ATE277003T1 - Zwischenprodukt zur herstellung von kondensierten benzazepinderivate - Google Patents

Zwischenprodukt zur herstellung von kondensierten benzazepinderivate

Info

Publication number: ATE277003T1
Authority: AT; Austria
Prior art keywords: intermediate product; benzazepine derivatives; producing condensed; condensed benzazepine; derivatives
Prior art date: 1993-07-21

Application number

AT00204704T

Other languages

English (en)

Inventor

Akihiro Tanaka

Hiroyuki Koshio

Nobuaki Taniguchi

Akira Matsuhisa

Ken-Ichiro Sakamoto

Atsuki Yamazaki

Takeyuki Yatsu

Original Assignee

Yamanouchi Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-21

Filing date

1994-07-19

Publication date

2004-10-15

1994-07-19 Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE277003T1 publication Critical patent/ATE277003T1/de

Links

150000008038 benzoazepines Chemical class 0.000 title abstract 2
239000013067 intermediate product Substances 0.000 title 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
GTKIGDZXPDCIKR-UHFFFAOYSA-N 2-phenylbenzamide Chemical compound NC(=O)C1=CC=CC=C1C1=CC=CC=C1 GTKIGDZXPDCIKR-UHFFFAOYSA-N 0.000 abstract 1
101800001144 Arg-vasopressin Proteins 0.000 abstract 1
239000005711 Benzoic acid Substances 0.000 abstract 1
229940116211 Vasopressin antagonist Drugs 0.000 abstract 1
102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 abstract 1
KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 abstract 1
235000010233 benzoic acid Nutrition 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
239000003038 vasopressin antagonist Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Output Control And Ontrol Of Special Type Engine (AREA)

AT00204704T 1993-07-21 1994-07-19 Zwischenprodukt zur herstellung von kondensierten benzazepinderivate ATE277003T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP18043593		1993-07-21

Publications (1)

Publication Number	Publication Date
ATE277003T1 true ATE277003T1 (de)	2004-10-15

Family

ID=16083198

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT94921117T ATE239726T1 (de)	1993-07-21	1994-07-19	Verschmolzene benzazepinderivate und diese enthaltende pharmazeutische zubereitungen
AT00204704T ATE277003T1 (de)	1993-07-21	1994-07-19	Zwischenprodukt zur herstellung von kondensierten benzazepinderivate

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT94921117T ATE239726T1 (de)	1993-07-21	1994-07-19	Verschmolzene benzazepinderivate und diese enthaltende pharmazeutische zubereitungen

Country Status (18)

Country	Link
US (2)	US5723606A (de)
EP (2)	EP0709386B1 (de)
KR (1)	KR100304331B1 (de)
CN (1)	CN1040210C (de)
AT (2)	ATE239726T1 (de)
AU (2)	AU683483B2 (de)
CA (1)	CA2167673C (de)
DE (2)	DE69432632T2 (de)
ES (2)	ES2198418T3 (de)
FI (1)	FI113178B (de)
HU (1)	HUT74582A (de)
NO (1)	NO306303B1 (de)
NZ (1)	NZ268671A (de)
PL (1)	PL177738B1 (de)
RU (1)	RU2129123C1 (de)
TW (1)	TW279163B (de)
UA (1)	UA64690C2 (de)
WO (1)	WO1995003305A1 (de)

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KR20010034461A (ko) *	1998-01-28	2001-04-25	요시다 쇼지	시기능 장해의 예방 또는 치료제
AR018818A1 (es) *	1998-04-03	2001-12-12	Yamano Masaki	Una composicion farmaceutica para la terapia de un edema.
AU4168999A (en) *	1998-06-19	2000-01-05	Wakamoto Pharmaceutical Co., Ltd.	Ocular tension lowering agents and phosphoric ester derivatives
RU2250899C2 (ru) *	1999-01-19	2005-04-27	Орто-Макнейл Фармасьютикал, Инк.	Трициклические бензодиазепины, фармацевтическая композиция на их основе и способы лечения гипертензии
US7015212B1 (en)	1999-05-12	2006-03-21	The United States Of America As Represented By The Department Of Health And Human Services	Thiazepine inhibitors of HIV-1 integrase
US6765004B1 (en)	1999-06-17	2004-07-20	Ortho-Mcneil Pharmaceutical, Inc.	Indoloazepines as vasopressin receptor antagonists
DE19932555A1 (de) *	1999-07-13	2001-01-18	Solvay Pharm Gmbh	Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen
US6437006B1 (en)	1999-09-27	2002-08-20	American Cyanamid Company	Pharmaceutical carrier formulation
US6645959B1 (en)	2000-01-26	2003-11-11	Warner-Lambert Company	Method for treating postoperative ileus
US20030103983A1 (en) *	2002-05-09	2003-06-05	Pressler Milton Lethan	Ace inhibitor-vasopressin antagonist combinations
WO2001054677A2 (en) *	2000-01-26	2001-08-02	Warner-Lambert Company	Ace inhibitor-vasopressin antagonist combinations
US20030008860A1 (en) *	2002-05-09	2003-01-09	Bakker-Arkema Rebecca Guggemos	Treatment of congestive heart failure
AU779929B2 (en) *	2000-10-04	2005-02-17	Warner-Lambert Company	Treatment of pulmonary hypertension
EP1195166B1 (de)	2000-10-04	2007-07-25	Astellas Pharma Inc.	Verwendung von einem Vasopressin-Antagonisten wie Conivaptan zur Herstellung eines Medikaments für die Behandlung der pulmonalen Hypertension
CA2425892A1 (en) *	2000-11-28	2003-04-11	Hiroyuki Koshio	1,4,5,6-tetrahydroimidazo[4,5-d]diazepine derivative or salt thereof
EP1632494A1 (de) *	2004-08-24	2006-03-08	Ferring B.V.	Vasopressin v1a antagonisten
US7671221B2 (en) *	2005-12-28	2010-03-02	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
AU2006336504C9 (en) *	2005-12-28	2015-05-14	Vertex Pharmaceuticals Incorporated	1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis
US20080221084A1 (en) *	2006-10-30	2008-09-11	Otsuka Pharmaceutical Co., Ltd.	Method for reducing infarction using vasopressin antagonist compounds, and compositions and combinations therefor
US20090069295A1 (en) *	2007-09-09	2009-03-12	Protia, Llc	Deuterium-enriched conivaptan
EP2240029A4 (de) *	2008-01-07	2012-08-22	Synta Pharmaceuticals Corp	Verbindungen zur verwendung gegen entzündungs- und immunspezifische erkrankungen
WO2009102761A1 (en) *	2008-02-12	2009-08-20	Bristol-Myers Squibb Company	1,2,3-triazoles as 11-beta hydroxysteroid dehydrogenase type i inhibitors
US20110086834A1 (en) *	2008-06-26	2011-04-14	Amgen Inc.	Alkynyl alcohols as kinase inhibitors
WO2011052519A1 (ja)	2009-10-26	2011-05-05	大塚製薬株式会社	ベンズアゼピン化合物
US20150238502A1 (en)	2012-10-18	2015-08-27	University Of South Florida	Compositions and Methods for Treating Stroke
CN103497195B (zh) *	2013-10-21	2016-01-27	北京科莱博医药开发有限责任公司	盐酸考尼伐坦新晶型及其制备方法
CN105310978A (zh) *	2014-08-04	2016-02-10	李峰	一种含有活性成分盐酸考尼伐坦的药物组合物及其制剂
CN105884778A (zh) *	2014-09-24	2016-08-24	李峰	一种化合物和制备方法
CN105153168A (zh) *	2015-09-29	2015-12-16	上海天慈国际药业有限公司	N-[4-(2-甲基-4,5-二氢-3H-咪唑并[4,5-d][1]苯并氮杂卓-6-甲酰基)苯基]-2-苯基苯甲酰胺盐酸盐的制备方法
CN106317060B (zh) *	2016-08-22	2019-02-15	山东罗欣药业集团恒欣药业有限公司	一种盐酸考尼伐坦的制备方法
WO2019036024A1 (en)	2017-08-17	2019-02-21	Bristol-Myers Squibb Company	2- (1,1'-BIPHENYL) -1H-BENZO [D] IMIDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS AGONISTS OF APELIN AND APJ FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
TW201938171A (zh)	2017-12-15	2019-10-01	匈牙利商羅特格登公司	作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
HU231206B1 (hu)	2017-12-15	2021-10-28	Richter Gedeon Nyrt.	Triazolobenzazepinek
EP4253367A4 (de) *	2020-11-26	2024-10-23	Shanghai Jemincare Pharmaceuticals Co., Ltd.	Neuartiges benzazepinspiroderivat
CN115427048A (zh)	2021-03-05	2022-12-02	上海济煜医药科技有限公司	新型苯并氮杂卓并环衍生物
KR102801544B1 (ko)	2023-07-27	2025-04-25	김주형	논슬립 기능을 구비한 자외선 차단 안면 보호커버
WO2025085662A1 (en)	2023-10-17	2025-04-24	Vanderbilt University	Compounds for tocolytic use

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US5011628A (en) *	1988-06-15	1991-04-30	Givaudan Corporation	N,N'-diarylbenzamidines useful as ultraviolet light absorbers
ATE80610T1 (de) *	1988-06-15	1992-10-15	Givaudan & Cie Sa	Benzamidine, verwendbar als uv-lichtabsorptionsmittel.
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JP2905909B2 (ja) *	1991-04-19	1999-06-14	大塚製薬株式会社	バソプレシン拮抗剤
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JP3255077B2 (ja) *	1997-04-23	2002-02-12	日本電気株式会社	電話機

1994
- 1994-07-19 CN CN94192831A patent/CN1040210C/zh not_active Expired - Fee Related
- 1994-07-19 US US08/586,686 patent/US5723606A/en not_active Expired - Lifetime
- 1994-07-19 PL PL94312654A patent/PL177738B1/pl not_active IP Right Cessation
- 1994-07-19 NZ NZ268671A patent/NZ268671A/en not_active IP Right Cessation
- 1994-07-19 HU HU9600102A patent/HUT74582A/hu unknown
- 1994-07-19 AT AT94921117T patent/ATE239726T1/de not_active IP Right Cessation
- 1994-07-19 AT AT00204704T patent/ATE277003T1/de not_active IP Right Cessation
- 1994-07-19 DE DE69432632T patent/DE69432632T2/de not_active Expired - Lifetime
- 1994-07-19 ES ES94921117T patent/ES2198418T3/es not_active Expired - Lifetime
- 1994-07-19 ES ES00204704T patent/ES2228405T3/es not_active Expired - Lifetime
- 1994-07-19 DE DE69434032T patent/DE69434032T2/de not_active Expired - Lifetime
- 1994-07-19 CA CA002167673A patent/CA2167673C/en not_active Expired - Lifetime
- 1994-07-19 RU RU96105390/04A patent/RU2129123C1/ru not_active IP Right Cessation
- 1994-07-19 UA UA96010145A patent/UA64690C2/uk unknown
- 1994-07-19 EP EP94921117A patent/EP0709386B1/de not_active Expired - Lifetime
- 1994-07-19 KR KR1019960700265A patent/KR100304331B1/ko not_active Expired - Fee Related
- 1994-07-19 EP EP00204704A patent/EP1097920B1/de not_active Expired - Lifetime
- 1994-07-19 AU AU71957/94A patent/AU683483B2/en not_active Ceased
- 1994-07-19 WO PCT/JP1994/001183 patent/WO1995003305A1/ja not_active Ceased
- 1994-07-20 TW TW083106656A patent/TW279163B/zh not_active IP Right Cessation
1996
- 1996-01-19 NO NO960231A patent/NO306303B1/no not_active IP Right Cessation
- 1996-01-19 FI FI960260A patent/FI113178B/fi active
1997
- 1997-10-02 AU AU39906/97A patent/AU3990697A/en not_active Abandoned
- 1997-11-18 US US08/972,271 patent/US5856564A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU3990697A (en)	1997-12-18
NO960231L (no)	1996-03-21
FI113178B (fi)	2004-03-15
HUT74582A (en)	1997-01-28
EP0709386A4 (de)	1997-06-25
NO960231D0 (no)	1996-01-19
UA64690C2 (en)	2004-03-15
DE69434032T2 (de)	2005-09-22
EP1097920B1 (de)	2004-09-22
DE69432632T2 (de)	2004-02-19
AU7195794A (en)	1995-02-20
FI960260A0 (fi)	1996-01-19
CA2167673A1 (en)	1995-02-02
KR100304331B1 (ko)	2001-11-22
RU2129123C1 (ru)	1999-04-20
EP1097920A1 (de)	2001-05-09
AU683483B2 (en)	1997-11-13
CA2167673C (en)	2004-09-21
CN1127508A (zh)	1996-07-24
CN1040210C (zh)	1998-10-14
ATE239726T1 (de)	2003-05-15
EP0709386A1 (de)	1996-05-01
PL177738B1 (pl)	2000-01-31
NO306303B1 (no)	1999-10-18
PL312654A1 (en)	1996-04-29
DE69434032D1 (de)	2004-10-28
DE69432632D1 (de)	2003-06-12
EP0709386B1 (de)	2003-05-07
TW279163B (de)	1996-06-21
KR960703917A (ko)	1996-08-31
WO1995003305A1 (en)	1995-02-02
ES2198418T3 (es)	2004-02-01
NZ268671A (en)	1997-09-22
US5723606A (en)	1998-03-03
ES2228405T3 (es)	2005-04-16
HU9600102D0 (en)	1996-03-28
US5856564A (en)	1999-01-05
FI960260A7 (fi)	1996-01-19

Legal Events

Date	Code	Title	Description
2005-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69434032D1 (de)	2004-10-28	Zwischenprodukt zur Herstellung von kondensierten benzazepinderivate
ATE415394T1 (de)	2008-12-15	Zwischeprodukte zur herstellung von retroviralen protease-hemmern
DE69201934D1 (de)	1995-05-11	Verfahren zur Herstellung von Sonnenschutzmitteln.
NO178969C (no)	1996-07-10	Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte kinazolinoner
FI961234L (fi)	1996-03-15	Adipiinihapon syntetisointi biomassaperäisistä hiililähteistä
DE69705292D1 (de)	2001-07-26	Iridium-katalysiertes Carbonylierungsverfahren zur Herstellung von Essigsäure
DE69425811D1 (de)	2000-10-12	Herstellung von Terephthalsäure
DE69903865D1 (de)	2002-12-19	Wasserfreies Carbonylierungsverfahren zur Herstellung von Essigsäure
DE69202307D1 (de)	1995-06-08	Kryogenisches Rektifikationsverfahren zur Herstellung von gereinigtem Argon.
DE69804421D1 (de)	2002-05-02	Verfahren zur Herstellung von Rhein und seinen Diacylderivaten
ATE178885T1 (de)	1999-04-15	Herstellung von amidosäuren aus carbonsäuren und lactamen
DE69231815D1 (de)	2001-06-13	Verfahren zur Herstellung von Cephalosporinen und Zwischenprodukte in diesem Verfahren
DE69424899D1 (de)	2000-07-20	Verfahren zur Herstellung von Essigsäure
ES2169053T3 (es)	2002-07-01	Compuestos intermedios en la sintesis de cefalosporinas.
RU94037761A (ru)	1997-05-27	Способ получения 3-ацилэстратриенов и ацилбензолов
DE59408417D1 (de)	1999-07-22	Verfahren zur Herstellung von substituierten Chinazolin-2,4-dionen
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