ATE316086T1 - Clathrat von azithromycin-hydrat mit 1,2- propylenglykol, verfahren zu dessen herstellung und dieses enthaltende pharmazeutische zusammensetzung - Google Patents

Clathrat von azithromycin-hydrat mit 1,2- propylenglykol, verfahren zu dessen herstellung und dieses enthaltende pharmazeutische zusammensetzung

Info

Publication number: ATE316086T1
Authority: AT; Austria
Prior art keywords: clathrate; pharmaceutical composition; composition containing; containing same; production
Prior art date: 2001-04-25

Application number

AT02722952T

Other languages

English (en)

Inventor

Kwee Hyun Suh

Gi Jeong Kim

Sang Min Yoon

Mi Ra Seong

Gwan Sun Lee

Original Assignee

Hanmi Pharm Ind Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-25

Filing date

2002-04-25

Publication date

2006-02-15

2002-04-25 Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd

2006-02-15 Application granted granted Critical

2006-02-15 Publication of ATE316086T1 publication Critical patent/ATE316086T1/de

Links

DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 title abstract 4
229960004099 azithromycin Drugs 0.000 title abstract 3
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
239000013078 crystal Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000000813 microbial effect Effects 0.000 abstract 1
229960004063 propylene glycol Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)

AT02722952T 2001-04-25 2002-04-25 Clathrat von azithromycin-hydrat mit 1,2- propylenglykol, verfahren zu dessen herstellung und dieses enthaltende pharmazeutische zusammensetzung ATE316086T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
KR10-2001-0022406A KR100431431B1 (ko)	2001-04-25	2001-04-25	아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물

Publications (1)

Publication Number	Publication Date
ATE316086T1 true ATE316086T1 (de)	2006-02-15

Family

ID=36578911

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02722952T ATE316086T1 (de)	2001-04-25	2002-04-25	Clathrat von azithromycin-hydrat mit 1,2- propylenglykol, verfahren zu dessen herstellung und dieses enthaltende pharmazeutische zusammensetzung

Country Status (19)

Country	Link
US (2)	US7205394B2 (de)
EP (1)	EP1381601B1 (de)
JP (1)	JP2004528336A (de)
KR (1)	KR100431431B1 (de)
CN (1)	CN1226297C (de)
AT (1)	ATE316086T1 (de)
AU (1)	AU2002253698B2 (de)
BR (1)	BR0209206A (de)
CA (1)	CA2445114A1 (de)
CZ (1)	CZ20033146A3 (de)
DE (1)	DE60208784T2 (de)
ES (1)	ES2253530T3 (de)
HU (1)	HUP0303975A3 (de)
IL (1)	IL158524A0 (de)
MX (1)	MXPA03009663A (de)
NZ (1)	NZ529082A (de)
PL (1)	PL366366A1 (de)
RU (1)	RU2253654C2 (de)
WO (1)	WO2002085898A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20020231A2 (en)	2002-03-18	2003-12-31	Pliva D D	ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
KR100431431B1 (ko) *	2001-04-25	2004-05-14	한미약품 주식회사	아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
US6861413B2 (en)	2001-05-22	2005-03-01	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
DE60209704T2 (de)	2001-05-22	2006-11-16	Pfizer Products Inc., Groton	Neue kristallforme von azithromycin
HRP20020614A2 (en)	2002-07-22	2004-06-30	PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o.	Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
EP1878432A1 (de) *	2003-07-24	2008-01-16	Pliva - Research and Development Ltd.	Schnellösliches Azithromycin in Einzeldosisform
EP1648473B1 (de)	2003-07-24	2009-01-28	PLIVA HRVATSKA d.o.o.	Schnellösliches azithromycin in einzeldosisform
US7468428B2 (en) *	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
US20060116336A1 (en) *	2004-03-17	2006-06-01	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
US7683162B2 (en)	2004-08-30	2010-03-23	Taro Pharmaceutical Industries Limited	Process of preparing a crystalline azithromycin monohydrate
US20090318375A1 (en) *	2005-06-08	2009-12-24	Hanmi Pharm Co., Ltd	Crystalline Azithromycin L-Malate Monohydrate and Pharmaceutical Composition Containing Same
TW200904405A (en)	2007-03-22	2009-02-01	Bristol Myers Squibb Co	Pharmaceutical formulations containing an SGLT2 inhibitor
US20100158821A1 (en) *	2008-12-22	2010-06-24	Eastman Chemical Company	Antimicrobial agents, compositions and products containing the same, and methods of using the compositions and products
US8106111B2 (en) *	2009-05-15	2012-01-31	Eastman Chemical Company	Antimicrobial effect of cycloaliphatic diol antimicrobial agents in coating compositions
CN105030704B (zh) *	2015-06-29	2018-09-07	石药集团欧意药业有限公司	阿奇霉素片剂及其制备方法
CN105061528B (zh) *	2015-08-05	2017-10-17	浙江维康药业股份有限公司	一种阿奇霉素化合物及含有该化合物的阿奇霉素软胶囊

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP940251B1 (en) *	1994-04-15	1998-12-31	Stjepan Mutak	Process for the preparation of azithromycin dihydrochloride
US5958888A (en) *	1996-07-02	1999-09-28	Merial, Inc.	Water miscible macrolide solutions
PT102130A (pt) *	1998-03-13	1999-09-30	Hovione Sociedade Quimica S A	Processo de preparacao de dihidrato de azitromicina
US6239112B1 (en) *	1998-07-09	2001-05-29	Merial, Inc.	Water miscible macrolide solutions
US6245903B1 (en) *	1998-08-21	2001-06-12	Apotex, Inc.	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
US6365574B2 (en) *	1998-11-30	2002-04-02	Teva Pharmaceutical Industries Ltd.	Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
US6239113B1 (en) *	1999-03-31	2001-05-29	Insite Vision, Incorporated	Topical treatment or prevention of ocular infections
CA2396426A1 (en) *	2000-01-04	2001-07-12	Teva Pharmaceutical Industries Ltd.	Preparation method of azithromycin dihydrate
GB0017952D0 (en) *	2000-07-22	2000-09-13	Univ Manchester	Treatment of dyskinesia
WO2002007736A1 (en) *	2000-07-24	2002-01-31	Cadila Pharmaceuticals Limited	The process for manufacturing of clear liquid pharmaceutical composition of azithromycin
KR100431431B1 (ko) *	2001-04-25	2004-05-14	한미약품 주식회사	아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
DE60209704T2 (de) *	2001-05-22	2006-11-16	Pfizer Products Inc., Groton	Neue kristallforme von azithromycin

2001
- 2001-04-25 KR KR10-2001-0022406A patent/KR100431431B1/ko not_active Expired - Fee Related
2002
- 2002-04-25 CA CA002445114A patent/CA2445114A1/en not_active Abandoned
- 2002-04-25 PL PL02366366A patent/PL366366A1/xx unknown
- 2002-04-25 NZ NZ529082A patent/NZ529082A/en unknown
- 2002-04-25 WO PCT/KR2002/000761 patent/WO2002085898A1/en not_active Ceased
- 2002-04-25 IL IL15852402A patent/IL158524A0/xx unknown
- 2002-04-25 ES ES02722952T patent/ES2253530T3/es not_active Expired - Lifetime
- 2002-04-25 RU RU2003134076/04A patent/RU2253654C2/ru not_active IP Right Cessation
- 2002-04-25 HU HU0303975A patent/HUP0303975A3/hu unknown
- 2002-04-25 CZ CZ20033146A patent/CZ20033146A3/cs unknown
- 2002-04-25 BR BR0209206-9A patent/BR0209206A/pt not_active IP Right Cessation
- 2002-04-25 JP JP2002583425A patent/JP2004528336A/ja not_active Withdrawn
- 2002-04-25 AU AU2002253698A patent/AU2002253698B2/en not_active Ceased
- 2002-04-25 CN CNB028089510A patent/CN1226297C/zh not_active Expired - Fee Related
- 2002-04-25 DE DE60208784T patent/DE60208784T2/de not_active Expired - Fee Related
- 2002-04-25 US US10/476,016 patent/US7205394B2/en not_active Expired - Fee Related
- 2002-04-25 EP EP02722952A patent/EP1381601B1/de not_active Expired - Lifetime
- 2002-04-25 MX MXPA03009663A patent/MXPA03009663A/es active IP Right Grant
- 2002-04-25 AT AT02722952T patent/ATE316086T1/de not_active IP Right Cessation
2007
- 2007-03-02 US US11/681,245 patent/US20080076725A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20080076725A1 (en)	2008-03-27
AU2002253698B2 (en)	2005-12-08
MXPA03009663A (es)	2004-07-08
WO2002085898A1 (en)	2002-10-31
EP1381601A4 (de)	2004-06-16
US20040132673A1 (en)	2004-07-08
US7205394B2 (en)	2007-04-17
EP1381601A1 (de)	2004-01-21
ES2253530T3 (es)	2006-06-01
RU2003134076A (ru)	2005-02-27
CN1226297C (zh)	2005-11-09
IL158524A0 (en)	2004-05-12
EP1381601B1 (de)	2006-01-18
NZ529082A (en)	2005-04-29
DE60208784D1 (de)	2006-04-06
CN1505629A (zh)	2004-06-16
PL366366A1 (en)	2005-01-24
HUP0303975A2 (hu)	2004-04-28
KR20020082682A (ko)	2002-10-31
DE60208784T2 (de)	2006-09-28
RU2253654C2 (ru)	2005-06-10
KR100431431B1 (ko)	2004-05-14
JP2004528336A (ja)	2004-09-16
HUP0303975A3 (en)	2007-11-28
BR0209206A (pt)	2004-07-06
CZ20033146A3 (cs)	2004-02-18
CA2445114A1 (en)	2002-10-31

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Legal Events

Date	Code	Title	Description
2006-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties