ATE311891T1 - Cytidin-diphosphocholin gegen diabetische neuropathie - Google Patents

Cytidin-diphosphocholin gegen diabetische neuropathie

Info

Publication number: ATE311891T1
Authority: AT; Austria
Prior art keywords: neuropathy; diphosphocholine; diabetic neuropathy; cytidine; against diabetic
Prior art date: 2001-09-05

Application number

AT02765405T

Other languages

English (en)

Inventor

Kazuki Endo

Toichi Abiru

Junzo Kamei

Original Assignee

Yamasa Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-09-05

Filing date

2002-09-03

Publication date

2005-12-15

2002-09-03 Application filed by Yamasa Corp filed Critical Yamasa Corp

2005-12-15 Application granted granted Critical

2005-12-15 Publication of ATE311891T1 publication Critical patent/ATE311891T1/de

Links

RZZPDXZPRHQOCG-OJAKKHQRSA-O CDP-choline(1+) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-O 0.000 title abstract 4
208000032131 Diabetic Neuropathies Diseases 0.000 title abstract 3
229960001284 citicoline Drugs 0.000 title 1
208000033808 peripheral neuropathy Diseases 0.000 abstract 3
201000001119 neuropathy Diseases 0.000 abstract 2
230000007823 neuropathy Effects 0.000 abstract 2
238000011321 prophylaxis Methods 0.000 abstract 2
238000011282 treatment Methods 0.000 abstract 2
206010003840 Autonomic nervous system imbalance Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
208000019479 dysautonomia Diseases 0.000 abstract 1
230000002503 metabolic effect Effects 0.000 abstract 1
208000018290 primary dysautonomia Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Obesity (AREA)
Endocrinology (AREA)
Hematology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT02765405T 2001-09-05 2002-09-03 Cytidin-diphosphocholin gegen diabetische neuropathie ATE311891T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2001268156		2001-09-05
JP2001340838		2001-11-06
PCT/JP2002/008916 WO2003022290A1 (en)	2001-09-05	2002-09-03	Medicinal compositions for diabetic neuropathy

Publications (1)

Publication Number	Publication Date
ATE311891T1 true ATE311891T1 (de)	2005-12-15

Family

ID=26621670

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02765405T ATE311891T1 (de)	2001-09-05	2002-09-03	Cytidin-diphosphocholin gegen diabetische neuropathie

Country Status (13)

Country	Link
US (2)	US6924272B2 (de)
EP (1)	EP1362593B1 (de)
JP (1)	JP3968347B2 (de)
KR (1)	KR100740079B1 (de)
CN (1)	CN1551778A (de)
AT (1)	ATE311891T1 (de)
CA (1)	CA2459469A1 (de)
DE (1)	DE60207824T2 (de)
EA (1)	EA006776B1 (de)
ES (1)	ES2249616T3 (de)
HU (1)	HU225988B1 (de)
MX (1)	MXPA04002099A (de)
WO (1)	WO2003022290A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100358533C (zh) *	2002-07-11	2008-01-02	雅玛山酱油株式会社	用于药物诱导的神经病的药物组合物
EP1720972B1 (de)	2004-03-05	2014-01-08	DSM IP Assets B.V.	Verfahren zur zellkultivierung mit dauerperfusion und wechselndem tangentialstrom
BRPI0714347A2 (pt)	2006-07-14	2013-05-07	Dsm Ip Assets Bv	processo aperfeiÇoado para o cultivo de cÉlulas
KR100812274B1 (ko) *	2006-10-30	2008-03-13	한양대학교 산학협력단	Ｇ-ｃｓｆ를 유효성분으로 하는 당뇨성 말초신경병 예방 및치료제
US7836540B2 (en)	2007-08-02	2010-11-23	3M Innovative Properties Company	Broom with particle capture sheet
ITMI20121223A1 (it) *	2012-07-13	2014-01-14	Gregorio Fabio De	Nuova composizione farmacologica comprendente citicolina in combinazione con glicerolo e/o acetazolamide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1188178B (it) *	1985-07-05	1988-01-07	Bioresearch Spa	Sali della citidin-difospocolina particolarmente idonei per uso orale
JPH0631306B2 (ja) *	1985-07-12	1994-04-27	武田薬品工業株式会社	シチジン―５′―ジリン酸コリン１水和物結晶の製造法
DE3883374T2 (de)	1987-10-28	1993-12-09	Pro Neuron Inc	Acylatiertes uridin und cytidin und deren verwendungen.
JP4530534B2 (ja) *	1997-12-24	2010-08-25	フエルレルインターナショナル、ソシエダッドアノニマ	超水和シチコリン、プロセスおよび使用
JP2000044472A (ja)	1998-07-30	2000-02-15	Kikkoman Corp	糖尿病性合併症の予防または治療薬剤
US6472378B2 (en) *	1998-08-31	2002-10-29	Pro-Neuron, Inc.	Compositions and methods for treatment of mitochondrial diseases

2002
- 2002-09-03 CN CNA028173015A patent/CN1551778A/zh active Pending
- 2002-09-03 DE DE60207824T patent/DE60207824T2/de not_active Expired - Fee Related
- 2002-09-03 US US10/381,716 patent/US6924272B2/en not_active Expired - Fee Related
- 2002-09-03 EA EA200400394A patent/EA006776B1/ru not_active IP Right Cessation
- 2002-09-03 WO PCT/JP2002/008916 patent/WO2003022290A1/ja not_active Ceased
- 2002-09-03 MX MXPA04002099A patent/MXPA04002099A/es active IP Right Grant
- 2002-09-03 HU HU0401940A patent/HU225988B1/hu unknown
- 2002-09-03 AT AT02765405T patent/ATE311891T1/de not_active IP Right Cessation
- 2002-09-03 CA CA002459469A patent/CA2459469A1/en not_active Abandoned
- 2002-09-03 EP EP02765405A patent/EP1362593B1/de not_active Expired - Lifetime
- 2002-09-03 JP JP2003526418A patent/JP3968347B2/ja not_active Expired - Fee Related
- 2002-09-03 KR KR1020047003171A patent/KR100740079B1/ko not_active Expired - Fee Related
- 2002-09-03 ES ES02765405T patent/ES2249616T3/es not_active Expired - Lifetime
2005
- 2005-04-05 US US11/098,439 patent/US7074773B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HU225988B1 (en)	2008-02-28
JP3968347B2 (ja)	2007-08-29
JPWO2003022290A1 (ja)	2004-12-24
DE60207824T2 (de)	2006-07-06
US20040014711A1 (en)	2004-01-22
KR20040033002A (ko)	2004-04-17
EP1362593A1 (de)	2003-11-19
DE60207824D1 (de)	2006-01-12
ES2249616T3 (es)	2006-04-01
KR100740079B1 (ko)	2007-07-18
US7074773B2 (en)	2006-07-11
US6924272B2 (en)	2005-08-02
WO2003022290A1 (en)	2003-03-20
EA200400394A1 (ru)	2004-08-26
MXPA04002099A (es)	2004-06-07
EP1362593A4 (de)	2004-06-30
EA006776B1 (ru)	2006-04-28
CA2459469A1 (en)	2003-03-20
EP1362593B1 (de)	2005-12-07
CN1551778A (zh)	2004-12-01
US20050171051A1 (en)	2005-08-04
HUP0401940A2 (hu)	2005-01-28

Legal Events

Date	Code	Title	Description
2006-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60236541D1 (de)	2010-07-08	Inhibitoren von 11-beta-hydroxysteroiddehydrogenase typ 1
MY140576A (en)	2009-12-31	Cannabinoid active pharmaceutical ingredient for improved dosage forms
DK1390378T3 (da)	2009-09-14	Farmaceutisk aktive uridin estere
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BR0312286A (pt)	2007-06-19	pró-medicamentos de 2' e 3' - nucleosìdeo modificado para tratamento de infecções por flaviviridae
EA200201262A1 (ru)	2003-08-28	Композиции для лечения флавивирусных и пестивирусных инфекций и способы их применения
PT1040830E (pt)	2005-08-31	Medicamento para doencas neurodegenerativas
BR0003897A (pt)	2001-04-03	Aditivo para aumento da resistência à água de formulações cosméticas ou dermatológicas e seus usos
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NO20034204D0 (no)	2003-09-22	Farmasöytiske kombinasjoner til behandling av kreft
BRPI0408655A (pt)	2006-03-28	formulações compreendendo um agente ativo e cacau em pó e a sua utilização
FI962493A0 (fi)	1996-06-14	Alfa-2-adrenoseptoriagonisteina käyttökelpoisia 6-(2-imidatsolinyyliamino)kinoksaliiniyhdisteitä
BR0209327A (pt)	2004-07-20	Composição para tratamento de constipação induzida por drogas
DK1256339T3 (da)	2004-02-09	Transdermalt terapeutisk system for opnåelse af høje plasmaniveauer af rotigotin i behandlingen af Parkinsons sygdom
BR0012696A (pt)	2002-04-09	Composição oftálmica
BR0208727A (pt)	2005-05-10	Eritropoietina melhorando a toxicidade in vivo induzida por quimioterapia
EA200001010A1 (ru)	2001-02-26	Применение дексмедетомидина для седативного воздействия в отделении интенсивной терапии
BR9910024A (pt)	2000-12-26	Agente contra resfriado
BR0210744A (pt)	2004-07-20	Combinação farmacêutica sinergìstica para a prevenção ou tratamento de diabetes
BR0201524A (pt)	2003-06-10	Tratamento de combinação para ansiedade e depressão
BR0201974A (pt)	2003-04-22	Composição farmacêutica para tratamento de alterações do sono
DE60207824D1 (de)	2006-01-12	Cytidin-diphosphocholin gegen diabetische neuropathie
SE0004101D0 (sv)	2000-11-09	New use
UA92498C2 (ru)	2010-11-10	Каннабиноидно активный фармацевтический ингредиент для улучшенных дозированных форм
BRPI0407271A (pt)	2006-01-31	Composição anti-helmìntica