ATE321139T1 - Gene und proteine zur rosaramicin biosynthese - Google Patents

Gene und proteine zur rosaramicin biosynthese

Info

Publication number
ATE321139T1
ATE321139T1 AT02750735T AT02750735T ATE321139T1 AT E321139 T1 ATE321139 T1 AT E321139T1 AT 02750735 T AT02750735 T AT 02750735T AT 02750735 T AT02750735 T AT 02750735T AT E321139 T1 ATE321139 T1 AT E321139T1
Authority
AT
Austria
Prior art keywords
rosaramicin
biosynthesis
genes
proteins
macrolides
Prior art date
Application number
AT02750735T
Other languages
English (en)
Inventor
Chris M Farnet
Alfredo Staffa
Xianshu Yang
Original Assignee
Ecopia Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ecopia Biosciences Inc filed Critical Ecopia Biosciences Inc
Application granted granted Critical
Publication of ATE321139T1 publication Critical patent/ATE321139T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT02750735T 2001-07-26 2002-07-26 Gene und proteine zur rosaramicin biosynthese ATE321139T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30762901P 2001-07-26 2001-07-26

Publications (1)

Publication Number Publication Date
ATE321139T1 true ATE321139T1 (de) 2006-04-15

Family

ID=23190548

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02750735T ATE321139T1 (de) 2001-07-26 2002-07-26 Gene und proteine zur rosaramicin biosynthese

Country Status (7)

Country Link
US (1) US20030113874A1 (de)
EP (1) EP1409686B1 (de)
AT (1) ATE321139T1 (de)
AU (1) AU2002355157A1 (de)
CA (1) CA2391131C (de)
DE (1) DE60210096D1 (de)
WO (1) WO2003010193A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2851773A1 (fr) * 2003-02-27 2004-09-03 Aventis Pharma Sa Polypeptides impliques dans la biosynthese des spiramycines, sequences nucleotidiques codant ces polypeptides et leurs applications
US7579167B2 (en) 2002-10-08 2009-08-25 Aventis Pharma S. Polypeptides involved in the biosynthesis of spiramycins, nucleotide sequences encoding these polypeptides and applications thereof
BRPI0314543B8 (pt) * 2002-10-08 2021-05-25 Aventis Pharma Sa células hospedeiras, dna recombinante, utilização dos mesmos, processos de produção de um polipeptídeo implicado na biossíntese das espiramicinas, de produção de macrolídeos e de produção de espiramicina(s), e micro-organismo transgênico mutante produtor de macrolídeo
WO2012035055A1 (en) 2010-09-17 2012-03-22 Glaxo Group Limited Novel compounds
EP4667564A2 (de) * 2013-08-14 2025-12-24 Institute Of Genetics And Developmental Biology, Chinese Academy of Sciences Verfahren zur modulation der samen- und organgrösse bei pflanzen
WO2017100650A1 (en) 2015-12-09 2017-06-15 Vanderbilt University Biosynthesis of everninomicin analogs in micromonospora carbonacea var aurantiaca

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234690A (en) * 1979-07-16 1980-11-18 Schering Corporation Method for producing rosaramicin (rosamicin)
US5149639A (en) * 1986-03-24 1992-09-22 Abbott Laboratories Biologically pure cultures of streptomyces and use thereof in macrolide antibiotic production
US4874748A (en) * 1986-03-24 1989-10-17 Abbott Laboratories Cloning vectors for streptomyces and use thereof in macrolide antibiotic production
US5063155A (en) * 1988-03-28 1991-11-05 Eli Lilly And Company Method for producing 2"'-o-demethyltylosin
US5098837A (en) * 1988-06-07 1992-03-24 Eli Lilly And Company Macrolide biosynthetic genes for use in streptomyces and other organisms
EP0725778B1 (de) * 1993-09-20 2001-09-26 The Leland Stanford Junior University Rekombinante herstellung von neuen polyketiden
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
US6117679A (en) * 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6361974B1 (en) * 1995-12-07 2002-03-26 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution

Also Published As

Publication number Publication date
EP1409686A2 (de) 2004-04-21
US20030113874A1 (en) 2003-06-19
WO2003010193A3 (en) 2003-04-10
EP1409686B1 (de) 2006-03-22
CA2391131A1 (en) 2002-11-19
DE60210096D1 (de) 2006-05-11
CA2391131C (en) 2004-10-12
AU2002355157A1 (en) 2003-02-17
WO2003010193A2 (en) 2003-02-06

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Legal Events

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