ATE297377T1 - Verfahren zur herstellung von n-((s)-1- carboxybutyl)-(s) alanine estern und verwendung zur synthese von perindopril - Google Patents

Verfahren zur herstellung von n-((s)-1- carboxybutyl)-(s) alanine estern und verwendung zur synthese von perindopril

Info

Publication number: ATE297377T1
Authority: AT; Austria
Prior art keywords: carboxybutyl; perindopril; synthesis; producing; alanine esters
Prior art date: 2000-03-31

Application number

AT01921440T

Other languages

English (en)

Inventor

Jean-Claude Souvie

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-31

Filing date

2001-03-30

Publication date

2005-06-15

2001-03-30 Application filed by Servier Lab filed Critical Servier Lab

2005-06-15 Application granted granted Critical

2005-06-15 Publication of ATE297377T1 publication Critical patent/ATE297377T1/de

Links

230000015572 biosynthetic process Effects 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title 1
229960002582 perindopril Drugs 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Indole Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT01921440T 2000-03-31 2001-03-30 Verfahren zur herstellung von n-((s)-1- carboxybutyl)-(s) alanine estern und verwendung zur synthese von perindopril ATE297377T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0004112A FR2807037B1 (fr)	2000-03-31	2000-03-31	NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
PCT/FR2001/000959 WO2001056353A2 (fr)	2000-03-31	2001-03-30	Nouveau procede de synthese de esters de la n-[(s)-1-carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Publications (1)

Publication Number	Publication Date
ATE297377T1 true ATE297377T1 (de)	2005-06-15

Family

ID=8848711

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01921440T ATE297377T1 (de)	2000-03-31	2001-03-30	Verfahren zur herstellung von n-((s)-1- carboxybutyl)-(s) alanine estern und verwendung zur synthese von perindopril

Country Status (35)

Country	Link
US (1)	US6818788B2 (de)
EP (1)	EP1268398B1 (de)
JP (1)	JP3930322B2 (de)
KR (1)	KR100498869B1 (de)
CN (1)	CN1171855C (de)
AP (1)	AP1483A (de)
AR (1)	AR027754A1 (de)
AT (1)	ATE297377T1 (de)
AU (2)	AU4843301A (de)
BG (1)	BG65832B1 (de)
BR (1)	BRPI0109609B1 (de)
CA (1)	CA2404700C (de)
CZ (1)	CZ302840B6 (de)
DE (1)	DE60111364T2 (de)
DK (1)	DK1268398T3 (de)
EA (1)	EA004314B1 (de)
EE (1)	EE05079B1 (de)
ES (1)	ES2242743T3 (de)
FR (1)	FR2807037B1 (de)
GE (1)	GEP20063796B (de)
HR (1)	HRP20020860B1 (de)
HU (1)	HU229188B1 (de)
ME (1)	ME00437B (de)
MX (1)	MXPA02009378A (de)
NO (1)	NO328064B1 (de)
NZ (1)	NZ521324A (de)
OA (1)	OA12324A (de)
PL (1)	PL199714B1 (de)
PT (1)	PT1268398E (de)
RS (1)	RS50239B (de)
SI (1)	SI1268398T1 (de)
SK (1)	SK286851B6 (de)
UA (1)	UA73562C2 (de)
WO (1)	WO2001056353A2 (de)
ZA (1)	ZA200207150B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2827860B1 (fr)	2001-07-24	2004-12-10	Servier Lab	Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
EP1603558B1 (de)	2003-02-28	2008-05-21	Les Laboratoires Servier S.A.	Verfahren zur herstellung von perindopril
DE60329648D1 (de) *	2003-09-01	2009-11-26	Servier Lab	Neues Verfahren zur Herstellung von Estern des N-((S)-1-Carboxybutyl)-(S)-alanins und seine Verwendung in der Synthese von Perindopril
DK1403278T3 (da) *	2003-09-30	2005-10-03	Servier Lab	Syntesefremgangsmåde for N-[(S)-1-ethoxycarbonylbutyl]-(S)-alanin og anvendelse heraf ved syntesen af perindopril
EP1400531B1 (de) *	2003-09-30	2006-01-04	Les Laboratoires Servier	Verfahren zur Herstellung von N-((S)-1-(Etoxycarbonyl)butyl)-(S)-alanin und Verwendung in der Synthese von Perindopril
PT1729739T (pt) *	2004-03-29	2016-12-01	Servier Lab	Processo para a preparação de uma composição farmacêutica sólida
GB2413128A (en) *	2004-04-13	2005-10-19	Neopharma Ltd	Process for the preparation of perindopril
SI21800A (sl) *	2004-05-14	2005-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nov postopek sinteze perindoprila
WO2006006183A2 (en) *	2004-07-12	2006-01-19	Matrix Laboratories Ltd	An improved process for the preparation of n-[(s)-ethoxycarbonyl-l-butyl]-(s)-alanine
EP1792896A1 (de) *	2005-12-01	2007-06-06	KRKA, tovarna zdravil, d.d., Novo mesto	Verfahren zur Herstellung von Perindopril und deren Salze

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4247716A (en) *	1977-09-02	1981-01-27	Mitsui Toatsu Chemicals, Inc.	Process for producing pyruvic acid
FR2620699B1 (fr) *	1987-09-17	1990-06-01	Adir	Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) *	1987-09-17	1990-09-07	Adir	Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807430B1 (fr) *	2000-04-11	2002-05-17	Adir	Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

2000
- 2000-03-31 FR FR0004112A patent/FR2807037B1/fr not_active Expired - Fee Related
2001
- 2001-03-20 PL PL346554A patent/PL199714B1/pl unknown
- 2001-03-30 AU AU4843301A patent/AU4843301A/xx active Pending
- 2001-03-30 RS YUP73202 patent/RS50239B/sr unknown
- 2001-03-30 UA UA2002108639A patent/UA73562C2/uk unknown
- 2001-03-30 PT PT01921440T patent/PT1268398E/pt unknown
- 2001-03-30 CN CNB018074936A patent/CN1171855C/zh not_active Expired - Fee Related
- 2001-03-30 MX MXPA02009378A patent/MXPA02009378A/es active IP Right Grant
- 2001-03-30 DE DE2001611364 patent/DE60111364T2/de not_active Expired - Lifetime
- 2001-03-30 US US10/221,973 patent/US6818788B2/en not_active Expired - Lifetime
- 2001-03-30 EP EP20010921440 patent/EP1268398B1/de not_active Expired - Lifetime
- 2001-03-30 DK DK01921440T patent/DK1268398T3/da active
- 2001-03-30 HU HU0101335A patent/HU229188B1/hu not_active IP Right Cessation
- 2001-03-30 WO PCT/FR2001/000959 patent/WO2001056353A2/fr not_active Ceased
- 2001-03-30 ME MEP-2008-664A patent/ME00437B/me unknown
- 2001-03-30 BR BRPI0109609-5A patent/BRPI0109609B1/pt not_active IP Right Cessation
- 2001-03-30 CA CA 2404700 patent/CA2404700C/fr not_active Expired - Fee Related
- 2001-03-30 KR KR10-2002-7012810A patent/KR100498869B1/ko not_active Expired - Fee Related
- 2001-03-30 AR ARP010101537 patent/AR027754A1/es not_active Application Discontinuation
- 2001-03-30 AU AU2001248433A patent/AU2001248433B2/en not_active Ceased
- 2001-03-30 OA OA1200200303A patent/OA12324A/en unknown
- 2001-03-30 JP JP2001556065A patent/JP3930322B2/ja not_active Expired - Fee Related
- 2001-03-30 SK SK1405-2002A patent/SK286851B6/sk not_active IP Right Cessation
- 2001-03-30 AP APAP/P/2002/002628A patent/AP1483A/en active
- 2001-03-30 CZ CZ20023235A patent/CZ302840B6/cs not_active IP Right Cessation
- 2001-03-30 EA EA200201027A patent/EA004314B1/ru not_active IP Right Cessation
- 2001-03-30 GE GEAP20016674A patent/GEP20063796B/en unknown
- 2001-03-30 SI SI200130380T patent/SI1268398T1/xx unknown
- 2001-03-30 EE EEP200200553A patent/EE05079B1/xx unknown
- 2001-03-30 ES ES01921440T patent/ES2242743T3/es not_active Expired - Lifetime
- 2001-03-30 AT AT01921440T patent/ATE297377T1/de active
- 2001-03-30 NZ NZ521324A patent/NZ521324A/en not_active IP Right Cessation
- 2001-03-30 HR HR20020860A patent/HRP20020860B1/xx not_active IP Right Cessation
2002
- 2002-09-05 ZA ZA200207150A patent/ZA200207150B/en unknown
- 2002-09-26 NO NO20024616A patent/NO328064B1/no not_active IP Right Cessation
- 2002-10-30 BG BG107234A patent/BG65832B1/bg unknown

Also Published As

Publication number	Publication date
SK14052002A3 (sk)	2003-02-04
ZA200207150B (en)	2003-09-05
NO20024616D0 (no)	2002-09-26
KR100498869B1 (ko)	2005-07-04
CN1171855C (zh)	2004-10-20
PL346554A1 (en)	2001-09-10
SI1268398T1 (en)	2005-10-31
NZ521324A (en)	2004-03-26
FR2807037A1 (fr)	2001-10-05
NO20024616L (no)	2002-09-26
AP2002002628A0 (en)	2002-09-30
ME00437B (me)	2011-10-10
CZ302840B6 (cs)	2011-12-07
BG107234A (bg)	2003-07-31
BR0109609A (pt)	2004-01-13
CN1420862A (zh)	2003-05-28
GEP20063796B (en)	2006-04-25
DE60111364D1 (de)	2005-07-14
EE05079B1 (et)	2008-10-15
BG65832B1 (bg)	2010-02-26
OA12324A (en)	2006-05-12
WO2001056353A2 (fr)	2001-08-09
HU0101335D0 (en)	2001-06-28
US6818788B2 (en)	2004-11-16
CA2404700A1 (fr)	2001-08-09
MXPA02009378A (es)	2003-02-12
BRPI0109609B1 (pt)	2015-04-14
EA200201027A1 (ru)	2003-02-27
EE200200553A (et)	2004-04-15
HUP0101335A3 (en)	2002-11-28
FR2807037B1 (fr)	2002-05-10
DK1268398T3 (da)	2005-10-03
DE60111364T2 (de)	2006-03-16
JP2003534241A (ja)	2003-11-18
EA004314B1 (ru)	2004-02-26
UA73562C2 (uk)	2005-08-15
JP3930322B2 (ja)	2007-06-13
AU2001248433B2 (en)	2004-10-28
SK286851B6 (sk)	2009-06-05
PT1268398E (pt)	2005-09-30
YU73202A (sh)	2006-03-03
NO328064B1 (no)	2009-11-16
AP1483A (en)	2005-10-31
CA2404700C (fr)	2007-02-20
HRP20020860A2 (en)	2004-02-29
HUP0101335A2 (hu)	2001-11-28
EP1268398B1 (de)	2005-06-08
US20030045744A1 (en)	2003-03-06
WO2001056353A3 (fr)	2002-04-18
RS50239B (sr)	2009-07-15
HU229188B1 (hu)	2013-09-30
AR027754A1 (es)	2003-04-09
HK1053301A1 (en)	2003-10-17
KR20030017484A (ko)	2003-03-03
ES2242743T3 (es)	2005-11-16
HRP20020860B1 (hr)	2011-02-28
AU4843301A (en)	2001-08-14
EP1268398A2 (de)	2003-01-02
PL199714B1 (pl)	2008-10-31

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2006-09-15

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