ATE283847T1 - Verfahren zur herstellung von zwischenprodukten des florfenicols - Google Patents

Verfahren zur herstellung von zwischenprodukten des florfenicols

Info

Publication number: ATE283847T1
Authority: AT; Austria
Prior art keywords: intermediate products; florfenicol intermediate; producing; producing florfenicol; products
Prior art date: 1996-08-19

Application number

AT97938263T

Other languages

English (en)

Inventor

James C Towson

Dhiru B Vashi

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-19

Filing date

1997-08-18

Publication date

2004-12-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24808601&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE283847(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-08-18 Application filed by Schering Corp filed Critical Schering Corp

2004-12-15 Application granted granted Critical

2004-12-15 Publication of ATE283847T1 publication Critical patent/ATE283847T1/de

Links

AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 title 1
229960003760 florfenicol Drugs 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/28—Nitrogen atoms not forming part of a nitro radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT97938263T 1996-08-19 1997-08-18 Verfahren zur herstellung von zwischenprodukten des florfenicols ATE283847T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/699,271 US5663361A (en)	1996-08-19	1996-08-19	Process for preparing intermediates to florfenicol
PCT/US1997/014205 WO1998007709A1 (en)	1996-08-19	1997-08-18	Process for preparing intermediates to florfenicol

Publications (1)

Publication Number	Publication Date
ATE283847T1 true ATE283847T1 (de)	2004-12-15

Family

ID=24808601

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97938263T ATE283847T1 (de)	1996-08-19	1997-08-18	Verfahren zur herstellung von zwischenprodukten des florfenicols

Country Status (30)

Country	Link
US (1)	US5663361A (de)
EP (1)	EP0922040B2 (de)
JP (1)	JP3274868B2 (de)
KR (1)	KR100286851B1 (de)
CN (1)	CN1097583C (de)
AR (1)	AR008298A1 (de)
AT (1)	ATE283847T1 (de)
AU (1)	AU714495B2 (de)
BR (1)	BR9711318B1 (de)
CA (1)	CA2264116C (de)
CO (1)	CO4560550A1 (de)
CZ (1)	CZ297915B6 (de)
DE (1)	DE69731835T3 (de)
DK (1)	DK0922040T3 (de)
ES (1)	ES2234026T5 (de)
HU (1)	HU229610B1 (de)
ID (1)	ID18047A (de)
IL (1)	IL128574A (de)
MY (1)	MY115679A (de)
NO (1)	NO312962B1 (de)
NZ (1)	NZ334111A (de)
PE (1)	PE99798A1 (de)
PL (2)	PL196454B1 (de)
PT (1)	PT922040E (de)
SI (1)	SI0922040T1 (de)
SK (1)	SK286124B6 (de)
TR (2)	TR199900354T2 (de)
TW (1)	TW381075B (de)
WO (1)	WO1998007709A1 (de)
ZA (1)	ZA977406B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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CN1173933C (zh) *	2001-06-01	2004-11-03	中国科学院上海有机化学研究所	一种从l型取代苯丝氨酸酯制备d－（－）－苏式1－r－取代苯基－2－二氯乙酰氨基－3－氟－1－丙醇的方法
WO2003077828A2 (en) *	2002-03-08	2003-09-25	Schering-Plough, Ltd.	Novel florfenicol-type antibiotics
TW200505425A (en)	2003-05-29	2005-02-16	Schering Plough Ltd	Compositions and method for treating infection in cattle and swine
US7439268B2 (en) *	2003-07-18	2008-10-21	Idexx Laboratories	Compositions containing prodrugs of florfenicol and methods of use
US20050049210A1 (en) *	2003-08-27	2005-03-03	Idexx Laboratories, Inc.	Methods for the controlled delivery of pharmacologically active compounds
US7126005B2 (en) *	2003-10-06	2006-10-24	Aurobindo Pharma Limited	Process for preparing florfenicol
JP4792032B2 (ja)	2004-08-13	2011-10-12	シェーリング−プラウ・リミテッド	抗生物質、トリアゾールおよびコルチコステロイドを含む薬学的処方物
AU2005286723A1 (en)	2004-09-23	2006-03-30	Schering-Plough Pty. Limited	Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
DE602005017419D1 (de) *	2004-11-19	2009-12-10	Schering Plough Ltd	Kontrolle von parasiten bei tieren mittels verwendung von parasitiziden 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitril-derivaten
MX2007007528A (es) *	2004-12-21	2007-10-08	Intervet Int Bv	Composicion veterinaria inyectable.
CA2609574A1 (en) *	2005-06-09	2006-12-21	Schering-Plough Ltd.	Control of parasites in animals by n-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and n-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US7786329B2 (en) *	2005-09-07	2010-08-31	Intervet Inc.	Process for preparing ester oxazolidine compounds and their conversion to Florfenicol
US8119667B2 (en) *	2005-12-29	2012-02-21	Schering-Plough Animal Health Corporation	Carbonates of fenicol antibiotics
US7518017B2 (en)	2006-02-17	2009-04-14	Idexx Laboratories	Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) *	2006-04-10	2007-10-11	Winzenberg Kevin N	N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
CN101605756A (zh) *	2006-12-13	2009-12-16	先灵-普劳有限公司	氟苯尼考及其类似物的水溶性前药
CA2672795A1 (en) *	2006-12-13	2008-06-26	Schering-Plough Ltd.	Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
CN101686956A (zh) *	2007-04-27	2010-03-31	谢尔英·普劳有限公司	用环糊精增加氟苯尼考及结构相关的抗生素的溶解度的化合物和方法
RU2009148864A (ru) *	2007-05-30	2011-07-10	Шеринг-Плоу Лтд. (CH)	Способ получения защищенных оксазолином соединений аминодиола, применяемых в качестве промежуточных соединений для флорфеникола
TWI430995B (zh)	2007-06-26	2014-03-21	Du Pont	萘異唑啉無脊椎有害動物控制劑
ES2549731T3 (es)	2007-06-27	2015-11-02	E. I. Du Pont De Nemours And Company	Método para el control de plagas en animales
CN101796037A (zh) *	2007-07-25	2010-08-04	英特威国际有限公司	制备噁唑烷-氨基二醇和噁唑烷酮-氨基二醇及相关中间体的方法
US7550625B2 (en) *	2007-10-19	2009-06-23	Idexx Laboratories	Esters of florfenicol
PL2217207T3 (pl) *	2007-11-09	2019-05-31	Intervet Int Bv	Preparat o szybkim uwalnianiu w postaci stałej, jego przygotowanie i zastosowanie
TWI401023B (zh)	2008-02-06	2013-07-11	Du Pont	中離子農藥
CN102131772B (zh) *	2008-07-30	2015-03-11	英特威国际有限公司	用作氟苯尼考的中间体的*唑啉-保护的氨基二醇化合物的制备方法
UA110924C2 (uk)	2009-08-05	2016-03-10	Е. І. Дю Пон Де Немур Енд Компані	Мезоіонні пестициди
AU2010279574A1 (en)	2009-08-05	2012-02-09	E. I. Du Pont De Nemours And Company	Mesoionic pesticides
UA107804C2 (xx)	2009-08-05	2015-02-25	Du Pont	Суміші мезоіонних пестицидів
MX2012001646A (es)	2009-08-05	2012-03-21	Du Pont	Pesticidas mesoionicos.
BRPI1002023A2 (pt)	2010-03-01	2011-10-25	Nanocore Biotecnologia S A	forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
RS54677B1 (sr)	2010-05-27	2016-08-31	E. I. Du Pont De Nemours And Company	Kristalni oblici 4-[5-[3-hloro-5-(trifluorometil)fenil]-4,5 -dihidro-5-(trifluorometil)-3-izoksazolil]-n-[2-okso-2-[(2,2,2-trifluoroetil)amino]etil]-1-naftalenkarboksamida
WO2012087630A1 (en)	2010-12-20	2012-06-28	E.I. Du Pont De Nemours And Company	Pyridine and pyrimidine compounds for controlling invertebrate
WO2013158422A1 (en)	2012-04-17	2013-10-24	E. I. Du Pont De Nemours And Company	Heterocyclic compounds for controlling invertebrate pests
CN102911133B (zh) *	2012-10-31	2014-07-02	绍兴民生医药有限公司	(4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103254147B (zh) *	2013-04-19	2016-04-06	浙江科技学院	一种d-苏式-2-(二氯甲基)-4,5-二氢-5-[对-（甲砜基）苯基]-4-噁唑甲醇的制备方法
CN106278964B (zh) *	2016-07-31	2018-01-16	浙江润康药业有限公司	氟苯尼考的制备方法
CN106631872A (zh) *	2016-12-13	2017-05-10	浙江普洛家园药业有限公司	一种氟苯尼考类似物中间体的合成方法
CN110272856B (zh) *	2019-05-08	2022-05-03	江南大学	一种表达d-苏氨酸醛缩酶的重组菌及其构建方法与应用
CN117466787B (zh) *	2023-12-28	2024-03-22	山东国邦药业有限公司	一种氟苯尼考中间体的制备方法

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2759001A (en) *	1952-03-01	1956-08-14	Parke Davis & Co	Process for the production of delta2-oxazolines
US4361557A (en) *	1980-01-28	1982-11-30	Schering Corporation	1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor
EP0677511A3 (de) *	1983-06-02	1996-07-24	Zambon Spa	Zwischenprodukte zur Herstellung von 1-Phenyl-1-hydroxy-2-amino-3-fluorpropan-Derivaten.
US4876352A (en) *	1988-09-14	1989-10-24	Schering Corporation	Pressurized fluorination of hydroxy alkyl groups
KR920701469A (ko) †	1989-05-15	1992-08-11	스테이너 브이. 캔스태드	향균성 화합물 및 이의 중간물질의 제조방법
CZ286239B6 (cs) *	1990-10-25	2000-02-16	Schering Corporation	Způsob přípravy florfenikolu, jeho analogy a oxazolinové meziprodukty

1996
- 1996-08-19 US US08/699,271 patent/US5663361A/en not_active Expired - Lifetime
1997
- 1997-08-15 AR ARP970103736A patent/AR008298A1/es not_active Application Discontinuation
- 1997-08-15 CO CO97047276A patent/CO4560550A1/es unknown
- 1997-08-18 BR BRPI9711318-2A patent/BR9711318B1/pt not_active IP Right Cessation
- 1997-08-18 CN CN97198768A patent/CN1097583C/zh not_active Expired - Lifetime
- 1997-08-18 AU AU40638/97A patent/AU714495B2/en not_active Expired
- 1997-08-18 PL PL331644A patent/PL196454B1/pl not_active IP Right Cessation
- 1997-08-18 PE PE1997000728A patent/PE99798A1/es not_active Application Discontinuation
- 1997-08-18 MY MYPI97003778A patent/MY115679A/en unknown
- 1997-08-18 CA CA002264116A patent/CA2264116C/en not_active Expired - Lifetime
- 1997-08-18 DE DE69731835T patent/DE69731835T3/de not_active Expired - Lifetime
- 1997-08-18 EP EP97938263.7A patent/EP0922040B2/de not_active Expired - Lifetime
- 1997-08-18 PL PL378741A patent/PL198553B1/pl not_active IP Right Cessation
- 1997-08-18 WO PCT/US1997/014205 patent/WO1998007709A1/en not_active Ceased
- 1997-08-18 JP JP51080598A patent/JP3274868B2/ja not_active Expired - Lifetime
- 1997-08-18 CZ CZ0054099A patent/CZ297915B6/cs not_active IP Right Cessation
- 1997-08-18 IL IL12857497A patent/IL128574A/en not_active IP Right Cessation
- 1997-08-18 ES ES97938263T patent/ES2234026T5/es not_active Expired - Lifetime
- 1997-08-18 TR TR1999/00354T patent/TR199900354T2/xx unknown
- 1997-08-18 HU HU9904166A patent/HU229610B1/hu unknown
- 1997-08-18 TR TR2008/00474T patent/TR200800474T2/xx unknown
- 1997-08-18 PT PT97938263T patent/PT922040E/pt unknown
- 1997-08-18 ID IDP972887A patent/ID18047A/id unknown
- 1997-08-18 DK DK97938263T patent/DK0922040T3/da active
- 1997-08-18 ZA ZA9707406A patent/ZA977406B/xx unknown
- 1997-08-18 AT AT97938263T patent/ATE283847T1/de active
- 1997-08-18 NZ NZ334111A patent/NZ334111A/en not_active IP Right Cessation
- 1997-08-18 SK SK199-99A patent/SK286124B6/sk not_active IP Right Cessation
- 1997-08-18 SI SI9730688T patent/SI0922040T1/xx unknown
- 1997-08-19 TW TW086111823A patent/TW381075B/zh not_active IP Right Cessation
1999
- 1999-02-18 NO NO19990756A patent/NO312962B1/no not_active IP Right Cessation
- 1999-02-18 KR KR1019997001290A patent/KR100286851B1/ko not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PL196454B1 (pl)	2008-01-31
BR9711318B1 (pt)	2009-01-13
JP3274868B2 (ja)	2002-04-15
ID18047A (id)	1998-02-19
AU714495B2 (en)	2000-01-06
HUP9904166A2 (hu)	2000-05-28
DE69731835D1 (de)	2005-01-05
JP2000501424A (ja)	2000-02-08
EP0922040A1 (de)	1999-06-16
TR200800474T2 (tr)	2008-04-21
HU229610B1 (en)	2014-03-28
NO990756D0 (no)	1999-02-18
CN1097583C (zh)	2003-01-01
SK286124B6 (sk)	2008-04-07
CA2264116C (en)	2002-07-02
IL128574A (en)	2002-04-21
BR9711318A (pt)	1999-08-17
SK19999A3 (en)	2000-02-14
PT922040E (pt)	2005-02-28
ES2234026T3 (es)	2005-06-16
IL128574A0 (en)	2000-01-31
DE69731835T3 (de)	2013-12-05
HUP9904166A3 (en)	2001-11-28
CZ297915B6 (cs)	2007-04-25
EP0922040B2 (de)	2013-07-17
ES2234026T5 (es)	2013-11-12
NZ334111A (en)	1999-10-28
PE99798A1 (es)	1998-12-28
TW381075B (en)	2000-02-01
MY115679A (en)	2003-08-30
EP0922040B1 (de)	2004-12-01
AU4063897A (en)	1998-03-06
PL331644A1 (en)	1999-08-02
DE69731835T2 (de)	2005-07-21
HK1017890A1 (en)	1999-12-03
US5663361A (en)	1997-09-02
PL198553B1 (pl)	2008-06-30
AR008298A1 (es)	1999-12-29
NO990756L (no)	1999-02-18
KR20000068178A (ko)	2000-11-25
WO1998007709A1 (en)	1998-02-26
ZA977406B (en)	1998-02-18
KR100286851B1 (ko)	2001-04-16
CN1233244A (zh)	1999-10-27
CA2264116A1 (en)	1998-02-26
CZ54099A3 (cs)	1999-07-14
TR199900354T2 (xx)	1999-05-21
SI0922040T1 (en)	2005-02-28
NO312962B1 (no)	2002-07-22
CO4560550A1 (es)	1998-02-10
DK0922040T3 (da)	2005-04-04

Legal Events

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2006-09-15

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