ATE275172T1 - Mobilitaetsveraendernde cyaninfarbstoffe - Google Patents

Mobilitaetsveraendernde cyaninfarbstoffe

Info

Publication number
ATE275172T1
ATE275172T1 AT01901693T AT01901693T ATE275172T1 AT E275172 T1 ATE275172 T1 AT E275172T1 AT 01901693 T AT01901693 T AT 01901693T AT 01901693 T AT01901693 T AT 01901693T AT E275172 T1 ATE275172 T1 AT E275172T1
Authority
AT
Austria
Prior art keywords
mobility
dyes
variety
permits
cyanine dyes
Prior art date
Application number
AT01901693T
Other languages
English (en)
Inventor
Steven M Menchen
Scott C Benson
Barnett B Rosenblum
Shaheer H Khan
Original Assignee
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applera Corp filed Critical Applera Corp
Application granted granted Critical
Publication of ATE275172T1 publication Critical patent/ATE275172T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G01N27/44726—Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Engineering & Computer Science (AREA)
  • Electrochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polymerisation Methods In General (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
AT01901693T 2000-01-04 2001-01-03 Mobilitaetsveraendernde cyaninfarbstoffe ATE275172T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/477,270 US6716994B1 (en) 2000-01-04 2000-01-04 Mobility-Modifying Cyanine Dyes
PCT/US2001/000152 WO2001049790A2 (en) 2000-01-04 2001-01-03 Mobility-modifying cyanine dyes

Publications (1)

Publication Number Publication Date
ATE275172T1 true ATE275172T1 (de) 2004-09-15

Family

ID=23895240

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01901693T ATE275172T1 (de) 2000-01-04 2001-01-03 Mobilitaetsveraendernde cyaninfarbstoffe

Country Status (10)

Country Link
US (2) US6716994B1 (de)
EP (1) EP1244749B1 (de)
JP (1) JP2003519275A (de)
AT (1) ATE275172T1 (de)
AU (1) AU2756901A (de)
CA (1) CA2396067A1 (de)
DE (1) DE60105258T2 (de)
DK (1) DK1244749T3 (de)
ES (1) ES2225468T3 (de)
WO (1) WO2001049790A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030054396A1 (en) * 2001-09-07 2003-03-20 Weiner Michael P. Enzymatic light amplification
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
WO2004003510A2 (en) * 2002-07-01 2004-01-08 Guava Technologies, Inc. Fluorescent dyes, energy transfer couples and methods
AU2003278832A1 (en) * 2002-09-13 2004-04-30 Carnegie Mellon University Optical biosensors and methods of use thereof
ITPZ20030002A1 (it) * 2003-08-12 2005-02-13 Giuseppe Caputo Composti del tipo cianina aventi un braccio di legame alchinilico
WO2005077125A2 (en) * 2004-02-11 2005-08-25 Applera Corporation Methods and compositions for detecting nucleic acids
US7230117B2 (en) * 2004-07-12 2007-06-12 Beckman Coulter, Inc. Stable cyanine dye phosphoramidites
US7767834B2 (en) * 2004-08-13 2010-08-03 Elitech Holding B.V. Phosphonylated fluorescent dyes and conjugates
JP5214967B2 (ja) * 2004-08-13 2013-06-19 エポック バイオサイエンシズ インコーポレーティッド ホスホン酸蛍光色素および複合体
US7579149B2 (en) * 2005-01-31 2009-08-25 International Business Machines Corporation Method and apparatus to separate molecules according to their mobilities
US8227621B2 (en) * 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
AU2005234696B2 (en) 2005-11-18 2012-02-16 Phanos Technologies, Inc. Fluorescent membrane intercalating probes and methods for their use
WO2008039997A2 (en) * 2006-09-28 2008-04-03 Applera Corporation Nucleobase conjugates with cationic backbone linkers
EP2629094A1 (de) * 2007-01-24 2013-08-21 Carnegie Mellon University Optische Biosensoren
US8247235B2 (en) 2007-06-08 2012-08-21 Quest Diagnostics Investments Incorporated Lipoprotein analysis by differential charged-particle mobility
US8426153B2 (en) * 2007-12-03 2013-04-23 Carnegie Mellon University Linked peptides fluorogenic biosensors
US9354200B1 (en) 2008-08-07 2016-05-31 Quest Diagnostics Investments Incorporated Detection apparatus for differential-charged particle mobility analyzer
JP2012524153A (ja) * 2009-04-17 2012-10-11 ライコア インコーポレイテッド 置換シアニン染料を用いた蛍光イメージング
US20100291706A1 (en) * 2009-05-15 2010-11-18 Millipore Corporation Dye conjugates and methods of use
WO2012048063A2 (en) * 2010-10-06 2012-04-12 Emd Millipore Corporation Cyanine compounds, conjugates and method of use
WO2012054784A1 (en) 2010-10-20 2012-04-26 Li-Cor, Inc. Fluorescent imaging with substituted cyanine dyes
US9250211B2 (en) 2010-12-30 2016-02-02 Quest Diagnostics Investments Incorporated Magnetic separation of lipoproteins using dextran sulfate
GB201516987D0 (en) 2015-09-25 2015-11-11 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
US10199815B2 (en) 2016-07-11 2019-02-05 Hunter Industries, Inc. Watertight electrical compartment for use in irrigation devices and methods of use
EP3461814A1 (de) 2017-09-29 2019-04-03 ATTO-TEC GmbH Neue poly-sulfonierte fluoreszenz-farbstoffe
EP4185596A1 (de) 2020-07-23 2023-05-31 Life Technologies Corporation Energieübertragungsfarbstoffkonjugate zur verwendung in biologischen tests
WO2022020731A2 (en) 2020-07-23 2022-01-27 Life Technologies Corporation Compositions, systems and methods for biological analysis involving energy transfer dye conjugates and analytes comprising the same
US20250092261A1 (en) * 2021-07-21 2025-03-20 Life Technologies Corporation Dibenzoxanthene Quenchers, Uses, and Methods of Preparation
JP2026505989A (ja) 2023-02-17 2026-02-20 デンマークス テクニスケ ユニバーシテト 腫瘍の治療のためのコポリマー薬物複合体
WO2025234029A1 (ja) * 2024-05-08 2025-11-13 株式会社日立ハイテク 変異遺伝子検出方法、変異遺伝子検出装置

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3734739A (en) 1971-07-29 1973-05-22 Polaroid Corp Silver halide emulsions sensitized with cyanine dyes containing a quaternary group
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
US5627027A (en) 1986-04-18 1997-05-06 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5569587A (en) 1986-04-18 1996-10-29 Carnegie Mellon University Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
CA1340806C (en) * 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US4981977A (en) 1989-06-09 1991-01-01 Carnegie-Mellon University Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups
CA2119126C (en) * 1991-09-16 1996-09-03 Molecular Probes, Inc. Dimers of unsymmetrical cyanine dyes
US5321130A (en) 1992-02-10 1994-06-14 Molecular Probes, Inc. Unsymmetrical cyanine dyes with a cationic side chain
JPH05307233A (ja) * 1992-04-30 1993-11-19 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US5658751A (en) * 1993-04-13 1997-08-19 Molecular Probes, Inc. Substituted unsymmetrical cyanine dyes with selected permeability
IT1276833B1 (it) 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa Coloranti fluorescenti della famiglia della solfo benz e indocianina
US6004536A (en) 1995-11-14 1999-12-21 Molecular Probes, Inc. Lipophilic cyanine dyes with enchanced aqueous solubilty
JP2000508709A (ja) 1996-04-19 2000-07-11 アマーシャム・ファルマシア・バイオテック・ユーケイ・リミテッド スクアラート染料類および蛍光配列決定法におけるそれらの使用
US5800996A (en) 1996-05-03 1998-09-01 The Perkin Elmer Corporation Energy transfer dyes with enchanced fluorescence
US5945526A (en) 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US5863727A (en) 1996-05-03 1999-01-26 The Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US5821356A (en) * 1996-08-12 1998-10-13 The Perkin Elmer Corporation Propargylethoxyamino nucleotides
JP3646277B2 (ja) * 1996-11-22 2005-05-11 コニカミノルタホールディングス株式会社 ハロゲン化銀写真感光材料
EP1037947B1 (de) 1997-07-28 2003-09-10 Amersham plc Cyaninfarbstoffe

Also Published As

Publication number Publication date
WO2001049790A3 (en) 2001-12-06
EP1244749B1 (de) 2004-09-01
US20050107617A1 (en) 2005-05-19
DE60105258T2 (de) 2005-09-08
US6716994B1 (en) 2004-04-06
AU2756901A (en) 2001-07-16
EP1244749A2 (de) 2002-10-02
WO2001049790A2 (en) 2001-07-12
CA2396067A1 (en) 2001-07-12
JP2003519275A (ja) 2003-06-17
DK1244749T3 (da) 2004-12-06
DE60105258D1 (de) 2004-10-07
ES2225468T3 (es) 2005-03-16

Similar Documents

Publication Publication Date Title
ATE275172T1 (de) Mobilitaetsveraendernde cyaninfarbstoffe
ATE315066T1 (de) Cyaninfarbstoffe
BR0301684A (pt) Corantes azo piridona dimérica
EA200300647A1 (ru) Изотермическая амплификация нуклеиновых кислот на твердой подложке
DE69925032D1 (de) Fluoreszenzfarbstoffe zum festphasen- und flüssigphasen-screening
DK1870417T3 (da) Peptidacceptor-ligeringsmetoder
TR200002618T2 (tr) Sübstitüe edilmiş heterosiklik üreler kullanılarak raf kinazın inhibe edilmesi
BR9807734A (pt) Composto para imunodiagnose de câncer de próstata e métodos para o uso dos memos
WO2004085539A3 (en) Cyanine dye labelling reagents with meso-substitution
ATE301122T1 (de) Kernerweiterte perylenbisimide und ihre verwendung als fluoreszenzfarbstoffe
DE60033689D1 (de) Inhibitoren von serinproteasen
TR200502316A2 (tr) Dağıtılmış azo boya karışımları
ATE284407T1 (de) Pyrimidinderivate als markierte bindungspartner
ES2196531T3 (es) Sintesis de terfenadina y sus derivados.
DK0981525T3 (da) (2-(2-Thienyl)-ethylamino)-(2-halophenyl)-acetonitriler som mellemprodukter og fremgangsmåde til deres fremstilling
BR0207119B1 (pt) processo para produzir microcápsulas azuis, e uso das mesmas.
CY1106447T1 (el) Ενωσεις για ρυθμιση πολλαπλασιασμου κυτταρου
AR011912A1 (es) PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS DE 5-AMINO-1-ARIL-3-CIANOPIRAZOL, COMPUESTOS INTERMEDIARIOS DE APLICACIoN EN EL MISMO Y PROCESOS PARA PREPARAR DICHOS COMPUESTOS INTERMEDIARIOS
ATE320422T1 (de) Metalloproteinase inhibitoren
DE69935219D1 (de) Klonierung und identifizierung des motilin-rezeptors
TR200001404A2 (tr) Turuncu-ve kızıl-renkli reaktif boya karışımları
PT1307436E (pt) Processo para a preparacao de derivados de bacatina iii
ATE276984T1 (de) Nitrierung in einem statischen mikromischer
AR036810A1 (es) Un tinte de complejo de metal 1:2, sus composiciones, su produccion y su uso
ATE239768T1 (de) Neue triphendisoxazinpigmente

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties