ATE298791T1 - Protease-varianten und zusammensetzungen - Google Patents

Protease-varianten und zusammensetzungen

Info

Publication number
ATE298791T1
ATE298791T1 AT98955392T AT98955392T ATE298791T1 AT E298791 T1 ATE298791 T1 AT E298791T1 AT 98955392 T AT98955392 T AT 98955392T AT 98955392 T AT98955392 T AT 98955392T AT E298791 T1 ATE298791 T1 AT E298791T1
Authority
AT
Austria
Prior art keywords
compositions
protease variants
protease
subtilase
enzyme
Prior art date
Application number
AT98955392T
Other languages
English (en)
Inventor
Peter Kamp Hansen
Peter Bauditz
Frank Mikkelsen
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8103679&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE298791(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of ATE298791T1 publication Critical patent/ATE298791T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT98955392T 1997-11-21 1998-11-17 Protease-varianten und zusammensetzungen ATE298791T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK133297 1997-11-21
PCT/DK1998/000496 WO1999027082A1 (en) 1997-11-21 1998-11-17 Protease variants and compositions

Publications (1)

Publication Number Publication Date
ATE298791T1 true ATE298791T1 (de) 2005-07-15

Family

ID=8103679

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98955392T ATE298791T1 (de) 1997-11-21 1998-11-17 Protease-varianten und zusammensetzungen

Country Status (11)

Country Link
US (2) US6605458B1 (de)
EP (1) EP1032655B1 (de)
JP (1) JP4246384B2 (de)
KR (1) KR100762164B1 (de)
CN (2) CN1279715A (de)
AT (1) ATE298791T1 (de)
AU (1) AU1225099A (de)
BR (1) BR9814236A (de)
CA (1) CA2310454C (de)
DE (1) DE69830743T2 (de)
WO (1) WO1999027082A1 (de)

Families Citing this family (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK6488D0 (da) * 1988-01-07 1988-01-07 Novo Industri As Enzymer
US20120165241A1 (en) * 1995-05-05 2012-06-28 Unilever Plc Subtilase Variants
US6682924B1 (en) * 1995-05-05 2004-01-27 Novozymes A/S Protease variants and compositions
EP1032655B1 (de) * 1997-11-21 2005-06-29 Novozymes A/S Protease-varianten und zusammensetzungen
US6780629B2 (en) * 1997-11-21 2004-08-24 Novozymes A/S Subtilase enzymes
US6773907B2 (en) * 1997-11-21 2004-08-10 Peter Kamp Hansen Subtilase enzymes
ATE504651T1 (de) * 1998-12-18 2011-04-15 Novozymes As Subtilase enzyme der i-s1- und i-s2-untergruppen mit einem zusätzlichen aminosäurerest in einer aktiven schleifenregion
JP4611530B2 (ja) * 1998-12-18 2011-01-12 ノボザイムス アクティーゼルスカブ 活性部位ループ領域中に追加のアミノ酸残基を有するサブチラーゼ酵素サブグループｉ−ｓ１及びｉ−ｓ２
KR100660806B1 (ko) * 1998-12-18 2006-12-26 노보자임스 에이/에스 활성부위 루프 영역에 추가적 아미노산 잔기를 가지는서브그룹 ｉ-ｓ１과 ｉ-ｓ２의 서브틸라제 효소
CA2355969C (en) * 1998-12-18 2011-03-15 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having an additional amino acid residue in an active site loop region
JP4611531B2 (ja) * 1998-12-18 2011-01-12 ノボザイムス アクティーゼルスカブ 活性部位ループ領域中に追加のアミノ酸残基を有するサブチラーゼ酵素サブグループｉ−ｓ１及びｉ−ｓ２
ATE342965T1 (de) * 1998-12-18 2006-11-15 Novozymes As Subtilase enzyme der i-s1 und is2 untergruppen, mit einem zusätzlichen aminosaürerest in einer aktiven schleifenregion
ATE355355T1 (de) * 1998-12-18 2006-03-15 Novozymes As Subtilasen der i-s1 und i-s2 untergruppen mit einem zusätzlichen aminosäurerest in der aktiven seitenschleifenregion
JP4647788B2 (ja) * 1998-12-18 2011-03-09 ノボザイムス アクティーゼルスカブ 活性部位ループ領域中に追加のアミノ酸残基を有するサブチラーゼ酵素サブグループｉ−ｓ１及びｉ−ｓ２
CN101294152A (zh) * 1998-12-18 2008-10-29 诺沃奇梅兹有限公司 在活性位点环区具有额外氨基酸残基的i-s1和i-s2亚族枯草杆菌酶
ATE407200T1 (de) * 1999-05-20 2008-09-15 Novozymes As Subtilase-enzyme der i-s1 und i-s2 untergruppen mit wenigstens einem zusätzlichen aminosäurenrest zwischen position 131 und 132
AU4393000A (en) † 1999-05-20 2000-12-12 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 128 and 129
WO2000071688A1 (en) 1999-05-20 2000-11-30 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 126 and 127
ATE408676T1 (de) 1999-05-20 2008-10-15 Novozymes As Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 132 und 133
WO2000071683A1 (en) * 1999-05-20 2000-11-30 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 130 and 131
JP5563180B2 (ja) * 1999-05-20 2014-07-30 ノボザイムス アクティーゼルスカブ ９７位と９８位との間に少なくとも１個の追加のアミノ酸残基を有するｉ−ｓ１及びｉ−ｓ２サブグループのズブチラーゼ酵素
ATE408679T1 (de) 1999-05-20 2008-10-15 Novozymes As Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 127 und 128
DE60040284D1 (de) 1999-05-20 2008-10-30 Novozymes As Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 129 und 130
ATE402996T1 (de) 1999-05-20 2008-08-15 Novozymes As Subtilase-enzyme der i-s1 und i-s2 untergruppen mit wenigstens einem zusätzlichen aminosäurerest zwischen positionen 125 und 126
JP2003516751A (ja) * 1999-12-15 2003-05-20 ノボザイムス アクティーゼルスカブ 卵の染みに及ぼす洗浄性能改良を示すズブチラーゼ変異体
EP1244779B1 (de) * 1999-12-15 2014-05-07 Novozymes A/S Subtilasevarianten mit verbesserter waschleistung bei eierflecken
US6777218B1 (en) 2000-03-14 2004-08-17 Novozymes A/S Subtilase enzymes having an improved wash performance on egg stains
EP1280817A2 (de) * 2000-04-28 2003-02-05 Novozymes A/S Identifizierung, produktion und verwendung von proteinvarianten mit veränderten immunogenzität
CN100591763C (zh) * 2000-08-21 2010-02-24 诺维信公司 枯草杆菌酶
US7109016B2 (en) 2000-08-21 2006-09-19 Novozymes A/S Subtilase enzymes
US6893855B2 (en) 2000-10-13 2005-05-17 Novozymes A/S Subtilase variants
ATE505537T1 (de) 2000-10-13 2011-04-15 Novozymes As Subtilase varianten
DK200101090A (da) 2001-07-12 2001-08-16 Novozymes As Subtilase variants
DE10153792A1 (de) 2001-10-31 2003-05-22 Henkel Kgaa Neue Alkalische Protease-Varianten und Wasch- und Reinigungsmittel enthaltend diese neuen Alkalischen Protease-Varianten
DE10162728A1 (de) 2001-12-20 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii (DSM 14393) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
DE10162727A1 (de) 2001-12-20 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii (DSM 14391) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
DE10163884A1 (de) 2001-12-22 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus sp. (DSM 14392) und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease
JP2005535284A (ja) * 2001-12-31 2005-11-24 ジェネンコー・インターナショナル・インク 免疫反応の変化を生じるプロテアーゼ、ならびにその製造および利用方法
ES2336092T3 (es) * 2002-01-16 2010-04-08 Genencor International, Inc. Variantes de proteasas con multiples sustituciones.
TWI319007B (en) * 2002-11-06 2010-01-01 Novozymes As Subtilase variants
US7888093B2 (en) 2002-11-06 2011-02-15 Novozymes A/S Subtilase variants
DE602004022967D1 (de) 2003-10-30 2009-10-15 Novozymes As Kohlenhydratbindende module
US7985569B2 (en) 2003-11-19 2011-07-26 Danisco Us Inc. Cellulomonas 69B4 serine protease variants
US8535927B1 (en) 2003-11-19 2013-09-17 Danisco Us Inc. Micrococcineae serine protease polypeptides and compositions thereof
US20090060933A1 (en) * 2004-06-14 2009-03-05 Estell David A Proteases producing an altered immunogenic response and methods of making and using the same
EP2363460A3 (de) * 2004-12-30 2011-12-28 Genencor International, Inc. Säureaktive fungale Protease
US20070161531A1 (en) 2005-07-08 2007-07-12 Novozymes A/S Subtilase variants
EP2385111B1 (de) 2005-07-08 2016-09-07 Novozymes A/S Subtilasevarianten
CN101473036B (zh) * 2006-06-23 2012-12-12 丹尼斯科美国公司 利用用于工程改造多种性质的位点评价文库对序列和活性关系进行系统评价
EP2272943B1 (de) * 2006-10-06 2018-02-28 Novozymes A/S Waschmittel und die Verwendung von Enzymkombinationen darin
ES2534471T3 (es) * 2006-10-27 2015-04-23 E.I. Du Pont De Nemours And Company Método para la descontaminación de priones
US8093016B2 (en) * 2007-05-21 2012-01-10 Danisco Us Inc. Use of an aspartic protease (NS24) signal sequence for heterologous protein expression
CA2690055A1 (en) * 2007-06-06 2008-12-18 Danisco Us Inc. Methods for improving protein performance
DE102007038031A1 (de) * 2007-08-10 2009-06-04 Henkel Ag & Co. Kgaa Mittel enthaltend Proteasen
US7618801B2 (en) * 2007-10-30 2009-11-17 Danison US Inc. Streptomyces protease
WO2009058518A1 (en) * 2007-10-31 2009-05-07 Danisco Us Inc., Genencor Division Use and production of neutral metallproteases in a serine protease-free background
WO2009058956A1 (en) * 2007-11-01 2009-05-07 Danisco Us, Inc. Signal sequences and co-expressed chaperones for improving protein production in a host cell
KR20100075993A (ko) 2007-11-01 2010-07-05 다니스코 유에스 인크. 써몰리신 및 이의 변이체의 생성, 및 액체 세제에서의 용도
CN102046783A (zh) 2008-06-06 2011-05-04 丹尼斯科美国公司 包含变体微生物蛋白酶的组合物和方法
MX2011004801A (es) 2008-11-11 2011-06-16 Danisco Inc Composiciones y metodos que comprenden una variante de subtilisina.
WO2010056671A1 (en) 2008-11-11 2010-05-20 Danisco Us Inc. Compositions and methods comprising a subtilisin variant
US20100192985A1 (en) 2008-11-11 2010-08-05 Wolfgang Aehle Compositions and methods comprising serine protease variants
RU2560978C2 (ru) 2008-11-11 2015-08-20 ДАНИСКО ЮЭс ИНК. Протеазы, содержащие одну или несколько комбинируемых мутаций
AR079338A1 (es) 2009-12-09 2012-01-18 Danisco Us Inc Variantes de proteasa de bacillus y acidos nucleicos que codifican dichas variantes
BR112012017056A2 (pt) 2009-12-21 2016-11-22 Danisco Us Inc "composições detergentes contendo lipase de bacillus subtilis e métodos para uso das mesmas"
US20120258507A1 (en) 2009-12-21 2012-10-11 Danisco Us Inc. Detergent compositions containing thermobifida fusca lipase and methods of use thereof
EP2516611A1 (de) 2009-12-21 2012-10-31 Danisco US Inc. Waschmittelzusammensetzungen mit geobacillus stearothermophilus-lipase und verfahren zu ihrer verwendung
KR101130643B1 (ko) 2010-02-18 2012-04-02 (주) 베리콤 치과 및 의료기구의 세정을 위한 이원 단백질분해 효소-중성세정제 조성물
PL2558573T3 (pl) 2010-04-15 2017-08-31 Danisco Us Inc. Kompozycje i sposoby obejmujące warianty proteazy
PL2380963T3 (pl) 2010-04-23 2016-07-29 Procter & Gamble Sposób perfumowania
PL2380961T3 (pl) 2010-04-23 2018-10-31 The Procter & Gamble Company Kompozycja detergentu
EP2383329A1 (de) 2010-04-23 2011-11-02 The Procter & Gamble Company Partikel
EP2380481B1 (de) 2010-04-23 2014-12-31 The Procter and Gamble Company Automatisches Geschirrspülprodukt
EP2380478A1 (de) 2010-04-23 2011-10-26 The Procter & Gamble Company Automatisches Geschirrspülprodukt
PL2380962T3 (pl) 2010-04-23 2017-01-31 The Procter And Gamble Company Cząstka
JP6448904B2 (ja) 2010-05-06 2019-01-09 ダニスコ・ユーエス・インク サブチリシン変異体を含む組成物及び方法
WO2011150157A2 (en) 2010-05-28 2011-12-01 Danisco Us Inc. Detergent compositions containing streptomyces griseus lipase and methods of use thereof
AR086214A1 (es) 2011-04-29 2013-11-27 Danisco Us Inc Composiciones detergentes que contienen mananasa de bacillus agaradhaerens y sus metodos de uso
WO2012149333A1 (en) 2011-04-29 2012-11-01 Danisco Us Inc. Detergent compositions containing bacillus sp. mannanase and methods of use thereof
EP2712363A1 (de) 2011-04-29 2014-04-02 Danisco US Inc. Waschmittelzusammensetzungen mit geobacillus tepidamans mannanase und verfahren zu ihrer verwendung
JP6105560B2 (ja) 2011-05-05 2017-03-29 ダニスコ・ユーエス・インク セリンプロテアーゼ変異体を含む組成物及び方法
WO2012151480A2 (en) 2011-05-05 2012-11-08 The Procter & Gamble Company Compositions and methods comprising serine protease variants
EP2751263A1 (de) 2011-08-31 2014-07-09 Danisco US Inc. Zusammensetzungen und verfahren mit einer variante eines lipolytischen enzyms
BR112014014410A2 (pt) 2011-12-22 2019-09-24 Danisco Us Inc composições e métodos que compreendem uma variante de enzima lipolítica
JP2012149267A (ja) * 2012-03-23 2012-08-09 Spartan Chemical Co Inc 硬質表面洗浄用殺菌性水系組成物および使用方法
EP3842531A1 (de) 2012-10-12 2021-06-30 Danisco US Inc. Zusammensetzungen und verfahren mit einer variante eines lipolytischen enzyms
CN104781400A (zh) 2012-11-05 2015-07-15 丹尼斯科美国公司 包含嗜热菌蛋白酶变体的组合物和方法
WO2014100018A1 (en) 2012-12-19 2014-06-26 Danisco Us Inc. Novel mannanase, compositions and methods of use thereof
WO2014194034A2 (en) 2013-05-29 2014-12-04 Danisco Us Inc. Novel metalloproteases
EP3004342B1 (de) 2013-05-29 2023-01-11 Danisco US Inc. Neuartige metalloproteasen
US20160108388A1 (en) 2013-05-29 2016-04-21 Danisco Us Inc. Novel metalloproteases
WO2014194032A1 (en) 2013-05-29 2014-12-04 Danisco Us Inc. Novel metalloproteases
EP3696264B1 (de) 2013-07-19 2023-06-28 Danisco US Inc. Zusammensetzungen und verfahren mit einer variante eines lipolytischen enzyms
EP3044313B1 (de) 2013-09-12 2019-11-06 Danisco US Inc. Zusammensetzungen und verfahren mit protease varianten der lg12-klade
DK3080262T3 (da) 2013-12-13 2019-05-06 Danisco Us Inc Serinproteaser af bacillus-arter
EP3910057A1 (de) 2013-12-13 2021-11-17 Danisco US Inc. Serinproteasen des bazillus gibsonii-clade
US20170096653A1 (en) 2014-03-21 2017-04-06 Danisco Us Inc. Serine proteases of bacillus species
DK3207129T3 (da) 2014-10-17 2020-02-24 Danisco Us Inc Serinproteaser af bacillus-arten
DK3212662T3 (da) 2014-10-27 2020-07-20 Danisco Us Inc Serinproteaser
CN107148472A (zh) 2014-10-27 2017-09-08 丹尼斯科美国公司 芽孢杆菌属物种的丝氨酸蛋白酶
EP3957729A1 (de) 2014-10-27 2022-02-23 Danisco US Inc. Serinproteasen
DK3212781T3 (da) 2014-10-27 2019-12-16 Danisco Us Inc Serinproteaser
EP3212783B1 (de) 2014-10-27 2024-06-26 Danisco US Inc. Serinproteasen
CN107454914B (zh) 2015-03-12 2021-09-21 丹尼斯科美国公司 包含lg12进化枝蛋白酶变体的组合物和方法
CN107835855B (zh) 2015-05-13 2022-05-13 丹尼斯科美国公司 AprL-进化枝蛋白酶变体及其用途
US11499146B2 (en) 2015-06-17 2022-11-15 Danisco Us Inc. Bacillus gibsonii-clade serine proteases
EP4071244A1 (de) * 2015-06-18 2022-10-12 Novozymes A/S Subtilasevarianten und polynukleotide zur codierung davon
MX2018001358A (es) * 2015-10-09 2018-06-15 Novozymes As Metodo de lavanderia, uso de polipeptidos y composicion de detergente.
EP4141113A1 (de) 2015-11-05 2023-03-01 Danisco US Inc Paenibacillus sp. mannanasen
JP7364330B2 (ja) 2015-11-05 2023-10-18 ダニスコ・ユーエス・インク パエニバチルス（Ｐａｅｎｉｂａｃｉｌｌｕｓ）属種及びバチルス（Ｂａｃｉｌｌｕｓ）属種のマンナナーゼ
EP3390625B1 (de) 2015-12-18 2023-09-06 Danisco US Inc. Polypeptide mit endoglucanaseaktivität und verwendungen davon
US11623885B2 (en) 2015-12-23 2023-04-11 Novozymes A/S Methods for enhancing the dewaterability of sludge with enzyme treatment
JP7284891B2 (ja) 2015-12-23 2023-06-01 エンバイロザイム リミティド ライアビリティ カンパニー 酵素処理でスラッジの脱水性を高める方法
JP2019518440A (ja) 2016-05-03 2019-07-04 ダニスコ・ユーエス・インク プロテアーゼ変異体およびその使用
CN109072213A (zh) 2016-05-05 2018-12-21 丹尼斯科美国公司 蛋白酶变体及其用途
WO2017210295A1 (en) 2016-05-31 2017-12-07 Danisco Us Inc. Protease variants and uses thereof
EP3472313B1 (de) 2016-06-17 2022-08-31 Danisco US Inc. Proteasevarianten und verwendungen davon
EP3535365A2 (de) 2016-11-07 2019-09-11 Danisco US Inc. Wäschewaschmittelzusammensetzung
CN110312795B (zh) 2016-12-21 2024-07-23 丹尼斯科美国公司 蛋白酶变体及其用途
EP3559226B1 (de) 2016-12-21 2023-01-04 Danisco US Inc. Bacillus-gibboni-clade-serin-proteasen
US11453871B2 (en) 2017-03-15 2022-09-27 Danisco Us Inc. Trypsin-like serine proteases and uses thereof
EP3601515A1 (de) 2017-03-31 2020-02-05 Danisco US Inc. Enzymformulierungen mit verzögerter freisetzung für bleichmittelhaltige waschmittel
MX2019014556A (es) 2017-06-30 2020-02-07 Danisco Us Inc Particulas que contienen enzimas de baja aglomeracion.
US20200354708A1 (en) 2017-11-29 2020-11-12 Danisco Us Inc. Subtilisin variants having improved stability
WO2019245704A1 (en) 2018-06-19 2019-12-26 Danisco Us Inc Subtilisin variants
EP3799601A1 (de) 2018-06-19 2021-04-07 Danisco US Inc. Subtilisinvarianten
US12509672B2 (en) 2018-11-28 2025-12-30 Danisco Us Inc. Subtilisin variants having improved stability
US20220220419A1 (en) 2019-05-24 2022-07-14 Danisco Us Inc Subtilisin variants and methods of use
US20220306968A1 (en) 2019-06-06 2022-09-29 Danisco Us Inc Methods and compositions for cleaning
EP4204553A1 (de) 2020-08-27 2023-07-05 Danisco US Inc. Enzyme und enzymzusammensetzungen zur reinigung
US20230365947A1 (en) 2020-09-16 2023-11-16 Danisco Us Inc. Esterase and methods of use, thereof
BR112023004843A2 (pt) * 2020-09-21 2023-04-18 Bayer Cropscience Lp Serina proteases
EP4284906A1 (de) 2021-01-29 2023-12-06 Danisco US Inc. Zusammensetzungen zur reinigung und zugehörige verfahren
US20240158834A1 (en) * 2021-03-15 2024-05-16 Gen-Probe Incorporated Compositions and methods for biological sample processing
EP4363565A1 (de) 2021-06-30 2024-05-08 Danisco US Inc. Variante lipasen und verwendungen davon
WO2023114794A1 (en) 2021-12-16 2023-06-22 The Procter & Gamble Company Fabric and home care composition comprising a protease
CN118679251A (zh) 2021-12-16 2024-09-20 丹尼斯科美国公司 枯草杆菌蛋白酶变体和使用方法
JP7842216B2 (ja) 2021-12-16 2026-04-07 ザ プロクター アンド ギャンブル カンパニー プロテアーゼを含む自動食器洗浄組成物
WO2023114939A2 (en) 2021-12-16 2023-06-22 Danisco Us Inc. Subtilisin variants and methods of use
EP4448750A2 (de) 2021-12-16 2024-10-23 Danisco US Inc. Subtilisinvarianten und verwendungen davon
CN118974227A (zh) 2022-03-01 2024-11-15 丹尼斯科美国公司 用于清洁的酶和酶组合物
EP4525615A2 (de) 2022-05-14 2025-03-26 Novozymes A/S Zusammensetzungen und verfahren zur prävention, behandlung, unterdrückung und/oder beseitigung von phytopathogenen befällen und infektionen
WO2023250301A1 (en) 2022-06-21 2023-12-28 Danisco Us Inc. Methods and compositions for cleaning comprising a polypeptide having thermolysin activity
CN120112635A (zh) 2022-09-02 2025-06-06 丹尼斯科美国公司 枯草杆菌蛋白酶变体及其相关方法
EP4581119A1 (de) 2022-09-02 2025-07-09 Danisco US Inc. Waschmittelzusammensetzungen und zugehörige verfahren
WO2024050339A1 (en) 2022-09-02 2024-03-07 Danisco Us Inc. Mannanase variants and methods of use
EP4615968A1 (de) 2022-11-09 2025-09-17 Danisco US Inc. Subtilisinvarianten und verfahren zur verwendung
WO2024163584A1 (en) 2023-02-01 2024-08-08 Danisco Us Inc. Subtilisin variants and methods of use
EP4410941A1 (de) 2023-02-01 2024-08-07 The Procter & Gamble Company Enzymhaltige waschmittelzusammensetzungen
CN120712348A (zh) 2023-03-06 2025-09-26 丹尼斯科美国公司 枯草杆菌蛋白酶变体和使用方法
EP4680013A1 (de) 2023-03-16 2026-01-21 Nutrition & Biosciences USA 4, Inc. Brevibacillus-fermentat-extrakte zur reinigung und bekämpfung von schlechtem geruch und verwendung davon
CN121909283A (zh) 2023-09-28 2026-04-21 丹尼斯科美国公司 具有改善的溶解度的变体角质酶及其用途
CN121969733A (zh) 2023-10-20 2026-05-01 丹尼斯科美国公司 枯草杆菌蛋白酶变体和使用方法
WO2026024921A1 (en) 2024-07-25 2026-01-29 The Procter & Gamble Company Detergent composition comprising a subtilisin variant and methods of use
WO2026050315A1 (en) 2024-08-29 2026-03-05 Danisco Us Inc. Subtilisin variants and methods of use

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760025A (en) 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
NZ208612A (en) 1983-06-24 1991-09-25 Genentech Inc Method of producing "procaryotic carbonyl hydrolases" containing predetermined, site specific mutations
DE3527913A1 (de) 1985-08-03 1987-02-12 Henkel Kgaa Alkalische protease, verfahren zur herstellung von hybridvektoren und genetisch transformierte mikroorganismen
EP0254735B2 (de) 1986-01-15 1998-06-17 Amgen Inc. Herstellung von ph- und wärmestabile subtilisinanaloge
JPS63502959A (ja) 1986-02-12 1988-11-02 ジェネックス、コ−ポレ−ション 突然変異誘発及びスクリ−ニング方法並びに生成物
IE65767B1 (en) 1986-04-30 1995-11-15 Genencor Int Non-human carbonyl hydrolase mutants DNA sequences and vectors encoding same and hosts transformed with said vectors
NZ221627A (en) 1986-09-09 1993-04-28 Genencor Inc Preparation of enzymes, modifications, catalytic triads to alter ratios or transesterification/hydrolysis ratios
DE3856593D1 (de) 1987-04-06 2007-10-04 Novozymes As Regelung von elektrostatischen interaktionen an metallionen-Bindungsstellen zur Stabilisierung von Proteinen
US4914031A (en) 1987-04-10 1990-04-03 Amgen, Inc. Subtilisin analogs
DK6488D0 (da) 1988-01-07 1988-01-07 Novo Industri As Enzymer
US5543302A (en) 1988-05-27 1996-08-06 Solvay Enzymes, Inc. Proteases of altered stability to autolytic degradation
US5665587A (en) * 1989-06-26 1997-09-09 Novo Nordisk A/S Modified subtilisins and detergent compositions containing same
DK316989D0 (da) 1989-06-26 1989-06-26 Novo Nordisk As Enzymer
BR9006827A (pt) * 1989-06-26 1991-08-06 Unilever Nv Composicoes detergentes enzimaticas
EP0525610A3 (en) 1991-07-27 1993-03-24 Solvay Enzymes Gmbh & Co. Kg Process for increasing the stability of enzymes and stabilized enzymes
KR950702633A (ko) 1992-07-17 1995-07-29 한스 발터 라벤 고알칼리성 세린 프로테아제(high alkaline serine proteases)
US5567601A (en) * 1993-06-01 1996-10-22 University Of Maryland Subtilisin mutants lacking a primary calcium binding site
US6436690B1 (en) 1993-09-15 2002-08-20 The Procter & Gamble Company BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted
DE4411223A1 (de) 1994-03-31 1995-10-05 Solvay Enzymes Gmbh & Co Kg Verwendung alkalischer Proteasen in gewerblichen Textilwaschverfahren
US6599730B1 (en) 1994-05-02 2003-07-29 Procter & Gamble Company Subtilisin 309 variants having decreased adsorption and increased hydrolysis
ZA952220B (en) 1994-05-02 1995-12-14 Procter & Gamble Bpn' variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted
US6455295B1 (en) * 1995-03-08 2002-09-24 The Procter & Gamble Company Subtilisin Carlsberg variants having decreased adsorption and increased hydrolysis
US5837517A (en) * 1995-05-05 1998-11-17 Novo Nordisk A/S Protease variants and compositions
WO1996034935A2 (en) * 1995-05-05 1996-11-07 Unilever N.V. Subtilisin variants
US6682924B1 (en) * 1995-05-05 2004-01-27 Novozymes A/S Protease variants and compositions
EP0932667B1 (de) * 1996-11-04 2008-10-01 Novozymes A/S Subtilase varianten und verbindungen
BR9811248B1 (pt) * 1997-08-29 2011-10-04 variante de enzima subtilase derivada de uma subtilase originária selecionada a partir do sub-grupo i-s1 ou do sub-grupo i-s2, dita variante tendo melhorado desempenho de lavagem em detergentes em comparação com a subtilase originária, sequência de dna isolada, vetor de expressão, célula hospedeira microbiana, processo para produzir uma variante, composição, uso de uma variante de subtilase.
JP2001514846A (ja) * 1997-08-29 2001-09-18 ノボ ノルディスク アクティーゼルスカブ プロテアーゼ変異体及び組成物
EP1032655B1 (de) * 1997-11-21 2005-06-29 Novozymes A/S Protease-varianten und zusammensetzungen
US6780629B2 (en) * 1997-11-21 2004-08-24 Novozymes A/S Subtilase enzymes
US6773907B2 (en) * 1997-11-21 2004-08-10 Peter Kamp Hansen Subtilase enzymes

Also Published As

Publication number Publication date
EP1032655B1 (de) 2005-06-29
EP1032655A1 (de) 2000-09-06
US7026153B2 (en) 2006-04-11
US6605458B1 (en) 2003-08-12
CN101440360A (zh) 2009-05-27
US20030180933A1 (en) 2003-09-25
WO1999027082A1 (en) 1999-06-03
CN1279715A (zh) 2001-01-10
DE69830743D1 (de) 2005-08-04
JP4246384B2 (ja) 2009-04-02
BR9814236A (pt) 2000-10-03
DE69830743T2 (de) 2006-04-27
CA2310454A1 (en) 1999-06-03
AU1225099A (en) 1999-06-15
JP2002508926A (ja) 2002-03-26
KR20010032277A (ko) 2001-04-16
CA2310454C (en) 2012-01-24
KR100762164B1 (ko) 2007-10-01

Similar Documents

Publication Publication Date Title
DE69830743D1 (de) Protease-varianten und zusammensetzungen
ATE428773T1 (de) Subtilase enzyme der i-s2 untergruppe, mit einem zusätzlichen aminosäurenrest in einer aktiven schleifenregion
DE69935349D1 (de) Subtilasen der i-s1 und i-s2 untergruppen mit einem zusätzlichen aminosäurerest in der aktiven seitenschleifenregion
DE59805725D1 (de) Glucanasehaltiges waschmittel
ATE250669T1 (de) Proteolytische enzyme und ihre verwendung in waschmitteln
BR9811187A (pt) Composições detergentes compreendendo uma mananase e uma protease
DE69933694D1 (de) SUBTILASE ENZYME DER I-S1 und IS2 UNTERGRUPPEN, MIT EINEM ZUSÄTZLICHEN AMINOSAÜREREST IN EINER AKTIVEN SCHLEIFENREGION
DE60117026D1 (de) Verbesserungen in enzyme enthaltende tabletten
AU4393100A (en) Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 125 and 126
ATE262577T1 (de) Waschmittel
BR9713171A (pt) Composições detergentes compreendendo atividade enzimática controlada por anticorpo
AU4392300A (en) Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 130 and 131
DE69933695D1 (de) Subtilase enzyme der i-s1 und i-s2 untergruppen, mit einem zusätzlichen aminosäurerest in einer aktiven schleifenregion
ATE408677T1 (de) Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 97 und 98
DE69937160D1 (de) Subtilase enzyme der i-s1 und i-s2 untergruppen, mit einem zusätzlichen aminosäurenrest in einer aktiven schleifenregion
ATE371023T1 (de) Subtilase enzyme der i-s1 und i-s2 untergruppen mit einem zusätzlichen aminosaürerest in einer aktiven schleifenregion
DE60040287D1 (de) Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 128 und 129
DE59404831D1 (de) Enzymatisches waschmittel
DE60040148D1 (de) Subtilase-enzyme der i-s1 und i-s2 untergruppen mit wenigstens einem zusätzlichen aminosäurenrest zwischen position 131 und 132
AU4392500A (en) Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 132 and 133
AU4392900A (en) Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 127 and 128
AU4392700A (en) Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 129 and 130
AU4392800A (en) Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additionalamino acid residue between positions 126 and 127
DK1121146T3 (da) Påvirkning af hyperaktive T-celler med proteolytiske enzymer
ATE504651T1 (de) Subtilase enzyme der i-s1- und i-s2-untergruppen mit einem zusätzlichen aminosäurerest in einer aktiven schleifenregion

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties