ATE295412T1 - Methoden für die ex-vivo replikation und stabile genetische transformation von menschlichen stamm- zellen - Google Patents
Methoden für die ex-vivo replikation und stabile genetische transformation von menschlichen stamm- zellenInfo
- Publication number
- ATE295412T1 ATE295412T1 AT92904136T AT92904136T ATE295412T1 AT E295412 T1 ATE295412 T1 AT E295412T1 AT 92904136 T AT92904136 T AT 92904136T AT 92904136 T AT92904136 T AT 92904136T AT E295412 T1 ATE295412 T1 AT E295412T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- human stem
- stem cells
- genetic transformation
- stable genetic
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 210000000130 stem cell Anatomy 0.000 title abstract 2
- 230000002068 genetic effect Effects 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
- 230000009466 transformation Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 238000001415 gene therapy Methods 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 210000001185 bone marrow Anatomy 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 230000024642 stem cell division Effects 0.000 abstract 1
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
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- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
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- Cell Biology (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62834390A | 1990-12-17 | 1990-12-17 | |
| US73702491A | 1991-07-29 | 1991-07-29 | |
| US07/740,590 US5399493A (en) | 1989-06-15 | 1991-08-05 | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
| PCT/US1991/009173 WO1992011355A1 (en) | 1990-12-17 | 1991-12-17 | Method for culturing and transforming human stem cell-containing compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE295412T1 true ATE295412T1 (de) | 2005-05-15 |
Family
ID=27417447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92904136T ATE295412T1 (de) | 1990-12-17 | 1991-12-17 | Methoden für die ex-vivo replikation und stabile genetische transformation von menschlichen stamm- zellen |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5399493A (de) |
| EP (2) | EP0575350B1 (de) |
| JP (5) | JPH06505151A (de) |
| KR (1) | KR100225307B1 (de) |
| AT (1) | ATE295412T1 (de) |
| AU (1) | AU687674B2 (de) |
| CA (1) | CA2100268C (de) |
| DE (1) | DE69133459T2 (de) |
| WO (1) | WO1992011355A1 (de) |
Families Citing this family (197)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69012601T2 (de) * | 1989-02-02 | 1995-01-19 | Joel S Greenberger | Gentherapie durch stützgewebebezügliche Zellen. |
| US5399493A (en) * | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
| US5635386A (en) | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
| US5605822A (en) * | 1989-06-15 | 1997-02-25 | The Regents Of The University Of Michigan | Methods, compositions and devices for growing human hematopoietic cells |
| US5635387A (en) * | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| ATE164076T1 (de) * | 1990-06-08 | 1998-04-15 | Univ New York | Stimulierung der stroma- und vorläuferzellen im knochenmark |
| US5612211A (en) * | 1990-06-08 | 1997-03-18 | New York University | Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors |
| US20030125519A1 (en) | 1990-08-27 | 2003-07-03 | Peter Besmer | Ligand for the c-kit receptor and methods of use thereof |
| US5744361A (en) * | 1991-04-09 | 1998-04-28 | Indiana University | Expansion of human hematopoietic progenitor cells in a liquid medium |
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-
1991
- 1991-08-05 US US07/740,590 patent/US5399493A/en not_active Expired - Lifetime
- 1991-12-17 EP EP92904136A patent/EP0575350B1/de not_active Expired - Lifetime
- 1991-12-17 EP EP04101846A patent/EP1473360A3/de not_active Withdrawn
- 1991-12-17 KR KR1019930701843A patent/KR100225307B1/ko not_active Expired - Fee Related
- 1991-12-17 DE DE69133459T patent/DE69133459T2/de not_active Expired - Lifetime
- 1991-12-17 AT AT92904136T patent/ATE295412T1/de not_active IP Right Cessation
- 1991-12-17 WO PCT/US1991/009173 patent/WO1992011355A1/en not_active Ceased
- 1991-12-17 CA CA002100268A patent/CA2100268C/en not_active Expired - Lifetime
- 1991-12-17 JP JP4504303A patent/JPH06505151A/ja active Pending
-
1994
- 1994-12-30 US US08/366,493 patent/US5670351A/en not_active Expired - Lifetime
-
1996
- 1996-04-10 AU AU50592/96A patent/AU687674B2/en not_active Ceased
-
1998
- 1998-12-02 JP JP10342917A patent/JPH11221074A/ja active Pending
-
2000
- 2000-01-26 JP JP2000017257A patent/JP2000189157A/ja active Pending
- 2000-09-26 JP JP2000291494A patent/JP2001120261A/ja active Pending
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2006
- 2006-01-05 JP JP2006000956A patent/JP2006158401A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR930703434A (ko) | 1993-11-30 |
| EP0575350A1 (de) | 1993-12-29 |
| EP1473360A2 (de) | 2004-11-03 |
| EP0575350A4 (en) | 1997-07-02 |
| AU5059296A (en) | 1996-07-11 |
| WO1992011355A1 (en) | 1992-07-09 |
| AU687674B2 (en) | 1998-02-26 |
| US5670351A (en) | 1997-09-23 |
| JPH06505151A (ja) | 1994-06-16 |
| AU9175091A (en) | 1992-07-22 |
| JP2000189157A (ja) | 2000-07-11 |
| EP1473360A3 (de) | 2005-02-02 |
| KR100225307B1 (ko) | 1999-10-15 |
| EP0575350B1 (de) | 2005-05-11 |
| CA2100268A1 (en) | 1992-06-18 |
| JPH11221074A (ja) | 1999-08-17 |
| US5399493A (en) | 1995-03-21 |
| JP2001120261A (ja) | 2001-05-08 |
| AU665525B2 (en) | 1996-01-11 |
| EP1473360A8 (de) | 2010-07-28 |
| JP2006158401A (ja) | 2006-06-22 |
| DE69133459T2 (de) | 2006-01-19 |
| CA2100268C (en) | 2008-12-02 |
| DE69133459D1 (de) | 2005-06-16 |
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