ATE310530T1 - Lang wirkende injektionssuspensionen von lhrh- analogen und ein verfahren für ihre herstellung - Google Patents

Lang wirkende injektionssuspensionen von lhrh- analogen und ein verfahren für ihre herstellung

Info

Publication number: ATE310530T1
Authority: AT; Austria
Prior art keywords: production; long; injection suspensions; lhrh analogues; acting injection
Prior art date: 1993-12-09

Application number

AT95903282T

Other languages

English (en)

Inventor

Juergen Engel

Karin Klokkers-Bethke

Thomas Reissman

Peter Hilgard

Original Assignee

Zentaris Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-09

Filing date

1994-11-25

Publication date

2005-12-15

1994-11-25 Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh

1996-06-10 Priority claimed from US08/661,017 external-priority patent/US5773032A/en

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE310530T1 publication Critical patent/ATE310530T1/de

Links

XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical class C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 title abstract 2
238000002347 injection Methods 0.000 title 1
239000007924 injection Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000725 suspension Substances 0.000 title 1
UCANQOXFIYWYIX-IDEADWEOSA-N (2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(carbamoylamino)pentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid Chemical compound OC(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc23)C(O)=O)c1O.CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O.CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O UCANQOXFIYWYIX-IDEADWEOSA-N 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000013268 sustained release Methods 0.000 abstract 1
239000012730 sustained-release form Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
- A61K38/105—Bombesin; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Reproductive Health (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT95903282T 1993-12-09 1994-11-25 Lang wirkende injektionssuspensionen von lhrh- analogen und ein verfahren für ihre herstellung ATE310530T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE4342092A DE4342092B4 (de)	1993-12-09	1993-12-09	Langwirkende Injektionssuspension und Verfahren zur Herstellung
PCT/EP1994/003904 WO1995015767A1 (en)	1993-12-09	1994-11-25	Long-acting injection suspensions and a process for their preparation
US08/661,017 US5773032A (en)	1993-12-09	1996-06-10	Long-acting injection suspensions and a process for their preparation

Publications (1)

Publication Number	Publication Date
ATE310530T1 true ATE310530T1 (de)	2005-12-15

Family

ID=25931926

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95903282T ATE310530T1 (de)	1993-12-09	1994-11-25	Lang wirkende injektionssuspensionen von lhrh- analogen und ein verfahren für ihre herstellung

Country Status (26)

Country	Link
EP (1)	EP0732934B1 (de)
JP (1)	JPH09509145A (de)
CN (2)	CN1136916C (de)
AT (1)	ATE310530T1 (de)
AU (1)	AU677748B2 (de)
BR (1)	BR9408272A (de)
CZ (1)	CZ291025B6 (de)
DE (1)	DE4342092B4 (de)
DK (1)	DK0732934T3 (de)
EE (1)	EE03224B1 (de)
EG (1)	EG20787A (de)
ES (1)	ES2251715T3 (de)
FI (1)	FI116121B (de)
HR (1)	HRP940978B1 (de)
HU (1)	HU217081B (de)
IL (1)	IL111928A (de)
LV (1)	LV11596B (de)
NO (1)	NO318984B1 (de)
NZ (1)	NZ277239A (de)
PL (1)	PL186929B1 (de)
RO (1)	RO119343B1 (de)
RS (1)	RS49511B (de)
RU (1)	RU2152222C1 (de)
SK (2)	SK284981B6 (de)
WO (1)	WO1995015767A1 (de)
ZA (1)	ZA949798B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6828415B2 (en) *	1993-02-19	2004-12-07	Zentaris Gmbh	Oligopeptide lyophilisate, their preparation and use
SI0732934T1 (sl) *	1993-12-09	2006-02-28	Zentaris Gmbh	Dolgo delujoce injekcijske suspenzije LHRH analoga in postopek njihove izdelave
WO1998032423A1 (en) *	1997-01-29	1998-07-30	Takeda Chemical Industries, Ltd.	Sustained-release microspheres, their production and use
DE10040700A1 (de) *	2000-08-17	2002-02-28	Asta Medica Ag	Salze von biologisch aktiven Peptiden, ihre Herstellung und Verwendung
WO2002047722A1 (en) *	2000-12-15	2002-06-20	Takeda Chemical Industries, Ltd.	Medicinal compositions of nonpeptidyl gonadotropin-releasing hormone agonist or antagonist, process for producing the same and use thereof
TW200526267A (en) *	2001-06-29	2005-08-16	Takeda Chemical Industries Ltd	Controlled release composition and method of producing the same
US7098305B2 (en)	2001-09-06	2006-08-29	Ardana Bioscience Limited	Sustained release of microcrystalline peptide suspensions
EP1674082A1 (de)	2004-12-22	2006-06-28	Zentaris GmbH	Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel
MY148370A (en)	2006-12-18	2013-04-15	Takeda Pharmaceutical	Sustained-release composition and method for producing the same
JP5486690B2 (ja)	2009-11-16	2014-05-07	イプセンファルマソシエテパールアクシオンサンプリフィエ	メラノコルチン受容体リガンドの医薬組成物
CN102504018A (zh) *	2011-10-28	2012-06-20	沈阳药科大学	可持续释放的蜂毒肽帕莫酸盐及其制剂
JP6669932B2 (ja) *	2016-03-29	2020-03-18	シャンハイ・シナジー・ファーマシューティカル・サイエンシーズ・カンパニー・リミテッド	ボルチオキセチンのパモ酸塩及びその結晶形
CN108969478A (zh) *	2018-08-29	2018-12-11	江南大学	一种美金刚难溶盐缓释注射剂及其制备方法
CN110003195B (zh) *	2019-05-21	2020-05-26	湖北中医药大学	鲁拉西酮晶体及其制备方法和在注射给药系统中的应用
US20230355612A1 (en) *	2020-08-26	2023-11-09	Shanghai Bocimed Pharmaceutical Co., Ltd.	Pharmaceutically acceptable salt of cariprazine and crystal form thereof, and preparation method therefor and use thereof
CN112569340A (zh) *	2020-12-31	2021-03-30	苏州素仕生物科技有限公司	一种无菌布舍瑞林注射液及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3852422A (en) *	1971-06-26	1974-12-03	Serono Ist Farm	Long-active gonadotropins
NZ181036A (en) *	1975-06-12	1978-12-18	A Schally	Luteinising hormone releasing hormone analogues and intermediates therefor
GB2209937B (en) *	1987-09-21	1991-07-03	Depiopharm S A	Water insoluble polypeptides
FR2647677B1 (fr) *	1989-05-31	1991-09-27	Roussel Uclaf	Nouvelles micro-proteines, procede de preparation et application a titre de medicaments de ces nouvelles micro-proteines
CH679207A5 (de) *	1989-07-28	1992-01-15	Debiopharm Sa
CH683149A5 (fr) *	1991-07-22	1994-01-31	Debio Rech Pharma Sa	Procédé pour la préparation de microsphères en matériau polymère biodégradable.

1993
- 1993-12-09 DE DE4342092A patent/DE4342092B4/de not_active Expired - Fee Related
1994
- 1994-11-25 SK SK5090-2005A patent/SK284981B6/sk not_active IP Right Cessation
- 1994-11-25 WO PCT/EP1994/003904 patent/WO1995015767A1/en not_active Ceased
- 1994-11-25 DK DK95903282T patent/DK0732934T3/da active
- 1994-11-25 ES ES95903282T patent/ES2251715T3/es not_active Expired - Lifetime
- 1994-11-25 JP JP7515921A patent/JPH09509145A/ja not_active Ceased
- 1994-11-25 AT AT95903282T patent/ATE310530T1/de not_active IP Right Cessation
- 1994-11-25 RO RO96-01143A patent/RO119343B1/ro unknown
- 1994-11-25 PL PL94314913A patent/PL186929B1/pl not_active IP Right Cessation
- 1994-11-25 AU AU12199/95A patent/AU677748B2/en not_active Ceased
- 1994-11-25 BR BR9408272A patent/BR9408272A/pt not_active Application Discontinuation
- 1994-11-25 EP EP95903282A patent/EP0732934B1/de not_active Expired - Lifetime
- 1994-11-25 RU RU96115021/14A patent/RU2152222C1/ru not_active IP Right Cessation
- 1994-11-25 CN CNB941944050A patent/CN1136916C/zh not_active Expired - Fee Related
- 1994-11-25 HU HU9601584A patent/HU217081B/hu not_active IP Right Cessation
- 1994-11-25 CZ CZ19961420A patent/CZ291025B6/cs not_active IP Right Cessation
- 1994-11-25 NZ NZ277239A patent/NZ277239A/en not_active IP Right Cessation
- 1994-11-25 SK SK667-96A patent/SK284980B6/sk not_active IP Right Cessation
- 1994-11-25 CN CNB021593949A patent/CN1248732C/zh not_active Expired - Fee Related
- 1994-11-25 EE EE9600061A patent/EE03224B1/xx not_active IP Right Cessation
- 1994-12-07 EG EG77194A patent/EG20787A/xx active
- 1994-12-08 HR HR940978A patent/HRP940978B1/xx not_active IP Right Cessation
- 1994-12-08 RS YU72194A patent/RS49511B/sr unknown
- 1994-12-08 IL IL11192894A patent/IL111928A/xx not_active IP Right Cessation
- 1994-12-08 ZA ZA949798A patent/ZA949798B/xx unknown
1996
- 1996-05-09 NO NO19961877A patent/NO318984B1/no not_active IP Right Cessation
- 1996-06-06 FI FI962354A patent/FI116121B/fi not_active IP Right Cessation
- 1996-07-09 LV LVP-96-226A patent/LV11596B/en unknown

Also Published As

Publication number	Publication date
PL186929B1 (pl)	2004-04-30
WO1995015767A1 (en)	1995-06-15
SK66796A3 (en)	1997-08-06
CN1136916C (zh)	2004-02-04
HU9601584D0 (en)	1996-08-28
RU2152222C1 (ru)	2000-07-10
YU72194A (sh)	1997-03-07
NO961877L (no)	1996-05-09
IL111928A (en)	1999-11-30
HK1063746A1 (en)	2005-01-14
NO961877D0 (no)	1996-05-09
HRP940978B1 (en)	2006-08-31
NO318984B1 (no)	2005-05-30
LV11596A (lv)	1996-12-20
HUT75712A (en)	1997-05-28
AU1219995A (en)	1995-06-27
EP0732934A1 (de)	1996-09-25
BR9408272A (pt)	1996-12-17
SK284980B6 (sk)	2006-03-02
FI962354L (fi)	1996-06-06
DE4342092A1 (de)	1995-06-14
NZ277239A (en)	1997-03-24
JPH09509145A (ja)	1997-09-16
DE4342092B4 (de)	2007-01-11
CZ291025B6 (cs)	2002-12-11
SK284981B6 (sk)	2006-03-02
IL111928A0 (en)	1995-03-15
CN1248732C (zh)	2006-04-05
DK0732934T3 (da)	2006-03-27
ZA949798B (en)	1995-08-18
CZ142096A3 (en)	1996-12-11
FI116121B (fi)	2005-09-30
AU677748B2 (en)	1997-05-01
CN1494919A (zh)	2004-05-12
LV11596B (en)	1997-06-20
RO119343B1 (ro)	2004-08-30
RS49511B (sr)	2006-10-27
CN1136779A (zh)	1996-11-27
HU217081B (hu)	1999-11-29
FI962354A0 (fi)	1996-06-06
PL314913A1 (en)	1996-09-30
EE03224B1 (et)	1999-10-15
EP0732934B1 (de)	2005-11-23
EG20787A (en)	2000-02-29
HRP940978A2 (en)	1997-02-28
ES2251715T3 (es)	2006-05-01

Legal Events

Date

Code

Title

Description

2006-06-15

UEP

Publication of translation of european patent specification

Ref document number: 0732934

Country of ref document: EP

2011-08-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
LV11596A (lv)	1996-12-20	Ilgstosas darbibas injekciju suspensijas un metode to sagatavosanai
DE68907057D1 (de)	1993-07-15	Naehrstoffzusammensetzung und verfahren zu deren herstellung.
AU5707294A (en)	1994-08-15	3,3 diphenyl prop-2-yl amino acid derivatives and their use as tachykinin antagonists
DE59307218D1 (de)	1997-10-02	Modifizierte polyasparaginsäuren, verfahren zu ihrer herstellung und ihre verwendung
DE3880515D1 (de)	1993-06-03	Granuliertes mittel fuer wiederkaeuer und verfahren zu dessen herstellung.
DE69408454D1 (de)	1998-03-12	Verfahren zur herstellung von amid-modifiziertem carboxyl enthaltenden polysaccharid und so erzeugtes fettsäureamid modifiziertes polysaccharid
DE69733651D1 (de)	2005-08-04	Lipid a-analoge enthaltende injektionen und verfahren zu deren herstellung
ATE131736T1 (de)	1996-01-15	Boulekugel sowie verfahren zu deren herstellung
DE69717629D1 (de)	2003-01-16	Verfahren zur produktion von polypeptiden
ATE174953T1 (de)	1999-01-15	Zusammensetzung zur inhibierung von spannungsrissen in kunststoffartikeln und verfahren zu deren anwendung
DE69125035D1 (de)	1997-04-10	Verfahren zur herstellung von interferon-alpha-2 kristallen
ATE249245T1 (de)	2003-09-15	Komplexe des lhrh-antagonisten cetrorelix mit polyaminosäuren sowie verfahren zu deren herstellung
AU6215194A (en)	1994-10-11	Open web
DE69001573D1 (de)	1993-06-17	Zusammensetzungen zur herstellung von in dosisformen aktiven vitaminen d3 sowie verfahren zur herstellung stabiler, in dosisformen aktiver vitamine d3 unter deren verwendung.
TR199700834T1 (xx)	1998-01-21	1-Aril-2-Akilamino ethan bile�ikleri ve bunlar�n n�rokinin olarak �zellikle n�rokinin 1 has�mlar� olarak kullan�mlar�.
ATE123069T1 (de)	1995-06-15	Verfahren zur herstellung von humanem faktor viii und dessen analogen.
ATE211155T1 (de)	2002-01-15	Verzweigte polyoxyalkyl makromoleküle, verfahren zu ihrer herstellung und ihre verwendung
ATE92060T1 (de)	1993-08-15	Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen.
DE59606907D1 (de)	2001-06-21	Arzneiform zur abgabe von kollagenase an wunden und verfahren zu ihrer herstellung
DE3875512D1 (de)	1992-12-03	Dufterzeugnis mit gesteuerter abgabe und verfahren zu seiner herstellung.
DE3884609D1 (de)	1993-11-04	Verfahren und anordnung bei magnetostritiven bewegungssystemen.
BG101983A (en)	1998-04-30	Substituted phenylamidines, medicamentous forms containing them and mehtod for their preparation
MY119896A (en)	2005-08-30	Long-acting injection suspensions and a process for their preparation.
DE68903594D1 (de)	1993-01-07	Doppelseitig gerippter riemen und verfahren zu dessen herstellung.
DE69013403D1 (de)	1994-11-24	Polypeptid mit thrombin-inhibierender Wirkung und Verfahren zu dessen Herstellung.