ATE275550T1 - Alpha-substituierte pyrimidin-thioalkylderivate und alkylether als inhibitoren viraler reverser transkriptfase - Google Patents

Alpha-substituierte pyrimidin-thioalkylderivate und alkylether als inhibitoren viraler reverser transkriptfase

Info

Publication number: ATE275550T1
Authority: AT; Austria
Prior art keywords: inhibitors; fase; alpha; alkyl ethers; viral reverse
Prior art date: 1995-05-08

Application number

AT96913306T

Other languages

German (de)

English (en)

Inventor

Richard A Nugent

Donn G Wishka

Gary J Cleek

David R Graber

Stephen Thomas Schlachter

Michael J Murphy

Joel Morris

Richard C Thomas

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-08

Filing date

1996-05-03

Publication date

2004-09-15

1996-05-03 Application filed by Upjohn Co filed Critical Upjohn Co

2004-09-15 Application granted granted Critical

2004-09-15 Publication of ATE275550T1 publication Critical patent/ATE275550T1/de

Links

150000005215 alkyl ethers Chemical class 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
230000003612 virological effect Effects 0.000 title abstract 2
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
102100034343 Integrase Human genes 0.000 abstract 1
108010092799 RNA-directed DNA polymerase Proteins 0.000 abstract 1
-1 alkylether compounds Chemical class 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)

AT96913306T 1995-05-08 1996-05-03 Alpha-substituierte pyrimidin-thioalkylderivate und alkylether als inhibitoren viraler reverser transkriptfase ATE275550T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US43670895A	1995-05-08	1995-05-08
PCT/US1996/006119 WO1996035678A1 (en)	1995-05-08	1996-05-03	Alpha-substituted pyrimidine-thioalkyl and alkylether compounds as inhibitors of viral reverse transcriptase

Publications (1)

Publication Number	Publication Date
ATE275550T1 true ATE275550T1 (de)	2004-09-15

Family

ID=23733510

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96913306T ATE275550T1 (de)	1995-05-08	1996-05-03	Alpha-substituierte pyrimidin-thioalkylderivate und alkylether als inhibitoren viraler reverser transkriptfase

Country Status (26)

Country	Link
US (1)	US6043248A (2)
EP (2)	EP0824524B1 (2)
JP (1)	JPH11507017A (2)
KR (1)	KR100445498B1 (2)
CN (2)	CN1535958A (2)
AT (1)	ATE275550T1 (2)
AU (1)	AU712404B2 (2)
BR (1)	BR9608265A (2)
CA (1)	CA2216099C (2)
CZ (1)	CZ293135B6 (2)
DE (1)	DE69633332T2 (2)
ES (1)	ES2227586T3 (2)
GE (1)	GEP20002297B (2)
HU (1)	HUP9801995A3 (2)
IL (1)	IL118075A0 (2)
MX (1)	MX9708582A (2)
NO (1)	NO310287B1 (2)
NZ (1)	NZ307089A (2)
PL (1)	PL323240A1 (2)
PT (1)	PT824524E (2)
RU (1)	RU2167155C2 (2)
SK (1)	SK150297A3 (2)
TW (1)	TW450962B (2)
UA (1)	UA56992C2 (2)
WO (1)	WO1996035678A1 (2)
ZA (1)	ZA963281B (2)

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JP2003503354A (ja)	1999-06-30	2003-01-28	メルクエンドカムパニーインコーポレーテッド	Ｓｒｃキナーゼ阻害剤化合物
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US7138404B2 (en) *	2001-05-23	2006-11-21	Hoffmann-La Roche Inc.	4-aminopyrimidine derivatives
MX2007006635A (es) *	2004-12-03	2007-06-19	Merck & Co Inc	Formulacion farmaceutica de inhibidores dela carboxamida vih integrasa que contienen una composicion que controla la velocidad de liberacion.
RU2401261C2 (ru) *	2005-03-04	2010-10-10	Тиботек Фармасьютикалз Лтд.	Ингибирующие вич 2-(4-цианофенил)-6-гидроксиламинопиримидины
US7923056B2 (en)	2007-06-01	2011-04-12	Illinois Tool Works Inc.	Method and apparatus for dispensing material on a substrate
US9040538B2 (en)	2009-05-21	2015-05-26	Universite Laval	Pyrimidines as novel therapeutic agents
CN101638391B (zh) *	2009-08-21	2011-04-27	山东大学	2-[(取代苯氨基)羰基甲硫基]-6-(2,6-二氯苄基)-3h-嘧啶-4-酮类衍生物及其制备方法与应用
US9226970B2 (en)	2010-02-22	2016-01-05	Nektar Therapeutics	Oligomer modified diaromatic substituted compounds
CA2793959C (en)	2010-03-25	2019-06-04	Oregon Health & Science University	Cmv glycoproteins and recombinant vectors
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CA2832109C (en)	2011-06-10	2021-07-06	Oregon Health & Science University	Cmv glycoproteins and recombinant vectors
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US20150065381A1 (en)	2013-09-05	2015-03-05	International Aids Vaccine Initiative	Methods of identifying novel hiv-1 immunogens
US10058604B2 (en)	2013-10-07	2018-08-28	International Aids Vaccine Initiative	Soluble HIV-1 envelope glycoprotein trimers
US10174292B2 (en)	2015-03-20	2019-01-08	International Aids Vaccine Initiative	Soluble HIV-1 envelope glycoprotein trimers
US9931394B2 (en)	2015-03-23	2018-04-03	International Aids Vaccine Initiative	Soluble HIV-1 envelope glycoprotein trimers
EP3324977B1 (en)	2015-07-22	2022-07-13	Enanta Pharmaceuticals, Inc.	Benzodiazepine derivatives as rsv inhibitors
GB201807898D0 (en) *	2018-05-15	2018-06-27	Kancera Ab	New processes and products with increased chiral purity
US11505558B1 (en)	2019-10-04	2022-11-22	Enanta Pharmaceuticals, Inc.	Antiviral heterocyclic compounds
WO2021066922A1 (en) *	2019-10-04	2021-04-08	Enanta Pharmaceuticals, Inc.	Antiviral heterocyclic compounds
WO2021149051A1 (en) *	2020-01-20	2021-07-29	Agrematch Ltd.	Compositions for crop protection
KR20240056718A (ko)	2021-08-10	2024-04-30	아이에프엠 듀, 인크.	Sting 활성과 연합된 상태를 치료하기 위한 화합물 및 조성물
CN114057707A (zh) *	2021-11-24	2022-02-18	上海应用技术大学	一种n-4-吲哚基-2-呋喃甲酰胺化合物的制备方法
JP2025504415A (ja) *	2022-01-12	2025-02-12	アイエフエムデューインコーポレイテッド	Ｓｔｉｎｇ活性に関連する病態を治療するための化合物及び組成物

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1996
- 1996-03-05 UA UA97125800A patent/UA56992C2/uk unknown
- 1996-04-24 ZA ZA9603281A patent/ZA963281B/xx unknown
- 1996-04-29 IL IL11807596A patent/IL118075A0/xx unknown
- 1996-05-03 MX MX9708582A patent/MX9708582A/es not_active IP Right Cessation
- 1996-05-03 CZ CZ19973491A patent/CZ293135B6/cs not_active IP Right Cessation
- 1996-05-03 BR BR9608265A patent/BR9608265A/pt not_active Application Discontinuation
- 1996-05-03 GE GEAP19964013A patent/GEP20002297B/en unknown
- 1996-05-03 PL PL96323240A patent/PL323240A1/xx unknown
- 1996-05-03 ES ES96913306T patent/ES2227586T3/es not_active Expired - Lifetime
- 1996-05-03 WO PCT/US1996/006119 patent/WO1996035678A1/en not_active Ceased
- 1996-05-03 CA CA002216099A patent/CA2216099C/en not_active Expired - Fee Related
- 1996-05-03 AU AU56353/96A patent/AU712404B2/en not_active Ceased
- 1996-05-03 CN CNA200410032589XA patent/CN1535958A/zh active Pending
- 1996-05-03 PT PT96913306T patent/PT824524E/pt unknown
- 1996-05-03 AT AT96913306T patent/ATE275550T1/de not_active IP Right Cessation
- 1996-05-03 CN CNB961937912A patent/CN1152022C/zh not_active Expired - Fee Related
- 1996-05-03 NZ NZ307089A patent/NZ307089A/xx unknown
- 1996-05-03 SK SK1502-97A patent/SK150297A3/sk unknown
- 1996-05-03 EP EP96913306A patent/EP0824524B1/en not_active Expired - Lifetime
- 1996-05-03 JP JP8534120A patent/JPH11507017A/ja not_active Withdrawn
- 1996-05-03 KR KR1019970707927A patent/KR100445498B1/ko not_active Expired - Fee Related
- 1996-05-03 US US08/945,153 patent/US6043248A/en not_active Expired - Fee Related
- 1996-05-03 RU RU97120116/04A patent/RU2167155C2/ru not_active IP Right Cessation
- 1996-05-03 EP EP04010159A patent/EP1449835A3/en not_active Withdrawn
- 1996-05-03 HU HU9801995A patent/HUP9801995A3/hu unknown
- 1996-05-03 DE DE69633332T patent/DE69633332T2/de not_active Expired - Fee Related
- 1996-05-07 TW TW085105432A patent/TW450962B/zh not_active IP Right Cessation
1997
- 1997-11-07 NO NO19975129A patent/NO310287B1/no unknown

Also Published As

Publication number	Publication date
TW450962B (en)	2001-08-21
RU2167155C2 (ru)	2001-05-20
CZ293135B6 (cs)	2004-02-18
HUP9801995A2 (hu)	1999-03-29
ES2227586T3 (es)	2005-04-01
EP0824524A1 (en)	1998-02-25
EP1449835A3 (en)	2004-09-15
DE69633332T2 (de)	2005-09-22
WO1996035678A1 (en)	1996-11-14
CZ349197A3 (cs)	1998-04-15
HK1009446A1 (en)	1999-09-10
BR9608265A (pt)	1999-02-02
MX9708582A (es)	1998-02-28
PL323240A1 (en)	1998-03-16
AU712404B2 (en)	1999-11-04
CN1183773A (zh)	1998-06-03
KR100445498B1 (ko)	2004-11-16
PT824524E (pt)	2005-01-31
HUP9801995A3 (en)	1999-04-28
EP1449835A2 (en)	2004-08-25
AU5635396A (en)	1996-11-29
EP0824524B1 (en)	2004-09-08
CN1535958A (zh)	2004-10-13
GEP20002297B (en)	2000-11-25
UA56992C2 (uk)	2003-06-16
CA2216099A1 (en)	1996-11-14
CN1152022C (zh)	2004-06-02
NO975129D0 (no)	1997-11-07
US6043248A (en)	2000-03-28
CA2216099C (en)	2005-09-13
ZA963281B (en)	1997-10-24
NZ307089A (en)	1999-07-29
DE69633332D1 (de)	2004-10-14
SK150297A3 (en)	1998-10-07
IL118075A0 (en)	1996-08-04
NO975129L (no)	1998-01-07
JPH11507017A (ja)	1999-06-22
KR19990008400A (ko)	1999-01-25
NO310287B1 (no)	2001-06-18

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