ATE273514T1 - Methode zum bestimmen der aktivierung von zytokinrezeptoren mit hilfe eines antikörpers - Google Patents

Methode zum bestimmen der aktivierung von zytokinrezeptoren mit hilfe eines antikörpers

Info

Publication number
ATE273514T1
ATE273514T1 AT98911331T AT98911331T ATE273514T1 AT E273514 T1 ATE273514 T1 AT E273514T1 AT 98911331 T AT98911331 T AT 98911331T AT 98911331 T AT98911331 T AT 98911331T AT E273514 T1 ATE273514 T1 AT E273514T1
Authority
AT
Austria
Prior art keywords
antibody
receptor
conformation
inactive
growth hormone
Prior art date
Application number
AT98911331T
Other languages
English (en)
Inventor
Alonso Carlos Martinez
Garcia Jose Mario Mellado
Baron Leonor Kremer
Frade Jose Miguel Rodriguez
Original Assignee
Pharmacia Spain S A
Consejo Superior Investigacion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spain S A, Consejo Superior Investigacion filed Critical Pharmacia Spain S A
Application granted granted Critical
Publication of ATE273514T1 publication Critical patent/ATE273514T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/61—Growth hormones [GH] (Somatotropin)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
AT98911331T 1997-03-19 1998-03-19 Methode zum bestimmen der aktivierung von zytokinrezeptoren mit hilfe eines antikörpers ATE273514T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9701010A SE9701010D0 (sv) 1997-03-19 1997-03-19 Antibody
PCT/SE1998/000496 WO1998041872A1 (en) 1997-03-19 1998-03-19 Method for determining cytokine receptor activation by the use of an antibody

Publications (1)

Publication Number Publication Date
ATE273514T1 true ATE273514T1 (de) 2004-08-15

Family

ID=20406234

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98911331T ATE273514T1 (de) 1997-03-19 1998-03-19 Methode zum bestimmen der aktivierung von zytokinrezeptoren mit hilfe eines antikörpers

Country Status (13)

Country Link
US (1) US6645723B2 (de)
EP (1) EP0979410B1 (de)
JP (1) JP2001524816A (de)
AT (1) ATE273514T1 (de)
AU (1) AU739758B2 (de)
CA (1) CA2285036A1 (de)
DE (1) DE69825583T2 (de)
DK (1) DK0979410T3 (de)
ES (1) ES2224367T3 (de)
NZ (1) NZ337636A (de)
PT (1) PT979410E (de)
SE (1) SE9701010D0 (de)
WO (1) WO1998041872A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6821738B2 (en) 1999-01-20 2004-11-23 The Board Of Regents For Oklahoma State University Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents
GB9904395D0 (en) * 1999-02-25 1999-04-21 Fluorescience Ltd Protein assay
US6972198B2 (en) * 1999-02-26 2005-12-06 Cyclacel, Ltd. Methods and compositions using protein binding partners
DE10306992A1 (de) * 2003-02-19 2005-08-11 Klinikum der Universität München Großhadern-Innenstadt Verfahren zur quantitativen Messung von Liganden in der Probe gelöster Bindungsproteine
SE0301917D0 (sv) 2003-06-30 2003-06-30 Biovitrum Ab Methods for identifying active compounds
JP2005325055A (ja) * 2004-05-14 2005-11-24 Peptide Door Co Ltd リガンド結合タンパク質含有複合体及びリガンド結合タンパク質に結合する物質のスクリーニング方法
JP6930916B2 (ja) * 2015-02-12 2021-09-01 ユニヴァーシティ オブ サザン カリフォルニアＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｓｏｕｔｈｅｒｎ Ｃａｌｉｆｏｒｎｉａ 疾患予防および治療における成長ホルモン受容体の遮断剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593844A (en) 1990-11-19 1997-01-14 Genentech, Inc. Ligand-mediated immunofunctional hormone binding protein assay method
JP3417558B2 (ja) 1991-05-10 2003-06-16 ジェネンテク，インコーポレイテッド 配位子作用薬および拮抗薬の選択
WO1993021230A1 (en) * 1992-04-10 1993-10-28 Dana-Farber Cancer Institute, Inc. Activation-state-specific phosphoprotein immunodetection
US5470952A (en) * 1993-10-20 1995-11-28 Regeneron Pharmaceuticals, Inc. CNTF and IL-6 antagonists

Also Published As

Publication number Publication date
AU6530498A (en) 1998-10-12
NZ337636A (en) 2001-06-29
US6645723B2 (en) 2003-11-11
DK0979410T3 (da) 2004-11-22
AU739758B2 (en) 2001-10-18
ES2224367T3 (es) 2005-03-01
EP0979410B1 (de) 2004-08-11
JP2001524816A (ja) 2001-12-04
DE69825583D1 (de) 2004-09-16
CA2285036A1 (en) 1998-09-24
PT979410E (pt) 2004-11-30
DE69825583T2 (de) 2005-08-11
SE9701010D0 (sv) 1997-03-19
EP0979410A1 (de) 2000-02-16
US20030077663A1 (en) 2003-04-24
WO1998041872A1 (en) 1998-09-24

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