ATE297196T1 - Verfahren zur herstellung von nanometer partikeln durch fliessbett- sprühtrocknung - Google Patents
Verfahren zur herstellung von nanometer partikeln durch fliessbett- sprühtrocknungInfo
- Publication number
- ATE297196T1 ATE297196T1 AT00986607T AT00986607T ATE297196T1 AT E297196 T1 ATE297196 T1 AT E297196T1 AT 00986607 T AT00986607 T AT 00986607T AT 00986607 T AT00986607 T AT 00986607T AT E297196 T1 ATE297196 T1 AT E297196T1
- Authority
- AT
- Austria
- Prior art keywords
- spray drying
- fluid bed
- nanometer particles
- bed spray
- particles
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 4
- 239000012530 fluid Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000001694 spray drying Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- General Preparation And Processing Of Foods (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17257399P | 1999-12-20 | 1999-12-20 | |
| PCT/US2000/034606 WO2001045677A1 (en) | 1999-12-20 | 2000-12-19 | Process for producing nanometer particles by fluid bed spray-drying |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE297196T1 true ATE297196T1 (de) | 2005-06-15 |
Family
ID=22628280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00986607T ATE297196T1 (de) | 1999-12-20 | 2000-12-19 | Verfahren zur herstellung von nanometer partikeln durch fliessbett- sprühtrocknung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7078057B2 (de) |
| EP (1) | EP1239844B1 (de) |
| JP (3) | JP2003518038A (de) |
| AT (1) | ATE297196T1 (de) |
| AU (2) | AU2583401A (de) |
| CA (1) | CA2395129C (de) |
| DE (1) | DE60020732T2 (de) |
| ES (1) | ES2240222T3 (de) |
| MX (1) | MXPA02006079A (de) |
| WO (2) | WO2001045674A1 (de) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0901786T3 (da) | 1997-08-11 | 2007-10-08 | Pfizer Prod Inc | Faste farmaceutiske dispersioner med foröget biotilgængelighed |
| US8236352B2 (en) | 1998-10-01 | 2012-08-07 | Alkermes Pharma Ireland Limited | Glipizide compositions |
| JP2003518038A (ja) * | 1999-12-20 | 2003-06-03 | ニコラス， ジェイ カークホフ， | 流動床噴霧乾燥によるナノ粒子製造方法 |
| US8771740B2 (en) * | 1999-12-20 | 2014-07-08 | Nicholas J. Kerkhof | Process for producing nanoparticles by spray drying |
| US6316029B1 (en) * | 2000-05-18 | 2001-11-13 | Flak Pharma International, Ltd. | Rapidly disintegrating solid oral dosage form |
| EP1186347A1 (de) * | 2000-09-05 | 2002-03-13 | F. Hoffmann-La Roche Ag | Verfahren und Vorrichtung zum Zerstäuben von Flüssigkeiten |
| JP2004537401A (ja) | 2001-08-08 | 2004-12-16 | ブラウン ユニバーシティ リサーチ ファウンデーション | 疎水性薬物の微粉砕方法 |
| DE60211004T2 (de) * | 2001-10-10 | 2006-08-31 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Pulververarbeitung mit unter druck stehenden gasförmigen fluids |
| AU2002365893C1 (en) * | 2001-11-30 | 2009-07-09 | Invitrogen Corporation | Cell culture media |
| AU2002351626A1 (en) * | 2001-12-21 | 2003-07-15 | Celator Technologies Inc. | Improved polymer-lipid delivery vehicles |
| US20070059358A1 (en) * | 2003-07-02 | 2007-03-15 | Tianjin Tasly Pharmaceutical Co., Ltd., China | Matrix adjuvants and the drop pills prepared with them |
| US7198653B2 (en) | 2003-07-31 | 2007-04-03 | Delavau Llc | Calcium carbonate granulation |
| US8188067B2 (en) | 2004-04-01 | 2012-05-29 | Teva Pharmaceutical Industries Ltd. | Formulations of 6-mercaptopurine |
| CA2560654A1 (en) * | 2004-04-01 | 2006-09-20 | Teva Pharmaceutical Industries Ltd. | Imroved formulations of 6-mercaptopurine |
| AU2005263550C1 (en) * | 2004-07-16 | 2013-01-17 | Lek Pharmaceuticals D.D. | Oxidative degradation products of atorvastatin calcium |
| EP1806129A1 (de) * | 2004-10-01 | 2007-07-11 | Eisai R&D Management Co., Ltd. | Feine teilchen enthaltende zusammensetzung und verfahren zu ihrer herstellung |
| US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| DK1848430T3 (da) | 2004-12-31 | 2017-11-06 | Dr Reddys Laboratories Ltd | Nye benzylamin-derivativer som cetp-inhibitors |
| RU2007133547A (ru) | 2005-02-10 | 2009-03-20 | Глаксо Груп Лимитед (GB) | Способы получения лактозы с использованием методов предварительной сортировки и приготовляемые из нее фармацевтические композиции |
| DE102005011786A1 (de) | 2005-03-11 | 2006-09-14 | Pharmasol Gmbh | Verfahren zur Herstellung ultrafeiner Submicron-Suspensionen |
| CA2606861C (en) * | 2005-05-05 | 2012-08-07 | Sanofi-Aventis U.S. Llc | Stable nanoparticle formulations |
| ES2812250T3 (es) * | 2005-11-28 | 2021-03-16 | Marinus Pharmaceuticals Inc | Formulaciones de ganaxolona y procedimientos para la preparación y uso de las mismas |
| JP2007297348A (ja) * | 2006-05-02 | 2007-11-15 | Daito Kk | エバスチンを含有する錠剤 |
| WO2007132852A1 (ja) * | 2006-05-15 | 2007-11-22 | Ebara Corporation | 難水溶性医薬 |
| JP2007306950A (ja) | 2006-05-15 | 2007-11-29 | Osaka Univ | 薬効成分ナノ粒子分散液の製造方法 |
| RU2009103660A (ru) * | 2006-07-07 | 2010-08-20 | Тева Фармасьютикал Индастриес Лтд. (Il) | Твердые фармацевтические композиции, включающие тадалафил и по меньшей мере один носитель |
| US9138414B1 (en) | 2006-09-15 | 2015-09-22 | Delavau Llc | Calcium supplement having enhanced absorption |
| WO2008066899A2 (en) | 2006-11-28 | 2008-06-05 | Marinus Pharmaceuticals | Nanoparticulate formulations and methods for the making and use thereof |
| US20080161594A1 (en) * | 2006-12-29 | 2008-07-03 | Industrial Technology Research Institute | Method for fabricating nanoparticles containing fenofibrate |
| WO2008138755A2 (en) * | 2007-05-11 | 2008-11-20 | F. Hoffmann-La Roche Ag | Pharmaceutical compositions for poorly soluble drugs |
| DE102007028869A1 (de) * | 2007-06-22 | 2008-12-24 | Ratiopharm Gmbh | Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil |
| FR2918277B1 (fr) * | 2007-07-06 | 2012-10-05 | Coretecholding | Nouveau procede de production de formes pharmaceutiques seches hydrodispersibles et les compositions hydrodispersibles ainsi obtenues |
| KR100991675B1 (ko) * | 2007-08-06 | 2010-11-04 | 한국식품연구원 | 식물 정유를 함유하는 나노에멀션과 나노입자 및 그제조방법 |
| GB0720516D0 (en) * | 2007-10-18 | 2007-11-28 | Cadbury Schweppes Plc | Comestible products |
| FI121990B (fi) * | 2007-12-20 | 2011-07-15 | Beneq Oy | Laite sumun ja hiukkasten tuottamiseksi |
| US20100055187A1 (en) * | 2008-08-28 | 2010-03-04 | Dong June Ahn | Nanovitamin synthesis |
| US20100055246A1 (en) * | 2008-08-28 | 2010-03-04 | Dong June Ahn | Nutrition delivery capsules for functional foods |
| GB0815852D0 (en) * | 2008-09-01 | 2008-10-08 | Unilever Plc | Improvements relating to pharmaceutical compositions |
| CA2744377A1 (en) * | 2008-11-20 | 2010-05-27 | Avantor Performance Materials, Inc. | Directly compressible high functionality granular dibasic calcium phosphate based co-processed excipient |
| US8889213B2 (en) | 2009-01-26 | 2014-11-18 | Teva Pharmaceutical Industries Ltd. | Processes for coating a carrier with microparticles |
| WO2010111132A2 (en) | 2009-03-27 | 2010-09-30 | Bend Research, Inc. | Spray-drying process |
| EP2611529B1 (de) | 2010-09-03 | 2019-01-23 | Bend Research, Inc. | Sprühtrocknungsverfahren |
| PT2611530T (pt) | 2010-09-03 | 2019-05-09 | Bend Res Inc | Aparelho de secagem por pulverização e métodos de utilização do mesmo |
| US8815294B2 (en) | 2010-09-03 | 2014-08-26 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives and a carrier material |
| EP2618924A1 (de) | 2010-09-24 | 2013-07-31 | Bend Research, Inc. | Hochtemperatur-sprühtrocknungsverfahren und verfahren |
| EP2675434A1 (de) | 2011-02-17 | 2013-12-25 | F.Hoffmann-La Roche Ag | Verfahren zur kontrollierten kristallisierung eines wirkstoffes aus einem unterkühlten flüssigkeitszustand durch schmelzextrusion |
| CA2845284C (en) | 2011-08-18 | 2018-03-06 | Dr. Reddy's Laboratories Ltd. | Substituted heterocyclic amine compounds as cholesteryl ester-transfer protein (cetp) inhibitors |
| JP6140168B2 (ja) | 2011-09-27 | 2017-05-31 | ドクター レディズ ラボラトリーズ リミテッド | アテローム性動脈硬化症の処置のために有用なコレステリルエステル転送タンパク質（ｃｅｔｐ）インヒビターとしての５−ベンジルアミノメチル−６−アミノピラゾロ［３，４−ｂ］ピリジン誘導体 |
| US10076496B2 (en) * | 2011-11-11 | 2018-09-18 | The Chinese University Of Hong Kong | Engineering of polymer-stabilized nanoparticles for drugs with Log P values below 6 by controlled antisolvent precipitation |
| US9789071B2 (en) | 2012-06-27 | 2017-10-17 | G2B Pharma, Inc. | Intranasal formulation of epinephrine for the treatment of anaphylaxis |
| WO2014028796A2 (en) * | 2012-08-17 | 2014-02-20 | Smartek International Llc | Preparation of desiccated liposomes for use in compressible delivery systems |
| CA2891502A1 (en) | 2012-11-19 | 2014-05-22 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions of cetp inhibitors |
| CN104255715A (zh) * | 2014-09-01 | 2015-01-07 | 李晓枫 | 一种纳米生物农药组合物及其制备方法 |
| EP3212169B1 (de) | 2014-10-31 | 2021-01-13 | Bend Research, Inc. | Verfahren zur herstellung von in einer matrix dispergierten aktiven domänen |
| EP3340982B1 (de) | 2015-08-26 | 2021-12-15 | Achillion Pharmaceuticals, Inc. | Verbindungen zur behandlung von immun- und entzündungserkrankungen |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| AU2016338672A1 (en) * | 2015-10-16 | 2018-04-12 | Marinus Pharmaceuticals, Inc. | Injectable neurosteroid formulations containing nanoparticles |
| WO2017066619A1 (en) | 2015-10-16 | 2017-04-20 | Teva Pharmaceutical Industries Ltd. | Treatment of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis with delayed-release 6-mercaptopurine |
| US20190292515A1 (en) * | 2015-12-30 | 2019-09-26 | Life Technologies Corporation | Layered cell culture media particles and methods of making thereof |
| CN109414441A (zh) | 2016-06-27 | 2019-03-01 | 艾其林医药公司 | 治疗医学障碍的喹唑啉和吲哚化合物 |
| EP4233861A3 (de) | 2016-08-11 | 2023-10-11 | Ovid Therapeutics, Inc. | Zusammensetzungen zur behandlung von essentiellem tremor |
| US10391105B2 (en) | 2016-09-09 | 2019-08-27 | Marinus Pharmaceuticals Inc. | Methods of treating certain depressive disorders and delirium tremens |
| KR102632860B1 (ko) | 2017-03-01 | 2024-02-02 | 아칠리온 파르마세우티칼스 인코포레이티드 | 의학적 장애의 치료를 위한 아릴, 헤테로아릴, 및 헤테로사이클릭 약학적 화합물 |
| CN108586624A (zh) * | 2018-05-15 | 2018-09-28 | 郑州轻工业学院 | 一种空气常压等离子体射流改性微晶淀粉的方法 |
| US20230022157A1 (en) | 2018-08-20 | 2023-01-26 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement factor d medical disorders |
| EP3846803A4 (de) | 2018-09-06 | 2022-08-10 | Achillion Pharmaceuticals, Inc. | Makrocyclische verbindungen zur behandlung von medizinischen erkrankungen |
| WO2020081723A1 (en) | 2018-10-16 | 2020-04-23 | Georgia State University Research Foundation, Inc. | Carbon monoxide prodrugs for the treatment of medical disorders |
| US11266662B2 (en) | 2018-12-07 | 2022-03-08 | Marinus Pharmaceuticals, Inc. | Ganaxolone for use in prophylaxis and treatment of postpartum depression |
| CN114728012A (zh) | 2019-08-05 | 2022-07-08 | 马瑞纳斯制药公司 | 用于治疗癫痫持续状态的加奈索酮 |
| CN114828889B (zh) | 2019-12-06 | 2025-02-14 | 马瑞纳斯制药公司 | 用于治疗结节性硬化症的加奈索酮 |
| CN119837855A (zh) | 2019-12-19 | 2025-04-18 | 乔治亚州大学研究基金会 | 用于治疗细菌感染和增强抗生素的化合物 |
| CN115362162A (zh) | 2020-02-20 | 2022-11-18 | 艾其林医药公司 | 用于治疗补体因子d介导的障碍的杂芳基化合物 |
| CA3193488A1 (en) | 2020-09-23 | 2022-03-31 | Jason Allan Wiles | Pharmaceutical compounds for the treatment of complement mediated disorders |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK125813B (da) | 1971-04-16 | 1973-05-07 | Niro Atomizer As | Apparat til tørring af fugtige pulvere. |
| US4511592A (en) | 1982-03-11 | 1985-04-16 | Scm Corporation | Preparation of acidulated meat emulsions |
| US4623588A (en) * | 1984-02-06 | 1986-11-18 | Biotek, Inc. | Controlled release composite core coated microparticles |
| US4663364A (en) | 1984-09-05 | 1987-05-05 | Kao Corporation | Biocidal fine powder, its manufacturing method and a suspension for agricultural use containing the above powder |
| US4689297A (en) | 1985-03-05 | 1987-08-25 | Miles Laboratories, Inc. | Dust free particulate enzyme formulation |
| DK158532C (da) | 1987-07-14 | 1990-10-29 | Niro Atomizer As | Toerreapparat, der arbejder med fluid bed, og lejeplade dertil |
| US5232917A (en) * | 1987-08-25 | 1993-08-03 | University Of Southern California | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series |
| US5015480A (en) * | 1987-11-25 | 1991-05-14 | Eli Lilly And Company | Film coating formulations |
| JP2528706B2 (ja) * | 1988-05-30 | 1996-08-28 | ゼリア新薬工業株式会社 | ジヒドロピリジン化合物の製剤組成物 |
| US5006204A (en) | 1988-08-10 | 1991-04-09 | A/S Niro Atomizer | Apparatus for crystallizing whey |
| JP2642486B2 (ja) | 1989-08-04 | 1997-08-20 | 田辺製薬株式会社 | 難溶性薬物の超微粒子化法 |
| EP0441092A1 (de) | 1990-02-08 | 1991-08-14 | Niro Holding A/S | Verfahren und Vorrichtung zur Wärmebehandlung eines körnigen Produktes |
| ES2067007T3 (es) | 1990-09-11 | 1995-03-16 | Niro Holding As | Metodo y aparato para el tratamiento con gas de un material o producto pulverulento o en particulas. |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| IE67345B1 (en) * | 1991-03-12 | 1996-03-20 | Akzo Nv | Low dose dry pharmaceutical preparations |
| DE69104183T2 (de) | 1991-04-05 | 1995-05-11 | Niro Holding As | Wirbelbettvorrichtung und Verfahren zu ihrer Herstellung. |
| EP0611567B1 (de) * | 1992-06-12 | 2002-08-28 | Teijin Limited | Ultrafeines pulver zur inhalation und dessen herstellung |
| US5325606A (en) | 1992-12-23 | 1994-07-05 | Niro A/S | Process and apparatus for drying and calcining sodium bicarbonate |
| CA2128820A1 (en) * | 1993-07-27 | 1995-01-28 | Walter G. Gowan, Jr. | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof |
| JP2700141B2 (ja) * | 1993-09-17 | 1998-01-19 | 富士化学工業株式会社 | リン酸水素カルシウム及びその製法並びにそれを用いた賦形剤 |
| DK0752860T3 (da) | 1994-02-14 | 2000-11-13 | Euro Celtique Sa | Androstaner og pregnaner til allosterisk modulering af GABA-receptor |
| US5955448A (en) * | 1994-08-19 | 1999-09-21 | Quadrant Holdings Cambridge Limited | Method for stabilization of biological substances during drying and subsequent storage and compositions thereof |
| JPH0820537A (ja) * | 1994-07-06 | 1996-01-23 | Toa Eiyoo Kk | 抗潰瘍剤含有固形製剤 |
| KR970705979A (ko) | 1994-09-29 | 1997-11-03 | 디 히스 | 치료용 매개체로서의 분무-건조 미소입자 (Spray-dried microparticles as therapeutic vehicles) |
| AP653A (en) | 1994-11-23 | 1998-07-21 | Cocensys Inc | Androstane and pregnane series for allosteric modulations of gaba receptor. |
| US5573783A (en) * | 1995-02-13 | 1996-11-12 | Nano Systems L.L.C. | Redispersible nanoparticulate film matrices with protective overcoats |
| US5510118A (en) | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
| US5741818A (en) | 1995-06-07 | 1998-04-21 | University Of Saskatchewan | Semicarbazones having CNS activity and pharmaceutical preparations containing same |
| WO1997013503A1 (en) | 1995-10-13 | 1997-04-17 | The Penn State Research Foundation | Synthesis of drug nanoparticles by spray drying |
| JP4183279B2 (ja) * | 1997-04-15 | 2008-11-19 | アール ピー シェーラー テクノロジーズ インコーポレーテッド | 医薬用加水分解セルロース顆粒 |
| JP3293524B2 (ja) * | 1997-06-17 | 2002-06-17 | 有限会社薬研 | イチョウ葉抽出エキス担持粉体複合物及びその製造方法 |
| JP2003518038A (ja) * | 1999-12-20 | 2003-06-03 | ニコラス， ジェイ カークホフ， | 流動床噴霧乾燥によるナノ粒子製造方法 |
-
2000
- 2000-12-19 JP JP2001546416A patent/JP2003518038A/ja not_active Withdrawn
- 2000-12-19 AU AU25834/01A patent/AU2583401A/en not_active Abandoned
- 2000-12-19 WO PCT/US2000/034479 patent/WO2001045674A1/en not_active Ceased
- 2000-12-19 MX MXPA02006079A patent/MXPA02006079A/es active IP Right Grant
- 2000-12-19 DE DE60020732T patent/DE60020732T2/de not_active Expired - Lifetime
- 2000-12-19 ES ES00986607T patent/ES2240222T3/es not_active Expired - Lifetime
- 2000-12-19 US US10/168,520 patent/US7078057B2/en not_active Expired - Lifetime
- 2000-12-19 CA CA002395129A patent/CA2395129C/en not_active Expired - Lifetime
- 2000-12-19 EP EP00986607A patent/EP1239844B1/de not_active Expired - Lifetime
- 2000-12-19 AU AU22814/01A patent/AU778931B2/en not_active Ceased
- 2000-12-19 WO PCT/US2000/034606 patent/WO2001045677A1/en not_active Ceased
- 2000-12-19 AT AT00986607T patent/ATE297196T1/de not_active IP Right Cessation
-
2009
- 2009-11-27 JP JP2009270841A patent/JP2010090132A/ja active Pending
-
2012
- 2012-01-12 JP JP2012004371A patent/JP2012102135A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE60020732D1 (de) | 2005-07-14 |
| MXPA02006079A (es) | 2004-08-23 |
| AU2281401A (en) | 2001-07-03 |
| DE60020732T2 (de) | 2006-05-11 |
| CA2395129A1 (en) | 2001-06-28 |
| CA2395129C (en) | 2008-12-16 |
| US20030211162A1 (en) | 2003-11-13 |
| ES2240222T3 (es) | 2005-10-16 |
| AU778931B2 (en) | 2004-12-23 |
| JP2012102135A (ja) | 2012-05-31 |
| WO2001045674A1 (en) | 2001-06-28 |
| EP1239844B1 (de) | 2005-06-08 |
| JP2010090132A (ja) | 2010-04-22 |
| EP1239844A1 (de) | 2002-09-18 |
| US7078057B2 (en) | 2006-07-18 |
| AU2583401A (en) | 2001-07-03 |
| WO2001045677A1 (en) | 2001-06-28 |
| JP2003518038A (ja) | 2003-06-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60020732D1 (de) | Verfahren zur herstellung von nanometer partikeln durch fliessbett- sprühtrocknung | |
| DE50001620D1 (de) | Verfahren zur herstellung von perlpolymerisaten | |
| DE50205571D1 (de) | Verfahren zur Herstellung von direkt tablettierbaren Beta-Mannit | |
| DE59007616D1 (de) | Verfahren zur Herstellung von kugelförmigen, harten mono- oder oligodispersen Teilchen aus Melaminharz. | |
| ATE344275T1 (de) | Verfahren zur herstellung eines agglomerats von n-(n-(3,3-dimethylbutyl)-l- alpha aspartyl)-l- phenylalanine-1-methylester | |
| ATE342714T1 (de) | Verfahren zur herstellung von oralen calcium zusammensetzungen | |
| ATE513885T1 (de) | Agglomeriertes schleifmittelkorn und verfahren zu seiner herstellung | |
| DE60030999D1 (de) | Verfahren zur herstellung von teilchen | |
| DE59810804D1 (de) | Verfahren zur herstellung von gemischen monoolefinischer c 5-mononitrile durch katalytische hydrocyanierung in gebenwart eines katalysators, umfassend wenigstens einen metallocenphosphor (iii)-nickel(0)-komplex | |
| RU2002133059A (ru) | Полиамидный порошок для применения в составе косметических средств | |
| DE69920676D1 (de) | Verfahren zur Herstellung von Amin-Umsetzungsprodukt-Teilchen | |
| DE60225433D1 (de) | Verfahren zur herstellung von 1,3-substituierte indene und aryl-annellierte azapolycyclische verbindungen | |
| DE59402607D1 (de) | Verfahren zur herstellung von granulaten | |
| DE69936250D1 (de) | Mittel zur Entfernung von sauren Komponenten, Verfahren zu seiner Herstellung und Methode zur Entfernung von sauren Komponenten | |
| ATE141518T1 (de) | Echogene partikel, verfahren zu deren herstellung und deren verwendung | |
| ATE238323T1 (de) | Pulverisierte-sorbitol und ihr verfahren zur herstellung | |
| ATE295153T1 (de) | Verfahren zur herstellung von metoprolol enthaltenden mikropartikeln | |
| ATE286081T1 (de) | Verfahren zur herstellung von polymerteilchen | |
| DE69723503D1 (de) | Ultrafeines Partikel, Verfahren seiner Herstellung, Herstellung von Formkörper aus diesen Partikeln und Fullerenes und deren Herstellungsverfahren | |
| DE50105968D1 (de) | VERFAHREN ZUR HERSTELLUNG VON AlKYLVERBRÜCKTEN LIGANDSYSTEMEN UND ÜBERGANGSMETALLVERBINDUNGEN | |
| DE60042777D1 (de) | Verfahren für die herstellung von monodispergierten polymerteilchen | |
| DE69428880D1 (de) | Verfahren zur herstellung beschichteter teilchen | |
| DE69836496D1 (de) | Verfahren zur herstellung von beta-(1,3)-d-glukan aus pilzen | |
| DE60022415D1 (de) | Verfahren zur Herstellung von Resistmustern | |
| ATE140013T1 (de) | Verfahren zur herstellung von syndiotaktischen copolymeren aus propylen und olefinen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |