ATE341617T1 - Prozess zur reinigung von vitamin k abhängigen koagulationsfaktoren durch chromatographie - Google Patents

Prozess zur reinigung von vitamin k abhängigen koagulationsfaktoren durch chromatographie

Info

Publication number: ATE341617T1
Authority: AT; Austria
Prior art keywords: vitamin; factors; chromatography; dependent; coagulation factors
Prior art date: 1995-02-15

Application number

AT96904055T

Other languages

English (en)

Inventor

Djuro Josic

Frank Morfeld

Original Assignee

Octapharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-15

Filing date

1996-02-10

Publication date

2006-10-15

1996-02-10 Application filed by Octapharma Ag filed Critical Octapharma Ag

2006-10-15 Application granted granted Critical

2006-10-15 Publication of ATE341617T1 publication Critical patent/ATE341617T1/de

Links

230000001419 dependent effect Effects 0.000 title abstract 5
108010039209 Blood Coagulation Factors Proteins 0.000 title abstract 3
102000015081 Blood Coagulation Factors Human genes 0.000 title abstract 3
239000003114 blood coagulation factor Substances 0.000 title abstract 3
238000004587 chromatography analysis Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 title 1
229930003448 Vitamin K Natural products 0.000 abstract 4
SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 abstract 4
235000019168 vitamin K Nutrition 0.000 abstract 4
239000011712 vitamin K Substances 0.000 abstract 4
150000003721 vitamin K derivatives Chemical class 0.000 abstract 4
229940046010 vitamin k Drugs 0.000 abstract 4
239000000463 material Substances 0.000 abstract 3
238000001042 affinity chromatography Methods 0.000 abstract 2
239000007853 buffer solution Substances 0.000 abstract 2
-1 2-hydroxyaminopropyl groups Chemical group 0.000 abstract 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
238000005349 anion exchange Methods 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
238000011210 chromatographic step Methods 0.000 abstract 1
229960002897 heparin Drugs 0.000 abstract 1
229920000669 heparin Polymers 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
108010012557 prothrombin complex concentrates Proteins 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
238000005406 washing Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Peptides Or Proteins (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Compounds Of Unknown Constitution (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

AT96904055T 1995-02-15 1996-02-10 Prozess zur reinigung von vitamin k abhängigen koagulationsfaktoren durch chromatographie ATE341617T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19504852A DE19504852C2 (de)	1995-02-15	1995-02-15	Verfahren zur Reinigung Vitamin K-abhängiger Gerinnungsfaktoren durch Affinitäts-Chromatographie

Publications (1)

Publication Number	Publication Date
ATE341617T1 true ATE341617T1 (de)	2006-10-15

Family

ID=7753901

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96904055T ATE341617T1 (de)	1995-02-15	1996-02-10	Prozess zur reinigung von vitamin k abhängigen koagulationsfaktoren durch chromatographie

Country Status (9)

Country	Link
EP (1)	EP0813597B1 (de)
AT (1)	ATE341617T1 (de)
AU (1)	AU4830596A (de)
DE (2)	DE19504852C2 (de)
DK (1)	DK0813597T3 (de)
ES (1)	ES2274524T3 (de)
IL (1)	IL117110A (de)
PT (1)	PT813597E (de)
WO (1)	WO1996025490A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6387633B1 (en) *	2001-05-11	2002-05-14	Supratek Pharma, Inc.	Method for identifying unstable genes
KR100667860B1 (ko)	2005-10-18	2007-01-11	주식회사 녹십자	고순도 사람 혈액응고 제9인자의 정제 방법
WO2009141384A2 (en) *	2008-05-21	2009-11-26	Novo Nordisk A/S	Process for the purification of factor vii polypeptides using affinity resins comprising specific ligands
AU2011343813B2 (en)	2010-12-15	2015-05-21	Takeda Pharmaceutical Company Limited	Eluate collection using conductivity gradient
BRPI1105317A2 (pt)	2011-01-24	2013-04-30	Fundacco Hemoct De Ribeirco Preto	produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0317376B2 (de) *	1987-10-23	1996-04-03	Centre Regional De Transfusion Sanguine De Lille	Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat
DE3826792C1 (de) *	1988-08-06	1989-07-06	Biotest Pharma Gmbh, 6072 Dreieich, De
DE3914869C1 (de) *	1989-05-05	1990-08-09	Biotest Pharma Gmbh, 6072 Dreieich, De
IT1262899B (it) *	1992-03-27	1996-07-22	Sclavo Spa	Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano

1995
- 1995-02-15 DE DE19504852A patent/DE19504852C2/de not_active Expired - Fee Related
1996
- 1996-02-10 AT AT96904055T patent/ATE341617T1/de active
- 1996-02-10 DE DE69636594T patent/DE69636594T2/de not_active Expired - Lifetime
- 1996-02-10 WO PCT/EP1996/000569 patent/WO1996025490A1/en not_active Ceased
- 1996-02-10 ES ES96904055T patent/ES2274524T3/es not_active Expired - Lifetime
- 1996-02-10 EP EP96904055A patent/EP0813597B1/de not_active Expired - Lifetime
- 1996-02-10 DK DK96904055T patent/DK0813597T3/da active
- 1996-02-10 AU AU48305/96A patent/AU4830596A/en not_active Abandoned
- 1996-02-10 PT PT96904055T patent/PT813597E/pt unknown
- 1996-02-12 IL IL11711096A patent/IL117110A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69636594T2 (de)	2007-05-16
EP0813597A1 (de)	1997-12-29
EP0813597B1 (de)	2006-10-04
IL117110A (en)	2002-05-23
WO1996025490A1 (en)	1996-08-22
DE19504852C2 (de)	2003-01-23
DK0813597T3 (da)	2007-02-05
PT813597E (pt)	2006-12-29
ES2274524T3 (es)	2007-05-16
DE69636594D1 (de)	2006-11-16
AU4830596A (en)	1996-09-04
DE19504852A1 (de)	1996-08-22
IL117110A0 (en)	1996-06-18

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