BR0109609A - Processo de sìntese de ésteres da n-[(s)-1-carboxibutil]-(s)-alanina, e a aplicação à sìntese do perindopril - Google Patents

Processo de sìntese de ésteres da n-[(s)-1-carboxibutil]-(s)-alanina, e a aplicação à sìntese do perindopril

Info

Publication number
BR0109609A
BR0109609A BR0109609A BR0109609A BR0109609A BR 0109609 A BR0109609 A BR 0109609A BR 0109609 A BR0109609 A BR 0109609A BR 0109609 A BR0109609 A BR 0109609A BR 0109609 A BR0109609 A BR 0109609A
Authority
BR
Brazil
Prior art keywords
synthesis
application
perindopril
carboxybutyl
alanine esters
Prior art date
Application number
BR0109609A
Other languages
English (en)
Other versions
BRPI0109609B1 (pt
Inventor
Jean-Claude Souvie
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BR0109609A publication Critical patent/BR0109609A/pt
Publication of BRPI0109609B1 publication Critical patent/BRPI0109609B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"PROCESSO DE SìNTESE DE éSTERES DA N-[(S)-1-CARBOXIBUTIL]-(S)-ALANINA, E A APLICAçãO à SìNTESE DO PERINDOPRIL". Processo estereosseletivo de síntese industrial de derivados de fórmula (I), na qual R representa um grupamento alquila (C~ 1~-C~ 6~), linear ou ramificado. Aplicação à síntese do perindopril e de seus sais farmaceuticamente aceitáveis.
BRPI0109609-5A 2000-03-31 2001-03-30 Processo de síntese de ésteres da n-[(s)-1-carboxibutil]-(s)-alanina BRPI0109609B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0004112A FR2807037B1 (fr) 2000-03-31 2000-03-31 NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
PCT/FR2001/000959 WO2001056353A2 (fr) 2000-03-31 2001-03-30 Nouveau procede de synthese de esters de la n-[(s)-1-carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Publications (2)

Publication Number Publication Date
BR0109609A true BR0109609A (pt) 2004-01-13
BRPI0109609B1 BRPI0109609B1 (pt) 2015-04-14

Family

ID=8848711

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0109609-5A BRPI0109609B1 (pt) 2000-03-31 2001-03-30 Processo de síntese de ésteres da n-[(s)-1-carboxibutil]-(s)-alanina

Country Status (35)

Country Link
US (1) US6818788B2 (pt)
EP (1) EP1268398B1 (pt)
JP (1) JP3930322B2 (pt)
KR (1) KR100498869B1 (pt)
CN (1) CN1171855C (pt)
AP (1) AP1483A (pt)
AR (1) AR027754A1 (pt)
AT (1) ATE297377T1 (pt)
AU (2) AU2001248433B2 (pt)
BG (1) BG65832B1 (pt)
BR (1) BRPI0109609B1 (pt)
CA (1) CA2404700C (pt)
CZ (1) CZ302840B6 (pt)
DE (1) DE60111364T2 (pt)
DK (1) DK1268398T3 (pt)
EA (1) EA004314B1 (pt)
EE (1) EE05079B1 (pt)
ES (1) ES2242743T3 (pt)
FR (1) FR2807037B1 (pt)
GE (1) GEP20063796B (pt)
HR (1) HRP20020860B1 (pt)
HU (1) HU229188B1 (pt)
ME (1) ME00437B (pt)
MX (1) MXPA02009378A (pt)
NO (1) NO328064B1 (pt)
NZ (1) NZ521324A (pt)
OA (1) OA12324A (pt)
PL (1) PL199714B1 (pt)
PT (1) PT1268398E (pt)
RS (1) RS50239B (pt)
SI (1) SI1268398T1 (pt)
SK (1) SK286851B6 (pt)
UA (1) UA73562C2 (pt)
WO (1) WO2001056353A2 (pt)
ZA (1) ZA200207150B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
PT1603558E (pt) 2003-02-28 2008-08-19 Servier S A Lab Processo para a preparação de perindopril e dos seus sais
DE60329648D1 (de) * 2003-09-01 2009-11-26 Servier Lab Neues Verfahren zur Herstellung von Estern des N-((S)-1-Carboxybutyl)-(S)-alanins und seine Verwendung in der Synthese von Perindopril
ATE315046T1 (de) * 2003-09-30 2006-02-15 Servier Lab Verfahren zur herstellung von n-((s)-1- (etoxycarbonyl)butyl)-(s)-alanin und verwendung in der synthese von perindopril
SI1403278T1 (en) * 2003-09-30 2005-10-31 Les Laboratoires Servier Process for the synthesis of N-((S)-1-(ethoxycarbonyl)butyl)-(S)-alanine and use in the synthese of perindopril
JP4948392B2 (ja) * 2004-03-29 2012-06-06 レ ラボラトア セルビエ 固形薬学的組成物を調製するためのプロセス
GB2413128A (en) 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
SI21800A (sl) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
WO2006006183A2 (en) * 2004-07-12 2006-01-19 Matrix Laboratories Ltd An improved process for the preparation of n-[(s)-ethoxycarbonyl-l-butyl]-(s)-alanine
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247716A (en) * 1977-09-02 1981-01-27 Mitsui Toatsu Chemicals, Inc. Process for producing pyruvic acid
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Also Published As

Publication number Publication date
ES2242743T3 (es) 2005-11-16
EA200201027A1 (ru) 2003-02-27
WO2001056353A3 (fr) 2002-04-18
SK14052002A3 (sk) 2003-02-04
CA2404700A1 (fr) 2001-08-09
MXPA02009378A (es) 2003-02-12
DE60111364D1 (de) 2005-07-14
FR2807037A1 (fr) 2001-10-05
HUP0101335A2 (hu) 2001-11-28
NO20024616D0 (no) 2002-09-26
RS50239B (sr) 2009-07-15
ME00437B (me) 2011-10-10
HRP20020860B1 (hr) 2011-02-28
HU229188B1 (hu) 2013-09-30
AP2002002628A0 (en) 2002-09-30
SI1268398T1 (en) 2005-10-31
OA12324A (en) 2006-05-12
NZ521324A (en) 2004-03-26
KR20030017484A (ko) 2003-03-03
NO328064B1 (no) 2009-11-16
SK286851B6 (sk) 2009-06-05
YU73202A (sh) 2006-03-03
CZ302840B6 (cs) 2011-12-07
HU0101335D0 (en) 2001-06-28
PL346554A1 (en) 2001-09-10
PL199714B1 (pl) 2008-10-31
AP1483A (en) 2005-10-31
EE05079B1 (et) 2008-10-15
EP1268398B1 (fr) 2005-06-08
AR027754A1 (es) 2003-04-09
DK1268398T3 (da) 2005-10-03
CN1171855C (zh) 2004-10-20
PT1268398E (pt) 2005-09-30
BG65832B1 (bg) 2010-02-26
BG107234A (bg) 2003-07-31
AU4843301A (en) 2001-08-14
HRP20020860A2 (en) 2004-02-29
WO2001056353A2 (fr) 2001-08-09
HUP0101335A3 (en) 2002-11-28
KR100498869B1 (ko) 2005-07-04
EP1268398A2 (fr) 2003-01-02
BRPI0109609B1 (pt) 2015-04-14
DE60111364T2 (de) 2006-03-16
EA004314B1 (ru) 2004-02-26
HK1053301A1 (en) 2003-10-17
GEP20063796B (en) 2006-04-25
CN1420862A (zh) 2003-05-28
NO20024616L (no) 2002-09-26
FR2807037B1 (fr) 2002-05-10
ZA200207150B (en) 2003-09-05
US20030045744A1 (en) 2003-03-06
UA73562C2 (uk) 2005-08-15
JP2003534241A (ja) 2003-11-18
CA2404700C (fr) 2007-02-20
AU2001248433B2 (en) 2004-10-28
ATE297377T1 (de) 2005-06-15
EE200200553A (et) 2004-04-15
JP3930322B2 (ja) 2007-06-13
US6818788B2 (en) 2004-11-16

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 14/04/2015, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2508 DE 29-01-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.