DK1318986T3 - Fremgangsmåde til fremstilling af 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazoler - Google Patents

Fremgangsmåde til fremstilling af 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazoler

Info

Publication number
DK1318986T3
DK1318986T3 DK01979066T DK01979066T DK1318986T3 DK 1318986 T3 DK1318986 T3 DK 1318986T3 DK 01979066 T DK01979066 T DK 01979066T DK 01979066 T DK01979066 T DK 01979066T DK 1318986 T3 DK1318986 T3 DK 1318986T3
Authority
DK
Denmark
Prior art keywords
amino
group
tetrahydrobenzothiazoles
alkyl
preparation
Prior art date
Application number
DK01979066T
Other languages
Danish (da)
English (en)
Inventor
Theodorus Hendricus Ant Peters
Karel Pospisilik
Hans Jan Hoorn
Jacobus Maria Lemmens
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Application granted granted Critical
Publication of DK1318986T3 publication Critical patent/DK1318986T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK01979066T 2000-09-18 2001-09-14 Fremgangsmåde til fremstilling af 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazoler DK1318986T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200002262A ES2187249B1 (es) 2000-09-18 2000-09-18 Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.

Publications (1)

Publication Number Publication Date
DK1318986T3 true DK1318986T3 (da) 2006-10-02

Family

ID=8494959

Family Applications (2)

Application Number Title Priority Date Filing Date
DK01979066T DK1318986T3 (da) 2000-09-18 2001-09-14 Fremgangsmåde til fremstilling af 2-amino-6-(alkyl)amino-4,5,6,7-tetrahydrobenzothiazoler
DK01981155T DK1318987T3 (da) 2000-09-18 2001-09-18 Fremgangsmåde til resolution af 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazol og forbindelser til brug hertil

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK01981155T DK1318987T3 (da) 2000-09-18 2001-09-18 Fremgangsmåde til resolution af 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazol og forbindelser til brug hertil

Country Status (10)

Country Link
US (3) US6770761B2 (de)
EP (2) EP1318986B1 (de)
AT (2) ATE327985T1 (de)
AU (2) AU2002211055A1 (de)
DE (1) DE60120197T2 (de)
DK (2) DK1318986T3 (de)
ES (3) ES2187249B1 (de)
PT (2) PT1318986E (de)
SI (1) SI1318986T1 (de)
WO (2) WO2002022590A1 (de)

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US20060281797A1 (en) * 2001-12-11 2006-12-14 University Of Virginia Patent Foundation Neurorestoration with R(+) Pramipexole
MY142204A (en) 2002-07-25 2010-10-29 Pharmacia Corp Pramipexole once-daily dosage form
US20050226926A1 (en) 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
GB0221513D0 (en) * 2002-09-17 2002-10-23 Generics Uk Ltd Novel compounds and processes
GB2394951A (en) * 2002-11-04 2004-05-12 Cipla Ltd One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole
US7365086B2 (en) * 2003-07-25 2008-04-29 Synthon Ip Inc. Pramipexole acid addition salts
US7741490B2 (en) 2004-03-19 2010-06-22 Dipharma S.P.A. Intermediates for the preparation of pramipexole
EP1773793A2 (de) * 2004-07-03 2007-04-18 Merck Generics (UK) Limited Verfahren zur herstellung von pramipexol durch chirale chromatographie
UA88477C2 (ru) 2004-08-13 2009-10-26 Бёрингер Ингельхайм Интернациональ Гмбх Композиция пеллеты пролонгированного высвобождения, которая содержит прамипексол или его фармацевтически приемлемую соль, способ ее изготовления и ее применение
ME01316B (me) * 2004-08-13 2013-12-20 Boehringer Ingelheim Int Formulacija tablete sa produženim oslobađanjem koji sadrži pramipeksol ili njegovu farmaceutski prihvatljivu so
US20060069263A1 (en) * 2004-09-30 2006-03-30 Irina Gribun Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole
IL172561A0 (en) * 2004-12-30 2006-04-10 Chemagis Ltd Novel process for preparing pramipexole and its optical isomeric mixture by reduction with sodium triacetoxyborohydride
CN1834092B (zh) * 2005-03-15 2010-04-28 姜能桥 盐酸普拉克索的制备方法
WO2006117614A1 (en) * 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited Process for the preparation of pramipexole and new anhydrous forms of its dihydrochloride
ES2264378B1 (es) 2005-05-09 2007-11-01 Ragactives, S.L. Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios.
ATE444750T1 (de) * 2005-08-15 2009-10-15 Univ Virginia Neurorestauration mit r(+) pramipexol
EP1926486A4 (de) * 2005-09-21 2009-06-10 Chemagis Ltd Neue polymorphen von (s)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazolmonotartrat und herstellungs- und anwendungsverfahren dafür
WO2007054970A2 (en) * 2005-10-25 2007-05-18 Alembic Limited Novel polymorphic forms of (s)-(-)-2-amino-6-(n- propylamino) 4,5,6,7- tetrahydrobenzothiazole
PL378587A1 (pl) * 2005-12-29 2007-07-09 Instytut Farmaceutyczny Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ITMI20060044A1 (it) * 2006-01-13 2007-07-14 Dipharma Spa Sintesi di intermedi pr la preparazione di pramipexolo
US20090041844A1 (en) * 2006-02-10 2009-02-12 Boehringer Ingelheim International Gmbh Modified Release Formulation
US20090098202A1 (en) * 2006-02-10 2009-04-16 Boehringer Ingelheim International Gmbh Extended Release Formulation
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
US8518926B2 (en) * 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
CN102160865A (zh) 2006-05-16 2011-08-24 诺普神经科学股份有限公司 R(+)和s(-)普拉克索的组合物以及使用该组合物的方法
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WO2008001204A2 (en) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Transdermal compositions of pramipexole having enhanced permeation properties
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US8519148B2 (en) 2007-03-14 2013-08-27 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
EP2225199A2 (de) * 2007-12-18 2010-09-08 Watson Pharma Private Limited Verbessertes herstellungsverfahren für (s)-pregabalin
JP2012500283A (ja) 2008-08-19 2012-01-05 ノップ ニューロサイエンシーズ、インク． （ｒ）−プラミペキソールを使用した組成物並びにその方法
AU2010262970A1 (en) * 2009-06-19 2012-01-12 Knopp Neurosciences, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
ITMI20101998A1 (it) * 2010-10-27 2012-04-28 Dipharma Francis Srl Procedimento per la racemizzazione di acidi carbossilici
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
CN104072442B (zh) * 2013-03-28 2016-09-28 成都弘达药业有限公司 一种化合物及其制备方法
RS67279B1 (sr) 2013-07-12 2025-10-31 Areteia Therapeutics Inc Lečenje povišenih nivoa eozinofila i/ili bazofila
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
EP3033081B1 (de) 2013-08-13 2021-05-12 Knopp Biosciences LLC Zusammensetzungen und verfahren zur behandlung von chronischer nesselsucht
ES2813674T3 (es) 2013-08-13 2021-03-24 Knopp Biosciences Llc Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b
CN108084115B (zh) * 2017-12-28 2020-03-17 上海博志研新药物技术有限公司 盐酸普拉克索及其中间体的制备方法
CN110669024A (zh) * 2019-10-30 2020-01-10 福建福瑞明德药业有限公司 一种(s)-2,6-二氨基-4,5,6,7-四氢苯并噻唑*l-酒石酸盐的碱析方法
CN116178304B (zh) * 2023-03-10 2024-10-25 中国药科大学 一种盐酸普拉克索的合成方法

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DE3572485D1 (en) * 1984-12-22 1989-09-28 Thomae Gmbh Dr K Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs
EP0207696A1 (de) 1985-06-24 1987-01-07 Eli Lilly And Company Dialkylaminotetrahydrobenzothiazole und -oxazole
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Also Published As

Publication number Publication date
DE60120197D1 (de) 2006-07-06
ES2242778T3 (es) 2005-11-16
ES2187249A1 (es) 2003-05-16
EP1318986A1 (de) 2003-06-18
WO2002022590A1 (en) 2002-03-21
AU2002212815A1 (en) 2002-03-26
ATE301646T1 (de) 2005-08-15
EP1318987B1 (de) 2005-08-10
ES2260296T3 (es) 2006-11-01
US20020103240A1 (en) 2002-08-01
DK1318987T3 (da) 2005-12-12
PT1318987E (pt) 2005-10-31
US20040029936A1 (en) 2004-02-12
ATE327985T1 (de) 2006-06-15
SI1318986T1 (sl) 2006-10-31
ES2187249B1 (es) 2004-09-16
EP1318987A1 (de) 2003-06-18
US20040068119A1 (en) 2004-04-08
AU2002211055A1 (en) 2002-03-26
US6770761B2 (en) 2004-08-03
EP1318986B1 (de) 2006-05-31
US6727367B2 (en) 2004-04-27
WO2002022591A1 (en) 2002-03-21
DE60120197T2 (de) 2007-03-15
PT1318986E (pt) 2006-10-31

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