ATE279407T1 - Fsh mimetika zur behandlung von infertilität - Google Patents
Fsh mimetika zur behandlung von infertilitätInfo
- Publication number
- ATE279407T1 ATE279407T1 AT99939686T AT99939686T ATE279407T1 AT E279407 T1 ATE279407 T1 AT E279407T1 AT 99939686 T AT99939686 T AT 99939686T AT 99939686 T AT99939686 T AT 99939686T AT E279407 T1 ATE279407 T1 AT E279407T1
- Authority
- AT
- Austria
- Prior art keywords
- infertility
- treatment
- fsh mimetics
- fsh
- mimetics
- Prior art date
Links
- 208000000509 infertility Diseases 0.000 title 1
- 230000036512 infertility Effects 0.000 title 1
- 231100000535 infertility Toxicity 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9571298P | 1998-08-07 | 1998-08-07 | |
| PCT/US1999/017755 WO2000008015A2 (en) | 1998-08-07 | 1999-08-05 | Fsh mimetics for the treatment of infertility |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE279407T1 true ATE279407T1 (de) | 2004-10-15 |
Family
ID=22253270
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03023514T ATE329911T1 (de) | 1998-08-07 | 1999-08-05 | Fsh mimetika zur behandlung von infertilität |
| AT99939686T ATE279407T1 (de) | 1998-08-07 | 1999-08-05 | Fsh mimetika zur behandlung von infertilität |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03023514T ATE329911T1 (de) | 1998-08-07 | 1999-08-05 | Fsh mimetika zur behandlung von infertilität |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US6235755B1 (de) |
| EP (1) | EP1102763B1 (de) |
| JP (1) | JP4511042B2 (de) |
| AR (1) | AR021755A1 (de) |
| AT (2) | ATE329911T1 (de) |
| AU (1) | AU772373B2 (de) |
| CA (1) | CA2339018A1 (de) |
| DE (2) | DE69921147T2 (de) |
| ES (2) | ES2261844T3 (de) |
| IL (1) | IL141063A (de) |
| PT (2) | PT1102763E (de) |
| WO (1) | WO2000008015A2 (de) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6025355A (en) | 1997-05-19 | 2000-02-15 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
| CA2360305A1 (en) | 1999-02-09 | 2000-08-17 | Bristol-Myers Squibb Company | Lactam inhibitors of fxa and method |
| DE60120661T2 (de) | 2000-03-27 | 2007-07-05 | Applied Research Systems Ars Holding N.V. | Pharmazeutisch wirksame pyrrolidin-derivate als bax-inhibitoren |
| DK1268419T3 (da) * | 2000-03-27 | 2006-10-02 | Applied Research Systems | Farmaceutisk aktive pyrrolidinderivater som BAX-inhibitorer |
| GB0010757D0 (en) | 2000-05-05 | 2000-06-28 | Astrazeneca Ab | Chemical compounds |
| US6511973B2 (en) | 2000-08-02 | 2003-01-28 | Bristol-Myers Squibb Co. | Lactam inhibitors of FXa and method |
| ATE277913T1 (de) * | 2001-01-19 | 2004-10-15 | Pharmacopeia Inc | Bisarylderivate mit fsh rezeptor modulierender aktivität |
| US6900213B2 (en) | 2001-01-19 | 2005-05-31 | Pharmacopeia Drug Discovery, Inc. | Bisaryl derivatives having FSH modulatory activity |
| PL364625A1 (en) | 2001-02-23 | 2004-12-13 | Merck & Co, Inc. | N-substituted nonaryl-heterocyclic nmda/nr2b antagonists |
| CA2443108A1 (en) | 2001-04-03 | 2002-10-17 | Merck & Co. Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
| WO2002090355A1 (en) | 2001-05-05 | 2002-11-14 | Smithkline Beecham P.L.C. | N-aroyl cyclic amines |
| GB0115862D0 (en) * | 2001-06-28 | 2001-08-22 | Smithkline Beecham Plc | Compounds |
| CZ20042A3 (en) * | 2001-07-02 | 2004-04-14 | Akzo Nobel N. V. | Tetrahydroquinoline derivatives |
| GB0121941D0 (en) | 2001-09-11 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| MEP38608A (en) * | 2001-10-22 | 2011-02-10 | Merck Serono Sa | Gonadotrophins for folliculogenesis |
| EP1542993B1 (de) * | 2002-09-20 | 2012-12-19 | Merck Serono SA | Piperazin derivate und ihre verwendung |
| TWI306855B (en) * | 2002-12-20 | 2009-03-01 | Organon Nv | Tetrahydroquinoline derivatives |
| TWI322012B (en) | 2002-12-20 | 2010-03-21 | Organon Nv | Tetrahydroquinoline derivatives |
| CN100404508C (zh) * | 2002-12-20 | 2008-07-23 | 欧加农股份有限公司 | 四氢喹啉衍生物 |
| CN100386318C (zh) * | 2002-12-20 | 2008-05-07 | 欧加农股份有限公司 | 四氢喹啉衍生物及其作为fsh受体调节剂的用途 |
| UA88879C2 (en) * | 2003-09-02 | 2009-12-10 | Эплайд Рисерч Системз Эрс Холдинг Н.В. | Fsh glycosylation mutant |
| BRPI0507174A (pt) * | 2004-01-28 | 2008-04-01 | Syntonix Pharmaceuticals Inc | proteìnas de fusão hormÈnio-fc (fsh-fc) heterodiméricas estimuladoras de folìculo para o tratamento da infertilidade |
| US7691848B2 (en) | 2005-03-02 | 2010-04-06 | Wyeth | Pyrrolobenzodiazepine arylcarboxamides and derivatives thereof as follicle-stimulating hormone receptor antagonists |
| EP1857444A4 (de) * | 2005-03-10 | 2009-04-29 | Kyoto Pharma Ind | Tetrahydroisochinolinverbindung und deren medizinische verwendung |
| UA92008C2 (en) | 2005-05-04 | 2010-09-27 | Н.В. Органон | 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY |
| UA92009C2 (ru) | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия |
| RS51784B (sr) | 2005-05-04 | 2011-12-31 | N.V. Organon | Derivati dihidropiridina |
| UA92007C2 (ru) | 2005-05-04 | 2010-09-27 | Н.В. Органон | Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности |
| EP1879898A2 (de) | 2005-05-12 | 2008-01-23 | Wyeth a Corporation of the State of Delaware | Pyrrolobenzodiazepine und heterozyklische carboxamid-derivate als follikelstimulierende hormonrezeptor-antagonisten |
| EP1893615A1 (de) | 2005-06-09 | 2008-03-05 | Wyeth a Corporation of the State of Delaware | Pyrrolobenzodiazepin-pyridin-carboxamide und deren derivate als follikelstimulierende hormonrezeptor-antagonisten |
| US20090018142A9 (en) * | 2006-05-02 | 2009-01-15 | Zhengping Zhuang | Use of phosphatases to treat tumors overexpressing N-CoR |
| WO2007136776A2 (en) * | 2006-05-17 | 2007-11-29 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Pyrimidine low molecular weight ligands for modulating hormone receptors |
| CA2657247A1 (en) | 2006-07-28 | 2008-01-31 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| CA2676422C (en) | 2007-02-06 | 2018-10-16 | Lixte Biotechnology Holdings, Inc. | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use |
| EA018618B1 (ru) * | 2007-10-01 | 2013-09-30 | Ликсте Байотекнолоджи, Инк. | Ингибиторы hdac |
| CA2704684A1 (en) | 2007-11-07 | 2009-05-14 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| TW200944523A (en) * | 2008-02-08 | 2009-11-01 | Organon Nv | (Dihydro)pyrrolo[2,1-a]isoquinolines |
| US8178568B2 (en) | 2008-07-10 | 2012-05-15 | Boehringer Ingelheim International Gmbh | Sulfone compounds which modulate the CB2 receptor |
| WO2010147612A1 (en) | 2009-06-18 | 2010-12-23 | Lixte Biotechnology, Inc. | Methods of modulating cell regulation by inhibiting p53 |
| CA2730148C (en) | 2008-08-01 | 2018-04-03 | Lixte Biotechnology, Inc. | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases |
| US8227473B2 (en) | 2008-08-01 | 2012-07-24 | Lixte Biotechnology, Inc. | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use |
| CA2737639A1 (en) | 2008-09-25 | 2010-04-01 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the cb2 receptor |
| CA2749163A1 (en) | 2009-01-14 | 2010-07-22 | The Salk Institute For Biological Studies | Methods for screening and compounds that protect against amyloid diseases |
| JP5705748B2 (ja) | 2009-02-18 | 2015-04-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を変調する複素環化合物 |
| TWI461426B (zh) * | 2009-05-27 | 2014-11-21 | Merck Sharp & Dohme | (二氫)咪唑並異〔5,1-a〕喹啉類 |
| US8071587B2 (en) | 2009-05-27 | 2011-12-06 | N. V. Organon | (Dihydro)imidazoiso[5,1-A]quinolines |
| US8299103B2 (en) | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| JP5756800B2 (ja) * | 2009-06-16 | 2015-07-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を調節するアゼチジン2−カルボキサミド誘導体 |
| US8431564B2 (en) | 2009-07-29 | 2013-04-30 | Merck Sharp & Dohme B.V. | Ring-annulated dihydropyrrolo[2,1-α]isoquinolines |
| TW201116531A (en) | 2009-07-29 | 2011-05-16 | Organon Nv | Ring-annulated dihydropyrrolo[2,1-a]isoquinolines |
| TW201116515A (en) * | 2009-07-31 | 2011-05-16 | Organon Nv | Dihydrobenzoindazoles |
| WO2011028689A1 (en) | 2009-09-01 | 2011-03-10 | Catabasis Pharmaceuticals, Inc. | Fatty acid niacin conjugates and their uses |
| USRE46608E1 (en) | 2009-09-01 | 2017-11-14 | Catabasis Pharmaceuticals, Inc. | Fatty acid niacin conjugates and their uses |
| WO2011037795A1 (en) | 2009-09-22 | 2011-03-31 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the cb2 receptor |
| WO2011088015A1 (en) | 2010-01-15 | 2011-07-21 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| US8329735B2 (en) | 2010-03-05 | 2012-12-11 | Boehringer Ingelheim International Gmbh | Tetrazole compounds which selectively modulate the CB2 receptor |
| WO2012012307A1 (en) | 2010-07-22 | 2012-01-26 | Boehringer Ingelheim International Gmbh | Sulfonyl compounds which modulate the cb2 rece |
| WO2013006308A2 (en) * | 2011-07-01 | 2013-01-10 | Merck Patent Gmbh | Dihydropyrazoles |
| WO2013012848A1 (en) | 2011-07-18 | 2013-01-24 | Merck Patent Gmbh | Benzamides |
| WO2013106409A1 (en) | 2012-01-10 | 2013-07-18 | Merck Patent Gmbh | Benzamide derivatives as modulators of the follicle stimulating hormone |
| HK1201837A1 (en) | 2012-02-08 | 2015-09-11 | 默克专利有限公司 | Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor |
| EP2983661B1 (de) | 2013-04-09 | 2024-05-29 | Lixte Biotechnology, Inc. | Formulierungen von oxabicycloheptanen und oxabicycloheptenen |
| EP2803668A1 (de) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Neuartige (Cyano-dimethyl-methyl)-isoxazole und -[1,3,4]-thiadiazole |
| WO2014209978A1 (en) | 2013-06-24 | 2014-12-31 | Merck Patent Gmbh | Imidazole compounds as modulators of fshr and uses thereof |
| KR102318498B1 (ko) | 2013-06-24 | 2021-10-27 | 메르크 파텐트 게엠베하 | Fshr의 조절인자로서의 피라졸 화합물 및 이의 용도 |
| US11433047B2 (en) * | 2015-10-09 | 2022-09-06 | Neurotheryx Canada Ltd. | Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases |
| MX2019006694A (es) | 2016-12-08 | 2019-08-21 | Lixte Biotechnology Inc | Oxabicicloheptanos para la modulacion de la respuesta inmunitaria. |
| WO2019084037A1 (en) | 2017-10-26 | 2019-05-02 | University Of Puerto Rico | NOVEL CARBAZOLE EHOP-016 DERIVATIVES AS ANTICANCER AGENTS AND ANTI-MIGRATORY AGENTS |
| EP4048664A1 (de) | 2019-10-25 | 2022-08-31 | Gilead Sciences, Inc. | Glp-1r-modulatorverbindungen |
| ES3016132T3 (en) | 2020-01-29 | 2025-05-08 | Gilead Sciences Inc | Glp-1r modulating compounds |
| EP4247804A1 (de) | 2020-11-20 | 2023-09-27 | Gilead Sciences, Inc. | Polyheterocyclische glp-1 r modulierende verbindungen |
| WO2022192428A1 (en) | 2021-03-11 | 2022-09-15 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
| EP4304712A1 (de) | 2021-03-11 | 2024-01-17 | Gilead Sciences, Inc. | Verbindungen zur glp-1r-modulation |
| IL306110A (en) | 2021-04-21 | 2023-11-01 | Gilead Sciences Inc | Carboxy-benzimidazole glp-1r modulating compounds |
| IL322905A (en) | 2023-03-08 | 2025-10-01 | Ferring Bv | Small molecule FSH receptor modulators |
| CN117510475A (zh) * | 2023-11-01 | 2024-02-06 | 江苏缘龙医院管理有限责任公司 | 干扰RNA-蛋白相互作用的Musashi蛋白抑制剂及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3947569A (en) * | 1972-04-12 | 1976-03-30 | American Home Products Corporation | Process for preparing the releasing hormone of luteinizing hormone (LH) and of follicle stimulating hormone (FSH), salts and compositions thereof, and intermediates therefor |
| JPS5331669A (en) * | 1976-09-06 | 1978-03-25 | Kissei Pharmaceut Co Ltd | Novel n-acylpiperidinecaroxyanilide derivatives and their preparation |
| DE3636278A1 (de) * | 1986-10-24 | 1988-05-05 | Hoechst Ag | Herbizide mittel auf der basis von cyclischen (alpha)-iminocarbon-saeureaniliden sowie neue (alpha)-iminocarbonsaeureanilide und verfahren zu ihrer herstellung |
| US4800432A (en) * | 1986-10-24 | 1989-01-24 | The Grass Valley Group, Inc. | Video Difference key generator |
| US5071823A (en) | 1988-10-12 | 1991-12-10 | Mitsubishi Paper Mills Limited | Image-receiving sheet for transfer recording |
| DE3842010A1 (de) * | 1988-12-14 | 1990-06-21 | Hoechst Ag | Kompetitive gonadoliberin-antagonisten |
| DK0610487T3 (da) * | 1992-09-03 | 2000-05-15 | Boehringer Ingelheim Pharma | Nye aminosyrederivater, fremgangsmåde til deres fremstilling og farmaceutiske præparater indeholdende disse forbindelser |
| US5455229A (en) * | 1992-12-23 | 1995-10-03 | Eli Lilly And Company | Method for minimizing and containing ischemic and reperfusion injury |
| PE45195A1 (es) * | 1994-03-03 | 1996-01-17 | Boehringer Ingelheim Kg | Derivado de aminoacido, procedimiento para su preparacion y composicion farmaceutica que lo contiene |
| JP2002505318A (ja) * | 1998-03-05 | 2002-02-19 | アゴーロン・ファーマシューティカルズ・インコーポレイテッド | 非ペプチドGnRH因子 |
-
1999
- 1999-08-05 US US09/369,222 patent/US6235755B1/en not_active Expired - Lifetime
- 1999-08-05 ES ES03023514T patent/ES2261844T3/es not_active Expired - Lifetime
- 1999-08-05 PT PT99939686T patent/PT1102763E/pt unknown
- 1999-08-05 CA CA002339018A patent/CA2339018A1/en not_active Abandoned
- 1999-08-05 ES ES99939686T patent/ES2228084T3/es not_active Expired - Lifetime
- 1999-08-05 AT AT03023514T patent/ATE329911T1/de active
- 1999-08-05 EP EP99939686A patent/EP1102763B1/de not_active Expired - Lifetime
- 1999-08-05 DE DE69921147T patent/DE69921147T2/de not_active Expired - Lifetime
- 1999-08-05 DE DE69931975T patent/DE69931975T2/de not_active Expired - Lifetime
- 1999-08-05 AU AU53931/99A patent/AU772373B2/en not_active Ceased
- 1999-08-05 JP JP2000563648A patent/JP4511042B2/ja not_active Expired - Fee Related
- 1999-08-05 IL IL14106399A patent/IL141063A/xx not_active IP Right Cessation
- 1999-08-05 AT AT99939686T patent/ATE279407T1/de active
- 1999-08-05 WO PCT/US1999/017755 patent/WO2000008015A2/en not_active Ceased
- 1999-08-06 AR ARP990103937A patent/AR021755A1/es active IP Right Grant
- 1999-08-08 PT PT03023514T patent/PT1380582E/pt unknown
-
2000
- 2000-11-28 US US09/723,495 patent/US6423723B1/en not_active Expired - Fee Related
-
2002
- 2002-05-28 US US10/156,431 patent/US6653338B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6423723B1 (en) | 2002-07-23 |
| WO2000008015A2 (en) | 2000-02-17 |
| IL141063A (en) | 2005-06-19 |
| DE69921147T2 (de) | 2005-02-24 |
| ES2228084T3 (es) | 2005-04-01 |
| PT1380582E (pt) | 2006-08-31 |
| ES2261844T3 (es) | 2006-11-16 |
| DE69921147D1 (de) | 2004-11-18 |
| US20020147345A1 (en) | 2002-10-10 |
| AU5393199A (en) | 2000-02-28 |
| JP2002522433A (ja) | 2002-07-23 |
| US6235755B1 (en) | 2001-05-22 |
| JP4511042B2 (ja) | 2010-07-28 |
| IL141063A0 (en) | 2002-02-10 |
| EP1102763B1 (de) | 2004-10-13 |
| DE69931975T2 (de) | 2006-10-05 |
| US6653338B2 (en) | 2003-11-25 |
| EP1102763A2 (de) | 2001-05-30 |
| CA2339018A1 (en) | 2000-02-17 |
| DE69931975D1 (de) | 2006-07-27 |
| WO2000008015A3 (en) | 2000-05-11 |
| AR021755A1 (es) | 2002-08-07 |
| ATE329911T1 (de) | 2006-07-15 |
| AU772373B2 (en) | 2004-04-22 |
| PT1102763E (pt) | 2005-01-31 |
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