ATE316967T1 - Zyklische amidderivate die cathepsin k hemmen - Google Patents

Zyklische amidderivate die cathepsin k hemmen

Info

Publication number: ATE316967T1
Authority: AT; Austria
Prior art keywords: substituted; group; unsubstituted; hydrogen atom; alkyl group
Prior art date: 1998-11-12

Application number

AT99402811T

Other languages

English (en)

Inventor

Akihiko Hosoda

Nobuo Kobayashi

Naoko Tanabe

Tsuneo Koji

Masahiro Shibata

Akihiro Sekine

Masaharu Dozen

Original Assignee

Seikagaku Kogyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-12

Filing date

1999-11-12

Publication date

2006-02-15

1999-11-12 Application filed by Seikagaku Kogyo Co Ltd filed Critical Seikagaku Kogyo Co Ltd

2006-02-15 Application granted granted Critical

2006-02-15 Publication of ATE316967T1 publication Critical patent/ATE316967T1/de

Links

150000003950 cyclic amides Chemical class 0.000 title abstract 2
102000005600 Cathepsins Human genes 0.000 title 1
108010084457 Cathepsins Proteins 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
125000002029 aromatic hydrocarbon group Chemical group 0.000 abstract 3
125000000623 heterocyclic group Chemical group 0.000 abstract 3
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
102000004171 Cathepsin K Human genes 0.000 abstract 1
108090000625 Cathepsin K Proteins 0.000 abstract 1
150000001298 alcohols Chemical class 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000006165 cyclic alkyl group Chemical group 0.000 abstract 1
-1 cyclic carboxylic acid derivatives Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000000565 sulfonamide group Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
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- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pyridine Compounds (AREA)

AT99402811T 1998-11-12 1999-11-12 Zyklische amidderivate die cathepsin k hemmen ATE316967T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP32228398		1998-11-12

Publications (1)

Publication Number	Publication Date
ATE316967T1 true ATE316967T1 (de)	2006-02-15

Family

ID=18141919

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99402811T ATE316967T1 (de)	1998-11-12	1999-11-12	Zyklische amidderivate die cathepsin k hemmen

Country Status (7)

Country	Link
US (1)	US6117870A (de)
EP (4)	EP1616859B1 (de)
KR (1)	KR100659651B1 (de)
AT (1)	ATE316967T1 (de)
DE (1)	DE69929669T2 (de)
DK (1)	DK1008592T3 (de)
ES (1)	ES2258318T3 (de)

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WO2014199644A1 (ja) *	2013-06-14	2014-12-18	生化学工業株式会社	α－オキソアシルアミノカプロラクタム誘導体
JP6226437B2 (ja)	2013-06-14	2017-11-08	生化学工業株式会社	α−オキソアシルアミノカプロラクタム体
GB201604029D0 (en)	2016-03-09	2016-04-20	Ctxt Pty Ltd	Compounds
GB201604027D0 (en)	2016-03-09	2016-04-20	Ctxt Pty Ltd	Compounds
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GB201604031D0 (en) *	2016-03-09	2016-04-20	Ctxt Pty Ltd	Compounds
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1999
- 1999-11-10 US US09/437,438 patent/US6117870A/en not_active Expired - Lifetime
- 1999-11-11 KR KR1019990049831A patent/KR100659651B1/ko not_active Expired - Fee Related
- 1999-11-12 EP EP05018361.5A patent/EP1616859B1/de not_active Expired - Lifetime
- 1999-11-12 DE DE69929669T patent/DE69929669T2/de not_active Expired - Lifetime
- 1999-11-12 EP EP05018359.9A patent/EP1619189B1/de not_active Expired - Lifetime
- 1999-11-12 EP EP05018360A patent/EP1616867A1/de not_active Withdrawn
- 1999-11-12 EP EP99402811A patent/EP1008592B1/de not_active Expired - Lifetime
- 1999-11-12 AT AT99402811T patent/ATE316967T1/de active
- 1999-11-12 ES ES99402811T patent/ES2258318T3/es not_active Expired - Lifetime
- 1999-11-12 DK DK99402811T patent/DK1008592T3/da active

Also Published As

Publication number	Publication date
ES2258318T3 (es)	2006-08-16
EP1616867A1 (de)	2006-01-18
DK1008592T3 (da)	2006-06-06
EP1619189A1 (de)	2006-01-25
DE69929669T2 (de)	2006-09-07
EP1616859B1 (de)	2013-09-04
EP1008592A3 (de)	2000-08-02
KR20000035402A (ko)	2000-06-26
EP1008592A2 (de)	2000-06-14
DE69929669D1 (de)	2006-04-13
US6117870A (en)	2000-09-12
EP1008592B1 (de)	2006-02-01
EP1616859A1 (de)	2006-01-18
EP1619189B1 (de)	2013-09-04
KR100659651B1 (ko)	2007-02-28

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