ATE301646T1 - Verfahren zur racematspaltung von 2-amino-6- propylamino-4,5,6,7-tetrahydrobenzothiazol sowie verbindungen dafür - Google Patents

Verfahren zur racematspaltung von 2-amino-6- propylamino-4,5,6,7-tetrahydrobenzothiazol sowie verbindungen dafür

Info

Publication number
ATE301646T1
ATE301646T1 AT01981155T AT01981155T ATE301646T1 AT E301646 T1 ATE301646 T1 AT E301646T1 AT 01981155 T AT01981155 T AT 01981155T AT 01981155 T AT01981155 T AT 01981155T AT E301646 T1 ATE301646 T1 AT E301646T1
Authority
AT
Austria
Prior art keywords
compounds
racemat
tetrahydrobenzothiazole
propylamino
cleavage
Prior art date
Application number
AT01981155T
Other languages
English (en)
Inventor
Karel Pospisilik
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Application granted granted Critical
Publication of ATE301646T1 publication Critical patent/ATE301646T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Indole Compounds (AREA)
AT01981155T 2000-09-18 2001-09-18 Verfahren zur racematspaltung von 2-amino-6- propylamino-4,5,6,7-tetrahydrobenzothiazol sowie verbindungen dafür ATE301646T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200002262A ES2187249B1 (es) 2000-09-18 2000-09-18 Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.
PCT/NL2001/000691 WO2002022591A1 (en) 2000-09-18 2001-09-18 Process for resolution of 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole and compounds therefor

Publications (1)

Publication Number Publication Date
ATE301646T1 true ATE301646T1 (de) 2005-08-15

Family

ID=8494959

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01979066T ATE327985T1 (de) 2000-09-18 2001-09-14 Verfahren zur herstellung von 2-amino-6- (alkyl)amino-4,5,6,7-tetrahydrobenzothiazolen
AT01981155T ATE301646T1 (de) 2000-09-18 2001-09-18 Verfahren zur racematspaltung von 2-amino-6- propylamino-4,5,6,7-tetrahydrobenzothiazol sowie verbindungen dafür

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT01979066T ATE327985T1 (de) 2000-09-18 2001-09-14 Verfahren zur herstellung von 2-amino-6- (alkyl)amino-4,5,6,7-tetrahydrobenzothiazolen

Country Status (10)

Country Link
US (3) US6770761B2 (de)
EP (2) EP1318986B1 (de)
AT (2) ATE327985T1 (de)
AU (2) AU2002211055A1 (de)
DE (1) DE60120197T2 (de)
DK (2) DK1318986T3 (de)
ES (3) ES2187249B1 (de)
PT (2) PT1318986E (de)
SI (1) SI1318986T1 (de)
WO (2) WO2002022590A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2241118A (en) * 1990-02-15 1991-08-21 Ibm Electrical apparatus with forced air cooling
US20060281797A1 (en) * 2001-12-11 2006-12-14 University Of Virginia Patent Foundation Neurorestoration with R(+) Pramipexole
ES2432527T3 (es) * 2001-12-11 2013-12-04 University Of Virginia Patent Foundation Uso de pramipexol para tratar la esclerosis lateral amiotrófica
PA8578501A1 (es) * 2002-07-25 2005-02-04 Pharmacia Corp Forma de dosificacion una vez al dia de pramipexol
US20050226926A1 (en) 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
GB0221513D0 (en) * 2002-09-17 2002-10-23 Generics Uk Ltd Novel compounds and processes
GB2394951A (en) * 2002-11-04 2004-05-12 Cipla Ltd One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole
US7365086B2 (en) * 2003-07-25 2008-04-29 Synthon Ip Inc. Pramipexole acid addition salts
ATE496036T1 (de) 2004-03-19 2011-02-15 Dipharma Francis Srl Zwischenprodukte für die herstellung von pramipexol
EP1773793A2 (de) * 2004-07-03 2007-04-18 Merck Generics (UK) Limited Verfahren zur herstellung von pramipexol durch chirale chromatographie
UA93608C2 (ru) * 2004-08-13 2011-02-25 Берингер Ингельхайм Интернациональ Гмбх композициЯ таблетки пролонгированного высвобождения, которая содержит прамипексол или его фармацевтически приемлемую соль, СПОСОБ EE ИЗГОТОВЛЕНИЯ И EE ПРИМЕНЕНИЕ
CN101022788B (zh) * 2004-08-13 2010-11-10 贝林格尔·英格海姆国际有限公司 包含普拉克索或其可药用盐的延长释放小球制剂、其制备方法及其用途
US20060069263A1 (en) * 2004-09-30 2006-03-30 Irina Gribun Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole
ES2310146B1 (es) * 2004-12-30 2009-11-11 Chemagis Ltd. Nuevo procedimiento para preparar pramipexol y su mezcla isomerica optica mediante reduccion con triacetoxiborohidruro de sodio.
CN1834092B (zh) * 2005-03-15 2010-04-28 姜能桥 盐酸普拉克索的制备方法
WO2006117614A1 (en) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited Process for the preparation of pramipexole and new anhydrous forms of its dihydrochloride
ES2264378B1 (es) * 2005-05-09 2007-11-01 Ragactives, S.L. Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios.
ATE444750T1 (de) * 2005-08-15 2009-10-15 Univ Virginia Neurorestauration mit r(+) pramipexol
EP1926486A4 (de) * 2005-09-21 2009-06-10 Chemagis Ltd Neue polymorphen von (s)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazolmonotartrat und herstellungs- und anwendungsverfahren dafür
WO2007054970A2 (en) * 2005-10-25 2007-05-18 Alembic Limited Novel polymorphic forms of (s)-(-)-2-amino-6-(n- propylamino) 4,5,6,7- tetrahydrobenzothiazole
PL378587A1 (pl) * 2005-12-29 2007-07-09 Instytut Farmaceutyczny Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ITMI20060044A1 (it) * 2006-01-13 2007-07-14 Dipharma Spa Sintesi di intermedi pr la preparazione di pramipexolo
WO2007090883A1 (en) * 2006-02-10 2007-08-16 Boehringer Ingelheim International Gmbh Extended release formulation
EP1988875A2 (de) * 2006-02-10 2008-11-12 Boehringer Ingelheim International GmbH Modifizierte freisetzungsformulierung
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
US8518926B2 (en) * 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
ATE537826T1 (de) 2006-05-16 2012-01-15 Knopp Neurosciences Inc Zusammensetzungen aus r(+)- und s(-)-pramipexol sowie verfahren zu ihrer anwendung
ATE405554T1 (de) * 2006-06-26 2008-09-15 Helm Ag Verfahren zur herstellung von pramipexole
WO2008001204A2 (en) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Transdermal compositions of pramipexole having enhanced permeation properties
US8524695B2 (en) * 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
JP2010521496A (ja) * 2007-03-14 2010-06-24 ノップ ニューロサイエンシーズ、インク． キラル精製置換ベンゾチアゾールジアミンの合成
EP2225199A2 (de) * 2007-12-18 2010-09-08 Watson Pharma Private Limited Verbessertes herstellungsverfahren für (s)-pregabalin
US20110190356A1 (en) * 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
AU2010262970A1 (en) * 2009-06-19 2012-01-12 Knopp Neurosciences, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
ITMI20101998A1 (it) * 2010-10-27 2012-04-28 Dipharma Francis Srl Procedimento per la racemizzazione di acidi carbossilici
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
CN104072442B (zh) * 2013-03-28 2016-09-28 成都弘达药业有限公司 一种化合物及其制备方法
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
PL3019167T3 (pl) 2013-07-12 2021-06-14 Knopp Biosciences Llc Leczenie podwyższonych poziomów eozynofili i/lub bazofili
DK3033081T3 (da) 2013-08-13 2021-05-31 Knopp Biosciences Llc Sammensætninger og fremgangsmåder til behandling af kronisk urticaria
EP3038467B1 (de) 2013-08-13 2020-07-29 Knopp Biosciences LLC Zusammensetzungen und verfahren zur behandlung von plasmazellenerkrankungen und prolymphozytischen b-zellen-erkrankungen
CN108084115B (zh) * 2017-12-28 2020-03-17 上海博志研新药物技术有限公司 盐酸普拉克索及其中间体的制备方法
CN110669024A (zh) * 2019-10-30 2020-01-10 福建福瑞明德药业有限公司 一种(s)-2,6-二氨基-4,5,6,7-四氢苯并噻唑*l-酒石酸盐的碱析方法
CN116178304B (zh) * 2023-03-10 2024-10-25 中国药科大学 一种盐酸普拉克索的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3572485D1 (en) * 1984-12-22 1989-09-28 Thomae Gmbh Dr K Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs
EP0207696A1 (de) * 1985-06-24 1987-01-07 Eli Lilly And Company Dialkylaminotetrahydrobenzothiazole und -oxazole
DE3620813A1 (de) * 1986-06-21 1987-12-23 Boehringer Ingelheim Kg Neue tetrahydro-benzothiazole, ihre herstellung und verwendung

Also Published As

Publication number Publication date
AU2002212815A1 (en) 2002-03-26
US20040068119A1 (en) 2004-04-08
ES2187249A1 (es) 2003-05-16
PT1318986E (pt) 2006-10-31
DE60120197D1 (de) 2006-07-06
US6770761B2 (en) 2004-08-03
AU2002211055A1 (en) 2002-03-26
EP1318986A1 (de) 2003-06-18
EP1318987A1 (de) 2003-06-18
PT1318987E (pt) 2005-10-31
WO2002022590A1 (en) 2002-03-21
US6727367B2 (en) 2004-04-27
DK1318986T3 (da) 2006-10-02
US20040029936A1 (en) 2004-02-12
EP1318986B1 (de) 2006-05-31
WO2002022591A1 (en) 2002-03-21
DE60120197T2 (de) 2007-03-15
SI1318986T1 (sl) 2006-10-31
EP1318987B1 (de) 2005-08-10
ES2260296T3 (es) 2006-11-01
US20020103240A1 (en) 2002-08-01
ES2187249B1 (es) 2004-09-16
ES2242778T3 (es) 2005-11-16
DK1318987T3 (da) 2005-12-12
ATE327985T1 (de) 2006-06-15

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