DK1256590T3 - Ny syntesefremgangsmåde af derivater af (2S,3aS,7aS)-1-(S)-alanyloctahydro-1H-indol-2-carboxylsyre og anvendelse heraf til syntese af perindopril - Google Patents

Ny syntesefremgangsmåde af derivater af (2S,3aS,7aS)-1-(S)-alanyloctahydro-1H-indol-2-carboxylsyre og anvendelse heraf til syntese af perindopril

Info

Publication number: DK1256590T3
Authority: DK; Denmark
Prior art keywords: synthesis; carboxylic acid; formula; mole; perindopril
Prior art date: 2001-07-24

Application number

DK02291853T

Other languages

English (en)

Inventor

Marta Porcs-Makkay

Gyula Simig

Tibor Mezei

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-24

Filing date

2002-07-23

Publication date

2006-06-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8865826&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1256590(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-07-23 Application filed by Servier Lab filed Critical Servier Lab

2006-06-06 Application granted granted Critical

2006-06-06 Publication of DK1256590T3 publication Critical patent/DK1256590T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Indole Compounds (AREA)

DK02291853T 2001-07-24 2002-07-23 Ny syntesefremgangsmåde af derivater af (2S,3aS,7aS)-1-(S)-alanyloctahydro-1H-indol-2-carboxylsyre og anvendelse heraf til syntese af perindopril DK1256590T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0109839A FR2827860B1 (fr)	2001-07-24	2001-07-24	Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril

Publications (1)

Publication Number	Publication Date
DK1256590T3 true DK1256590T3 (da)	2006-06-06

Family

ID=8865826

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02291853T DK1256590T3 (da)	2001-07-24	2002-07-23	Ny syntesefremgangsmåde af derivater af (2S,3aS,7aS)-1-(S)-alanyloctahydro-1H-indol-2-carboxylsyre og anvendelse heraf til syntese af perindopril

Country Status (25)

Country	Link
US (1)	US7060842B2 (da)
EP (1)	EP1256590B1 (da)
JP (1)	JP3868957B2 (da)
KR (1)	KR100607556B1 (da)
CN (1)	CN1533398A (da)
AR (1)	AR035081A1 (da)
AT (1)	ATE318838T1 (da)
AU (1)	AU2002334027B8 (da)
BR (1)	BR0211334A (da)
CA (1)	CA2455706C (da)
DE (1)	DE60209458T2 (da)
DK (1)	DK1256590T3 (da)
EA (1)	EA005490B1 (da)
ES (1)	ES2259071T3 (da)
FR (1)	FR2827860B1 (da)
HU (1)	HU229396B1 (da)
MA (1)	MA27130A1 (da)
MX (1)	MXPA04000443A (da)
NO (1)	NO328234B1 (da)
NZ (1)	NZ530427A (da)
PL (1)	PL212408B1 (da)
PT (1)	PT1256590E (da)
SI (1)	SI1256590T1 (da)
WO (1)	WO2003016336A1 (da)
ZA (1)	ZA200400246B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE365714T1 (de) *	2002-01-30	2007-07-15	Servier Lab	Verfahren zur herstellung von hochreinem perindopril und zwischenverbindungen nützlich in der synthese
SI1403275T1 (sl) *	2003-02-28	2006-02-28	Servier Lab	Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
ATE307801T1 (de) *	2003-02-28	2005-11-15	Servier Lab	Verfahren zur synthese des (2s,3as,7as)- perhydroindol-2-carbonsäures und seiner estern, verwendung in der synthese von perindopril
EP1603558B1 (en)	2003-02-28	2008-05-21	Les Laboratoires Servier S.A.	Process for preparation of perindopril and salts thereof
DE60301774T2 (de) *	2003-02-28	2006-07-20	Les Laboratoires Servier	Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril
EP1323729B1 (fr) *	2003-03-12	2004-11-03	Les Laboratoires Servier	Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril
DK1321471T3 (da) *	2003-03-12	2005-08-29	Servier Lab	Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf
EP1319668B1 (fr) *	2003-03-12	2004-10-27	Les Laboratoires Servier	Nouveau procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS)-1-[(S)]-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
DK1636185T3 (da)	2003-06-24	2012-05-07	Servier Lab	Nye krystalformer af Perindopril erbumin
SI1367063T1 (sl) *	2003-07-31	2006-10-31	Servier Lab	Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
JP4720132B2 (ja) *	2003-10-30	2011-07-13	住友化学株式会社	光学活性なｎ−保護−オクタヒドロ−１ｈ−インドール−２−カルボン酸の製造方法
EP1420030A3 (fr) *	2003-12-10	2004-05-26	Les Laboratoires Servier	Procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS) - 1 - [(S)-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
GB2413128A (en) *	2004-04-13	2005-10-19	Neopharma Ltd	Process for the preparation of perindopril
ITFI20040174A1 (it) *	2004-08-03	2004-11-03	Protera S R L	Derivati arilsolfonammidici dell'acido idrossammico ad azione inibitoria di metalloproteinasi
KR101329457B1 (ko)	2006-12-19	2013-11-15	에스케이바이오팜 주식회사	옥타하이드로인돌-2-카르복시산의 제조방법
RU2433998C1 (ru) *	2010-03-16	2011-11-20	Закрытое акционерное общество "Активный Компонент"	Способ получения периндоприла и его фармацевтически приемлемых солей
PH12018502155B1 (en)	2016-04-20	2024-03-27	Servier Lab	Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2503155A2 (fr) *	1980-10-02	1982-10-08	Science Union & Cie	Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620709B1 (fr) *	1987-09-17	1990-09-07	Adir	Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807037B1 (fr) *	2000-03-31	2002-05-10	Adir	NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) *	2000-04-06	2002-07-19	Adir	Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr)	2000-04-11	2002-05-17	Adir	Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

2001
- 2001-07-24 FR FR0109839A patent/FR2827860B1/fr not_active Expired - Fee Related
2002
- 2002-07-23 DK DK02291853T patent/DK1256590T3/da active
- 2002-07-23 DE DE60209458T patent/DE60209458T2/de not_active Expired - Lifetime
- 2002-07-23 US US10/484,022 patent/US7060842B2/en not_active Expired - Lifetime
- 2002-07-23 WO PCT/FR2002/002627 patent/WO2003016336A1/fr not_active Ceased
- 2002-07-23 ES ES02291853T patent/ES2259071T3/es not_active Expired - Lifetime
- 2002-07-23 KR KR1020047001052A patent/KR100607556B1/ko not_active Expired - Fee Related
- 2002-07-23 PT PT02291853T patent/PT1256590E/pt unknown
- 2002-07-23 EP EP02291853A patent/EP1256590B1/fr not_active Expired - Lifetime
- 2002-07-23 JP JP2003521258A patent/JP3868957B2/ja not_active Expired - Fee Related
- 2002-07-23 NZ NZ530427A patent/NZ530427A/en not_active IP Right Cessation
- 2002-07-23 CA CA2455706A patent/CA2455706C/fr not_active Expired - Fee Related
- 2002-07-23 CN CNA028146093A patent/CN1533398A/zh active Pending
- 2002-07-23 EA EA200400110A patent/EA005490B1/ru not_active IP Right Cessation
- 2002-07-23 AT AT02291853T patent/ATE318838T1/de active
- 2002-07-23 SI SI200230292T patent/SI1256590T1/sl unknown
- 2002-07-23 AU AU2002334027A patent/AU2002334027B8/en not_active Ceased
- 2002-07-23 BR BR0211334-1A patent/BR0211334A/pt not_active IP Right Cessation
- 2002-07-23 AR ARP020102757A patent/AR035081A1/es not_active Application Discontinuation
- 2002-07-23 MX MXPA04000443A patent/MXPA04000443A/es active IP Right Grant
- 2002-07-24 HU HU0202437A patent/HU229396B1/hu not_active IP Right Cessation
- 2002-07-24 PL PL355159A patent/PL212408B1/pl unknown
2004
- 2004-01-08 MA MA27474A patent/MA27130A1/fr unknown
- 2004-01-13 NO NO20040151A patent/NO328234B1/no not_active IP Right Cessation
- 2004-01-13 ZA ZA200400246A patent/ZA200400246B/en unknown

Also Published As

Publication number	Publication date
US20040198988A1 (en)	2004-10-07
DE60209458T2 (de)	2006-10-12
CA2455706A1 (fr)	2003-02-27
DE60209458D1 (de)	2006-04-27
SI1256590T1 (sl)	2006-06-30
EP1256590B1 (fr)	2006-03-01
WO2003016336A1 (fr)	2003-02-27
PL212408B1 (pl)	2012-09-28
CA2455706C (fr)	2012-01-24
ATE318838T1 (de)	2006-03-15
US7060842B2 (en)	2006-06-13
NO20040151L (no)	2004-01-13
HU229396B1 (hu)	2013-11-28
JP2005500386A (ja)	2005-01-06
MXPA04000443A (es)	2004-03-18
JP3868957B2 (ja)	2007-01-17
FR2827860A1 (fr)	2003-01-31
NO328234B1 (no)	2010-01-11
HUP0202437A3 (en)	2003-05-28
PT1256590E (pt)	2006-06-30
AU2002334027B8 (en)	2007-01-25
FR2827860B1 (fr)	2004-12-10
HUP0202437A2 (hu)	2003-02-28
EA005490B1 (ru)	2005-02-24
BR0211334A (pt)	2004-09-28
AU2002334027B2 (en)	2006-12-14
MA27130A1 (fr)	2005-01-03
CN1533398A (zh)	2004-09-29
KR100607556B1 (ko)	2006-08-02
KR20040023673A (ko)	2004-03-18
ES2259071T3 (es)	2006-09-16
EP1256590A1 (fr)	2002-11-13
AR035081A1 (es)	2004-04-14
NZ530427A (en)	2005-08-26
EA200400110A1 (ru)	2004-06-24
AU2002334027A1 (en)	2003-03-03
HU0202437D0 (da)	2002-10-28
ZA200400246B (en)	2006-07-26
PL355159A1 (en)	2003-01-13

Publication	Publication Date	Title
HU0202437D0 (da)	2002-10-28
EA199900690A1 (ru)	2000-04-24	Способ получения и очистки n-алкилированного производного аспартама
DE3784799D1 (de)	1993-04-22	Malonsaeurederivate und ihre synthesemethoden.
TR199802518T2 (xx)	1999-04-21	4-Diketon ikameli yeni tiazolidon-2 t�revleri.
ATE383858T1 (de)	2008-02-15	Substituierte tetrhydroisochinolin-derivate zur behandlung von entzündlichen erkrankungen
Carlström et al.	1989	Palladium-catalyzed synthesis of didehydroamino acid derivatives
Werner et al.	1997	Preparation of 4-Oxo-l-norvaline via diazomethane homologation of β-Aspartyl semialdehyde
Courcambeck et al.	2001	Design of potential new HIV protease inhibitors: enantioconvergent synthesis of new pyrrolidin-3-ol, and pyrrolidin-3-one peptide conjugates
Sutton et al.	2001	Synthesis and biological evaluation of analogues of the antibiotic pantocin B
Kempf et al.	1987	Renin inhibitors based on novel dipeptide analogs. Incorporation of the dehydrohydroxyethylene isostere at the scissile bond
Gibson et al.	2002	CCK2 receptor antagonists containing the conformationally constrained phenylalanine derivatives, including the new amino acid Xic
RU95102102A (ru)	1996-11-20	Nальфа -2(4-НИТРОФЕНИЛСУЛЬФОНИЛ)ЭТОКСИКАРБОНИЛ-АМИНОКИСЛОТЫ
AR043410A1 (es)	2005-07-27	Procedimiento para la sintesis de compuestos del acido 2s,3as 7as ) -1-(s) -alanil-octahidro-1 h-indol -2 carboxilico y aplicacion en la sintesis de perindopril
PL379627A1 (pl)	2006-10-30	Nowy sposób syntezy perindoprylu oraz jego farmaceutycznie dopuszczalnych soli
CA2404700A1 (fr)	2001-08-09	Nouveau procede de synthese de esters de la n-[(s)-1-carboxybutyl]-(s)-alanine et application a la synthese du perindopril
US6034247A (en)	2000-03-07	Oxazolidinones and methods for the synthesis and use of same
AR043567A1 (es)	2005-08-03	Procedimiento para la sintesis de perindopril y sales farmaceuticamente aceptables del mismo
AR043411A1 (es)	2005-07-27	Procedimiento para la sintesis del acido 2s, 3as ,7as carboxilico y esteresdel mismo, y aplicacion en la sintesis de perindopril
ES2250846T3 (es)	2006-04-16	Nuevo procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables.
ES2191587T3 (es)	2003-09-16	Procedimiento para la preparacion de derivados de 4-fenil-piperidina 3-sustituida.
Moumné et al.	2007	New Scalable Asymmetric Aminomethylation Reaction for the Synthesis of β2‐Amino Acids
ES2240926T3 (es)	2005-10-16	Procedimiento de sintesis de n-((s)-1-(etoxicarbonil)butil)-(s)-alanina y su utilizacion en la sintesis de perindopril.
DK0771792T3 (da)	1999-11-15	Fremgangsmåde til fremstilling af (4,5)-trans-oxazolidinderivater
JPH01275553A (ja)	1989-11-06	ベンジルカルバメートからｔ−ブチルカルバメートへの変換法
NO20063027L (no)	2006-06-28	Fremgangsmaten for syntesen av derivater av (2S,3aS,7aS)-1-[(S)-alkanyl]-oktahydro-lH-indol-2-karboksylsyre og anvendelse derav i syntesen av perindopril