ATE288918T1 - 1-(4-(1-(4-fluorphenyl)-1h-indol-3-yl)1-butyl)- spiro-(isobenzofuran-1(3h),4'-piperidin)- hydrohalogenide - Google Patents

1-(4-(1-(4-fluorphenyl)-1h-indol-3-yl)1-butyl)- spiro-(isobenzofuran-1(3h),4'-piperidin)- hydrohalogenide

Info

Publication number
ATE288918T1
ATE288918T1 AT98952580T AT98952580T ATE288918T1 AT E288918 T1 ATE288918 T1 AT E288918T1 AT 98952580 T AT98952580 T AT 98952580T AT 98952580 T AT98952580 T AT 98952580T AT E288918 T1 ATE288918 T1 AT E288918T1
Authority
AT
Austria
Prior art keywords
hydrohalogenides
isobenzofuran
indol
spiro
fluorophenyl
Prior art date
Application number
AT98952580T
Other languages
English (en)
Inventor
Niels Mork
De Diego Heidi Lopez
Ole Nielsen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of ATE288918T1 publication Critical patent/ATE288918T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT98952580T 1997-11-07 1998-11-06 1-(4-(1-(4-fluorphenyl)-1h-indol-3-yl)1-butyl)- spiro-(isobenzofuran-1(3h),4'-piperidin)- hydrohalogenide ATE288918T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK126797 1997-11-07
PCT/DK1998/000480 WO1999024436A1 (en) 1997-11-07 1998-11-06 1'-[4-[1- (4-fluorophenyl)- 1h-indole-3-yl] -1-butyl]-spiro [isobenzofuran- 1(3h),4'- piperidine] hydrohalogenides

Publications (1)

Publication Number Publication Date
ATE288918T1 true ATE288918T1 (de) 2005-02-15

Family

ID=8102935

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98952580T ATE288918T1 (de) 1997-11-07 1998-11-06 1-(4-(1-(4-fluorphenyl)-1h-indol-3-yl)1-butyl)- spiro-(isobenzofuran-1(3h),4'-piperidin)- hydrohalogenide

Country Status (38)

Country Link
US (2) US6844352B2 (de)
EP (1) EP1044202B1 (de)
JP (1) JP3605358B2 (de)
KR (1) KR100399274B1 (de)
CN (1) CN1105115C (de)
AR (1) AR023010A1 (de)
AT (1) ATE288918T1 (de)
AU (1) AU749094B2 (de)
BG (1) BG64906B1 (de)
BR (1) BR9813949A (de)
CA (1) CA2308745C (de)
CZ (1) CZ288666B6 (de)
DE (1) DE69828999T2 (de)
DZ (1) DZ2642A1 (de)
EA (1) EA002092B1 (de)
EG (1) EG23791A (de)
ES (1) ES2234162T3 (de)
HR (1) HRP20000261B1 (de)
HU (1) HUP0100991A3 (de)
ID (1) ID25776A (de)
IL (1) IL135723A (de)
IS (1) IS2342B (de)
JO (1) JO2052B1 (de)
MA (1) MA25585A1 (de)
NO (1) NO325920B1 (de)
NZ (1) NZ504065A (de)
PE (1) PE130299A1 (de)
PL (1) PL190538B1 (de)
PT (1) PT1044202E (de)
RS (1) RS49777B (de)
SK (1) SK285245B6 (de)
TN (1) TNSN98201A1 (de)
TR (1) TR200001267T2 (de)
TW (1) TW483894B (de)
UA (1) UA64769C2 (de)
UY (1) UY25236A1 (de)
WO (1) WO1999024436A1 (de)
ZA (1) ZA9810116B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030453A1 (es) * 2000-08-15 2003-08-20 Lundbeck & Co As H Composicion farmaceutica con contenido de 1' [4-[1-(4-fluorofenil)-1h-indol-3-il]-1-butil] espiro [isobenzofuran-1 (3h), 4'-piperidina]
AU2003263155A1 (en) * 2002-09-20 2004-04-08 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
US20050032827A1 (en) * 2003-06-12 2005-02-10 Donna Oksenberg Sigma ligands for neuronal regeneration and functional recovery
DE112006002660A5 (de) * 2005-07-29 2008-07-10 Sigma-Aldrich Production Gmbh Ionisierungsadditive enthaltende LC/MS-Blends
EP1940389A2 (de) 2005-10-21 2008-07-09 Braincells, Inc. Modulation von neurogenese durch pde-hemmung
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
EP1991212A1 (de) * 2006-03-08 2008-11-19 Braincells, Inc. Neurogenesemodulation durch nootropika
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2068872A1 (de) * 2006-09-08 2009-06-17 Braincells, Inc. Kombinationen mit einem 4-acylaminopyridin-derivat
AU2007299920A1 (en) * 2006-09-19 2008-03-27 Braincells, Inc. PPAR Mediated Modulation of Neurogenesis
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109002A (en) * 1989-09-08 1992-04-28 Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
JO2052B1 (en) 1999-05-15
EG23791A (en) 2007-08-13
US6844352B2 (en) 2005-01-18
YU23500A (sh) 2003-12-31
WO1999024436A1 (en) 1999-05-20
EA002092B1 (ru) 2001-12-24
IL135723A (en) 2005-11-20
NZ504065A (en) 2002-05-31
KR20010031791A (ko) 2001-04-16
SK6462000A3 (en) 2000-10-09
CN1278823A (zh) 2001-01-03
JP2001522852A (ja) 2001-11-20
US20030055074A1 (en) 2003-03-20
CN1105115C (zh) 2003-04-09
ES2234162T3 (es) 2005-06-16
BG64906B1 (bg) 2006-08-31
RS49777B (sr) 2008-06-05
CZ20001663A3 (cs) 2000-10-11
HRP20000261B1 (en) 2009-04-30
US20050171135A1 (en) 2005-08-04
TNSN98201A1 (fr) 2005-03-15
HUP0100991A3 (en) 2003-03-28
AR023010A1 (es) 2002-09-04
HRP20000261A2 (en) 2001-04-30
MA25585A1 (fr) 2002-12-31
CZ288666B6 (cs) 2001-08-15
ID25776A (id) 2000-11-02
UA64769C2 (uk) 2004-03-15
DZ2642A1 (fr) 2004-12-28
JP3605358B2 (ja) 2004-12-22
EP1044202B1 (de) 2005-02-09
BR9813949A (pt) 2000-09-26
EP1044202A1 (de) 2000-10-18
PT1044202E (pt) 2005-04-29
NO20002188L (no) 2000-06-14
UY25236A1 (es) 2000-12-29
TR200001267T2 (tr) 2000-09-21
BG104485A (en) 2001-01-31
HUP0100991A2 (hu) 2001-09-28
AU749094B2 (en) 2002-06-20
IS2342B (is) 2008-02-15
AU1022699A (en) 1999-05-31
IL135723A0 (en) 2001-05-20
ZA9810116B (en) 1999-05-07
CA2308745C (en) 2004-01-20
PL190538B1 (pl) 2005-12-30
HK1034075A1 (en) 2001-10-12
KR100399274B1 (ko) 2003-09-26
DE69828999T2 (de) 2005-07-21
EA200000502A1 (ru) 2000-10-30
DE69828999D1 (de) 2005-03-17
SK285245B6 (sk) 2006-09-07
IS5460A (is) 2000-04-18
NO325920B1 (no) 2008-08-18
PL340220A1 (en) 2001-01-15
TW483894B (en) 2002-04-21
PE130299A1 (es) 1999-12-16
NO20002188D0 (no) 2000-04-27
CA2308745A1 (en) 1999-05-20

Similar Documents

Publication Publication Date Title
ATE288918T1 (de) 1-(4-(1-(4-fluorphenyl)-1h-indol-3-yl)1-butyl)- spiro-(isobenzofuran-1(3h),4'-piperidin)- hydrohalogenide
DE59507209D1 (de) Volkeramikbohrer
NO980240L (no) Paroxetin-kontrollert frigjörings-blandinger
DE69925105D1 (de) Iontophoretische vorrichtung enthaltend piperidinderivate
ATE278695T1 (de) Piperidinderivate
BR9611075A (pt) Derivados de ciclopentan-1,3-diona
IL125177A0 (en) Novel benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists
IS5336A (is) 2-(4-Arýl eða heteróarýl-píperazín-1-ýlmetýl)-1H-indól afleiður
NO20001215D0 (no) Substituerte 2-pyrrolidinonaktivatorer for PKC
DE69629454D1 (en) Antipsychotische 4-(1h-indolyl-1-yl)-1-substituierte piperidine derivate
DE69801556D1 (de) Spirocyclische Verbindungen
NO992302L (no) Piperidin-derivater
IL123860A0 (en) Phenoxymethyl piperidine derivatives
DK0846683T3 (da) 4-hydroxypiperidinderivater
DE69000324D1 (de) Bohrspindel-tiefeneinstellvorrichtung.
ITMI950389A0 (it) Procedimento per la metilazione del 2,2,6,6-tetrametil-4-piperidone (triacetonammina)
ATE193701T1 (de) Substituierte indol-derivate
NO20001705D0 (no) Optisk plate, og anordning til skanning av den optiske platen
ITTO991117A0 (it) Procedimento per produrre 2,2,6,6-tetrametil-4-piperidone
KR960005394U (ko) 굴착장비의 수직방향 조정장치
DK1044202T3 (da) 1'-[4-[1-(4-Fluorphenyl)-1H-indol-3-yl]-1-butyl]-spiro[isobenzofuran-1(3H),4'-piperidin]hydrohalogenider
NO20001778L (no) Substituerte piperidinderivater
TW380747U (en) Improvement of the striking device for upright piano
KR970016441U (ko) 센터드릴 홀더장치
TR199800596A3 (tr) Fenoksimetil piperidin türevleri

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1044202

Country of ref document: EP

REN Ceased due to non-payment of the annual fee