SG68049A1 - Taxanes having alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing same - Google Patents

Taxanes having alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing same

Info

Publication number: SG68049A1
Authority: SG; Singapore
Prior art keywords: pharmaceutical compositions; alkenoxy; taxanes; alkoxy; chain
Prior art date: 1993-03-22

Application number

SG9801036A

Other languages

English (en)

Inventor

Ki-Byung Chai

Robert A Holton

Hamd Idmoumaz

Hossain Nadizadeh

Yukio Suzuki

Chun Lin Tao

Kasthuri Rengan

Original Assignee

Univ Florida State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-22

Filing date

1994-03-21

Publication date

2001-08-21

1994-03-21 Application filed by Univ Florida State filed Critical Univ Florida State

2001-08-21 Publication of SG68049A1 publication Critical patent/SG68049A1/en

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
229940123237 Taxane Drugs 0.000 title 1
125000003545 alkoxy group Chemical group 0.000 title 1
125000004104 aryloxy group Chemical group 0.000 title 1
239000002671 adjuvant Substances 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
- C07C2603/62—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)
Orthopedics, Nursing, And Contraception (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)
Pyrrole Compounds (AREA)

SG9801036A 1993-03-22 1994-03-21 Taxanes having alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing same SG68049A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3485293A	1993-03-22	1993-03-22
US9471793A	1993-07-20	1993-07-20

Publications (1)

Publication Number	Publication Date
SG68049A1 true SG68049A1 (en)	2001-08-21

Family

ID=26711460

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
SG9801036A SG68049A1 (en)	1993-03-22	1994-03-21	Taxanes having alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing same
SG9904638A SG89298A1 (en)	1993-03-22	1994-03-21	Novel taxanes having a furyl or thienyl substituted side-chain and pharmaceutical compositions containing them
SG1996006328A SG73401A1 (en)	1993-03-22	1994-03-21	Taxanes having alkoxy alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing the same

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
SG9904638A SG89298A1 (en)	1993-03-22	1994-03-21	Novel taxanes having a furyl or thienyl substituted side-chain and pharmaceutical compositions containing them
SG1996006328A SG73401A1 (en)	1993-03-22	1994-03-21	Taxanes having alkoxy alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing the same

Country Status (12)

Country	Link
EP (6)	EP0690867B1 (de)
JP (2)	JPH08508255A (de)
AT (5)	ATE295164T1 (de)
AU (3)	AU691804B2 (de)
CA (2)	CA2158454C (de)
DE (5)	DE69432141T2 (de)
DK (5)	DK1227093T3 (de)
ES (5)	ES2193155T3 (de)
IL (4)	IL180090A0 (de)
PT (5)	PT1228759E (de)
SG (3)	SG68049A1 (de)
WO (2)	WO1994021250A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2712289B1 (fr) *	1993-11-08	1996-01-05	Rhone Poulenc Rorer Sa	Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5677470A (en) *	1994-06-28	1997-10-14	Tanabe Seiyaku Co., Ltd.	Baccatin derivatives and processes for preparing the same
WO1996013495A1 (en) *	1994-10-28	1996-05-09	The Research Foundation Of State University Of New York	Taxoid derivatives, their preparation and their use as antitumor agents
US6458976B1 (en)	1994-10-28	2002-10-01	The Research Foundation Of State University Of New York	Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods
US6500858B2 (en)	1994-10-28	2002-12-31	The Research Foundation Of The State University Of New York	Taxoid anti-tumor agents and pharmaceutical compositions thereof
CA2162759A1 (en) *	1994-11-17	1996-05-18	Kenji Tsujihara	Baccatin derivatives and processes for preparing the same
JP2964475B2 (ja)	1994-11-17	1999-10-18	田辺製薬株式会社	バッカチン誘導体及びその製法
US6075140A (en) *	1995-04-28	2000-06-13	Daiichi Pharmaceutical Co., Ltd.	Pentacyclic compound
JP2001524067A (ja) *	1995-09-13	2001-11-27	フロリダ・ステイト・ユニバーシティ	放射線感作性タキサン類およびその医薬製剤
FR2745814B1 (fr) *	1996-03-06	1998-04-03	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2746797B1 (fr) *	1996-03-27	1998-06-19	Centre Nat Rech Scient	Nouveaux derives du 10-acetyldocetaxel et leur procede de preparation
IL126856A0 (en) *	1996-05-06	1999-09-22	Univ Florida State	1-Deoxy baccatin iii 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
AU4768797A (en)	1996-10-24	1998-05-15	Institute Armand-Frappier	A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
JP2003522169A (ja) *	2000-02-02	2003-07-22	フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド	抗腫瘍剤としてのｃ７ヘテロ置換アセテートタキサン
CO5280224A1 (es) *	2000-02-02	2003-05-30	Univ Florida State Res Found	Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
PL202957B1 (pl) *	2000-02-02	2009-08-31	Univ Florida State Res Found	Podstawione grupą estrową C10 taksany, kompozycja farmaceutyczna zawierająca te związki i zastosowanie tych związków do wytwarzania leku
AU2004275881A1 (en) *	2003-09-25	2005-04-07	Tapestry Pharmaceuticals, Inc.	9,10-alpha,alpha-OH-taxane analogs and methods for production thereof
SI1664033T1 (sl) *	2003-09-25	2008-04-30	Tapestry Pharmaceuticals Inc	Analogi 9,10-alfa,alfa-oh-taksana in postopki za proizvodnjo le-teh
CN1960721A (zh) *	2004-03-05	2007-05-09	佛罗里达州立大学研究基金有限公司	C7乳酰氧基取代的紫杉烷类
JP2008546646A (ja) *	2005-06-10	2008-12-25	フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド	β−ラクタムの鏡像異性体混合物の分離
US11786504B2 (en)	2006-09-28	2023-10-17	Tapestry Pharmaceuticals, Inc.	Taxane analogs for the treatment of brain cancer
WO2008121476A1 (en)	2007-03-28	2008-10-09	Tapestry Pharmaceuticals, Inc.	Biologically active taxane analogs and methods of treatment by oral administration
US11873308B2 (en)	2006-11-06	2024-01-16	Tapestry Pharmaceuticals, Inc.	Biologically active taxane analogs and methods of treatment by oral administration
WO2008109360A1 (en)	2007-02-28	2008-09-12	Tapestry Pharmaceuticals, Inc	Taxane analogs for the treatment of brain cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6075458A (ja) *	1983-06-17	1985-04-27	Osaka Soda Co Ltd	３，４−ジフエニル−１−（４−置換）アリ−ルメチルアゼチジン−２−オンの製法
EP0144840A2 (de) *	1983-11-18	1985-06-19	Takeda Chemical Industries, Ltd.	Optisch wirkende beta-Laktame und Verfahren zu ihrer Herstellung
US5006650A (en) *	1987-02-11	1991-04-09	The Upjohn Company	Novel N-1 substituted beta-lactams as antibiotics

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JPS61243079A (ja) *	1985-04-01	1986-10-29	Mect Corp	１−（アルコキシカルボニルアルキル）−４−（２−フリル）−３−置換−２−アゼチジノン及びその製造方法
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US4942184A (en) *	1988-03-07	1990-07-17	The United States Of America As Represented By The Department Of Health And Human Services	Water soluble, antineoplastic derivatives of taxol
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
AU637109B2 (en) *	1989-06-22	1993-05-20	Rijksuniversiteit Utrecht	Improved synthesis of beta-lactams using a metal compound
US5136060A (en) *	1989-11-14	1992-08-04	Florida State University	Method for preparation of taxol using an oxazinone
US5227400A (en) *	1991-09-23	1993-07-13	Florida State University	Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5250683A (en) *	1991-09-23	1993-10-05	Florida State University	Certain substituted taxanes and pharmaceutical compositions containing them
AU663732B2 (en) *	1991-09-23	1995-10-19	Bristol-Myers Squibb Company	10-desacetoxytaxol derivatives
US5243045A (en) *	1991-09-23	1993-09-07	Florida State University	Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
HU226369B1 (en) *	1991-09-23	2008-09-29	Univ Florida State	Process for preparing substituted isoserine-esters using metal alkoxides and beta-lactams
US5283253A (en) *	1991-09-23	1994-02-01	Florida State University	Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5284865A (en) *	1991-09-23	1994-02-08	Holton Robert A	Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5229526A (en) *	1991-09-23	1993-07-20	Florida State University	Metal alkoxides
FR2688518B1 (fr) *	1992-03-13	1994-05-06	Rhone Poulenc Rorer Sa	Procede de preparation de derives du taxane.
WO1993021173A1 (en) *	1992-04-17	1993-10-28	Abbott Laboratories	Taxol derivatives
FR2696460B1 (fr) *	1992-10-05	1994-11-25	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.

1994
- 1994-03-21 DK DK02009840T patent/DK1227093T3/da active
- 1994-03-21 DK DK02009839T patent/DK1228759T3/da active
- 1994-03-21 AU AU64138/94A patent/AU691804B2/en not_active Ceased
- 1994-03-21 ES ES94911675T patent/ES2193155T3/es not_active Expired - Lifetime
- 1994-03-21 AT AT02019282T patent/ATE295164T1/de not_active IP Right Cessation
- 1994-03-21 CA CA002158454A patent/CA2158454C/en not_active Expired - Fee Related
- 1994-03-21 EP EP94911675A patent/EP0690867B1/de not_active Expired - Lifetime
- 1994-03-21 IL IL180090A patent/IL180090A0/en unknown
- 1994-03-21 AT AT02009839T patent/ATE284689T1/de not_active IP Right Cessation
- 1994-03-21 ES ES94910982T patent/ES2211879T3/es not_active Expired - Lifetime
- 1994-03-21 WO PCT/US1994/003053 patent/WO1994021250A1/en not_active Ceased
- 1994-03-21 EP EP02019282A patent/EP1260223B1/de not_active Expired - Lifetime
- 1994-03-21 EP EP94910982A patent/EP0689436B1/de not_active Expired - Lifetime
- 1994-03-21 SG SG9801036A patent/SG68049A1/en unknown
- 1994-03-21 AT AT02009840T patent/ATE295363T1/de not_active IP Right Cessation
- 1994-03-21 DE DE69432141T patent/DE69432141T2/de not_active Expired - Fee Related
- 1994-03-21 ES ES02019282T patent/ES2242807T3/es not_active Expired - Lifetime
- 1994-03-21 DK DK94910982T patent/DK0689436T3/da active
- 1994-03-21 SG SG9904638A patent/SG89298A1/en unknown
- 1994-03-21 PT PT02009839T patent/PT1228759E/pt unknown
- 1994-03-21 EP EP02009840A patent/EP1227093B1/de not_active Expired - Lifetime
- 1994-03-21 DE DE69434374T patent/DE69434374T2/de not_active Expired - Fee Related
- 1994-03-21 EP EP02009839A patent/EP1228759B1/de not_active Expired - Lifetime
- 1994-03-21 DE DE69433355T patent/DE69433355T2/de not_active Expired - Fee Related
- 1994-03-21 DE DE69434373T patent/DE69434373T2/de not_active Expired - Fee Related
- 1994-03-21 JP JP6521330A patent/JPH08508255A/ja active Pending
- 1994-03-21 CA CA002158862A patent/CA2158862C/en not_active Expired - Fee Related
- 1994-03-21 DK DK94911675T patent/DK0690867T3/da active
- 1994-03-21 ES ES02009840T patent/ES2241923T3/es not_active Expired - Lifetime
- 1994-03-21 AT AT94910982T patent/ATE254914T1/de not_active IP Right Cessation
- 1994-03-21 IL IL109052A patent/IL109052A/en not_active IP Right Cessation
- 1994-03-21 WO PCT/US1994/003097 patent/WO1994021651A1/en not_active Ceased
- 1994-03-21 JP JP6521307A patent/JPH08508469A/ja active Pending
- 1994-03-21 SG SG1996006328A patent/SG73401A1/en unknown
- 1994-03-21 EP EP03027078A patent/EP1398028A3/de not_active Withdrawn
- 1994-03-21 ES ES02009839T patent/ES2232694T3/es not_active Expired - Lifetime
- 1994-03-21 IL IL10905094A patent/IL109050A0/xx unknown
- 1994-03-21 AT AT94911675T patent/ATE232871T1/de not_active IP Right Cessation
- 1994-03-21 PT PT02019282T patent/PT1260223E/pt unknown
- 1994-03-21 DE DE69434190T patent/DE69434190T2/de not_active Expired - Fee Related
- 1994-03-21 PT PT94910982T patent/PT689436E/pt unknown
- 1994-03-21 PT PT94911675T patent/PT690867E/pt unknown
- 1994-03-21 PT PT02009840T patent/PT1227093E/pt unknown
- 1994-03-21 DK DK02019282T patent/DK1260223T3/da active
- 1994-03-21 AU AU63679/94A patent/AU6367994A/en not_active Abandoned
1998
- 1998-08-03 AU AU78636/98A patent/AU714180B2/en not_active Ceased
2008
- 2008-04-17 IL IL190945A patent/IL190945A0/en unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6075458A (ja) *	1983-06-17	1985-04-27	Osaka Soda Co Ltd	３，４−ジフエニル−１−（４−置換）アリ−ルメチルアゼチジン−２−オンの製法
EP0144840A2 (de) *	1983-11-18	1985-06-19	Takeda Chemical Industries, Ltd.	Optisch wirkende beta-Laktame und Verfahren zu ihrer Herstellung
US5006650A (en) *	1987-02-11	1991-04-09	The Upjohn Company	Novel N-1 substituted beta-lactams as antibiotics

Also Published As

Publication number	Publication date
EP0690867B1 (de)	2003-02-19
IL109050A0 (en)	1994-06-24
EP0689436A4 (de)	1996-02-07
DE69433355T2 (de)	2004-05-27
EP1227093B1 (de)	2005-05-11
EP1260223B1 (de)	2005-05-11
ES2242807T3 (es)	2005-11-16
PT1227093E (pt)	2005-09-30
AU6367994A (en)	1994-10-11
EP0689436A1 (de)	1996-01-03
DE69434373D1 (de)	2005-06-16
IL109052A0 (en)	1994-06-24
CA2158862A1 (en)	1994-09-29
DK1227093T3 (da)	2005-08-29
AU714180B2 (en)	1999-12-23
WO1994021250A1 (en)	1994-09-29
JPH08508255A (ja)	1996-09-03
DE69434374D1 (de)	2005-06-16
ATE284689T1 (de)	2005-01-15
SG73401A1 (en)	2000-06-20
CA2158862C (en)	2006-10-10
EP1227093A2 (de)	2002-07-31
DK1260223T3 (da)	2005-09-05
IL190945A0 (en)	2009-02-11
PT1260223E (pt)	2005-09-30
PT689436E (pt)	2004-04-30
SG89298A1 (en)	2002-06-18
EP1227093A3 (de)	2002-08-07
ES2193155T3 (es)	2003-11-01
EP1228759A3 (de)	2002-09-25
CA2158454A1 (en)	1994-09-29
EP1398028A2 (de)	2004-03-17
EP1398028A3 (de)	2004-03-24
DE69434190D1 (de)	2005-01-20
EP0689436B1 (de)	2003-11-26
DE69434374T2 (de)	2005-11-24
EP1228759A2 (de)	2002-08-07
PT690867E (pt)	2003-06-30
DE69434373T2 (de)	2006-03-09
ATE232871T1 (de)	2003-03-15
WO1994021651A1 (en)	1994-09-29
DK0689436T3 (da)	2004-03-29
EP1228759B1 (de)	2004-12-15
DK1228759T3 (da)	2005-04-18
ES2241923T3 (es)	2005-11-01
ATE254914T1 (de)	2003-12-15
CA2158454C (en)	2006-05-23
EP1260223A1 (de)	2002-11-27
DE69434190T2 (de)	2005-05-25
JPH08508469A (ja)	1996-09-10
EP0690867A1 (de)	1996-01-10
ATE295363T1 (de)	2005-05-15
ES2211879T3 (es)	2004-07-16
AU691804B2 (en)	1998-05-28
AU6413894A (en)	1994-10-11
IL180090A0 (en)	2007-05-15
IL109052A (en)	2009-07-20
EP0690867A4 (de)	1996-03-20
AU7863698A (en)	1998-10-01
DE69433355D1 (de)	2004-01-08
PT1228759E (pt)	2005-04-29
DE69432141D1 (de)	2003-03-27
DK0690867T3 (da)	2003-06-10
DE69432141T2 (de)	2003-07-31
ATE295164T1 (de)	2005-05-15
ES2232694T3 (es)	2005-06-01

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