ATE298759T1 - Verfahren zur herstellung von 2'-fluoro-beta-l- arabinofuranosylnukleosiden - Google Patents

Verfahren zur herstellung von 2'-fluoro-beta-l- arabinofuranosylnukleosiden

Info

Publication number: ATE298759T1
Authority: AT; Austria
Prior art keywords: beta; fluoro; producing; arabinofuranosyl; arabinofuranosyl nucleosides
Prior art date: 2001-03-30

Application number

AT02731195T

Other languages

English (en)

Inventor

Marcos Sznaidman

Original Assignee

Gilead Sciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-30

Filing date

2002-03-29

Publication date

2005-07-15

2002-03-29 Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc

2005-07-15 Application granted granted Critical

2005-07-15 Publication of ATE298759T1 publication Critical patent/ATE298759T1/de

Links

239000002777 nucleoside Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 abstract 2
SRBFZHDQGSBBOR-HWQSCIPKSA-N L-arabinopyranose Chemical compound O[C@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-HWQSCIPKSA-N 0.000 abstract 1
RWQNBRDOKXIBIV-UHFFFAOYSA-N Thymine Natural products CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 1
PYMYPHUHKUWMLA-MROZADKFSA-N aldehydo-L-ribose Chemical compound OC[C@H](O)[C@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-MROZADKFSA-N 0.000 abstract 1
PYMYPHUHKUWMLA-WISUUJSJSA-N aldehydo-L-xylose Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WISUUJSJSA-N 0.000 abstract 1
229930195726 aldehydo-L-xylose Natural products 0.000 abstract 1
HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 abstract 1
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
GBBJCSTXCAQSSJ-XQXXSGGOSA-N clevudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1[C@H](F)[C@@H](O)[C@H](CO)O1 GBBJCSTXCAQSSJ-XQXXSGGOSA-N 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
229940113082 thymine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Crystallography & Structural Chemistry (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT02731195T 2001-03-30 2002-03-29 Verfahren zur herstellung von 2'-fluoro-beta-l- arabinofuranosylnukleosiden ATE298759T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28030701P	2001-03-30	2001-03-30
PCT/US2002/009848 WO2002079213A1 (en)	2001-03-30	2002-03-29	Process for the preparation of 2'-halo-$g(b)-l-arabinofuranosyl nucleosides

Publications (1)

Publication Number	Publication Date
ATE298759T1 true ATE298759T1 (de)	2005-07-15

Family

ID=23072521

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02731195T ATE298759T1 (de)	2001-03-30	2002-03-29	Verfahren zur herstellung von 2'-fluoro-beta-l- arabinofuranosylnukleosiden

Country Status (16)

Country	Link
US (2)	US6870048B2 (de)
EP (1)	EP1373288B1 (de)
JP (1)	JP4430307B2 (de)
KR (1)	KR100910791B1 (de)
CN (2)	CN101117346B (de)
AT (1)	ATE298759T1 (de)
AU (1)	AU2002303187C1 (de)
BR (1)	BR0208517A (de)
CA (1)	CA2442979C (de)
DE (1)	DE60204859T2 (de)
ES (1)	ES2243726T3 (de)
IL (2)	IL158185A0 (de)
MX (1)	MXPA03008870A (de)
NZ (1)	NZ528575A (de)
WO (1)	WO2002079213A1 (de)
ZA (1)	ZA200307588B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6870048B2 (en) *	2001-03-30	2005-03-22	Triangle Pharmaceuticals	Process for the preparation of 2'-halo-β-L-arabinofuranosyl nucleosides
JP2005522443A (ja) *	2002-02-14	2005-07-28	フアーマセツト・リミテツド	改変フッ素化ヌクレオシド類似体
JP2006265156A (ja) *	2005-03-23	2006-10-05	Ajinomoto Co Inc	２−デオキシ−ｌ−リボフラノシルクロリド化合物の製造方法
US20090298708A1 (en) *	2006-08-23	2009-12-03	Masad Damha J	2'-deoxy-2'-fluoro-beta-d-arabinonucleoside 5'-triphosphates and their use in enzymatic nucleic acid synthesis
CN101469012B (zh) *	2007-12-26	2013-03-27	杭州容立医药科技有限公司	2-氨基-6-甲氧基-9-(β-D-阿拉伯糖基)-9H-嘌呤的合成方法
US9790252B2 (en)	2009-07-01	2017-10-17	Cornell University	2-fluorinated riboses and arabinoses and methods of use and synthesis
CN102060899B (zh) *	2010-12-27	2012-07-25	江苏奥赛康药业股份有限公司	一种奈拉滨N-9位α型异构体、其制备方法及其应用
CN102344427B (zh) *	2011-08-10	2013-07-31	济南圣泉集团股份有限公司	一种烯糖的合成方法
CN102863479B (zh) *	2011-11-04	2015-06-17	济南圣泉唐和唐生物科技有限公司	一种制备全乙酰溴代-l-阿拉伯糖的方法
CN103694279B (zh) *	2013-12-23	2015-12-02	江西苏克尔新材料有限公司	一种制备2-脱氧-l-核糖的方法
CN105732732B (zh) *	2016-04-14	2018-04-06	四川理工学院	一种制备2‑脱氧‑d‑核糖的方法
WO2022008025A1 (en) *	2020-07-05	2022-01-13	Since & Technology Development Fund Authority	2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5008384A (en) *	1988-07-12	1991-04-16	Pfizer Inc.	Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine
US5587362A (en)	1994-01-28	1996-12-24	Univ. Of Ga Research Foundation	L-nucleosides
CN1039121C (zh) *	1994-10-18	1998-07-15	北京医科大学药学院	具有嘧啶或嘌呤取代基的氢化呋喃衍生物及其制法
US5808040A (en)	1995-01-30	1998-09-15	Yale University	L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
TW434252B (en) *	1997-07-23	2001-05-16	Univ Georgia Res Found	Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine
US6870048B2 (en) *	2001-03-30	2005-03-22	Triangle Pharmaceuticals	Process for the preparation of 2'-halo-β-L-arabinofuranosyl nucleosides

2002
- 2002-03-29 US US10/112,403 patent/US6870048B2/en not_active Expired - Lifetime
- 2002-03-29 MX MXPA03008870A patent/MXPA03008870A/es active IP Right Grant
- 2002-03-29 KR KR1020037012772A patent/KR100910791B1/ko not_active Expired - Lifetime
- 2002-03-29 CA CA2442979A patent/CA2442979C/en not_active Expired - Fee Related
- 2002-03-29 ES ES02731195T patent/ES2243726T3/es not_active Expired - Lifetime
- 2002-03-29 WO PCT/US2002/009848 patent/WO2002079213A1/en not_active Ceased
- 2002-03-29 AT AT02731195T patent/ATE298759T1/de not_active IP Right Cessation
- 2002-03-29 CN CN200710111954XA patent/CN101117346B/zh not_active Expired - Fee Related
- 2002-03-29 IL IL15818502A patent/IL158185A0/xx unknown
- 2002-03-29 BR BR0208517-8A patent/BR0208517A/pt not_active IP Right Cessation
- 2002-03-29 CN CNB02810644XA patent/CN1330660C/zh not_active Expired - Lifetime
- 2002-03-29 JP JP2002577837A patent/JP4430307B2/ja not_active Expired - Fee Related
- 2002-03-29 DE DE60204859T patent/DE60204859T2/de not_active Expired - Lifetime
- 2002-03-29 EP EP02731195A patent/EP1373288B1/de not_active Expired - Lifetime
- 2002-03-29 AU AU2002303187A patent/AU2002303187C1/en not_active Ceased
- 2002-03-29 NZ NZ528575A patent/NZ528575A/en not_active IP Right Cessation
2003
- 2003-09-29 ZA ZA200307588A patent/ZA200307588B/xx unknown
- 2003-09-30 IL IL158185A patent/IL158185A/en not_active IP Right Cessation
2005
- 2005-03-22 US US11/086,545 patent/US7291726B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1571792A (zh)	2005-01-26
DE60204859T2 (de)	2006-04-27
US7291726B2 (en)	2007-11-06
US20050187384A1 (en)	2005-08-25
DE60204859D1 (de)	2005-08-04
WO2002079213A1 (en)	2002-10-10
US6870048B2 (en)	2005-03-22
AU2002303187B2 (en)	2007-11-08
IL158185A (en)	2009-09-22
CN101117346B (zh)	2012-12-12
CA2442979A1 (en)	2002-10-10
CA2442979C (en)	2010-02-16
MXPA03008870A (es)	2004-01-29
US20030060622A1 (en)	2003-03-27
BR0208517A (pt)	2005-02-01
EP1373288B1 (de)	2005-06-29
KR20030092037A (ko)	2003-12-03
AU2002303187B8 (en)	2002-10-15
NZ528575A (en)	2006-04-28
KR100910791B1 (ko)	2009-08-04
EP1373288A1 (de)	2004-01-02
JP4430307B2 (ja)	2010-03-10
CN1330660C (zh)	2007-08-08
ES2243726T3 (es)	2005-12-01
JP2004526743A (ja)	2004-09-02
ZA200307588B (en)	2004-06-30
AU2002303187C1 (en)	2008-06-12
HK1117169A1 (en)	2009-01-09
IL158185A0 (en)	2004-03-28
CN101117346A (zh)	2008-02-06

Legal Events

Date	Code	Title	Description
2005-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE298759T1 (de)	2005-07-15	Verfahren zur herstellung von 2'-fluoro-beta-l- arabinofuranosylnukleosiden
DE69840678D1 (de)	2009-04-30	Verfahren zur produktion von purinnukleosiden durch fermentation
ATE521718T1 (de)	2011-09-15	Prozess zur synthetisierung von nukleinsäure
ATE506372T1 (de)	2011-05-15	Verfahren zur herstellung von nukleosidderivate
EP0861262A4 (de)	2000-07-12	Gruppen zum einfangen von nukleinsäuren
ATE152748T1 (de)	1997-05-15	Verfahren zur herstellung von siloxanoxyalkylencopolymeren
DE69623005D1 (de)	2002-09-19	Verbesserte verfahren zur enzymatischen synthese von oligosacchariden
ATE150487T1 (de)	1997-04-15	Verfahren zur herstellung von cytidin-diphosphat- cholin
ATE269351T1 (de)	2004-07-15	Verbessertea verfahren zur oligonucleotid- synthese
DE69607423D1 (de)	2000-05-04	Verfahren zur Beseitigung von Cyanwasserstoff aus Synthesegas
ATE194142T1 (de)	2000-07-15	Verfahren zur herstellung von nukleotiden
DE69910661D1 (de)	2003-10-02	Verfahren zur Abtrennung von Wasser aus Vakuumkammern oder aus Gasen
DE69921450D1 (de)	2004-12-02	Verfahren zur herstellung von behandelter kieselsäure
DK1504098T3 (da)	2007-06-11	Fremgangsmåde til molekyulær udvikling in vitro af proteinfunktion
ATE294186T1 (de)	2005-05-15	Verfahren zur herstellung von nukleotiden oder oligonukleotiden phosphoramitiden
ATE270301T1 (de)	2004-07-15	Verfahren zur herstellung von modifizierten p- chiralen nucleotid-analoga
DE69731112D1 (de)	2004-11-11	Verfahren zur synthese von phosphorothioat-oligonukelotiden
ATE199724T1 (de)	2001-03-15	Verfahren zur herstellung von 1-(2'-desoxy-2',2'- difluoro-d-ribo-pentofuranosyl)-cytosin aus 2- desoxy-2,2-difluoro-beta-d-ribo-pentopyranose
DE69842088D1 (de)	2011-02-17	Nukleinsäureleitern
ATA219297A (de)	2000-03-15	Enzymatisches verfahren zur herstellung von (s)-cyanhydrinen
DE69711174D1 (de)	2002-04-25	Verfahren zur herstellung von fluorverbindungen aus den entsprechenden aminen
DE59904576D1 (de)	2003-04-17	Verfahren zur herstellung von mono- oder di-organo-boranen
ATE393770T1 (de)	2008-05-15	Verfahren zur herstellung von halosilanen unter mikrowellenenergiebeaufschlagung
ATE299851T1 (de)	2005-08-15	Verfahren zur herstellung von zwischenprodukten
DE69811871D1 (de)	2003-04-10	Verfahren zur herstellung von uridine diphosphat-n-acetylglucosamine (13.04.99)