ATE362913T1 - Verfahren zur herstellung von estern des n-((s)-1-carboxybutyl)-(s)-alanins und ihre verwendung in der synthese von perindopril - Google Patents

Verfahren zur herstellung von estern des n-((s)-1-carboxybutyl)-(s)-alanins und ihre verwendung in der synthese von perindopril

Info

Publication number: ATE362913T1
Authority: AT; Austria
Prior art keywords: carboxybutyl; perindopril; alanine; synthesis; producing esters
Prior art date: 2000-04-11

Application number

AT01923776T

Other languages

English (en)

Inventor

Jean-Claude Souvie

Alain Renaud

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-11

Filing date

2001-04-10

Publication date

2007-06-15

2001-04-10 Application filed by Servier Lab filed Critical Servier Lab

2007-06-15 Application granted granted Critical

2007-06-15 Publication of ATE362913T1 publication Critical patent/ATE362913T1/de

Links

AMDDRMIFTJHJGD-WDSKDSINSA-N (2s)-2-[[(1s)-1-carboxyethyl]amino]pentanoic acid Chemical compound CCC[C@@H](C(O)=O)N[C@@H](C)C(O)=O AMDDRMIFTJHJGD-WDSKDSINSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title 1
229960002582 perindopril Drugs 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Indole Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT01923776T 2000-04-11 2001-04-10 Verfahren zur herstellung von estern des n-((s)-1-carboxybutyl)-(s)-alanins und ihre verwendung in der synthese von perindopril ATE362913T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0004610A FR2807430B1 (fr)	2000-04-11	2000-04-11	Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Publications (1)

Publication Number	Publication Date
ATE362913T1 true ATE362913T1 (de)	2007-06-15

Family

ID=8849107

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01923776T ATE362913T1 (de)	2000-04-11	2001-04-10	Verfahren zur herstellung von estern des n-((s)-1-carboxybutyl)-(s)-alanins und ihre verwendung in der synthese von perindopril

Country Status (35)

Country	Link
US (1)	US6774259B2 (de)
EP (1)	EP1272454B1 (de)
JP (1)	JP3872344B2 (de)
KR (1)	KR100520700B1 (de)
CN (1)	CN1176903C (de)
AP (1)	AP1417A (de)
AR (1)	AR027782A1 (de)
AT (1)	ATE362913T1 (de)
AU (2)	AU2001250467B2 (de)
BG (1)	BG65833B1 (de)
BR (1)	BR0109963A (de)
CA (1)	CA2405466C (de)
CY (1)	CY1106720T1 (de)
CZ (1)	CZ302603B6 (de)
DE (1)	DE60128554T2 (de)
DK (1)	DK1272454T3 (de)
EA (1)	EA004265B1 (de)
EE (1)	EE05030B1 (de)
ES (1)	ES2287114T3 (de)
FR (1)	FR2807430B1 (de)
GE (1)	GEP20063798B (de)
HR (1)	HRP20020887B1 (de)
HU (1)	HU229189B1 (de)
ME (1)	ME00442B (de)
MX (1)	MXPA02009888A (de)
NO (1)	NO327970B1 (de)
NZ (1)	NZ521846A (de)
OA (1)	OA12246A (de)
PL (1)	PL346553A1 (de)
PT (1)	PT1272454E (de)
RS (1)	RS50240B (de)
SK (1)	SK287067B6 (de)
UA (1)	UA72040C2 (de)
WO (1)	WO2001056972A1 (de)
ZA (1)	ZA200207689B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2807037B1 (fr) *	2000-03-31	2002-05-10	Adir	NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2827860B1 (fr) *	2001-07-24	2004-12-10	Servier Lab	Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
US7521566B2 (en)	2003-02-28	2009-04-21	Les Laboratoires Servier	Process for preparation of perindopril and salts thereof
ATE445588T1 (de) *	2003-09-01	2009-10-15	Servier Lab	Neues verfahren zur herstellung von estern des n- ((s)-1-carboxybutyl)-(s)-alanins und seine verwendung in der synthese von perindopril
SI1400531T1 (sl) *	2003-09-30	2006-04-30	Servier Lab	Postopek za sintezo n-((s)-1-karbetoksibutil)-(s)-alanina in uporaba pri sintezi perindoprila
SI1403278T1 (en) *	2003-09-30	2005-10-31	Les Laboratoires Servier	Process for the synthesis of N-((S)-1-(ethoxycarbonyl)butyl)-(S)-alanine and use in the synthese of perindopril
LT1729739T (lt) *	2004-03-29	2016-11-10	Les Laboratoires Servier	Kietos farmacinės kompozicijos gamybos būdas
SI21800A (sl) *	2004-05-14	2005-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nov postopek sinteze perindoprila
EP1792896A1 (de)	2005-12-01	2007-06-06	KRKA, tovarna zdravil, d.d., Novo mesto	Verfahren zur Herstellung von Perindopril und deren Salze
FI126564B (fi)	2011-02-28	2017-02-15	Andritz Oy	Menetelmä ja laitteisto meesan polttamiseksi
CN107098949B (zh) *	2017-04-20	2021-03-16	上药东英（江苏）药业有限公司	一种制备培哚普利叔丁胺盐的绿色合成新工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2503155A2 (fr) *	1980-10-02	1982-10-08	Science Union & Cie	Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4344949A (en) *	1980-10-03	1982-08-17	Warner-Lambert Company	Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4296110A (en) *	1980-10-28	1981-10-20	E. I. Du Pont De Nemours And Company	Antihypertensive I-substituted cyclic lactam-2-carboxylic acids
US4503043A (en) *	1981-12-07	1985-03-05	Warner-Lambert Company	Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids
FR2620699B1 (fr) *	1987-09-17	1990-06-01	Adir	Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) *	1987-09-17	1990-09-07	Adir	Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2620700B1 (fr) *	1987-09-17	1990-06-01	Adir	Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides

2000
- 2000-04-11 FR FR0004610A patent/FR2807430B1/fr not_active Expired - Fee Related
2001
- 2001-03-20 PL PL01346553A patent/PL346553A1/xx not_active Application Discontinuation
- 2001-03-30 HU HU0101337A patent/HU229189B1/hu not_active IP Right Cessation
- 2001-04-09 AR ARP010101670A patent/AR027782A1/es not_active Application Discontinuation
- 2001-04-10 GE GEAP20016688A patent/GEP20063798B/en unknown
- 2001-04-10 KR KR10-2002-7013604A patent/KR100520700B1/ko not_active Expired - Fee Related
- 2001-04-10 BR BR0109963-9A patent/BR0109963A/pt not_active Application Discontinuation
- 2001-04-10 ME MEP-2008-671A patent/ME00442B/me unknown
- 2001-04-10 RS YU76702A patent/RS50240B/sr unknown
- 2001-04-10 EA EA200201049A patent/EA004265B1/ru not_active IP Right Cessation
- 2001-04-10 DE DE60128554T patent/DE60128554T2/de not_active Expired - Lifetime
- 2001-04-10 HR HR20020887A patent/HRP20020887B1/xx not_active IP Right Cessation
- 2001-04-10 WO PCT/FR2001/001088 patent/WO2001056972A1/fr not_active Ceased
- 2001-04-10 ES ES01923776T patent/ES2287114T3/es not_active Expired - Lifetime
- 2001-04-10 SK SK1457-2002A patent/SK287067B6/sk not_active IP Right Cessation
- 2001-04-10 AU AU2001250467A patent/AU2001250467B2/en not_active Ceased
- 2001-04-10 PT PT01923776T patent/PT1272454E/pt unknown
- 2001-04-10 CZ CZ20023323A patent/CZ302603B6/cs not_active IP Right Cessation
- 2001-04-10 JP JP2001556822A patent/JP3872344B2/ja not_active Expired - Fee Related
- 2001-04-10 US US10/257,239 patent/US6774259B2/en not_active Expired - Lifetime
- 2001-04-10 AP APAP/P/2002/002639A patent/AP1417A/en active
- 2001-04-10 CN CNB018079210A patent/CN1176903C/zh not_active Expired - Fee Related
- 2001-04-10 AU AU5046701A patent/AU5046701A/xx active Pending
- 2001-04-10 OA OA1200200313A patent/OA12246A/en unknown
- 2001-04-10 CA CA002405466A patent/CA2405466C/fr not_active Expired - Fee Related
- 2001-04-10 DK DK01923776T patent/DK1272454T3/da active
- 2001-04-10 EP EP01923776A patent/EP1272454B1/de not_active Expired - Lifetime
- 2001-04-10 EE EEP200200586A patent/EE05030B1/xx not_active IP Right Cessation
- 2001-04-10 NZ NZ521846A patent/NZ521846A/en not_active IP Right Cessation
- 2001-04-10 AT AT01923776T patent/ATE362913T1/de active
- 2001-04-10 MX MXPA02009888A patent/MXPA02009888A/es active IP Right Grant
- 2001-10-04 UA UA2002118916A patent/UA72040C2/uk unknown
2002
- 2002-09-25 ZA ZA200207689A patent/ZA200207689B/xx unknown
- 2002-10-04 NO NO20024811A patent/NO327970B1/no not_active IP Right Cessation
- 2002-11-04 BG BG107250A patent/BG65833B1/bg unknown
2007
- 2007-07-12 CY CY20071100924T patent/CY1106720T1/el unknown

Also Published As

Publication number	Publication date
CZ20023323A3 (cs)	2003-01-15
EP1272454A1 (de)	2003-01-08
JP3872344B2 (ja)	2007-01-24
CN1422245A (zh)	2003-06-04
DE60128554D1 (de)	2007-07-05
US20030109743A1 (en)	2003-06-12
NO20024811D0 (no)	2002-10-04
CN1176903C (zh)	2004-11-24
HUP0101337A3 (en)	2002-11-28
EE05030B1 (et)	2008-06-16
CY1106720T1 (el)	2012-05-23
ZA200207689B (en)	2003-09-25
NO20024811L (no)	2002-10-04
BR0109963A (pt)	2003-08-05
BG107250A (bg)	2003-06-30
EE200200586A (et)	2004-04-15
AP1417A (en)	2005-05-24
NO327970B1 (no)	2009-11-02
DE60128554T2 (de)	2008-02-21
HUP0101337A2 (hu)	2001-11-28
GEP20063798B (en)	2006-04-25
HRP20020887B1 (en)	2011-03-31
PT1272454E (pt)	2007-08-01
CZ302603B6 (cs)	2011-08-03
DK1272454T3 (da)	2007-09-17
HRP20020887A2 (en)	2004-02-29
ME00442B (me)	2011-10-10
RS50240B (sr)	2009-07-15
AP2002002639A0 (en)	2002-09-30
KR20020093902A (ko)	2002-12-16
SK14572002A3 (sk)	2003-02-04
EA004265B1 (ru)	2004-02-26
CA2405466A1 (fr)	2001-08-09
PL346553A1 (en)	2001-09-10
AR027782A1 (es)	2003-04-09
WO2001056972A1 (fr)	2001-08-09
BG65833B1 (bg)	2010-02-26
AU2001250467B2 (en)	2005-02-17
SK287067B6 (sk)	2009-11-05
MXPA02009888A (es)	2004-09-06
UA72040C2 (en)	2005-01-17
HU0101337D0 (en)	2001-06-28
KR100520700B1 (ko)	2005-10-17
AU5046701A (en)	2001-08-14
YU76702A (sh)	2006-05-25
JP2003521530A (ja)	2003-07-15
EA200201049A1 (ru)	2003-02-27
HU229189B1 (hu)	2013-09-30
FR2807430A1 (fr)	2001-10-12
FR2807430B1 (fr)	2002-05-17
ES2287114T3 (es)	2007-12-16
CA2405466C (fr)	2005-02-15
NZ521846A (en)	2004-07-30
US6774259B2 (en)	2004-08-10
HK1053300A1 (en)	2003-10-17
OA12246A (en)	2003-12-08
EP1272454B1 (de)	2007-05-23

Similar Documents

Publication	Publication Date	Title
ATE369338T1 (de)	2007-08-15	Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salze
DE69739048D1 (de)	2008-11-27	Verfahren zur synthese von aminen und aminosäuren mit organoborverbindungen
ATE288278T1 (de)	2005-02-15	Verfahren und zusammensetzungen zur peptidsynthese
DE69733137D1 (de)	2005-06-02	Inhibitoren von picornavirus 3c protease und verfahren zur herstellung und verwendung
ATE362913T1 (de)	2007-06-15	Verfahren zur herstellung von estern des n-((s)-1-carboxybutyl)-(s)-alanins und ihre verwendung in der synthese von perindopril
DE69815098D1 (de)	2003-07-03	Verfahren zur herstellung von carbonsäureamiden
DE60009828D1 (de)	2004-05-19	Luftreifen und verfahren zur herstellung des luftreifens
ATE365714T1 (de)	2007-07-15	Verfahren zur herstellung von hochreinem perindopril und zwischenverbindungen nützlich in der synthese
ATE297377T1 (de)	2005-06-15	Verfahren zur herstellung von n-((s)-1- carboxybutyl)-(s) alanine estern und verwendung zur synthese von perindopril
ATE319668T1 (de)	2006-03-15	Verfahren zur synthese von (2s)-indolin-2- carbonsäure, und verwendung in der synthese von perindopril
ATE326443T1 (de)	2006-06-15	Verfahren zur stereoselektiven synthese zyklischer aminosäuren
ATE354586T1 (de)	2007-03-15	Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen
ATE315043T1 (de)	2006-02-15	Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen
AU2001248433A1 (en)	2001-10-25	Novel method for synthesis of N-((S)-1-carboxybutyl)-(S)-alanine esters and use in synthesis of perindopril
DE60217325D1 (de)	2007-02-15	Verfahren zur herstellung von wärmeempfindlichem aufzeichnungsmaterial und wärmeempfindliches aufzeichnungsmaterial
ATE294161T1 (de)	2005-05-15	Verfahren zur synthese von (2s,3as,7as)- perhydroindol-2-carbonsäure und seiner estern, und verwendung in der synthese von perindopril
ATE307801T1 (de)	2005-11-15	Verfahren zur synthese des (2s,3as,7as)- perhydroindol-2-carbonsäures und seiner estern, verwendung in der synthese von perindopril
ATE281465T1 (de)	2004-11-15	Verfahren zur synthese von (2s,3as,7as)- perhydroindol-2-carbonsäure und seiner estern, und verwendung in der synthese von perindopril
ATE294814T1 (de)	2005-05-15	Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen
ATE306496T1 (de)	2005-10-15	Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen
ATE445588T1 (de)	2009-10-15	Neues verfahren zur herstellung von estern des n- ((s)-1-carboxybutyl)-(s)-alanins und seine verwendung in der synthese von perindopril
ATE283258T1 (de)	2004-12-15	Verfahren zur synthese von (2s,3as,7as)- perhydroindol-2-carbonsäure und seiner estern, und verwendung in der synthese von perindopril
ATE283257T1 (de)	2004-12-15	Verfahren zur synthese von (2s,3as,7as)- perhydroindol-2-carbonsäure und seiner estern, und verwendung in der synthese von perindopril
ATE297407T1 (de)	2005-06-15	Verfahren zur herstellung von n-((s)-1- (ethoxycarbonyl)butyl)-(s)-alanin und verwendung in der synthese von perindopril
DE10393692D2 (de)	2005-09-29	Verfahren zur Herstellung von holografischen Aufzeichnungsmaterialien und holografische Aufzeichnungsmaterialien

Legal Events

Date

Code

Title

Description

2007-11-15

UEP

Publication of translation of european patent specification

Ref document number: 1272454

Country of ref document: EP