ATE306671T1 - Massenfingerabdrucken und seiner verwendung zur identifizierung von protein-affinitätsliganden - Google Patents

Massenfingerabdrucken und seiner verwendung zur identifizierung von protein-affinitätsliganden

Info

Publication number
ATE306671T1
ATE306671T1 AT99900568T AT99900568T ATE306671T1 AT E306671 T1 ATE306671 T1 AT E306671T1 AT 99900568 T AT99900568 T AT 99900568T AT 99900568 T AT99900568 T AT 99900568T AT E306671 T1 ATE306671 T1 AT E306671T1
Authority
AT
Austria
Prior art keywords
affinity ligands
protein affinity
proteins
protein
identifying protein
Prior art date
Application number
AT99900568T
Other languages
English (en)
Inventor
Stephen Roy Pennington
Original Assignee
Univ Dublin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Dublin filed Critical Univ Dublin
Application granted granted Critical
Publication of ATE306671T1 publication Critical patent/ATE306671T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2550/00—Electrophoretic profiling, e.g. for proteome analysis
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Paper (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT99900568T 1998-01-08 1999-01-08 Massenfingerabdrucken und seiner verwendung zur identifizierung von protein-affinitätsliganden ATE306671T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9800378.3A GB9800378D0 (en) 1998-01-08 1998-01-08 Proteome analysis
PCT/GB1999/000071 WO1999035502A1 (en) 1998-01-08 1999-01-08 Use of mass fingerprinting for identification of protein affinity ligands

Publications (1)

Publication Number Publication Date
ATE306671T1 true ATE306671T1 (de) 2005-10-15

Family

ID=10825008

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99900568T ATE306671T1 (de) 1998-01-08 1999-01-08 Massenfingerabdrucken und seiner verwendung zur identifizierung von protein-affinitätsliganden

Country Status (7)

Country Link
EP (1) EP1046038B1 (de)
JP (1) JP2002501176A (de)
AT (1) ATE306671T1 (de)
DE (1) DE69927668T2 (de)
ES (1) ES2251171T3 (de)
GB (1) GB9800378D0 (de)
WO (1) WO1999035502A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19943743C2 (de) * 1999-09-03 2002-02-07 Jerini Biotools Gmbh Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays
JP2004515786A (ja) 2000-12-14 2004-05-27 ポール・ストルーバント 特異的ファージ捕捉プロテオミクス
JP2002333430A (ja) * 2001-05-09 2002-11-22 Japan Science & Technology Corp プロテオーム解析方法
US8614303B2 (en) 2001-12-11 2013-12-24 University Of Medicine And Dentistry Diagnostic methods for ubiquinated protein profiling
AU2003278168A1 (en) * 2002-06-20 2004-01-06 Paul Stroobant Improved methods for performing differential capture proteomics
JP2007309689A (ja) * 2006-05-16 2007-11-29 Hitachi High-Technologies Corp タンパク質結合部位同定技術
CN106778032B (zh) * 2016-12-14 2019-06-04 南京邮电大学 药物设计中配体分子海量特征筛选方法
WO2020123268A1 (en) * 2018-12-11 2020-06-18 Merck Sharp & Dohme Corp. Method for identifying high affinity monoclonal antibody heavy and light chain pairs from high throughput screens of b-cell and hybridoma libraries

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6124107A (en) * 1988-06-10 2000-09-26 Merck & Co., Inc. Assay for marker of human polymorphonuclear leukocyte elastase activity
US5244816A (en) * 1989-10-11 1993-09-14 Akzo N.V. Method for purifying chelator conjugated compounds
JPH07101998A (ja) * 1993-08-09 1995-04-18 Sumitomo Electric Ind Ltd Ｐａｆ受容体に特異的に反応するモノクローナル抗体、その製造方法、及び該抗体を産生するハイブリドーマ
US5538897A (en) * 1994-03-14 1996-07-23 University Of Washington Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
GB9502112D0 (en) * 1995-02-03 1995-03-22 British Biocell Int Assay device and method
GB9507366D0 (en) * 1995-04-08 1995-05-31 Zeneca Ltd Assay
US5834318A (en) * 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
EP0929667A1 (de) * 1996-10-04 1999-07-21 Michael Mulvany Kennzeichen für bluthochdruck

Also Published As

Publication number Publication date
JP2002501176A (ja) 2002-01-15
ES2251171T3 (es) 2006-04-16
EP1046038A1 (de) 2000-10-25
DE69927668T2 (de) 2006-06-29
GB9800378D0 (en) 1998-03-04
WO1999035502A1 (en) 1999-07-15
DE69927668D1 (de) 2006-02-23
EP1046038B1 (de) 2005-10-12

Similar Documents

Publication Publication Date Title
DE69823985D1 (de) Nachweis der krankheitsbedingten konformation eines proteins
ATE198768T1 (de) Von l protein abgeleitete immunoglobulin-bindende proteine und deren anwendungen
ATE408422T1 (de) Methode zur hemmung immunstimulatorischer mit dna assoziierter antworten
ATE165397T1 (de) Screeningtest für den nachweis von dna-bindenden molekülen
ATE526019T1 (de) Verfahren zur behandlung von zellproliferationen störungen und virusinfektionen
ATE213507T1 (de) Methode zur bindung von material an das beta- amyloid-peptid
ATE449850T1 (de) Mutanten von flt3-l und ihre verwendungen
DE60023936D1 (de) Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen
DE60231651D1 (de) Proteinreinigungsverfahren
ATE334391T1 (de) Isolierung und analyse von proteinen
ATE529509T1 (de) Selektion von proteinen unter verwendung von rna- protein-fusionen
ATE439592T1 (de) Proteingerüste für antikörper-nachahmer und andere bindende proteine
DE69813158D1 (de) Assays zur Bestimmung von Proteinfragmenten in biologischen Medien
DE69433934D1 (de) Verfahren und Zusammensetzungen zur erhöhten Proteinproduktion von rekombinanter DNA
DE69833014D1 (de) Menschliche toll homologen
HUP0100037A2 (hu) Genomiális eljárás segítségével azonosított fehérjék funkió szerinti osztályozására szolgáló nagy teljesítményű eljárás
DE69932845D1 (de) Methoden zur quantifizierung von hla-dr und cd11b
ATE290315T1 (de) Von humanem hitzeschockprotein 60 hergeleitete peptide zur behandlung von diabetis, entsprechende zusammensetzungen, verfahren und kits
ATE306671T1 (de) Massenfingerabdrucken und seiner verwendung zur identifizierung von protein-affinitätsliganden
ATE477489T1 (de) Verfahren zur herstellung von protein expression arrays und anwendung derselben in schnellem screening
DE69433243D1 (de) Verwendunf von ApoE zum Binden von TAU und MAP2c Proteinen und zur Behandlung von Alzheimer's Krankheit
ATE186575T1 (de) Verfahren zur identifizierung von menschlichen und tierischen zellen mit der fähigkeit zu unbegrenzter proliferation oder zur tumorbildung
ATE305037T1 (de) Peptide, die fähig sind die sh3-domäne des gap- proteins zu binden, ihre kodierende dns, ihre zubereitung und verwendung
BR9710919A (pt) Proteina purificada sr-p70
ATE468396T1 (de) Nukleinsäureliganden mit hoher affinität für das c1q protein des komplementsystems

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties