ATE287878T1 - Disubstituierte morpholin-, oxazepin- oder thiazepinderivate, deren herstellung und verwendung als dopamin-d4-rezeptorantagonisten - Google Patents

Disubstituierte morpholin-, oxazepin- oder thiazepinderivate, deren herstellung und verwendung als dopamin-d4-rezeptorantagonisten

Info

Publication number: ATE287878T1
Authority: AT; Austria
Prior art keywords: oxazepine; dopamine; preparation; receptor antagonists; thiazepine derivatives
Prior art date: 1996-08-23

Application number

AT97942872T

Other languages

English (en)

Inventor

Oskar Axelsson

Dan Peters

Jorgen Scheel-Krueger

Nielsen Elsebet Stergaard

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-23

Filing date

1997-08-22

Publication date

2005-02-15

1997-08-22 Application filed by Neurosearch As filed Critical Neurosearch As

2005-02-15 Application granted granted Critical

2005-02-15 Publication of ATE287878T1 publication Critical patent/ATE287878T1/de

Links

229940124243 Dopamine D4 receptor antagonist Drugs 0.000 title 1
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical class C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 title 1
SFJGCXYXEFWEBK-UHFFFAOYSA-N oxazepine Chemical compound O1C=CC=CC=N1 SFJGCXYXEFWEBK-UHFFFAOYSA-N 0.000 title 1
150000004912 thiazepines Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
-1 nitro, cyano, amino Chemical group 0.000 abstract 1
125000003884 phenylalkyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

AT97942872T 1996-08-23 1997-08-22 Disubstituierte morpholin-, oxazepin- oder thiazepinderivate, deren herstellung und verwendung als dopamin-d4-rezeptorantagonisten ATE287878T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK88396		1996-08-23
PCT/EP1997/004587 WO1998007710A1 (en)	1996-08-23	1997-08-22	Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE287878T1 true ATE287878T1 (de)	2005-02-15

Family

ID=8098601

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97942872T ATE287878T1 (de)	1996-08-23	1997-08-22	Disubstituierte morpholin-, oxazepin- oder thiazepinderivate, deren herstellung und verwendung als dopamin-d4-rezeptorantagonisten

Country Status (6)

Country	Link
US (2)	US6207662B1 (de)
EP (1)	EP0920423B1 (de)
AT (1)	ATE287878T1 (de)
AU (1)	AU4455397A (de)
DE (1)	DE69732359T2 (de)
WO (1)	WO1998007710A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL137930A0 (en) *	1998-02-26	2001-10-31	Neurogen Corp	Benzylpiperazinyl and benzylpiperidinyl ethanone derivatives, their preparation and their use as a dopamine d4 receptor antagonists
US6084098A (en)	1999-02-26	2000-07-04	Neurogen Corporation	Benzylpiperazinyl and piperidinyl ethanone derivatives: dopamine receptor subtype specific ligands
US6284759B1 (en)	1998-09-30	2001-09-04	Neurogen Corporation	2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands
GB201108825D0 (en) *	2011-05-25	2011-07-06	Univ Dundee	Morpholino compounds, uses and methods
WO2016065576A1 (en) *	2014-10-30	2016-05-06	Tianjin Weijie Pharmaceutical Co., Ltd.	Process for preparation of high purity guaiacol glycidyl ether
WO2025219523A1 (en)	2024-04-19	2025-10-23	Cambrex Profarmaco Milano S.R.L.	"intermediates and processes for the preparation of viloxazine"

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1260886A (en)	1969-06-20	1972-01-19	Ici Ltd	Process for aryloxymethylmorpholine derivatives
GB1310236A (en)	1970-05-21	1973-03-14	Ici Ltd	Morpholine derivatives
GB1382526A (en)	1972-08-11	1975-02-05	Ici Ltd	Morpholine derivatives
JPS4982677A (de) *	1972-12-18	1974-08-08
GB1412546A (en)	1973-08-08	1975-11-05	Ici Ltd	Morpholine derivatives
GB1427097A (en)	1973-10-18	1976-03-03	Ici Ltd	Optically-active morpholine derivatives
GB1436395A (en)	1973-12-13	1976-05-19	Ici Ltd	Morpholine derivatives
GB1452701A (en)	1974-05-07	1976-10-13	Ici Ltd	Morpholine derivatives
DE2728898A1 (de)	1977-06-27	1979-01-18	Thomae Gmbh Dr K	Neue morpholinderivate
JPH01117860A (ja)	1987-10-30	1989-05-10	Dainippon Pharmaceut Co Ltd	安息香酸アミド誘導体
JPH02104572A (ja)	1988-10-13	1990-04-17	Dainippon Pharmaceut Co Ltd	安息香酸アミド誘導体
WO1993015052A1 (en)	1992-01-28	1993-08-05	Smithkline Beecham Plc	Compounds as calcium channel antagonists
GB9324018D0 (en)	1993-11-23	1994-01-12	Merck Sharp & Dohme	Therapeutic agents
GB9411045D0 (en) *	1994-06-02	1994-07-20	Smithkline Beecham Plc	Compounds and use

1997
- 1997-08-22 WO PCT/EP1997/004587 patent/WO1998007710A1/en not_active Ceased
- 1997-08-22 AU AU44553/97A patent/AU4455397A/en not_active Abandoned
- 1997-08-22 AT AT97942872T patent/ATE287878T1/de not_active IP Right Cessation
- 1997-08-22 DE DE69732359T patent/DE69732359T2/de not_active Expired - Lifetime
- 1997-08-22 US US09/242,693 patent/US6207662B1/en not_active Expired - Fee Related
- 1997-08-22 EP EP97942872A patent/EP0920423B1/de not_active Expired - Lifetime
2000
- 2000-11-13 US US09/709,297 patent/US6479491B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU4455397A (en)	1998-03-06
US6207662B1 (en)	2001-03-27
DE69732359T2 (de)	2005-06-23
EP0920423B1 (de)	2005-01-26
WO1998007710A1 (en)	1998-02-26
US6479491B1 (en)	2002-11-12
DE69732359D1 (de)	2005-03-03
EP0920423A1 (de)	1999-06-09

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Legal Events

Date	Code	Title	Description
2005-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties