ATE301125T1 - Heterocyclische verbindungen und mittel, die die hirnfunktion verbessern und als wirkstoff diese verbindungen enthalten - Google Patents

Heterocyclische verbindungen und mittel, die die hirnfunktion verbessern und als wirkstoff diese verbindungen enthalten

Info

Publication number
ATE301125T1
ATE301125T1 AT02711234T AT02711234T ATE301125T1 AT E301125 T1 ATE301125 T1 AT E301125T1 AT 02711234 T AT02711234 T AT 02711234T AT 02711234 T AT02711234 T AT 02711234T AT E301125 T1 ATE301125 T1 AT E301125T1
Authority
AT
Austria
Prior art keywords
compounds
alkyl
agents
contain
active ingredients
Prior art date
Application number
AT02711234T
Other languages
English (en)
Inventor
Seiichiro Kawashima
Toshiyuki Matsuno
Naoki Fukuda
Kenichi Saitoh
Yoshimasa Yamaguchi
Masaya Higashi
Original Assignee
Zenyaku Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenyaku Kogyo Kk filed Critical Zenyaku Kogyo Kk
Application granted granted Critical
Publication of ATE301125T1 publication Critical patent/ATE301125T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT02711234T 2001-01-30 2002-01-30 Heterocyclische verbindungen und mittel, die die hirnfunktion verbessern und als wirkstoff diese verbindungen enthalten ATE301125T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001022385 2001-01-30
PCT/JP2002/000694 WO2002060907A1 (en) 2001-01-30 2002-01-30 Heterocyclic compounds and cerebral function improvers containing the same as the active ingredient

Publications (1)

Publication Number Publication Date
ATE301125T1 true ATE301125T1 (de) 2005-08-15

Family

ID=18887808

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02711234T ATE301125T1 (de) 2001-01-30 2002-01-30 Heterocyclische verbindungen und mittel, die die hirnfunktion verbessern und als wirkstoff diese verbindungen enthalten

Country Status (11)

Country Link
US (2) US7141579B2 (de)
EP (1) EP1357124B1 (de)
JP (1) JP4285994B2 (de)
KR (1) KR100850818B1 (de)
CN (1) CN100338074C (de)
AT (1) ATE301125T1 (de)
AU (1) AU2002230098B2 (de)
CA (1) CA2436589C (de)
DE (1) DE60205338T2 (de)
ES (1) ES2247304T3 (de)
WO (1) WO2002060907A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1357124B1 (de) * 2001-01-30 2005-08-03 Zenyaku Kogyo Kabushiki Kaisha Heterocyclische verbindungen und mittel, die die hirnfunktion verbessern und als wirkstoff diese verbindungen enthalten
WO2006036497A2 (en) * 2004-09-24 2006-04-06 Allergan, Inc. 4-(condensed cyclicmethyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists
WO2006036480A1 (en) * 2004-09-24 2006-04-06 Allergan, Inc. 4-(phenylmethyl and substituted phenylmethyl)-imidazole-2-thiones acting as specific alpha2 adrenergic agonists
JP4953457B2 (ja) 2004-10-27 2012-06-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ プロゲステロン受容体モジュレーターとしてのピリジンイミダゾール及びアザ−インドール
CN101137382B (zh) * 2005-03-11 2012-11-21 全药工业株式会社 含有杂环化合物作为活性成分的免疫抑制剂和抗肿瘤剂
JP5160764B2 (ja) * 2006-10-13 2013-03-13 全薬工業株式会社 特定の構造の複素環化合物を含む抗鬱剤、脳保護剤、アミロイドβ沈着抑制剤または老化抑制剤
US20090221554A1 (en) * 2008-02-28 2009-09-03 Zenyaku Kogyo Kabushiki Kaisha Method of treating cognitive impairment
JP2012512173A (ja) * 2008-12-15 2012-05-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア アミロイド前駆体タンパク質の切断を誘導して新規断片を形成させる方法
EP2413929A4 (de) * 2009-04-02 2012-10-10 Zenyaku Kogyo Co Ltd Verfahren zur behandlung von kognitiver beeinträchtigung
EP2419100A4 (de) * 2009-04-14 2013-07-17 Kim Nicholas Green Verfahren zur senkung der pro-adam10-sekretase- und/oder beta-sekretase-konzentration
CN102573839A (zh) * 2009-05-11 2012-07-11 加利福尼亚大学董事会 降低泛素化蛋白水平的方法
JP6095122B2 (ja) * 2012-01-25 2017-03-15 国立大学法人東北大学 脳機能改善剤
GB201321736D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
CN106478638A (zh) * 2016-08-31 2017-03-08 安徽省鸿鑫生物科技有限公司 一种2‑羟基‑7‑甲基咪唑并[1,2‑a]嘧啶的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0774205B2 (ja) 1986-12-04 1995-08-09 三井石油化学工業株式会社 新規イミダゾ−ル誘導体
JPH0670064B2 (ja) * 1986-12-08 1994-09-07 三井石油化学工業株式会社 二環性イミダゾ−ル誘導体
EP0524055A1 (de) * 1991-07-19 1993-01-20 Synthelabo Imidazo(2,1-b)benzothiazolderivate, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung
US5464843A (en) * 1992-06-23 1995-11-07 G.D. Searle & Co. Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury
JPH0841065A (ja) * 1994-07-29 1996-02-13 Sanwa Kagaku Kenkyusho Co Ltd １−アザビシクロ［３．３．０］オクタン誘導体の製法
US6114334A (en) * 1995-07-13 2000-09-05 Knoll Aktiengesellschaft Piperazine derivatives as therapeutic agents
DE60006145T2 (de) 1999-07-30 2004-06-09 Zenyaku Kogyo K.K. Azaindolizinon-derivate und agenzien zur verbesserung der kognitiver fähigkeiten,die dieselben als aktive inhaltstoffe enthalten
EP1357124B1 (de) 2001-01-30 2005-08-03 Zenyaku Kogyo Kabushiki Kaisha Heterocyclische verbindungen und mittel, die die hirnfunktion verbessern und als wirkstoff diese verbindungen enthalten
JP5160764B2 (ja) * 2006-10-13 2013-03-13 全薬工業株式会社 特定の構造の複素環化合物を含む抗鬱剤、脳保護剤、アミロイドβ沈着抑制剤または老化抑制剤
US20090221554A1 (en) 2008-02-28 2009-09-03 Zenyaku Kogyo Kabushiki Kaisha Method of treating cognitive impairment

Also Published As

Publication number Publication date
US20040048879A1 (en) 2004-03-11
WO2002060907A1 (en) 2002-08-08
EP1357124B1 (de) 2005-08-03
US7767824B2 (en) 2010-08-03
ES2247304T3 (es) 2006-03-01
DE60205338D1 (de) 2005-09-08
AU2002230098B2 (en) 2007-06-14
JPWO2002060907A1 (ja) 2004-11-11
US20060205742A1 (en) 2006-09-14
US7141579B2 (en) 2006-11-28
DE60205338T2 (de) 2006-06-01
KR20030070145A (ko) 2003-08-27
CN100338074C (zh) 2007-09-19
KR100850818B1 (ko) 2008-08-06
CA2436589C (en) 2010-10-19
EP1357124A1 (de) 2003-10-29
CN1531540A (zh) 2004-09-22
CA2436589A1 (en) 2002-08-08
JP4285994B2 (ja) 2009-06-24
EP1357124A4 (de) 2004-02-04

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties