NO961877L - Langtidsvirkende injeksjonssuspensjoner og en fremgangsmåte for deres fremstilling - Google Patents

Langtidsvirkende injeksjonssuspensjoner og en fremgangsmåte for deres fremstilling

Info

Publication number: NO961877L
Authority: NO; Norway
Prior art keywords: preparation; long; injection suspensions; acting injection; acting
Prior art date: 1993-12-09

Application number

NO961877A

Other languages

English (en)

Other versions

NO961877D0 (no

NO318984B1 (no

Inventor

Juergen Engel

Karin Klokkers-Bethke

Thomas Reissman

Peter Hilgard

Original Assignee

Asta Medica Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-09

Filing date

1996-05-09

Publication date

1996-05-09

1996-05-09 Application filed by Asta Medica Ag filed Critical Asta Medica Ag

1996-05-09 Publication of NO961877L publication Critical patent/NO961877L/no

1996-05-09 Publication of NO961877D0 publication Critical patent/NO961877D0/no

1996-06-10 Priority claimed from US08/661,017 external-priority patent/US5773032A/en

2005-05-30 Publication of NO318984B1 publication Critical patent/NO318984B1/no

Links

238000002347 injection Methods 0.000 title 1
239000007924 injection Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000725 suspension Substances 0.000 title 1
UCANQOXFIYWYIX-IDEADWEOSA-N (2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(carbamoylamino)pentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid Chemical compound OC(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc23)C(O)=O)c1O.CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O.CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O UCANQOXFIYWYIX-IDEADWEOSA-N 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical class C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000013268 sustained release Methods 0.000 abstract 1
239000012730 sustained-release form Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
- A61K38/105—Bombesin; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

NO19961877A 1993-12-09 1996-05-09 Farmasoytisk preparat omfattende et lite opploslig salt av en LHRH analog samt anvendelse av et lite opploslig salt av en LHRH analog NO318984B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE4342092A DE4342092B4 (de)	1993-12-09	1993-12-09	Langwirkende Injektionssuspension und Verfahren zur Herstellung
PCT/EP1994/003904 WO1995015767A1 (en)	1993-12-09	1994-11-25	Long-acting injection suspensions and a process for their preparation
US08/661,017 US5773032A (en)	1993-12-09	1996-06-10	Long-acting injection suspensions and a process for their preparation

Publications (3)

Publication Number	Publication Date
NO961877L true NO961877L (no)	1996-05-09
NO961877D0 NO961877D0 (no)	1996-05-09
NO318984B1 NO318984B1 (no)	2005-05-30

Family

ID=25931926

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19961877A NO318984B1 (no)	1993-12-09	1996-05-09	Farmasoytisk preparat omfattende et lite opploslig salt av en LHRH analog samt anvendelse av et lite opploslig salt av en LHRH analog

Country Status (26)

Country	Link
EP (1)	EP0732934B1 (no)
JP (1)	JPH09509145A (no)
CN (2)	CN1248732C (no)
AT (1)	ATE310530T1 (no)
AU (1)	AU677748B2 (no)
BR (1)	BR9408272A (no)
CZ (1)	CZ291025B6 (no)
DE (1)	DE4342092B4 (no)
DK (1)	DK0732934T3 (no)
EE (1)	EE03224B1 (no)
EG (1)	EG20787A (no)
ES (1)	ES2251715T3 (no)
FI (1)	FI116121B (no)
HR (1)	HRP940978B1 (no)
HU (1)	HU217081B (no)
IL (1)	IL111928A (no)
LV (1)	LV11596B (no)
NO (1)	NO318984B1 (no)
NZ (1)	NZ277239A (no)
PL (1)	PL186929B1 (no)
RO (1)	RO119343B1 (no)
RS (1)	RS49511B (no)
RU (1)	RU2152222C1 (no)
SK (2)	SK284981B6 (no)
WO (1)	WO1995015767A1 (no)
ZA (1)	ZA949798B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6828415B2 (en) *	1993-02-19	2004-12-07	Zentaris Gmbh	Oligopeptide lyophilisate, their preparation and use
SI0732934T1 (sl) *	1993-12-09	2006-02-28	Zentaris Gmbh	Dolgo delujoce injekcijske suspenzije LHRH analoga in postopek njihove izdelave
WO1998032423A1 (en) *	1997-01-29	1998-07-30	Takeda Chemical Industries, Ltd.	Sustained-release microspheres, their production and use
DE10040700A1 (de) *	2000-08-17	2002-02-28	Asta Medica Ag	Salze von biologisch aktiven Peptiden, ihre Herstellung und Verwendung
AU2002221139A1 (en) *	2000-12-15	2002-06-24	Takeda Chemical Industries Ltd.	Medicinal compositions of nonpeptidyl gonadotropin-releasing hormone agonist or antagonist, process for producing the same and use thereof
TWI332407B (en)	2001-06-29	2010-11-01	Takeda Chemical Industries Ltd	Controlled release composition and method of producting the same
US7098305B2 (en) *	2001-09-06	2006-08-29	Ardana Bioscience Limited	Sustained release of microcrystalline peptide suspensions
EP1674082A1 (de)	2004-12-22	2006-06-28	Zentaris GmbH	Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel
MX2009006653A (es)	2006-12-18	2009-07-02	Takeda Pharmaceutical	Composicion de liberacion prolongada y metodo para producirla.
JP5486690B2 (ja) *	2009-11-16	2014-05-07	イプセンファルマソシエテパールアクシオンサンプリフィエ	メラノコルチン受容体リガンドの医薬組成物
CN102504018A (zh) *	2011-10-28	2012-06-20	沈阳药科大学	可持续释放的蜂毒肽帕莫酸盐及其制剂
WO2017167180A1 (zh) *	2016-03-29	2017-10-05	上海华汇拓医药科技有限公司	沃替西汀的帕莫酸盐及其晶型
CN108969478A (zh) *	2018-08-29	2018-12-11	江南大学	一种美金刚难溶盐缓释注射剂及其制备方法
CN110003195B (zh) *	2019-05-21	2020-05-26	湖北中医药大学	鲁拉西酮晶体及其制备方法和在注射给药系统中的应用
US20230355612A1 (en) *	2020-08-26	2023-11-09	Shanghai Bocimed Pharmaceutical Co., Ltd.	Pharmaceutically acceptable salt of cariprazine and crystal form thereof, and preparation method therefor and use thereof
CN112569340A (zh) *	2020-12-31	2021-03-30	苏州素仕生物科技有限公司	一种无菌布舍瑞林注射液及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3852422A (en) *	1971-06-26	1974-12-03	Serono Ist Farm	Long-active gonadotropins
NZ181036A (en) *	1975-06-12	1978-12-18	A Schally	Luteinising hormone releasing hormone analogues and intermediates therefor
GB2209937B (en) *	1987-09-21	1991-07-03	Depiopharm S A	Water insoluble polypeptides
FR2647677B1 (fr) *	1989-05-31	1991-09-27	Roussel Uclaf	Nouvelles micro-proteines, procede de preparation et application a titre de medicaments de ces nouvelles micro-proteines
CH679207A5 (no) *	1989-07-28	1992-01-15	Debiopharm Sa
CH683149A5 (fr) *	1991-07-22	1994-01-31	Debio Rech Pharma Sa	Procédé pour la préparation de microsphères en matériau polymère biodégradable.

1993
- 1993-12-09 DE DE4342092A patent/DE4342092B4/de not_active Expired - Fee Related
1994
- 1994-11-25 EP EP95903282A patent/EP0732934B1/en not_active Expired - Lifetime
- 1994-11-25 CZ CZ19961420A patent/CZ291025B6/cs not_active IP Right Cessation
- 1994-11-25 PL PL94314913A patent/PL186929B1/pl not_active IP Right Cessation
- 1994-11-25 AU AU12199/95A patent/AU677748B2/en not_active Ceased
- 1994-11-25 AT AT95903282T patent/ATE310530T1/de not_active IP Right Cessation
- 1994-11-25 CN CNB021593949A patent/CN1248732C/zh not_active Expired - Fee Related
- 1994-11-25 ES ES95903282T patent/ES2251715T3/es not_active Expired - Lifetime
- 1994-11-25 JP JP7515921A patent/JPH09509145A/ja not_active Ceased
- 1994-11-25 SK SK5090-2005A patent/SK284981B6/sk not_active IP Right Cessation
- 1994-11-25 SK SK667-96A patent/SK284980B6/sk not_active IP Right Cessation
- 1994-11-25 WO PCT/EP1994/003904 patent/WO1995015767A1/en not_active Ceased
- 1994-11-25 DK DK95903282T patent/DK0732934T3/da active
- 1994-11-25 NZ NZ277239A patent/NZ277239A/en not_active IP Right Cessation
- 1994-11-25 HU HU9601584A patent/HU217081B/hu not_active IP Right Cessation
- 1994-11-25 BR BR9408272A patent/BR9408272A/pt not_active Application Discontinuation
- 1994-11-25 EE EE9600061A patent/EE03224B1/xx not_active IP Right Cessation
- 1994-11-25 CN CNB941944050A patent/CN1136916C/zh not_active Expired - Fee Related
- 1994-11-25 RU RU96115021/14A patent/RU2152222C1/ru not_active IP Right Cessation
- 1994-11-25 RO RO96-01143A patent/RO119343B1/ro unknown
- 1994-12-07 EG EG77194A patent/EG20787A/xx active
- 1994-12-08 IL IL11192894A patent/IL111928A/xx not_active IP Right Cessation
- 1994-12-08 RS YU72194A patent/RS49511B/sr unknown
- 1994-12-08 HR HR940978A patent/HRP940978B1/xx not_active IP Right Cessation
- 1994-12-08 ZA ZA949798A patent/ZA949798B/xx unknown
1996
- 1996-05-09 NO NO19961877A patent/NO318984B1/no not_active IP Right Cessation
- 1996-06-06 FI FI962354A patent/FI116121B/fi not_active IP Right Cessation
- 1996-07-09 LV LVP-96-226A patent/LV11596B/en unknown

Also Published As

Publication number	Publication date
RS49511B (sr)	2006-10-27
HUT75712A (en)	1997-05-28
PL314913A1 (en)	1996-09-30
HU217081B (hu)	1999-11-29
CN1136916C (zh)	2004-02-04
ZA949798B (en)	1995-08-18
DK0732934T3 (da)	2006-03-27
LV11596B (en)	1997-06-20
FI962354A0 (fi)	1996-06-06
JPH09509145A (ja)	1997-09-16
SK284980B6 (sk)	2006-03-02
ATE310530T1 (de)	2005-12-15
LV11596A (lv)	1996-12-20
HRP940978B1 (en)	2006-08-31
CN1248732C (zh)	2006-04-05
BR9408272A (pt)	1996-12-17
IL111928A0 (en)	1995-03-15
AU1219995A (en)	1995-06-27
PL186929B1 (pl)	2004-04-30
HU9601584D0 (en)	1996-08-28
CN1136779A (zh)	1996-11-27
EP0732934A1 (en)	1996-09-25
EG20787A (en)	2000-02-29
SK284981B6 (sk)	2006-03-02
SK66796A3 (en)	1997-08-06
CZ142096A3 (en)	1996-12-11
EE03224B1 (et)	1999-10-15
EP0732934B1 (en)	2005-11-23
CZ291025B6 (cs)	2002-12-11
HRP940978A2 (en)	1997-02-28
ES2251715T3 (es)	2006-05-01
FI116121B (fi)	2005-09-30
WO1995015767A1 (en)	1995-06-15
NZ277239A (en)	1997-03-24
NO961877D0 (no)	1996-05-09
DE4342092B4 (de)	2007-01-11
RO119343B1 (ro)	2004-08-30
HK1063746A1 (en)	2005-01-14
FI962354L (fi)	1996-06-06
NO318984B1 (no)	2005-05-30
IL111928A (en)	1999-11-30
RU2152222C1 (ru)	2000-07-10
AU677748B2 (en)	1997-05-01
CN1494919A (zh)	2004-05-12
DE4342092A1 (de)	1995-06-14
YU72194A (sh)	1997-03-07

Legal Events

Date	Code	Title	Description
2011-06-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO961877L (no)	1996-05-09	Langtidsvirkende injeksjonssuspensjoner og en fremgangsmåte for deres fremstilling
CA2178592A1 (en)	1995-06-15	Long-acting injection suspensions and a process for their preparation
ATE203411T1 (de)	2001-08-15	Lagerstabile wässrige pharmazeutische zubereitungen von g-csf
GB8922026D0 (en)	1989-11-15	Novel anti-viral and cytotoxic agent
IL124411A0 (en)	1998-12-06	Lipopolyamines as transfection agents and pharmaceutical uses thereof
MXPA02007931A (es)	2004-10-15	Analogos de nucleosido con base monociclica modificada con carboxamidina.
IT1232243B (it)	1992-01-28	Composizioni farmaceutiche a base di ciclosporine
AU8418891A (en)	1992-02-18	Novel polyamines and method for preparation thereof
MX9710206A (es)	1998-03-31	Composicion farmaceutica de amiodarone para administracion parenteral.
HUT63374A (en)	1993-08-30	Process for producing new benzoic acid derivatives having cardiovascular activity and pharmaceutical compositions comprising such active ingredient
AU6215194A (en)	1994-10-11	Open web
PL327200A1 (en)	1998-11-23	Endothelium cells proliferation inhibitor and methods of using same
ES2062137T3 (es)	1994-12-16	Utilizacion de 5'-deoxi-5'-metil-tioadenosina, s-adenosilmetionina y sus sales para la preparacion de composiciones farmaceuticas reductoras de seborrea.
AU620218B2 (en)	1992-02-13	Anti-hiv drug
CA2072797A1 (en)	1993-01-06	Use of tri (n-butyl) phosphate at low ph in solutions of biologically active proteins for enhanced virucidal activity
MY119896A (en)	2005-08-30	Long-acting injection suspensions and a process for their preparation.
IT8921567A0 (it)	1989-08-28	Derivati peptidici farmacologicamente attivi e preparazioni farmaceutiche che li contengono.
MX9804120A (es)	1998-09-30	Nuevos antagonistas de la lh-rh con efectividad mejorada.
MY105110A (en)	1994-08-30	Low molecular weight derivatives of prourokinase and pharmaceutical compositions containing the same
BG101983A (en)	1998-04-30	Substituted phenylamidines, medicamentous forms containing them and mehtod for their preparation
ES1040318U (es)	1999-04-01	Expositor perfeccionado.