ATE277003T1 - Zwischenprodukt zur herstellung von kondensierten benzazepinderivate - Google Patents

Zwischenprodukt zur herstellung von kondensierten benzazepinderivate

Info

Publication number: ATE277003T1
Authority: AT; Austria
Prior art keywords: intermediate product; benzazepine derivatives; producing condensed; condensed benzazepine; derivatives
Prior art date: 1993-07-21

Application number

AT00204704T

Other languages

English (en)

Inventor

Akihiro Tanaka

Hiroyuki Koshio

Nobuaki Taniguchi

Akira Matsuhisa

Ken-Ichiro Sakamoto

Atsuki Yamazaki

Takeyuki Yatsu

Original Assignee

Yamanouchi Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-21

Filing date

1994-07-19

Publication date

2004-10-15

1994-07-19 Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE277003T1 publication Critical patent/ATE277003T1/de

Links

150000008038 benzoazepines Chemical class 0.000 title abstract 2
239000013067 intermediate product Substances 0.000 title 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
GTKIGDZXPDCIKR-UHFFFAOYSA-N 2-phenylbenzamide Chemical compound NC(=O)C1=CC=CC=C1C1=CC=CC=C1 GTKIGDZXPDCIKR-UHFFFAOYSA-N 0.000 abstract 1
101800001144 Arg-vasopressin Proteins 0.000 abstract 1
239000005711 Benzoic acid Substances 0.000 abstract 1
229940116211 Vasopressin antagonist Drugs 0.000 abstract 1
102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 abstract 1
KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 abstract 1
235000010233 benzoic acid Nutrition 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
239000003038 vasopressin antagonist Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Cardiology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Output Control And Ontrol Of Special Type Engine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT00204704T 1993-07-21 1994-07-19 Zwischenprodukt zur herstellung von kondensierten benzazepinderivate ATE277003T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP18043593		1993-07-21

Publications (1)

Publication Number	Publication Date
ATE277003T1 true ATE277003T1 (de)	2004-10-15

Family

ID=16083198

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT00204704T ATE277003T1 (de)	1993-07-21	1994-07-19	Zwischenprodukt zur herstellung von kondensierten benzazepinderivate
AT94921117T ATE239726T1 (de)	1993-07-21	1994-07-19	Verschmolzene benzazepinderivate und diese enthaltende pharmazeutische zubereitungen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT94921117T ATE239726T1 (de)	1993-07-21	1994-07-19	Verschmolzene benzazepinderivate und diese enthaltende pharmazeutische zubereitungen

Country Status (18)

Country	Link
US (2)	US5723606A (de)
EP (2)	EP1097920B1 (de)
KR (1)	KR100304331B1 (de)
CN (1)	CN1040210C (de)
AT (2)	ATE277003T1 (de)
AU (2)	AU683483B2 (de)
CA (1)	CA2167673C (de)
DE (2)	DE69434032T2 (de)
ES (2)	ES2228405T3 (de)
FI (1)	FI113178B (de)
HU (1)	HUT74582A (de)
NO (1)	NO306303B1 (de)
NZ (1)	NZ268671A (de)
PL (1)	PL177738B1 (de)
RU (1)	RU2129123C1 (de)
TW (1)	TW279163B (de)
UA (1)	UA64690C2 (de)
WO (1)	WO1995003305A1 (de)

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AR002459A1 (es) *	1995-01-17	1998-03-25	American Cyanamid Co	Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion.
KR20010034461A (ko)	1998-01-28	2001-04-25	요시다 쇼지	시기능 장해의 예방 또는 치료제
AR018818A1 (es) *	1998-04-03	2001-12-12	Yamano Masaki	Una composicion farmaceutica para la terapia de un edema.
AU4168999A (en) *	1998-06-19	2000-01-05	Wakamoto Pharmaceutical Co., Ltd.	Ocular tension lowering agents and phosphoric ester derivatives
RU2250899C2 (ru) *	1999-01-19	2005-04-27	Орто-Макнейл Фармасьютикал, Инк.	Трициклические бензодиазепины, фармацевтическая композиция на их основе и способы лечения гипертензии
US7015212B1 (en)	1999-05-12	2006-03-21	The United States Of America As Represented By The Department Of Health And Human Services	Thiazepine inhibitors of HIV-1 integrase
US6765004B1 (en)	1999-06-17	2004-07-20	Ortho-Mcneil Pharmaceutical, Inc.	Indoloazepines as vasopressin receptor antagonists
DE19932555A1 (de) *	1999-07-13	2001-01-18	Solvay Pharm Gmbh	Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen
US6437006B1 (en)	1999-09-27	2002-08-20	American Cyanamid Company	Pharmaceutical carrier formulation
US20030103983A1 (en) *	2002-05-09	2003-06-05	Pressler Milton Lethan	Ace inhibitor-vasopressin antagonist combinations
MXPA02006352A (es) *	2000-01-26	2002-11-29	Warner Lambert Co	Combinaciones del inhibidor ace con el antagonista vasopresina.
WO2001054698A1 (en) *	2000-01-26	2001-08-02	Warner-Lambert Company	Method for preventing or treating postoperative ileus
US20030008860A1 (en) *	2002-05-09	2003-01-09	Bakker-Arkema Rebecca Guggemos	Treatment of congestive heart failure
AU779929B2 (en) *	2000-10-04	2005-02-17	Warner-Lambert Company	Treatment of pulmonary hypertension
ATE367815T1 (de) *	2000-10-04	2007-08-15	Astellas Pharma Inc	Verwendung von einem vasopressin-antagonisten wie conivaptan zur herstellung eines medikaments für die behandlung der pulmonalen hypertension
CA2425892A1 (en) *	2000-11-28	2003-04-11	Hiroyuki Koshio	1,4,5,6-tetrahydroimidazo[4,5-d]diazepine derivative or salt thereof
EP1632494A1 (de) *	2004-08-24	2006-03-08	Ferring B.V.	Vasopressin v1a antagonisten
AU2006336504C9 (en) *	2005-12-28	2015-05-14	Vertex Pharmaceuticals Incorporated	1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis
US7671221B2 (en) *	2005-12-28	2010-03-02	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
US20080221084A1 (en) *	2006-10-30	2008-09-11	Otsuka Pharmaceutical Co., Ltd.	Method for reducing infarction using vasopressin antagonist compounds, and compositions and combinations therefor
US20090069295A1 (en) *	2007-09-09	2009-03-12	Protia, Llc	Deuterium-enriched conivaptan
US20110052643A1 (en) *	2008-01-07	2011-03-03	Synta Pharmaceuticals Corp.	Compounds for inflammation and immune-related uses
WO2009102761A1 (en) *	2008-02-12	2009-08-20	Bristol-Myers Squibb Company	1,2,3-triazoles as 11-beta hydroxysteroid dehydrogenase type i inhibitors
JP2011525915A (ja) *	2008-06-26	2011-09-29	アムジエン・インコーポレーテツド	キナーゼ阻害薬としてのアルキニルアルコール類
AU2010312651A1 (en)	2009-10-26	2012-05-03	Otsuka Pharmaceutical Co., Ltd.	Benzazepine compound
US20150238502A1 (en)	2012-10-18	2015-08-27	University Of South Florida	Compositions and Methods for Treating Stroke
CN103497195B (zh) *	2013-10-21	2016-01-27	北京科莱博医药开发有限责任公司	盐酸考尼伐坦新晶型及其制备方法
CN105310978A (zh) *	2014-08-04	2016-02-10	李峰	一种含有活性成分盐酸考尼伐坦的药物组合物及其制剂
CN105884778A (zh) *	2014-09-24	2016-08-24	李峰	一种化合物和制备方法
CN105153168A (zh) *	2015-09-29	2015-12-16	上海天慈国际药业有限公司	N-[4-(2-甲基-4,5-二氢-3H-咪唑并[4,5-d][1]苯并氮杂卓-6-甲酰基)苯基]-2-苯基苯甲酰胺盐酸盐的制备方法
CN106317060B (zh) *	2016-08-22	2019-02-15	山东罗欣药业集团恒欣药业有限公司	一种盐酸考尼伐坦的制备方法
US11498903B2 (en)	2017-08-17	2022-11-15	Bristol-Myers Squibb Company	2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases
HU231206B1 (hu)	2017-12-15	2021-10-28	Richter Gedeon Nyrt.	Triazolobenzazepinek
TW201938171A (zh)	2017-12-15	2019-10-01	匈牙利商羅特格登公司	作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
US20240101568A1 (en) *	2020-11-26	2024-03-28	Shanghai Jemincare Pharmaceutical Co., Ltd	Novel benzazepine spiro derivative
EP4302762A4 (de) *	2021-03-05	2025-03-26	Shanghai Jemincare Pharmaceuticals Co., Ltd.	New-type benzazepine fused ring derivative
KR102801544B1 (ko)	2023-07-27	2025-04-25	김주형	논슬립 기능을 구비한 자외선 차단 안면 보호커버
WO2025085662A1 (en)	2023-10-17	2025-04-24	Vanderbilt University	Compounds for tocolytic use

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EP0346713B1 (de) *	1988-06-15	1992-09-16	L. GIVAUDAN & CIE Société Anonyme	Benzamidine, verwendbar als UV-Licht-Absorptionsmittel
US5011628A (en) *	1988-06-15	1991-04-30	Givaudan Corporation	N,N'-diarylbenzamidines useful as ultraviolet light absorbers
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CA2066104C (en) *	1991-04-19	2003-05-27	Hidenori Ogawa	Benzazepine derivatives as vasopressin antagonists
US5512563A (en) *	1993-07-29	1996-04-30	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists
JP3255077B2 (ja) *	1997-04-23	2002-02-12	日本電気株式会社	電話機

1994
- 1994-07-19 DE DE69434032T patent/DE69434032T2/de not_active Expired - Lifetime
- 1994-07-19 US US08/586,686 patent/US5723606A/en not_active Expired - Lifetime
- 1994-07-19 RU RU96105390/04A patent/RU2129123C1/ru not_active IP Right Cessation
- 1994-07-19 DE DE69432632T patent/DE69432632T2/de not_active Expired - Lifetime
- 1994-07-19 CA CA002167673A patent/CA2167673C/en not_active Expired - Lifetime
- 1994-07-19 KR KR1019960700265A patent/KR100304331B1/ko not_active Expired - Fee Related
- 1994-07-19 HU HU9600102A patent/HUT74582A/hu unknown
- 1994-07-19 AT AT00204704T patent/ATE277003T1/de not_active IP Right Cessation
- 1994-07-19 CN CN94192831A patent/CN1040210C/zh not_active Expired - Fee Related
- 1994-07-19 ES ES00204704T patent/ES2228405T3/es not_active Expired - Lifetime
- 1994-07-19 EP EP00204704A patent/EP1097920B1/de not_active Expired - Lifetime
- 1994-07-19 PL PL94312654A patent/PL177738B1/pl not_active IP Right Cessation
- 1994-07-19 WO PCT/JP1994/001183 patent/WO1995003305A1/ja not_active Ceased
- 1994-07-19 EP EP94921117A patent/EP0709386B1/de not_active Expired - Lifetime
- 1994-07-19 AU AU71957/94A patent/AU683483B2/en not_active Ceased
- 1994-07-19 UA UA96010145A patent/UA64690C2/uk unknown
- 1994-07-19 NZ NZ268671A patent/NZ268671A/en not_active IP Right Cessation
- 1994-07-19 AT AT94921117T patent/ATE239726T1/de not_active IP Right Cessation
- 1994-07-19 ES ES94921117T patent/ES2198418T3/es not_active Expired - Lifetime
- 1994-07-20 TW TW083106656A patent/TW279163B/zh not_active IP Right Cessation
1996
- 1996-01-19 FI FI960260A patent/FI113178B/fi active
- 1996-01-19 NO NO960231A patent/NO306303B1/no not_active IP Right Cessation
1997
- 1997-10-02 AU AU39906/97A patent/AU3990697A/en not_active Abandoned
- 1997-11-18 US US08/972,271 patent/US5856564A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NO960231L (no)	1996-03-21
KR100304331B1 (ko)	2001-11-22
FI113178B (fi)	2004-03-15
UA64690C2 (en)	2004-03-15
HUT74582A (en)	1997-01-28
CN1127508A (zh)	1996-07-24
WO1995003305A1 (en)	1995-02-02
EP1097920A1 (de)	2001-05-09
FI960260A0 (fi)	1996-01-19
KR960703917A (ko)	1996-08-31
AU3990697A (en)	1997-12-18
NO306303B1 (no)	1999-10-18
NZ268671A (en)	1997-09-22
RU2129123C1 (ru)	1999-04-20
EP0709386B1 (de)	2003-05-07
ATE239726T1 (de)	2003-05-15
DE69434032D1 (de)	2004-10-28
TW279163B (de)	1996-06-21
DE69432632T2 (de)	2004-02-19
AU7195794A (en)	1995-02-20
US5723606A (en)	1998-03-03
CA2167673A1 (en)	1995-02-02
EP0709386A4 (de)	1997-06-25
NO960231D0 (no)	1996-01-19
DE69432632D1 (de)	2003-06-12
CN1040210C (zh)	1998-10-14
EP1097920B1 (de)	2004-09-22
HU9600102D0 (en)	1996-03-28
PL177738B1 (pl)	2000-01-31
ES2198418T3 (es)	2004-02-01
FI960260A7 (fi)	1996-01-19
US5856564A (en)	1999-01-05
ES2228405T3 (es)	2005-04-16
AU683483B2 (en)	1997-11-13
CA2167673C (en)	2004-09-21
EP0709386A1 (de)	1996-05-01
DE69434032T2 (de)	2005-09-22
PL312654A1 (en)	1996-04-29

Legal Events

Date	Code	Title	Description
2005-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE277003T1 (de)	2004-10-15	Zwischenprodukt zur herstellung von kondensierten benzazepinderivate
DE4397599T1 (de)	1997-07-24	Verfahren zur Herstellung von hochreinen Isomeren von Benzoldikarbonsäure
DE69201934D1 (de)	1995-05-11	Verfahren zur Herstellung von Sonnenschutzmitteln.
NO178969C (no)	1996-07-10	Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte kinazolinoner
FI961234L (fi)	1996-03-15	Adipiinihapon syntetisointi biomassaperäisistä hiililähteistä
DE69705292D1 (de)	2001-07-26	Iridium-katalysiertes Carbonylierungsverfahren zur Herstellung von Essigsäure
DE69505190D1 (de)	1998-11-12	Verfahren zur Herstellung von hochreiner Essigsäure
DE69425811D1 (de)	2000-10-12	Herstellung von Terephthalsäure
DE69804421D1 (de)	2002-05-02	Verfahren zur Herstellung von Rhein und seinen Diacylderivaten
DE69424024D1 (de)	2000-05-25	Verfahren zur Herstellung von Laktamen
GR3029956T3 (en)	1999-07-30	Synthesis of amido acids from carboxylic acids and lactams
DE69231815D1 (de)	2001-06-13	Verfahren zur Herstellung von Cephalosporinen und Zwischenprodukte in diesem Verfahren
DE69417028D1 (de)	1999-04-15	Polyolefin enthaltende mischung für die herstellung von abbaubaren gegenstände
DE69424899D1 (de)	2000-07-20	Verfahren zur Herstellung von Essigsäure
ES2169053T3 (es)	2002-07-01	Compuestos intermedios en la sintesis de cefalosporinas.
RU94037761A (ru)	1997-05-27	Способ получения 3-ацилэстратриенов и ацилбензолов
DK0623620T3 (da)	1999-06-07	5-HT3-pyrrolopyrazinderivater
DE59408417D1 (de)	1999-07-22	Verfahren zur Herstellung von substituierten Chinazolin-2,4-dionen
DE69804853D1 (de)	2002-05-16	Verfahren zur herstellung von mequitazin und zwischenprodukt der synthese
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