07-16 The Provost, Fellows, Scholars And Other Members Of Board Of Trinity College Dublin Composite viscoelastic hydrogel, and uses thereof for sealing a channel in tissue
ES2968412T3 (es) 2018-05-09 2024-05-09 Ferrosan Medical Devices As Método para preparar una composición hemostática
KR102248721B1 (ko) * 2018-09-13 2021-05-07 주식회사 엘지화학 황산화 히알루론산 기반의 하이드로겔 및 이를 포함하는 약제학적 조성물
EP3860613B1 (de) 2018-10-01 2025-09-10 The Board of Trustees of the Leland Stanford Junior University Injizierbare hydrogele zur kontrollierten freisetzung immunmodulatorischer verbindungen
CN109721744B (zh) * 2018-12-26 2020-06-16 清华大学 一种基于硼酸酯键的自修复抗菌水凝胶
CN109575269B (zh) * 2019-02-02 2020-06-02 清华大学 一种具有双重动态网络的自愈性水凝胶及其制备方法
EP3976123A1 (de) 2019-05-31 2022-04-06 University College Dublin Hyaluronsäurebasiertes hybridhydrogel
EP3994183B1 (de) 2019-07-03 2026-06-24 Molly Sandra Shoichet Hydrogelzusammensetzungen und verwendungen davon
KR20200055645A (ko) * 2019-08-08 2020-05-21 고려대학교 산학협력단 황산화된 히알루론산 유도체, 이의 제조방법 및 이를 포함하는 근골격계 관절질환의 예방 또는 치료용 약학 조성물
AU2020395955A1 (en) 2019-12-02 2022-07-14 Galderma Holding SA High molecular weight esthetic compositions
CN113024845A (zh) * 2021-03-17 2021-06-25 广西医科大学 一种醛肼交联型抗菌水凝胶敷料的制备方法
JP2025502169A (ja) 2022-01-11 2025-01-24 ワイコ・エセペア 革新的充填剤としての新規なヒアルロン酸誘導体
IT202300023433A1 (it) 2023-11-07 2025-05-07 Univ Degli Studi Di Catania Derivati di acido ialuronico fotogeneratori di ossido nitrico
CN117959485B (zh) * 2023-11-29 2026-07-24 浙江大学绍兴研究院 一种含类肽的抗菌水凝胶及其制备方法和应用
IT202400006892A1 (it) 2024-03-27 2025-09-27 Gpq S R L Riempitivi tissutali polisaccaridici reticolati con resveratrolo
WO2026104986A1 (en) 2024-11-12 2026-05-21 Fidia Farmaceutici S.P.A. New molecules and their use in the treatment of pathologies related to oxidative stress

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2953702B2 (ja) * 1989-01-20 1999-09-27 生化学工業株式会社 合成コンドロイチン硫酸プロテオグリカンを含有する組織癒着防止剤
US5616568A (en) * 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid

Also Published As

Publication number Publication date
EP1313772A1 (de) 2003-05-28
CA2423384A1 (en) 2002-03-07
JP2004507588A (ja) 2004-03-11
DE60104703D1 (de) 2004-09-09
AU1387002A (en) 2002-03-13
US7125860B1 (en) 2006-10-24
EP1313772B1 (de) 2004-08-04
CA2423384C (en) 2009-11-24
WO2002018450A1 (en) 2002-03-07
ITPD20000207A0 (it) 2000-08-31
IT1317358B1 (it) 2003-06-16
ITPD20000207A1 (it) 2002-03-03
ES2227297T3 (es) 2005-04-01
DE60104703T2 (de) 2005-07-14
AU2002213870B2 (en) 2005-11-03

Similar Documents

Publication Publication Date Title
DE60104703D1 (de) Neue vernetzte derivate der hyaluronsäure.
Kim et al. Co‐delivery of platelet‐derived growth factor (PDGF‐BB) and bone morphogenic protein (BMP‐2) coated onto heparinized titanium for improving osteoblast function and osteointegration
IL174561A0 (en) Drug coating providing high drug loading and methods for providing the same
WO2004039428A3 (en) Transdermal delivery system for dried particulate or lyophilized medications
EP2266590A3 (de) Wirkstoff-Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Wirkstoffen
ATE230978T1 (de) Verfahren und zubereitungen zum verbessern der bioadhäsiv-eigenschaften von polymeren unter verwendung organischer excipienten
WO2004094495A3 (en) Compositions and methods of using a transient colorant
ATE252919T1 (de) Zusammensetzungen und ihre verwendung zur verhütung von verklebungen zwischen körpergewebe
CY1110177T1 (el) Ω-καρβοξυαρυλο υποκατεστημενες διφαινυλουριες ως αναστολεις της raf κινασης
EP1140840A4 (de) -g(v)-carboxyaryl substituierte diphenyl harnstoffe als raf kinase inhibitoren
SI3404102T1 (sl) Konjugati za dodajanje kostem in njihova uporaba za ciljanje beljakovin na kosti
EP2664618A3 (de) Chemokinrezeptormodulatoren
CY1105120T1 (el) Η αντιμετωπιση αναπνευστικων νοσων
ATE345775T1 (de) Zusammensetzungen zur verabreichung von arzneimittelkombinationen
SE9300581L (sv) Komposition för nasalbehandling
BRPI0509074A (pt) composições farmacêuticas compreendendo agonistas do receptor da tiróide
BR0009472A (pt) Antagonistas de lhrh com propriedades desolubilidade aperfeiçoadas
CY1106967T1 (el) Παραγωγα πεπτιδιων χαμηλου μοριακου βαρους ως αναστολεις της αλληλεπιδρασης λαμινινης/εντακτινης
NO20082848L (no) Farmasoytisk formulering for behandling av osteoartritt inneholdende klodronsyre og hyaluronsyre
Vedakumari et al. Physiologically clotted fibrin–preparation and characterization for tissue engineering and drug delivery applications
AU2003251728A1 (en) Placental growth factor as a target for the treatment of osteoporosis
TW200630121A (en) Immediate release film coating
BR0011845A (pt) Complexo farmacêutico
BR9908394A (pt) Composições de hidroxipropilcelulose e de polìmero aniÈnico e uso das mesmas como revestimentos de pelìcula farmacêuticos
CA2486571A1 (en) Pharmaceutical composition

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties