ATE274522T1 - Abtrennung von antikörper-monomeren von deren multimeren mittels ionaustausch-chromatographie - Google Patents

Abtrennung von antikörper-monomeren von deren multimeren mittels ionaustausch-chromatographie

Info

Publication number
ATE274522T1
ATE274522T1 AT99925856T AT99925856T ATE274522T1 AT E274522 T1 ATE274522 T1 AT E274522T1 AT 99925856 T AT99925856 T AT 99925856T AT 99925856 T AT99925856 T AT 99925856T AT E274522 T1 ATE274522 T1 AT E274522T1
Authority
AT
Austria
Prior art keywords
multimers
exchange chromatography
separation
ion exchange
mixture
Prior art date
Application number
AT99925856T
Other languages
English (en)
Inventor
Deborah Ansaldi
Philip Lester
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22206161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE274522(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE274522T1 publication Critical patent/ATE274522T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT99925856T 1998-06-01 1999-05-24 Abtrennung von antikörper-monomeren von deren multimeren mittels ionaustausch-chromatographie ATE274522T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8760298P 1998-06-01 1998-06-01
PCT/US1999/011598 WO1999062936A1 (en) 1998-06-01 1999-05-24 Separation of protein monomers from aggregates by use of ion-exchange chromatography

Publications (1)

Publication Number Publication Date
ATE274522T1 true ATE274522T1 (de) 2004-09-15

Family

ID=22206161

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99925856T ATE274522T1 (de) 1998-06-01 1999-05-24 Abtrennung von antikörper-monomeren von deren multimeren mittels ionaustausch-chromatographie

Country Status (12)

Country Link
US (2) US6620918B2 (de)
EP (2) EP1500661A1 (de)
JP (3) JP2002517406A (de)
AT (1) ATE274522T1 (de)
AU (1) AU750977B2 (de)
CA (1) CA2333747C (de)
DE (1) DE69919701T2 (de)
DK (1) DK1084136T3 (de)
ES (1) ES2228052T3 (de)
IL (2) IL139609A (de)
PT (1) PT1084136E (de)
WO (1) WO1999062936A1 (de)

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CN112649538B (zh) * 2015-04-28 2024-03-29 深圳翰宇药业股份有限公司 多肽混合物高效液相色谱分析方法
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JP6749590B2 (ja) * 2015-09-17 2020-09-02 国立大学法人 東京大学 酸化型及び還元型アルブミンの分析方法、酸化型及び還元型アルブミンの分析装置、及び酸化型及び還元型アルブミンの分析キット
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JP7840636B2 (ja) 2018-04-02 2026-04-06 アムジェン インコーポレイテッド エレヌマブ組成物及びその使用
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Also Published As

Publication number Publication date
HK1037879A1 (en) 2002-02-22
JP2006071646A (ja) 2006-03-16
JP2004175806A (ja) 2004-06-24
IL139609A0 (en) 2002-02-10
AU750977B2 (en) 2002-08-01
EP1084136A1 (de) 2001-03-21
DE69919701D1 (de) 2004-09-30
US20040116674A1 (en) 2004-06-17
CA2333747C (en) 2008-02-19
AU4205999A (en) 1999-12-20
EP1500661A1 (de) 2005-01-26
DE69919701T2 (de) 2005-09-15
CA2333747A1 (en) 1999-12-09
US6620918B2 (en) 2003-09-16
PT1084136E (pt) 2004-12-31
WO1999062936A1 (en) 1999-12-09
EP1084136B1 (de) 2004-08-25
IL173432A0 (en) 2006-06-11
ES2228052T3 (es) 2005-04-01
JP2002517406A (ja) 2002-06-18
US20020010319A1 (en) 2002-01-24
IL139609A (en) 2006-06-11
DK1084136T3 (da) 2005-01-03

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