|
US7285416B2
(en)
*
|
2000-01-24 |
2007-10-23 |
Gendaq Limited |
Regulated gene expression in plants
|
|
GB9824544D0
(en)
|
1998-11-09 |
1999-01-06 |
Medical Res Council |
Screening system
|
|
US7262055B2
(en)
|
1998-08-25 |
2007-08-28 |
Gendaq Limited |
Regulated gene expression in plants
|
|
CA2196419C
(en)
|
1994-08-20 |
2007-08-21 |
Yen Choo |
Improvements in or relating to binding proteins for recognition of dna
|
|
US6410248B1
(en)
|
1998-01-30 |
2002-06-25 |
Massachusetts Institute Of Technology |
General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
|
|
DE69942334D1
(de)
|
1998-03-02 |
2010-06-17 |
Massachusetts Inst Technology |
Poly-zinkfinger-proteine mit verbesserten linkern
|
|
DE69932813D1
(de)
|
1998-03-17 |
2006-09-28 |
Gendaq Ltd |
Nukleinsäurebindungsproteine
|
|
US6140081A
(en)
*
|
1998-10-16 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger binding domains for GNN
|
|
US6599692B1
(en)
|
1999-09-14 |
2003-07-29 |
Sangamo Bioscience, Inc. |
Functional genomics using zinc finger proteins
|
|
US6503717B2
(en)
|
1999-12-06 |
2003-01-07 |
Sangamo Biosciences, Inc. |
Methods of using randomized libraries of zinc finger proteins for the identification of gene function
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US7070934B2
(en)
|
1999-01-12 |
2006-07-04 |
Sangamo Biosciences, Inc. |
Ligand-controlled regulation of endogenous gene expression
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US7013219B2
(en)
*
|
1999-01-12 |
2006-03-14 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US20030104526A1
(en)
|
1999-03-24 |
2003-06-05 |
Qiang Liu |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
|
US7030215B2
(en)
*
|
1999-03-24 |
2006-04-18 |
Sangamo Biosciences, Inc. |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
|
US6794136B1
(en)
|
2000-11-20 |
2004-09-21 |
Sangamo Biosciences, Inc. |
Iterative optimization in the design of binding proteins
|
|
US7329728B1
(en)
|
1999-10-25 |
2008-02-12 |
The Scripps Research Institute |
Ligand activated transcriptional regulator proteins
|
|
WO2001053480A1
(en)
*
|
2000-01-24 |
2001-07-26 |
Sangamo Biosciences, Inc. |
Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules
|
|
AU2001250774B2
(en)
|
2000-02-08 |
2005-01-27 |
Sangamo Biosciences, Inc. |
Cells expressing zinc finger proteins for drug discovery
|
|
US7923542B2
(en)
|
2000-04-28 |
2011-04-12 |
Sangamo Biosciences, Inc. |
Libraries of regulatory sequences, methods of making and using same
|
|
US7217509B2
(en)
|
2000-04-28 |
2007-05-15 |
Sangamo Biosciences, Inc. |
Databases of regulatory sequences; methods of making and using same
|
|
AU2001257421A1
(en)
|
2000-04-28 |
2001-11-12 |
Sangamo Biosciences, Inc. |
Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
|
|
AU2001257331A1
(en)
|
2000-04-28 |
2001-11-12 |
Sangamo Biosciences, Inc. |
Methods for designing exogenous regulatory molecules
|
|
EP1276859B1
(de)
|
2000-04-28 |
2007-02-07 |
Sangamo Biosciences Inc. |
Gezielten modifikation der chromatinstruktur
|
|
EP1908835A3
(de)
*
|
2000-07-18 |
2008-06-18 |
Novartis AG |
Regulierung von Genexpression durch einkettige, monomere, ligandenabhängige Polypeptidschalter
|
|
US7011972B2
(en)
|
2000-07-18 |
2006-03-14 |
The Scripps Research Institute |
Fusion polypeptide comprising two ligand binding domains
|
|
IL154059A0
(en)
*
|
2000-07-21 |
2003-07-31 |
Syngenta Participations Ag |
Zinc finger domain recognition code and uses thereof
|
|
US7067317B2
(en)
*
|
2000-12-07 |
2006-06-27 |
Sangamo Biosciences, Inc. |
Regulation of angiogenesis with zinc finger proteins
|
|
WO2002046412A2
(en)
*
|
2000-12-07 |
2002-06-13 |
Sangamo Biosciences, Inc. |
Regulation of angiogenesis with zinc finger proteins
|
|
US7273923B2
(en)
*
|
2001-01-22 |
2007-09-25 |
Sangamo Biosciences, Inc. |
Zinc finger proteins for DNA binding and gene regulation in plants
|
|
US7947469B2
(en)
*
|
2001-01-22 |
2011-05-24 |
Gendaq, Ltd. |
Modulation of HIV infection
|
|
EP1364027B1
(de)
*
|
2001-02-21 |
2009-09-02 |
Novartis AG |
Die nukleotidsequenz ann bindende zink-finger domänen
|
|
US7067617B2
(en)
*
|
2001-02-21 |
2006-06-27 |
The Scripps Research Institute |
Zinc finger binding domains for nucleotide sequence ANN
|
|
US20040197892A1
(en)
*
|
2001-04-04 |
2004-10-07 |
Michael Moore |
Composition binding polypeptides
|
|
WO2002097050A2
(en)
|
2001-05-31 |
2002-12-05 |
Novartis Ag |
Novel estrogen receptor ligand binding domain variants and novel ligands and pharmaceutical compositions
|
|
US20040224385A1
(en)
*
|
2001-08-20 |
2004-11-11 |
Barbas Carlos F |
Zinc finger binding domains for cnn
|
|
US7262054B2
(en)
*
|
2002-01-22 |
2007-08-28 |
Sangamo Biosciences, Inc. |
Zinc finger proteins for DNA binding and gene regulation in plants
|
|
ATE347593T1
(de)
*
|
2002-01-23 |
2006-12-15 |
Univ Utah Res Found |
Zielgerichtete chromosomale mutagenese mit zinkfingernukleasen
|
|
AU2003215094B2
(en)
*
|
2002-02-07 |
2008-05-29 |
The Scripps Research Institute |
Zinc finger libraries
|
|
EP1504092B2
(de)
*
|
2002-03-21 |
2014-06-25 |
Sangamo BioSciences, Inc. |
Verfahren und zusammensetzungen zur verwendung von zinkfinger-endonukleasen zur verbesserung der homologen rekombination
|
|
EP1532178A4
(de)
*
|
2002-06-11 |
2006-10-25 |
Scripps Research Inst |
Synthetische transkriptionsfaktoren
|
|
US7361635B2
(en)
|
2002-08-29 |
2008-04-22 |
Sangamo Biosciences, Inc. |
Simultaneous modulation of multiple genes
|
|
US9447434B2
(en)
*
|
2002-09-05 |
2016-09-20 |
California Institute Of Technology |
Use of chimeric nucleases to stimulate gene targeting
|
|
WO2004046387A1
(en)
*
|
2002-11-15 |
2004-06-03 |
Sangamo Biosciences, Inc. |
Methods and compositions for analysis of regulatory sequences
|
|
US8071285B1
(en)
|
2003-05-14 |
2011-12-06 |
Carl Henry Lawyer |
Zinc finger protein derivatives and methods of using same
|
|
US8409861B2
(en)
|
2003-08-08 |
2013-04-02 |
Sangamo Biosciences, Inc. |
Targeted deletion of cellular DNA sequences
|
|
EP2927318B1
(de)
|
2003-08-08 |
2020-05-20 |
Sangamo Therapeutics, Inc. |
Verfahren und Zusammensetzungen für gezielte Spaltung und Rekombination
|
|
US11311574B2
(en)
|
2003-08-08 |
2022-04-26 |
Sangamo Therapeutics, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
US20120196370A1
(en)
|
2010-12-03 |
2012-08-02 |
Fyodor Urnov |
Methods and compositions for targeted genomic deletion
|
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
CA2539439C
(en)
|
2003-09-19 |
2012-10-23 |
Sangamo Biosciences, Inc. |
Engineered zinc finger proteins for regulation of gene expression
|
|
US7972854B2
(en)
|
2004-02-05 |
2011-07-05 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
AU2005233583B2
(en)
*
|
2004-04-08 |
2011-02-03 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulating cardiac contractility
|
|
ATE418346T1
(de)
*
|
2004-04-08 |
2009-01-15 |
Sangamo Biosciences Inc |
Zusammensetzungen zur behandlung von neuropathischen und neurodegenerativen erkrankungen
|
|
US7253273B2
(en)
*
|
2004-04-08 |
2007-08-07 |
Sangamo Biosciences, Inc. |
Treatment of neuropathic pain with zinc finger proteins
|
|
KR20070060115A
(ko)
|
2004-09-16 |
2007-06-12 |
상가모 바이오사이언스 인코포레이티드 |
단백질 생산을 위한 조성물 및 방법
|
|
EP2163632A1
(de)
|
2004-10-05 |
2010-03-17 |
SunGene GmbH |
Konstitutive Expressionskassetten zur Regulation der Pflanzenexpression
|
|
EP1655364A3
(de)
|
2004-11-05 |
2006-08-02 |
BASF Plant Science GmbH |
Expressionskassetten zur bevorzugten Expression in Pflanzensamen
|
|
EP1662000B1
(de)
|
2004-11-25 |
2011-03-30 |
SunGene GmbH |
Expressionskassetten zur bevorzugten Expression in pflanzlichen Schliesszellen
|
|
EP1666599A3
(de)
|
2004-12-04 |
2006-07-12 |
SunGene GmbH |
Expressionskassetten zur bevorzugten Expression in Mesophyll- und/oder Epidermiszellen in Pflanzen
|
|
EP1669455B1
(de)
|
2004-12-08 |
2009-10-28 |
SunGene GmbH |
Expressionskassetten für preferentiell vaskuläre Expression in Pflanzen
|
|
EP1669456A3
(de)
|
2004-12-11 |
2006-07-12 |
SunGene GmbH |
Expressionskasseten für meristembevorzugte Expression in Pflanzen
|
|
EP2163633A1
(de)
|
2005-02-09 |
2010-03-17 |
BASF Plant Science GmbH |
Expressionskassetten zur Regulation der Expression in einkeimblättrigen Pflanzen
|
|
AU2006217847B2
(en)
|
2005-02-26 |
2011-04-07 |
Basf Plant Science Gmbh |
Expression cassettes for seed-preferential expression in plants
|
|
CA2599004C
(en)
|
2005-02-28 |
2015-05-26 |
Sangamo Biosciences, Inc. |
Anti-angiogenic methods and compositions
|
|
AU2006245701B2
(en)
|
2005-05-10 |
2011-04-28 |
Basf Plant Science Gmbh |
Expression cassettes for seed-preferential expression in plants
|
|
EP1913149A4
(de)
|
2005-07-26 |
2009-08-05 |
Sangamo Biosciences Inc |
Gezielte integration und expression exogener nukleinsäuresequenzen
|
|
JP2009504156A
(ja)
*
|
2005-08-11 |
2009-02-05 |
ザ スクリップス リサーチ インスティテュート |
Cnnに対するジンクフィンガー結合ドメイン
|
|
WO2007048127A2
(en)
*
|
2005-10-20 |
2007-04-26 |
The Scripps Research Institute |
Fc labeling for immunostaining and immunotargeting
|
|
CA2631422A1
(en)
*
|
2005-11-28 |
2007-05-31 |
The Scripps Research Institute |
Zinc finger binding domains for tnn
|
|
US20070154989A1
(en)
*
|
2006-01-03 |
2007-07-05 |
The Scripps Research Institute |
Zinc finger domains specifically binding agc
|
|
WO2007106603A2
(en)
*
|
2006-01-06 |
2007-09-20 |
The Scripps Research Institute |
Specific labeling of proteins with zinc finger tags and use of zinc-finger-tagged proteins for analysis
|
|
WO2007136685A2
(en)
*
|
2006-05-19 |
2007-11-29 |
Sangamo Biosciences, Inc. |
Methods and compositions for inactivation of dihydrofolate reductase
|
|
EP2027262B1
(de)
*
|
2006-05-25 |
2010-03-31 |
Sangamo Biosciences Inc. |
Variante foki-spaltungshälften-domänen
|
|
US7951925B2
(en)
|
2006-05-25 |
2011-05-31 |
Sangamo Biosciences, Inc. |
Methods and compositions for gene inactivation
|
|
JP2010500029A
(ja)
|
2006-08-11 |
2010-01-07 |
ダウ アグロサイエンシィズ エルエルシー |
ジンクフィンガーヌクレアーゼ媒介相同組換え
|
|
WO2008060510A2
(en)
|
2006-11-13 |
2008-05-22 |
Sangamo Biosciences, Inc. |
Zinc finger nuclease for targeting the human glucocorticoid receptor locus
|
|
CA2669746C
(en)
*
|
2006-12-14 |
2017-05-16 |
Dow Agrosciences Llc |
Optimized non-canonical zinc finger proteins
|
|
KR20090119910A
(ko)
|
2007-02-16 |
2009-11-20 |
바스프 플랜트 사이언스 게엠베하 |
외떡잎 식물에서 배-특이적 발현의 조절을 위한 핵산 서열
|
|
US8110379B2
(en)
|
2007-04-26 |
2012-02-07 |
Sangamo Biosciences, Inc. |
Targeted integration into the PPP1R12C locus
|
|
AU2008275649B2
(en)
|
2007-07-12 |
2013-09-05 |
Sangamo Therapeutics, Inc. |
Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT 8) gene expression
|
|
US8563314B2
(en)
|
2007-09-27 |
2013-10-22 |
Sangamo Biosciences, Inc. |
Methods and compositions for modulating PD1
|
|
JP5763341B2
(ja)
*
|
2007-09-27 |
2015-08-12 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
生物学的活性のあるヌクレアーゼの迅速なインビボ同定法
|
|
ES2585157T3
(es)
|
2007-09-27 |
2016-10-04 |
Dow Agrosciences Llc |
Proteínas de dedo de cinc de diseño que se dirigen a los genes de 5-enolpiruvil shikimato-3-fosfato sintasa
|
|
US11235026B2
(en)
|
2007-09-27 |
2022-02-01 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulating PD1
|
|
EP2597155B1
(de)
|
2007-10-25 |
2016-11-23 |
Sangamo BioSciences, Inc. |
Verfahren und Zusammensetzungen für gezielte Integration
|
|
CA2704271C
(en)
|
2007-12-03 |
2016-07-19 |
Syngenta Participations Ag |
Engineering enzymatically susceptible phytases
|
|
AU2009212247A1
(en)
*
|
2008-02-08 |
2009-08-13 |
Sangamo Therapeutics, Inc. |
Treatment of chronic pain with zinc finger proteins
|
|
WO2009130695A2
(en)
|
2008-04-21 |
2009-10-29 |
Danziger Innovation Ltd. |
Plant viral expression vectors and use of same for generating genotypic variations in plant genomes
|
|
PL2274430T3
(pl)
|
2008-04-30 |
2017-09-29 |
Sanbio Inc |
Komórki regenerujące nerwy ze zmianami w metylacji DNA
|
|
CA2725773C
(en)
*
|
2008-05-28 |
2017-12-05 |
Sangamo Biosciences, Inc. |
Compositions for linking dna-binding domains and cleavage domains
|
|
JP5763530B2
(ja)
*
|
2008-06-10 |
2015-08-12 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
Bax−およびBak−欠損細胞株の生成のための方法および組成物
|
|
JP5908725B2
(ja)
|
2008-08-22 |
2016-04-26 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
標的一本鎖開裂および標的組込みのための方法、並びに組成物
|
|
JP5756016B2
(ja)
*
|
2008-10-29 |
2015-07-29 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
グルタミンシンセターゼ遺伝子の発現を不活性化する方法及び組成物
|
|
WO2010056808A2
(en)
*
|
2008-11-12 |
2010-05-20 |
The Regents Of The University Of California |
Compositions and methods for re-programming and re-differentiating cells
|
|
US20110023156A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Feline genome editing with zinc finger nucleases
|
|
US20110023139A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in cardiovascular disease
|
|
US20110023146A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in secretase-associated disorders
|
|
US20110023151A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of abc transporters
|
|
EP3156494B8
(de)
|
2008-12-04 |
2018-09-19 |
Sangamo Therapeutics, Inc. |
Genomänderung bei ratten mithilfe von zink-finger-nukleasen
|
|
US20110023154A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Silkworm genome editing with zinc finger nucleases
|
|
US20110016543A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in inflammation
|
|
US20110023153A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in alzheimer's disease
|
|
US20110023141A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved with parkinson's disease
|
|
US20110016546A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Porcine genome editing with zinc finger nucleases
|
|
US20110016540A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of genes associated with trinucleotide repeat expansion disorders in animals
|
|
US20110023158A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Bovine genome editing with zinc finger nucleases
|
|
US20110023150A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of genes associated with schizophrenia in animals
|
|
US20110023145A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in autism spectrum disorders
|
|
US20110030072A1
(en)
*
|
2008-12-04 |
2011-02-03 |
Sigma-Aldrich Co. |
Genome editing of immunodeficiency genes in animals
|
|
US20110023140A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Rabbit genome editing with zinc finger nucleases
|
|
US20110023147A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of prion disorder-related genes in animals
|
|
US20110016539A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of neurotransmission-related genes in animals
|
|
US20110023149A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in tumor suppression in animals
|
|
US20110023144A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in amyotrophyic lateral sclerosis disease
|
|
US20110023143A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of neurodevelopmental genes in animals
|
|
US20110016541A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of sensory-related genes in animals
|
|
US20110023148A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of addiction-related genes in animals
|
|
US20110023152A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of cognition related genes in animals
|
|
AU2009333863B2
(en)
*
|
2008-12-17 |
2015-02-05 |
Corteva Agriscience Llc |
Targeted integration into the Zp15 locus
|
|
WO2010090744A1
(en)
|
2009-02-04 |
2010-08-12 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating neuropathies
|
|
CA2755192C
(en)
*
|
2009-03-20 |
2018-09-11 |
Sangamo Biosciences, Inc. |
Modification of cxcr4 using engineered zinc finger proteins
|
|
AU2010235161B2
(en)
*
|
2009-04-09 |
2015-01-22 |
Sangamo Therapeutics, Inc. |
Targeted integration into stem cells
|
|
US8772008B2
(en)
*
|
2009-05-18 |
2014-07-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for increasing nuclease activity
|
|
EP2449135B1
(de)
|
2009-06-30 |
2016-01-06 |
Sangamo BioSciences, Inc. |
Schnelles screening biologisch aktiver nukleasen und isolation nukleasemodifizierter zellen
|
|
CA2769262C
(en)
*
|
2009-07-28 |
2019-04-30 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating trinucleotide repeat disorders
|
|
NZ598457A
(en)
*
|
2009-08-03 |
2014-06-27 |
Recombinetics Inc |
Methods and compositions for targeted gene modification
|
|
CN102612565B
(zh)
|
2009-08-11 |
2016-04-06 |
桑格摩生物科学股份有限公司 |
靶向修饰的纯合生物体
|
|
US9476060B2
(en)
|
2009-10-21 |
2016-10-25 |
Danziger Innovations Ltd. |
Generating genotypic variations in plant genomes by gamete infection
|
|
CN102782140B
(zh)
|
2009-10-22 |
2016-04-13 |
陶氏农业科学有限公司 |
靶向参与脂肪酸生物合成的植物基因的工程改造锌指蛋白
|
|
US8956828B2
(en)
|
2009-11-10 |
2015-02-17 |
Sangamo Biosciences, Inc. |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
|
|
CN102725412B
(zh)
|
2009-11-27 |
2017-09-22 |
巴斯夫植物科学有限公司 |
优化的内切核酸酶及其用途
|
|
CA2787494C
(en)
|
2010-01-22 |
2019-09-17 |
Dow Agrosciences Llc |
Targeted genomic alteration
|
|
JP6137596B2
(ja)
|
2010-02-08 |
2017-05-31 |
サンガモ セラピューティクス, インコーポレイテッド |
遺伝子操作された切断ハーフドメイン
|
|
US9255259B2
(en)
|
2010-02-09 |
2016-02-09 |
Sangamo Biosciences, Inc. |
Targeted genomic modification with partially single-stranded donor molecules
|
|
US9567573B2
(en)
|
2010-04-26 |
2017-02-14 |
Sangamo Biosciences, Inc. |
Genome editing of a Rosa locus using nucleases
|
|
EP2566972B1
(de)
|
2010-05-03 |
2020-01-15 |
Sangamo Therapeutics, Inc. |
Zusammensetzungen zur verknüpfung von zinkfingermodulen
|
|
CA2805442C
(en)
|
2010-07-21 |
2020-05-12 |
Sangamo Biosciences, Inc. |
Methods and compositions for modification of an hla locus
|
|
EP3511420B1
(de)
|
2010-09-27 |
2021-04-07 |
Sangamo Therapeutics, Inc. |
Zusammensetzungen zur hemmung des eindringens von viren in zellen
|
|
EP2627665B1
(de)
|
2010-10-12 |
2015-12-16 |
The Children's Hospital Of Philadelphia |
Verfahren und Zusammensetzungen zur Behandlung von Hämophilie B
|
|
WO2012094132A1
(en)
|
2011-01-05 |
2012-07-12 |
Sangamo Biosciences, Inc. |
Methods and compositions for gene correction
|
|
MX2013010197A
(es)
|
2011-03-18 |
2013-09-26 |
Basf Plant Science Co Gmbh |
Promotores para regular la expresion en plantas.
|
|
US20140186340A1
(en)
|
2011-04-08 |
2014-07-03 |
Gilead Biologics, Inc. |
Methods and Compositions for Normalization of Tumor Vasculature by Inhibition of LOXL2
|
|
CA2841541C
(en)
|
2011-07-25 |
2019-11-12 |
Sangamo Biosciences, Inc. |
Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (cftr) gene
|
|
EP2758529B1
(de)
|
2011-09-21 |
2019-03-20 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zur regulierung der transgenexpression
|
|
US8951752B2
(en)
|
2011-10-20 |
2015-02-10 |
University Of Iowa Research Foundation |
N-demethyase genes and uses thereof
|
|
US9222105B2
(en)
|
2011-10-27 |
2015-12-29 |
Sangamo Biosciences, Inc. |
Methods and compositions for modification of the HPRT locus
|
|
JP6023218B2
(ja)
|
2012-01-27 |
2016-11-09 |
サンバイオ,インコーポレイティド |
血管新生及び血管発生を調節するための方法及び組成物
|
|
CA2865011C
(en)
|
2012-02-29 |
2021-06-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating huntington's disease
|
|
DK2839013T3
(da)
|
2012-04-18 |
2020-09-14 |
Univ Leland Stanford Junior |
Ikke-disruptiv-gen-targetering
|
|
EP2841572B1
(de)
|
2012-04-27 |
2019-06-19 |
Duke University |
Genetische korrektur mutierter gene
|
|
AU2013256240B2
(en)
|
2012-05-02 |
2018-09-20 |
Corteva Agriscience Llc |
Targeted modification of malate dehydrogenase
|
|
CA2871524C
(en)
|
2012-05-07 |
2021-07-27 |
Sangamo Biosciences, Inc. |
Methods and compositions for nuclease-mediated targeted integration of transgenes
|
|
US11120889B2
(en)
|
2012-05-09 |
2021-09-14 |
Georgia Tech Research Corporation |
Method for synthesizing a nuclease with reduced off-site cleavage
|
|
US20150184166A1
(en)
|
2012-06-15 |
2015-07-02 |
Uinversity of Iowa Research Foundation |
Caffeine responsive promoters and regulatory genes
|
|
HUE051612T2
(hu)
|
2012-07-11 |
2021-03-01 |
Sangamo Therapeutics Inc |
Eljárások és készítmények lizoszomális tárolási betegségek kezelésére
|
|
WO2014011901A2
(en)
|
2012-07-11 |
2014-01-16 |
Sangamo Biosciences, Inc. |
Methods and compositions for delivery of biologics
|
|
US10648001B2
(en)
|
2012-07-11 |
2020-05-12 |
Sangamo Therapeutics, Inc. |
Method of treating mucopolysaccharidosis type I or II
|
|
EP2890780B8
(de)
|
2012-08-29 |
2020-08-19 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zur behandlung eines genetischen leidens
|
|
EP4148134A1
(de)
|
2012-09-04 |
2023-03-15 |
The Scripps Research Institute |
Chimäre polypeptide mit gerichteter bindungsspezifität
|
|
BR112015004995B1
(pt)
|
2012-09-07 |
2023-05-02 |
Sangamo Biosciences, Inc. |
Método para modificação do genoma de uma célula, uso de uma célula, semente ou planta obtida pelo referido método e nuclease de dedo de zinco sítio específica
|
|
UA119135C2
(uk)
|
2012-09-07 |
2019-05-10 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб отримання трансгенної рослини
|
|
UA118090C2
(uk)
|
2012-09-07 |
2018-11-26 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
|
|
WO2014059173A2
(en)
|
2012-10-10 |
2014-04-17 |
Sangamo Biosciences, Inc. |
T cell modifying compounds and uses thereof
|
|
CA2892448A1
(en)
|
2012-12-05 |
2014-06-12 |
Sangamo Biosciences, Inc. |
Methods and compositions for regulation of metabolic disorders
|
|
CA2895117A1
(en)
|
2012-12-13 |
2014-06-19 |
James W. Bing |
Precision gene targeting to a particular locus in maize
|
|
US10227610B2
(en)
|
2013-02-25 |
2019-03-12 |
Sangamo Therapeutics, Inc. |
Methods and compositions for enhancing nuclease-mediated gene disruption
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
AU2014235968B2
(en)
|
2013-03-21 |
2018-05-24 |
Ospedale San Raffaele Srl |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
|
|
CN105263312A
(zh)
|
2013-04-05 |
2016-01-20 |
美国陶氏益农公司 |
用于在植物基因组内整合外源序列的方法和组合物
|
|
US10604771B2
(en)
|
2013-05-10 |
2020-03-31 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
WO2014186435A2
(en)
|
2013-05-14 |
2014-11-20 |
University Of Georgia Research Foundation, Inc. |
Compositions and methods for reducing neointima formation
|
|
EP2997146A4
(de)
|
2013-05-15 |
2017-04-26 |
Sangamo BioSciences, Inc. |
Verfahren und zusammensetzungen zur behandlung eines genetischen leidens
|
|
CA2920899C
(en)
|
2013-08-28 |
2023-02-28 |
Sangamo Biosciences, Inc. |
Compositions for linking dna-binding domains and cleavage domains
|
|
US10117899B2
(en)
|
2013-10-17 |
2018-11-06 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
|
|
EP3058072B1
(de)
|
2013-10-17 |
2021-05-19 |
Sangamo Therapeutics, Inc. |
Freisetzungsverfahren und zusammensetzungen für nukleasevermitteltes genomengineering
|
|
EP3066110B1
(de)
|
2013-11-04 |
2021-12-29 |
Corteva Agriscience LLC |
Optimale maispflanzen
|
|
JP6633532B2
(ja)
|
2013-11-04 |
2020-01-22 |
ダウ アグロサイエンシィズ エルエルシー |
最適なトウモロコシ遺伝子座
|
|
CN105980395A
(zh)
|
2013-11-04 |
2016-09-28 |
美国陶氏益农公司 |
最优大豆座位
|
|
WO2015066643A1
(en)
|
2013-11-04 |
2015-05-07 |
Dow Agrosciences Llc |
Optimal soybean loci
|
|
MX391904B
(es)
|
2013-11-11 |
2025-03-12 |
Sangamo Biosciences Inc |
Un represor genetico para usarse en el tratamiento de la enfermedad de huntington.
|
|
ES2721936T3
(es)
|
2013-11-13 |
2019-08-06 |
Childrens Medical Center |
Regulación de la expresión genética mediada por las nucleasas
|
|
US9932607B2
(en)
|
2013-11-15 |
2018-04-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Site-specific integration of transgenes into human cells
|
|
CA3229275A1
(en)
|
2013-12-09 |
2015-06-18 |
Sangamo Biosciences, Inc. |
Methods and compositions for genome engineering
|
|
US10774338B2
(en)
|
2014-01-16 |
2020-09-15 |
The Regents Of The University Of California |
Generation of heritable chimeric plant traits
|
|
PT3102673T
(pt)
|
2014-02-03 |
2020-05-21 |
Sangamo Biosciences Inc |
Métodos e composições para tratamento de beta-talassemia
|
|
EP3110454B1
(de)
|
2014-02-24 |
2020-11-18 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zur nukleasevermittelten gezielten integration
|
|
TW201538518A
(zh)
|
2014-02-28 |
2015-10-16 |
Dow Agrosciences Llc |
藉由嵌合基因調控元件所賦予之根部特異性表現
|
|
EP3929279A1
(de)
|
2014-03-18 |
2021-12-29 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zur regulierung der zinkfingerproteinexpression
|
|
US10612041B2
(en)
|
2014-03-21 |
2020-04-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Genome editing without nucleases
|
|
WO2015153889A2
(en)
|
2014-04-02 |
2015-10-08 |
University Of Florida Research Foundation, Incorporated |
Materials and methods for the treatment of latent viral infection
|
|
US9522936B2
(en)
|
2014-04-24 |
2016-12-20 |
Sangamo Biosciences, Inc. |
Engineered transcription activator like effector (TALE) proteins
|
|
BR112016025849A2
(pt)
|
2014-05-08 |
2017-10-17 |
Chdi Foundation Inc |
métodos e composições para o tratamento da doença de huntington
|
|
US11918695B2
(en)
|
2014-05-09 |
2024-03-05 |
Yale University |
Topical formulation of hyperbranched polymer-coated particles
|
|
EP3721875B1
(de)
|
2014-05-09 |
2023-11-08 |
Yale University |
Mit hyperverzweigtem polyglycerol beschichtete partikel und verfahren zu deren herstellung
|
|
WO2015175642A2
(en)
|
2014-05-13 |
2015-11-19 |
Sangamo Biosciences, Inc. |
Methods and compositions for prevention or treatment of a disease
|
|
US9970001B2
(en)
|
2014-06-05 |
2018-05-15 |
Sangamo Therapeutics, Inc. |
Methods and compositions for nuclease design
|
|
US20170159065A1
(en)
|
2014-07-08 |
2017-06-08 |
Vib Vzw |
Means and methods to increase plant yield
|
|
EP3169778B1
(de)
|
2014-07-14 |
2023-10-25 |
Washington State University |
Nanos-knock-out zur abladierung von keimbahnzellen
|
|
US10738278B2
(en)
|
2014-07-15 |
2020-08-11 |
Juno Therapeutics, Inc. |
Engineered cells for adoptive cell therapy
|
|
US11278572B2
(en)
|
2014-07-18 |
2022-03-22 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Reducing CXCR4 expression and/or function to enhance engraftment of hematopoietic stem cells
|
|
WO2016014837A1
(en)
|
2014-07-25 |
2016-01-28 |
Sangamo Biosciences, Inc. |
Gene editing for hiv gene therapy
|
|
WO2016014794A1
(en)
|
2014-07-25 |
2016-01-28 |
Sangamo Biosciences, Inc. |
Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
|
|
US9616090B2
(en)
|
2014-07-30 |
2017-04-11 |
Sangamo Biosciences, Inc. |
Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
|
|
CN113699113A
(zh)
|
2014-09-16 |
2021-11-26 |
桑格摩治疗股份有限公司 |
用于造血干细胞中核酸酶介导的基因组工程化和校正的方法和组合物
|
|
US10889834B2
(en)
|
2014-12-15 |
2021-01-12 |
Sangamo Therapeutics, Inc. |
Methods and compositions for enhancing targeted transgene integration
|
|
US20180002379A1
(en)
|
2015-01-21 |
2018-01-04 |
Sangamo Therapeutics, Inc. |
Methods and compositions for identification of highly specific nucleases
|
|
US10626372B1
(en)
|
2015-01-26 |
2020-04-21 |
Fate Therapeutics, Inc. |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
US10676726B2
(en)
|
2015-02-09 |
2020-06-09 |
Duke University |
Compositions and methods for epigenome editing
|
|
JP6964843B2
(ja)
*
|
2015-03-31 |
2021-11-10 |
国立研究開発法人農業・食品産業技術総合研究機構 |
バイナリー遺伝子発現システム
|
|
CA2981077A1
(en)
|
2015-04-03 |
2016-10-06 |
Dana-Farber Cancer Institute, Inc. |
Composition and methods of genome editing of b-cells
|
|
KR20170136573A
(ko)
|
2015-04-15 |
2017-12-11 |
다우 아그로사이언시즈 엘엘씨 |
트랜스젠 발현을 위한 식물 프로모터
|
|
BR112017021903B1
(pt)
|
2015-04-15 |
2023-12-05 |
Corteva Agriscience Llc |
Promotor de planta para expressão de transgene
|
|
EP3292219B9
(de)
|
2015-05-04 |
2022-05-18 |
Ramot at Tel-Aviv University Ltd. |
Verfahren und kits zur fragmentierung von dna
|
|
US10179918B2
(en)
|
2015-05-07 |
2019-01-15 |
Sangamo Therapeutics, Inc. |
Methods and compositions for increasing transgene activity
|
|
SG10202112057QA
(en)
|
2015-05-12 |
2021-12-30 |
Sangamo Therapeutics Inc |
Nuclease-mediated regulation of gene expression
|
|
MX2017015239A
(es)
|
2015-05-29 |
2018-02-19 |
Juno Therapeutics Inc |
Composicion y metodos para regular interacciones inhibitorias en celulas geneticamente modificadas.
|
|
US9957501B2
(en)
|
2015-06-18 |
2018-05-01 |
Sangamo Therapeutics, Inc. |
Nuclease-mediated regulation of gene expression
|
|
CA2991301A1
(en)
|
2015-07-13 |
2017-01-19 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
|
MA42895A
(fr)
|
2015-07-15 |
2018-05-23 |
Juno Therapeutics Inc |
Cellules modifiées pour thérapie cellulaire adoptive
|
|
HRP20240908T1
(hr)
|
2015-08-06 |
2024-10-25 |
The Curators Of The University Of Missouri |
Svinja i stanice otporne na virus reproduktivnog i respiratornog sindroma svinja (prrsv) koje imaju modificirane cd163 gene
|
|
TW201718861A
(zh)
|
2015-09-22 |
2017-06-01 |
道禮責任有限公司 |
用於轉殖基因表現之植物啟動子及3’utr
|
|
TW201718862A
(zh)
|
2015-09-22 |
2017-06-01 |
Dow Agrosciences Llc |
用於轉殖基因表現之植物啟動子及3’utr
|
|
DK3352776T3
(da)
|
2015-09-23 |
2025-06-23 |
Sangamo Therapeutics Inc |
Htt-repressorer og deres anvendelse
|
|
WO2017066497A2
(en)
|
2015-10-13 |
2017-04-20 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
|
EP3365451B1
(de)
|
2015-10-22 |
2020-06-24 |
Dow Agrosciences LLC |
Pflanzenpromoter zur transgenen expression
|
|
US20170121726A1
(en)
|
2015-11-04 |
2017-05-04 |
Dow Agrosciences Llc |
Plant promoter for transgene expression
|
|
CN122146606A
(zh)
|
2015-11-04 |
2026-06-05 |
菲特治疗公司 |
用于诱导造血细胞分化的方法和组合物
|
|
US12642852B1
(en)
|
2015-11-04 |
2026-06-02 |
Fate Therapeutics, Inc. |
Genomic engineering of pluripotent cells
|
|
EP3380622A4
(de)
|
2015-11-23 |
2019-08-07 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zum immunitäts-engineering
|
|
US12214054B2
(en)
|
2015-11-30 |
2025-02-04 |
Duke University |
Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use
|
|
US11352631B2
(en)
|
2015-12-18 |
2022-06-07 |
Sangamo Therapeutics, Inc. |
Targeted disruption of the T cell receptor
|
|
AU2016374253B2
(en)
|
2015-12-18 |
2021-10-21 |
Sangamo Therapeutics, Inc. |
Targeted disruption of the MHC cell receptor
|
|
EP3402533B1
(de)
|
2016-01-15 |
2021-08-04 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zur behandlung von neurologischer erkrankung
|
|
JP7012650B2
(ja)
|
2016-02-02 |
2022-01-28 |
サンガモ セラピューティクス, インコーポレイテッド |
Dna結合ドメインと切断ドメインとを連結するための組成物
|
|
JP2019508037A
(ja)
|
2016-02-16 |
2019-03-28 |
イェール ユニバーシティーYale Universit |
標的化遺伝子編集を増強するための組成物およびその使用方法
|
|
AU2017221424A1
(en)
|
2016-02-16 |
2018-09-20 |
Yale University |
Compositions and methods for treatment of cystic fibrosis
|
|
US11421218B2
(en)
|
2016-03-23 |
2022-08-23 |
Dana-Farber Cancer Institute, Inc. |
Methods for enhancing the efficiency of gene editing
|
|
WO2017173453A1
(en)
|
2016-04-01 |
2017-10-05 |
The Brigham And Women's Hospital, Inc. |
Stimuli-responsive nanoparticles for biomedical applications
|
|
EP3443081A4
(de)
|
2016-04-13 |
2019-10-30 |
Duke University |
Crispr/cas9-basierte repressoren zur in-vivo-ausschaltung von gen-targets und verfahren zur verwendung
|
|
US11410746B2
(en)
|
2016-04-27 |
2022-08-09 |
Massachusetts Institute Of Technology |
Stable nanoscale nucleic acid assemblies and methods thereof
|
|
US11514331B2
(en)
|
2016-04-27 |
2022-11-29 |
Massachusetts Institute Of Technology |
Sequence-controlled polymer random access memory storage
|
|
US20200182884A1
(en)
|
2016-06-27 |
2020-06-11 |
Juno Therapeutics, Inc. |
Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
|
|
JP7054397B2
(ja)
|
2016-06-27 |
2022-04-13 |
ジュノー セラピューティクス インコーポレイテッド |
Mhc-e拘束性エピトープ、結合分子ならびに関連する方法および使用
|
|
WO2018013840A1
(en)
|
2016-07-13 |
2018-01-18 |
Vertex Pharmaceuticals Incorporated |
Methods, compositions and kits for increasing genome editing efficiency
|
|
JP7490211B2
(ja)
|
2016-07-19 |
2024-05-27 |
デューク ユニバーシティ |
Cpf1に基づくゲノム編集の治療適用
|
|
JP7325104B2
(ja)
|
2016-07-27 |
2023-08-14 |
ケース ウェスタン リザーブ ユニバーシティ |
ミエリン形成を促進する化合物および方法
|
|
WO2018029034A1
(en)
|
2016-08-09 |
2018-02-15 |
Vib Vzw |
Cellulose synthase inhibitors and mutant plants
|
|
IL264792B2
(en)
|
2016-08-24 |
2023-10-01 |
Sangamo Therapeutics Inc |
Engineered target-specific zinc-finger nucleases
|
|
WO2018039440A1
(en)
|
2016-08-24 |
2018-03-01 |
Sangamo Therapeutics, Inc. |
Regulation of gene expression using engineered nucleases
|
|
JP7256739B2
(ja)
|
2016-09-07 |
2023-04-12 |
サンガモ セラピューティクス, インコーポレイテッド |
肝臓遺伝子のモジュレーション
|
|
KR20190062505A
(ko)
|
2016-10-03 |
2019-06-05 |
주노 쎄러퓨티크스 인코퍼레이티드 |
Hpv-특이적 결합 분자
|
|
WO2018067265A1
(en)
|
2016-10-03 |
2018-04-12 |
Dow Agrosciences Llc |
Plant promoter for transgene expression
|
|
CN110291199B
(zh)
|
2016-10-03 |
2023-12-22 |
美国陶氏益农公司 |
用于转基因表达的植物启动子
|
|
CA3038690A1
(en)
|
2016-10-05 |
2018-04-12 |
FUJIFILM Cellular Dynamics, Inc. |
Generating mature lineages from induced pluripotent stem cells with mecp2 disruption
|
|
EP3525803B1
(de)
|
2016-10-13 |
2022-12-07 |
Juno Therapeutics, Inc. |
Immuntherapieverfahren und zusammensetzungen mit tryptophan-stoffwechselweg-modulatoren
|
|
KR102712926B1
(ko)
|
2016-10-20 |
2024-10-07 |
상가모 테라퓨틱스, 인코포레이티드 |
파브리병의 치료를 위한 방법 및 조성물
|
|
US11766400B2
(en)
|
2016-10-24 |
2023-09-26 |
Yale University |
Biodegradable contraceptive implants
|
|
WO2018081775A1
(en)
|
2016-10-31 |
2018-05-03 |
Sangamo Therapeutics, Inc. |
Gene correction of scid-related genes in hematopoietic stem and progenitor cells
|
|
CN110214184B
(zh)
|
2016-12-01 |
2024-07-02 |
桑格摩生物治疗股份有限公司 |
τ蛋白调节剂以及用于其递送的方法和组合物
|
|
WO2018102612A1
(en)
|
2016-12-02 |
2018-06-07 |
Juno Therapeutics, Inc. |
Engineered b cells and related compositions and methods
|
|
WO2018106732A1
(en)
|
2016-12-05 |
2018-06-14 |
Juno Therapeutics, Inc. |
Production of engineered cells for adoptive cell therapy
|
|
EP4276187A3
(de)
|
2016-12-08 |
2024-01-17 |
Case Western Reserve University |
Verfahren und zusammensetzungen zur erhöhung der herstellung von funktionalem myelin
|
|
WO2018112470A1
(en)
|
2016-12-16 |
2018-06-21 |
The Brigham And Women's Hospital, Inc. |
Co-delivery of nucleic acids for simultaneous suppression and expression of target genes
|
|
AU2018224387B2
(en)
|
2017-02-22 |
2024-08-08 |
Crispr Therapeutics Ag |
Compositions and methods for gene editing
|
|
CN117821509A
(zh)
|
2017-04-03 |
2024-04-05 |
编码治疗公司 |
组织选择性转基因表达
|
|
WO2018187493A1
(en)
|
2017-04-04 |
2018-10-11 |
Yale University |
Compositions and methods for in utero delivery
|
|
MX2019010286A
(es)
|
2017-04-20 |
2019-10-21 |
Univ Oregon Health & Science |
Correccion de genes humanos.
|
|
US11820728B2
(en)
|
2017-04-28 |
2023-11-21 |
Acuitas Therapeutics, Inc. |
Carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
|
|
JP2020518245A
(ja)
|
2017-05-03 |
2020-06-25 |
サンガモ セラピューティクス, インコーポレイテッド |
嚢胞性線維症膜貫通コンダクタンス制御因子(cftr)遺伝子の改変のための方法および組成物
|
|
ES2875579T3
(es)
|
2017-06-06 |
2021-11-10 |
Zymergen Inc |
Plataforma de ingeniería genómica de HTP para mejorar Escherichia coli
|
|
US11512287B2
(en)
|
2017-06-16 |
2022-11-29 |
Sangamo Therapeutics, Inc. |
Targeted disruption of T cell and/or HLA receptors
|
|
CN111278276B
(zh)
|
2017-06-28 |
2023-05-26 |
美国陶氏益农公司 |
用于转基因表达的植物启动子
|
|
JP2020530997A
(ja)
|
2017-08-08 |
2020-11-05 |
サンガモ セラピューティクス, インコーポレイテッド |
キメラ抗原受容体媒介性細胞標的化
|
|
US11952408B2
(en)
|
2017-10-03 |
2024-04-09 |
Juno Therapeutics, Inc. |
HPV-specific binding molecules
|
|
WO2019089402A1
(en)
|
2017-10-30 |
2019-05-09 |
Dow Agrosciences Llc |
Plant promoter for transgene expression
|
|
US11851679B2
(en)
|
2017-11-01 |
2023-12-26 |
Juno Therapeutics, Inc. |
Method of assessing activity of recombinant antigen receptors
|
|
WO2019094725A2
(en)
|
2017-11-09 |
2019-05-16 |
Sangamo Therapeutics, Inc. |
Genetic modification of cytokine inducible sh2-containing protein (cish) gene
|
|
WO2019094928A1
(en)
|
2017-11-10 |
2019-05-16 |
Massachusetts Institute Of Technology |
Microbial production of pure single stranded nucleic acids
|
|
US10953036B2
(en)
|
2017-11-20 |
2021-03-23 |
University Of Georgia Research Foundation, Inc. |
Compositions and methods of modulating HIF-2A to improve muscle generation and repair
|
|
CN118345115A
(zh)
|
2017-12-01 |
2024-07-16 |
编码治疗公司 |
工程化的dna结合蛋白
|
|
WO2019125851A1
(en)
|
2017-12-18 |
2019-06-27 |
Syngenta Participations Ag |
Targeted insertion sites in the maize genome
|
|
BR112020011017A2
(pt)
|
2017-12-22 |
2020-11-17 |
Fate Therapeutics, Inc. |
células efetoras imunes intensificadas e uso das mesmas
|
|
US12269804B2
(en)
|
2018-01-17 |
2025-04-08 |
Vertex Pharmaceuticals Incorporated |
Quinoxalinone compounds, compositions, methods, and kits for increasing genome editing efficiency
|
|
WO2019143678A1
(en)
|
2018-01-17 |
2019-07-25 |
Vertex Pharmaceuticals Incorporated |
Dna-pk inhibitors
|
|
BR112020014140A2
(pt)
|
2018-01-17 |
2020-12-01 |
Vertex Pharmaceuticals Incorporated |
inibidores de dna-pk
|
|
US12509492B2
(en)
|
2018-01-19 |
2025-12-30 |
Duke University |
Genome engineering with CRISPR-Cas systems in eukaryotes
|
|
BR112020015488A2
(pt)
|
2018-02-08 |
2020-12-08 |
Sangamo Therapeutics, Inc. |
Nucleases alvo-específicas modificadas
|
|
AU2019243315A1
(en)
|
2018-03-29 |
2020-09-24 |
Fate Therapeutics, Inc. |
Engineered immune effector cells and use thereof
|
|
CN112585276A
(zh)
|
2018-04-05 |
2021-03-30 |
朱诺治疗学股份有限公司 |
产生表达重组受体的细胞的方法和相关组合物
|
|
CN112566698A
(zh)
|
2018-04-05 |
2021-03-26 |
朱诺治疗学股份有限公司 |
T细胞受体和表达该t细胞受体的工程化细胞
|
|
CN112585277A
(zh)
|
2018-04-05 |
2021-03-30 |
朱诺治疗学股份有限公司 |
表达重组受体的t细胞、相关多核苷酸和方法
|
|
JP7332622B2
(ja)
|
2018-04-18 |
2023-08-23 |
サンガモ セラピューティクス, インコーポレイテッド |
ハンチンチン(htt)の調節のためのジンクフィンガータンパク質組成物
|
|
US20200063100A1
(en)
|
2018-05-11 |
2020-02-27 |
Crispr Therapeutics Ag |
Methods and compositions for treating cancer
|
|
US11690921B2
(en)
|
2018-05-18 |
2023-07-04 |
Sangamo Therapeutics, Inc. |
Delivery of target specific nucleases
|
|
GB201809273D0
(en)
|
2018-06-06 |
2018-07-25 |
Vib Vzw |
Novel mutant plant cinnamoyl-coa reductase proteins
|
|
EP3802839A1
(de)
|
2018-06-07 |
2021-04-14 |
The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) |
Nukleinsäurekonstrukte und verfahren zu deren verwendung
|
|
EP3800998A1
(de)
|
2018-06-07 |
2021-04-14 |
The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) |
Verfahren zur regenerierung und transformation von cannabis
|
|
US11939593B2
(en)
|
2018-08-01 |
2024-03-26 |
University Of Georgia Research Foundation, Inc. |
Compositions and methods for improving embryo development
|
|
JP7541508B2
(ja)
|
2018-08-23 |
2024-08-28 |
サンガモ セラピューティクス, インコーポレイテッド |
操作された標的特異的な塩基エディター
|
|
EP3844287B1
(de)
|
2018-08-31 |
2024-05-22 |
Yale University |
Zusammensetzungen und verfahren zur verbesserung der oligonukleotidbasierten geneditierung
|
|
BR112021003823A2
(pt)
|
2018-08-31 |
2021-05-25 |
Yale University |
composição, composição farmacêutica e método para modificar o genoma de uma célula
|
|
EP4234570A3
(de)
|
2018-09-18 |
2023-12-13 |
Sangamo Therapeutics, Inc. |
Für programmierten zelltod 1 (pd1) spezifische nukleasen
|
|
EP3852911B1
(de)
|
2018-09-21 |
2025-01-22 |
Acuitas Therapeutics, Inc. |
Systeme und verfahren zur herstellung von lipidnanopartikeln und liposomen
|
|
IL326834A
(en)
|
2018-10-02 |
2026-04-01 |
Sangamo Therapeutics Inc |
Artificial zinc finger protein transcription factors repressing mapt expression for the prevention and/or treatment of tauopathies
|
|
CA3116576A1
(en)
|
2018-10-18 |
2020-04-23 |
Acuitas Therapeutics, Inc. |
Lipids for lipid nanoparticle delivery of active agents
|
|
EA202191257A1
(ru)
|
2018-11-07 |
2021-12-06 |
Криспр Терапьютикс Аг |
Противораковая терапия на основе иммуноцитов, связывающих liv1
|
|
SG11202103832SA
(en)
|
2018-11-07 |
2021-05-28 |
Crispr Therapeutics Ag |
Anti-cd33 immune cell cancer therapy
|
|
US12146157B2
(en)
|
2018-11-07 |
2024-11-19 |
Crispr Therapeutics Ag |
Anti-PTK7 immune cell cancer therapy
|
|
WO2020112195A1
(en)
|
2018-11-30 |
2020-06-04 |
Yale University |
Compositions, technologies and methods of using plerixafor to enhance gene editing
|
|
JP2022510207A
(ja)
|
2018-12-02 |
2022-01-26 |
フェイト セラピューティクス,インコーポレイテッド |
増強されたiPSC派生エフェクター細胞を使用した免疫療法
|
|
CA3121781A1
(en)
|
2018-12-05 |
2020-06-11 |
Vertex Pharmaceuticals Incorporated |
Gene-editing systems for editing a cystic fibrosis transmembrane regulator (cftr) gene
|
|
GB201820109D0
(en)
|
2018-12-11 |
2019-01-23 |
Vib Vzw |
Plants with a lignin trait and udp-glycosyltransferase mutation
|
|
CN113423419A
(zh)
|
2019-01-04 |
2021-09-21 |
桑格摩生物治疗股份有限公司 |
用于治疗法布里病的方法和组合物
|
|
PL3908568T3
(pl)
|
2019-01-11 |
2024-12-02 |
Acuitas Therapeutics, Inc. |
Lipidy do dostarczania środków czynnych w nanocząstkach lipidowych
|
|
US12156877B1
(en)
|
2019-01-15 |
2024-12-03 |
The Regents Of The University Of California |
Methods of treating conditions related to a thiamine deficiency, a thiamine-dependent enzyme, or an associated cofactor
|
|
US12642850B2
(en)
|
2019-01-24 |
2026-06-02 |
Massachusetts Institute Of Technology |
Nucleic acid nanostructure platform for programming immune stimulation
|
|
WO2020154595A1
(en)
|
2019-01-24 |
2020-07-30 |
Massachusetts Institute Of Technology |
Nucleic acid nanostructure platform for antigen presentation and vaccine formulations formed therefrom
|
|
CA3106693A1
(en)
|
2019-02-06 |
2020-08-13 |
Sangamo Therapeutics, Inc. |
Method for the treatment of mucopolysaccharidosis type i
|
|
BR112021017770A2
(pt)
|
2019-03-08 |
2021-11-16 |
Obsidian Therapeutics Inc |
Composições e métodos de cd40l para regulação ajustável
|
|
WO2020205838A1
(en)
|
2019-04-02 |
2020-10-08 |
Sangamo Therapeutics, Inc. |
Methods for the treatment of beta-thalassemia
|
|
TWI887234B
(zh)
|
2019-04-14 |
2025-06-21 |
美國公爵大學 |
治療杜興氏(duchenne)肌肉失養症之大型突變熱點之aav載體介導之刪除
|
|
JP7618581B2
(ja)
|
2019-04-23 |
2025-01-21 |
サンガモ セラピューティクス, インコーポレイテッド |
9番染色体オープンリーディングフレーム72遺伝子発現のモジュレーターおよびその使用
|
|
SG11202111372VA
(en)
|
2019-05-01 |
2021-11-29 |
Juno Therapeutics Inc |
Cells expressing a chimeric receptor from a modified cd247 locus, related polynucleotides and methods
|
|
CA3136737A1
(en)
|
2019-05-01 |
2020-11-05 |
Juno Therapeutics, Inc. |
Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods
|
|
SG11202113048SA
(en)
|
2019-05-29 |
2021-12-30 |
Encoded Therapeutics Inc |
Compositions and methods for selective gene regulation
|
|
US11905532B2
(en)
|
2019-06-25 |
2024-02-20 |
Massachusetts Institute Of Technology |
Compositions and methods for molecular memory storage and retrieval
|
|
AU2020307667A1
(en)
|
2019-06-27 |
2022-01-20 |
Crispr Therapeutics Ag |
Use of chimeric antigen receptor T cells and NK cell inhibitors for treating cancer
|
|
KR20220035190A
(ko)
|
2019-07-17 |
2022-03-21 |
페이트 세러퓨틱스, 인코포레이티드 |
면역 효과기 세포 조작 및 이의 용도
|
|
CA3144413A1
(en)
|
2019-07-17 |
2021-01-21 |
Rafick-Pierre Sekaly |
Long lived t cells for treating hiv infection
|
|
EP4007596A1
(de)
|
2019-08-01 |
2022-06-08 |
Sana Biotechnology, Inc. |
Dux4+-exprimierende zellen und ihre verwendungen
|
|
JP7728747B2
(ja)
|
2019-08-23 |
2025-08-25 |
サナ バイオテクノロジー,インコーポレイテッド |
Cd24発現細胞およびそれらの用途
|
|
KR20220101073A
(ko)
|
2019-08-30 |
2022-07-19 |
예일 유니버시티 |
핵산을 세포로 전달하기 위한 조성물 및 방법
|
|
PH12022550548A1
(en)
|
2019-09-06 |
2023-11-20 |
Crispr Therapeutics Ag |
Genetically engineered t cells having improved persistence in culture
|
|
US20230002459A1
(en)
|
2019-10-02 |
2023-01-05 |
Sangamo Therapeutics, Inc. |
Zinc Finger Protein Transcription Factors for Treatment of Prion Disease
|
|
TW202132565A
(zh)
|
2019-11-01 |
2021-09-01 |
美商聖加莫治療股份有限公司 |
Gin重組酶變異體
|
|
WO2021087366A1
(en)
|
2019-11-01 |
2021-05-06 |
Sangamo Therapeutics, Inc. |
Compositions and methods for genome engineering
|
|
AU2021205416B2
(en)
|
2020-01-08 |
2026-08-06 |
Obsidian Therapeutics, Inc. |
Compositions and methods for tunable regulation of transcription
|
|
CA3166153A1
(en)
|
2020-01-28 |
2021-08-05 |
The Broad Institute, Inc. |
Base editors, compositions, and methods for modifying the mitochondrial genome
|
|
EP4125961A1
(de)
|
2020-03-25 |
2023-02-08 |
Sana Biotechnology, Inc. |
Hypoimmunogene nervenzellen zur behandlung von neurologischen erkrankungen und zuständen
|
|
WO2021224395A1
(en)
|
2020-05-06 |
2021-11-11 |
Cellectis S.A. |
Methods for targeted insertion of exogenous sequences in cellular genomes
|
|
JP7891314B2
(ja)
|
2020-05-06 |
2026-07-16 |
セレクティス ソシエテ アノニム |
治療用タンパク質の送達のために細胞を遺伝子改変する方法
|
|
KR20230022868A
(ko)
|
2020-05-13 |
2023-02-16 |
주노 쎄러퓨티크스 인코퍼레이티드 |
재조합 수용체를 발현하는 공여자-배치 세포의 제조 방법
|
|
US20230190871A1
(en)
|
2020-05-20 |
2023-06-22 |
Sana Biotechnology, Inc. |
Methods and compositions for treatment of viral infections
|
|
WO2021247836A1
(en)
|
2020-06-03 |
2021-12-09 |
Board Of Regents, The University Of Texas System |
Methods for targeting shp-2 to overcome resistance
|
|
AU2021286555B2
(en)
|
2020-06-09 |
2025-04-03 |
Cold Spring Harbor Laboratory |
Heterozygous CENH3 monocots and methods of use thereof for haploid induction and simultaneous genome editing
|
|
KR20230040337A
(ko)
|
2020-06-19 |
2023-03-22 |
페이트 세러퓨틱스, 인코포레이티드 |
면역요법 사용을 위한 iPSC-유래 이펙터 세포 유형들의 조합
|
|
EP4171616A1
(de)
|
2020-06-26 |
2023-05-03 |
Juno Therapeutics GmbH |
Manipulierte t-zellen zur bedingten expression eines rekombinanten rezeptors, zugehörige polynukleotide und verfahren
|
|
KR20230051172A
(ko)
|
2020-07-16 |
2023-04-17 |
아퀴타스 테라퓨틱스 인크. |
지질 나노 입자에 사용하기 위한 양이온성 지질
|
|
AU2021325941A1
(en)
|
2020-08-13 |
2023-03-09 |
Sana Biotechnology, Inc. |
Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions
|
|
EP4501951A3
(de)
|
2020-08-25 |
2025-04-30 |
Kite Pharma, Inc. |
T-zellen mit verbesserter funktionalität
|
|
WO2022047424A1
(en)
|
2020-08-31 |
2022-03-03 |
Yale University |
Compositions and methods for delivery of nucleic acids to cells
|
|
KR20230074515A
(ko)
|
2020-09-23 |
2023-05-30 |
크리스퍼 테라퓨틱스 아게 |
개선된 기능성 및 지속성을 갖는 붕괴된 레그나제-1 및/또는 tgfbrii를 지니는 유전자 조작된 t 세포
|
|
JP2023542705A
(ja)
|
2020-09-25 |
2023-10-11 |
サンガモ セラピューティクス, インコーポレイテッド |
核酸塩基編集のためのジンクフィンガー融合タンパク質
|
|
JP2023549780A
(ja)
|
2020-11-04 |
2023-11-29 |
ジュノー セラピューティクス インコーポレイテッド |
改変されたインバリアントcd3免疫グロブリンスーパーファミリー鎖遺伝子座からキメラ受容体を発現する細胞ならびに関連するポリヌクレオチドおよび方法
|
|
US20240000051A1
(en)
|
2020-11-16 |
2024-01-04 |
Pig Improvement Company Uk Limited |
Influenza a-resistant animals having edited anp32 genes
|
|
IL303269A
(en)
|
2020-12-03 |
2023-07-01 |
Century Therapeutics Inc |
Genetically engineered cells and uses thereof
|
|
US11661459B2
(en)
|
2020-12-03 |
2023-05-30 |
Century Therapeutics, Inc. |
Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
|
|
WO2022137181A1
(en)
|
2020-12-23 |
2022-06-30 |
Crispr Therapeutics Ag |
Co-use of lenalidomide with car-t cells
|
|
US11965022B2
(en)
|
2020-12-31 |
2024-04-23 |
Sana Biotechnology, Inc. |
Methods and compositions for modulating CAR-T activity
|
|
CN117321197A
(zh)
|
2021-01-12 |
2023-12-29 |
马奇疗法公司 |
背景依赖性、双链dna特异性脱氨酶及其用途
|
|
WO2022170117A1
(en)
*
|
2021-02-04 |
2022-08-11 |
New York University |
Seamless integration of engineered zinc fingers into endogenous transcription factors to commandeer their natural functions
|
|
EP4305153A1
(de)
|
2021-03-09 |
2024-01-17 |
CRISPR Therapeutics AG |
Genetisch veränderte t-zellen mit ptpn2-knockout mit verbesserter funktionalität und antitumoraktivität
|
|
WO2022204071A1
(en)
|
2021-03-22 |
2022-09-29 |
Juno Therapeutics, Inc. |
Method to assess potency of viral vector particles
|
|
AU2022252997A1
(en)
|
2021-04-07 |
2023-09-28 |
Century Therapeutics, Inc. |
Compositions and methods for generating gamma-delta t cells from induced pluripotent stem cells
|
|
CA3214473A1
(en)
|
2021-04-07 |
2022-10-13 |
Century Therapeutics, Inc. |
Compositions and methods for generating alpha-beta t cells from induced pluripotent stem cells
|
|
AU2022253223A1
(en)
|
2021-04-07 |
2023-09-28 |
Century Therapeutics, Inc. |
Combined artificial cell death/reporter system polypeptide for chimeric antigen receptor cell and uses thereof
|
|
KR20240006059A
(ko)
|
2021-05-05 |
2024-01-12 |
후지필름 셀룰러 다이내믹스, 인코포레이티드 |
Ipsc-유래된 미세아교세포에 대한 방법 및 조성물
|
|
WO2022251443A1
(en)
|
2021-05-26 |
2022-12-01 |
FUJIFILM Cellular Dynamics, Inc. |
Methods to prevent rapid silencing of genes in pluripotent stem cells
|
|
US20240226164A1
(en)
|
2021-05-27 |
2024-07-11 |
Sana Biotechnology, Inc. |
Hypoimmunogenic cells comprising engineered hla-e or hla-g
|
|
CN113429487B
(zh)
*
|
2021-06-21 |
2022-04-22 |
山东大学 |
一种能在水环境中去除抗生素耐药基因的人工合成蛋白
|
|
CA3225283A1
(en)
|
2021-07-14 |
2023-01-19 |
Sonja SCHREPFER |
Altered expression of y chromosome-linked antigens in hypoimmunogenic cells
|
|
AU2022318664A1
(en)
|
2021-07-30 |
2024-02-29 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2)
|
|
US20240254483A1
(en)
|
2021-07-30 |
2024-08-01 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of frataxin (fxn)
|
|
AU2022325231A1
(en)
|
2021-08-11 |
2024-02-08 |
Sana Biotechnology, Inc. |
Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions
|
|
US20260053851A1
(en)
|
2021-08-11 |
2026-02-26 |
Sana Biotechnology, Inc. |
Inducible systems for altering gene expression in hypoimmunogenic cells
|
|
CA3227108A1
(en)
|
2021-08-11 |
2023-02-16 |
Xiaomeng HU |
Genetically modified primary cells for allogeneic cell therapy
|
|
AU2022326565A1
(en)
|
2021-08-11 |
2024-02-08 |
Sana Biotechnology, Inc. |
Genetically modified cells for allogeneic cell therapy
|
|
AU2022325955A1
(en)
|
2021-08-11 |
2024-02-08 |
Sana Biotechnology, Inc. |
Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions
|
|
KR20240055838A
(ko)
|
2021-09-10 |
2024-04-29 |
후지필름 셀룰러 다이내믹스, 인코포레이티드 |
유도된 만능 줄기 세포 유래된 세포의 조성물 및 이의 사용 방법
|
|
US20230128917A1
(en)
|
2021-09-14 |
2023-04-27 |
Crispr Therapeutics Ag |
Genetically engineered immune cells having a disrupted cd83 gene
|
|
WO2023070043A1
(en)
|
2021-10-20 |
2023-04-27 |
Yale University |
Compositions and methods for targeted editing and evolution of repetitive genetic elements
|
|
JP2024540987A
(ja)
|
2021-10-21 |
2024-11-06 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
低免疫細胞
|
|
US20250313861A1
(en)
|
2021-10-22 |
2025-10-09 |
Sana Biotechnology, Inc. |
Methods of engineering allogeneic t cells with a transgene in a tcr locus and associated compositions and methods
|
|
US20240409934A1
(en)
|
2021-10-25 |
2024-12-12 |
Board Of Regents, The University Of Texas System |
Foxo1-targeted therapy for the treatment of cancer
|
|
AU2022376962A1
(en)
|
2021-10-29 |
2024-04-18 |
FUJIFILM Cellular Dynamics, Inc. |
Dopaminergic neurons comprising mutations and methods of use thereof
|
|
US20250043269A1
(en)
|
2021-11-03 |
2025-02-06 |
The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glad |
Precise Genome Editing Using Retrons
|
|
WO2023081900A1
(en)
|
2021-11-08 |
2023-05-11 |
Juno Therapeutics, Inc. |
Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
|
|
US20250064032A1
(en)
|
2021-12-10 |
2025-02-27 |
Pig Improvement Company Uk Limited |
Editing tmprss2/4 for disease resistance in livestock
|
|
WO2023111913A1
(en)
|
2021-12-15 |
2023-06-22 |
Crispr Therapeutics Ag |
Engineered anti-liv1 cell with regnase-1 and/or tgfbrii disruption
|
|
WO2023114943A2
(en)
|
2021-12-16 |
2023-06-22 |
Acuitas Therapeutics, Inc. |
Lipids for use in lipid nanoparticle formulations
|
|
US20230346836A1
(en)
|
2021-12-22 |
2023-11-02 |
Crispr Therapeutics Ag |
Genetically engineered t cells with disrupted casitas b-lineage lymphoma proto-oncogene-b (cblb) and uses thereof
|
|
EP4453202A1
(de)
|
2021-12-22 |
2024-10-30 |
Sangamo Therapeutics, Inc. |
Neue zinkfingerfusionsproteine zur nukleobaseneditierung
|
|
WO2023122337A1
(en)
|
2021-12-23 |
2023-06-29 |
Sana Biotechnology, Inc. |
Chimeric antigen receptor (car) t cells for treating autoimmune disease and associated methods
|
|
WO2023129937A1
(en)
|
2021-12-29 |
2023-07-06 |
Century Therapeutics, Inc. |
Genetically engineered cells having anti-cd19 / anti-cd22 chimeric antigen receptors, and uses thereof
|
|
WO2023131616A1
(en)
|
2022-01-05 |
2023-07-13 |
Vib Vzw |
Means and methods to increase abiotic stress tolerance in plants
|
|
WO2023131637A1
(en)
|
2022-01-06 |
2023-07-13 |
Vib Vzw |
Improved silage grasses
|
|
US20250134999A1
(en)
|
2022-01-14 |
2025-05-01 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation
|
|
EP4463549A2
(de)
|
2022-01-14 |
2024-11-20 |
Tune Therapeutics, Inc. |
Zusammensetzungen, systeme und verfahren zur programmierung von t-zell-phänotypen durch gezielte genunterdrückung
|
|
WO2023141602A2
(en)
|
2022-01-21 |
2023-07-27 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
WO2023144199A1
(en)
|
2022-01-26 |
2023-08-03 |
Vib Vzw |
Plants having reduced levels of bitter taste metabolites
|
|
EP4479084A1
(de)
|
2022-02-14 |
2024-12-25 |
Sana Biotechnology, Inc. |
Verfahren zur behandlung von patienten mit einer vorherigen fehlgeschlagenen therapie mit hypoimmunogenen zellen
|
|
WO2023158836A1
(en)
|
2022-02-17 |
2023-08-24 |
Sana Biotechnology, Inc. |
Engineered cd47 proteins and uses thereof
|
|
TW202340457A
(zh)
|
2022-02-28 |
2023-10-16 |
美商凱特製藥公司 |
同種異體治療細胞
|
|
WO2023166425A1
(en)
|
2022-03-01 |
2023-09-07 |
Crispr Therapeutics Ag |
Methods and compositions for treating angiopoietin-like 3 (angptl3) related conditions
|
|
WO2023173123A1
(en)
|
2022-03-11 |
2023-09-14 |
Sana Biotechnology, Inc. |
Genetically modified cells and compositions and uses thereof
|
|
US20230293646A1
(en)
|
2022-03-21 |
2023-09-21 |
Crispr Therapeutics Ag |
Methods and compositions for treating lipoprotein-related diseases
|
|
US20230331841A1
(en)
|
2022-03-23 |
2023-10-19 |
Crispr Therapeutics Ag |
Anti-cd83 car-t cells with regnase-1 and/or tgfbrii disruption
|
|
WO2023180968A1
(en)
|
2022-03-23 |
2023-09-28 |
Crispr Therapeutics Ag |
Anti-cd19 car-t cells with multiple gene edits and therapeutic uses thereof
|
|
WO2023192872A1
(en)
|
2022-03-28 |
2023-10-05 |
Massachusetts Institute Of Technology |
Rna scaffolded wireframe origami and methods thereof
|
|
KR20250004622A
(ko)
|
2022-04-08 |
2025-01-08 |
페이트 세러퓨틱스, 인코포레이티드 |
종양 표적화를 위한 키메라 항원 수용체
|
|
KR20250005097A
(ko)
|
2022-04-08 |
2025-01-09 |
페이트 세러퓨틱스, 인코포레이티드 |
고형 종양 표적화 골격을 갖는 세포 및 이의 용도
|
|
EP4532527A1
(de)
|
2022-05-27 |
2025-04-09 |
The Broad Institute, Inc. |
Verbesserte editoren für mitochondriale basen und verfahren zur bearbeitung mitochondrialer dna
|
|
US20250090582A1
(en)
|
2022-06-08 |
2025-03-20 |
Century Therapeutics, Inc. |
Genetically engineered cells having anti-cd133 / anti-egfr chimeric antigen receptors, and uses thereof
|
|
EP4536814A1
(de)
|
2022-06-08 |
2025-04-16 |
Century Therapeutics, Inc. |
Immuneffektorzellen aus induzierten pluripotenten stammzellen, die genetisch mit membrangebundenem il12 manipuliert wurden, und verwendungen davon
|
|
CN119630695A
(zh)
|
2022-06-08 |
2025-03-14 |
世纪治疗股份有限公司 |
表达cd16变体和nkg2d的遗传工程化细胞及其用途
|
|
CN119522284A
(zh)
|
2022-06-17 |
2025-02-25 |
克里斯珀医疗股份公司 |
基于脂质纳米颗粒(lnp)的眼部递送
|
|
WO2023248145A1
(en)
|
2022-06-21 |
2023-12-28 |
Crispr Therapeutics Ag |
Compositions and methods for treating human immunodeficiency virus
|
|
WO2023248147A1
(en)
|
2022-06-21 |
2023-12-28 |
Crispr Therapeutics Ag |
Methods and compositions for in vivo editing of stem cells
|
|
CA3260237A1
(en)
|
2022-06-24 |
2023-12-28 |
Tune Therapeutics, Inc. |
Compositions, systems and methods for reducing low-density lipoprotein by targeted gene repression
|
|
CN119451992A
(zh)
|
2022-06-29 |
2025-02-14 |
克里斯珀医疗股份公司 |
靶向gpc-3的嵌合抗原受体和表达其的免疫细胞用于治疗用途
|
|
US20240003871A1
(en)
|
2022-06-29 |
2024-01-04 |
FUJIFILM Cellular Dynamics, Inc. |
Ipsc-derived astrocytes and methods of use thereof
|
|
EP4554967A2
(de)
|
2022-07-12 |
2025-05-21 |
Tune Therapeutics, Inc. |
Zusammensetzungen, systeme und verfahren zur gezielten transkriptionsaktivierung
|
|
WO2024013514A2
(en)
|
2022-07-15 |
2024-01-18 |
Pig Improvement Company Uk Limited |
Gene edited livestock animals having coronavirus resistance
|
|
JP2025523965A
(ja)
|
2022-07-22 |
2025-07-25 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
デンドリマーが可能にする標的化細胞内crispr/casシステム送達および遺伝子編集
|
|
WO2024023802A2
(en)
|
2022-07-29 |
2024-02-01 |
Crispr Therapeutics Ag |
Genetically engineered immune cells having disrupted transporter associated with antigen processing-2 (tap-2) gene
|
|
WO2024023801A2
(en)
|
2022-07-29 |
2024-02-01 |
Crispr Therapeutics Ag |
Genetically engineered immune cells having disrupted transporter associated with antigen processing-1 (tap-1) gene
|
|
WO2024023804A2
(en)
|
2022-07-29 |
2024-02-01 |
Crispr Therapeutics Ag |
Genetically engineered immune cells having disrupted transporter associated with antigen processing binding protein (tapbp) gene
|
|
WO2024040254A2
(en)
|
2022-08-19 |
2024-02-22 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for regulation of hepatitis b virus through targeted gene repression
|
|
AU2023329392A1
(en)
|
2022-08-25 |
2025-02-27 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
JP2025531268A
(ja)
|
2022-09-19 |
2025-09-19 |
チューン セラピューティクス インコーポレイテッド |
T細胞機能を調節するための組成物、システム、および方法
|
|
WO2024062388A2
(en)
|
2022-09-20 |
2024-03-28 |
Crispr Therapeutics Ag |
Genetically engineered immune cells expressing chimeric antigen receptor targeting cd20
|
|
JP2025536260A
(ja)
|
2022-10-11 |
2025-11-05 |
イェール ユニバーシティー |
細胞透過性抗体の組成物および使用方法
|
|
WO2024100604A1
(en)
|
2022-11-09 |
2024-05-16 |
Juno Therapeutics Gmbh |
Methods for manufacturing engineered immune cells
|
|
WO2024102838A1
(en)
|
2022-11-09 |
2024-05-16 |
Century Therapeutics, Inc. |
Engineered interleukin-7 receptors and uses thereof
|
|
CN120435498A
(zh)
|
2022-11-10 |
2025-08-05 |
世纪治疗股份有限公司 |
具有抗-nectin4嵌合抗原受体的基因工程化细胞及其用途
|
|
CN120641131A
(zh)
|
2022-12-01 |
2025-09-12 |
耶鲁大学 |
用于细胞内有效载荷递送的刺激反应性无痕工程化平台
|
|
US20240269189A1
(en)
|
2022-12-19 |
2024-08-15 |
FUJIFILM Holdings America Corporation |
Extracellular vesicle-enriched secretome composition derived from induced pluripotent stem cell derived-microglia and methods of use thereof
|
|
JP2026500040A
(ja)
|
2022-12-23 |
2026-01-05 |
エピジェニック セラピューティクス プライベート リミテッド |
複合体及びその使用
|
|
KR20250128349A
(ko)
|
2022-12-23 |
2025-08-27 |
에피제닉 테라퓨틱스 피티이 리미티드 |
융합체 및 이의 용도
|
|
WO2024151541A1
(en)
|
2023-01-09 |
2024-07-18 |
Sana Biotechnology, Inc. |
Type-1 diabetes autoimmune mouse
|
|
WO2024163678A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Fusion proteins and systems for targeted activation of frataxin (fxn) and related methods
|
|
WO2024163683A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Systems, compositions, and methods for modulating expression of methyl-cpg binding protein 2 (mecp2) and x-inactive specific transcript (xist)
|
|
US20260232729A1
(en)
|
2023-02-03 |
2026-08-13 |
C3S2 Gmbh |
Methods for non-viral manufacturing of engineered immune cells
|
|
US20260232844A1
(en)
|
2023-02-15 |
2026-08-13 |
Arbor Biotechnologies, Inc. |
Gene editing method for inhibiting aberrant splicing in stathmin 2 (stmn2) transcript
|
|
WO2024192108A1
(en)
|
2023-03-14 |
2024-09-19 |
Evolveimmune Therapeutics, Inc. |
Genetically modified car t cells and methods of making and using the same
|
|
AU2024257643A1
(en)
|
2023-04-21 |
2025-10-16 |
Kite Pharma, Inc. |
Allogenic therapeutic cells with reduced risk of immune rejection
|
|
CN121843705A
(zh)
|
2023-05-03 |
2026-04-10 |
萨那生物科技公司 |
工程化胰岛细胞的给药和施用方法
|
|
WO2024243236A2
(en)
|
2023-05-22 |
2024-11-28 |
Sana Biotechnology, Inc. |
Methods of delivery of islet cells and related methods
|
|
TW202515898A
(zh)
|
2023-06-30 |
2025-04-16 |
日商武田藥品工業股份有限公司 |
Htt抑制物及其用途
|
|
WO2025019742A1
(en)
|
2023-07-19 |
2025-01-23 |
Omega Therapeutics, Inc. |
Methods and compositions for modulating ctnnb1 expression
|
|
WO2025022290A1
(en)
|
2023-07-21 |
2025-01-30 |
Crispr Therapeutics Ag |
Modulating expression of alas1 (5'-aminolevulinate synthase 1) gene
|
|
CN121909284A
(zh)
|
2023-07-31 |
2026-04-21 |
图恩疗法股份有限公司 |
用于调节il-2基因表达的组合物和方法
|
|
EP4754248A1
(de)
|
2023-07-31 |
2026-06-10 |
Tune Therapeutics, Inc. |
Zusammensetzungen und verfahren zur multiplex-aktivierung und -repression der t-zell-genexpression
|
|
WO2025038494A1
(en)
|
2023-08-11 |
2025-02-20 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for lymphoid cell differentiation using targeted gene activation
|
|
EP4771154A2
(de)
|
2023-09-01 |
2026-07-08 |
Renagade Therapeutics Management Inc. |
Geneditierungssysteme, zusammensetzungen und verfahren zur behandlung des vexas-syndroms
|
|
WO2025059073A1
(en)
|
2023-09-11 |
2025-03-20 |
Tune Therapeutics, Inc. |
Epigenetic editing methods and systems for differentiating stem cells
|
|
WO2025101938A2
(en)
|
2023-11-10 |
2025-05-15 |
Century Therapeutics, Inc. |
Genetically engineered cells having multi-transmembrane domain chimeric antigen receptors utilizing g protein-coupled receptor scaffolds, and uses thereof
|
|
WO2025106626A1
(en)
|
2023-11-15 |
2025-05-22 |
Century Therapeutics, Inc. |
Genetically engineered cells expressing c-x-c chemokine receptor type 4, and uses thereof
|
|
WO2025174765A1
(en)
|
2024-02-12 |
2025-08-21 |
Renagade Therapeutics Management Inc. |
Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
|
|
WO2025186726A1
(en)
|
2024-03-05 |
2025-09-12 |
Crispr Therapeutics Ag |
Modulating expression of agt (angiotensinogen) gene
|
|
WO2025207798A1
(en)
|
2024-03-26 |
2025-10-02 |
Century Therapeutics, Inc. |
Genetically engineered cells having anti-cd123 chimeric antigen receptors, and uses thereof
|
|
WO2025207795A1
(en)
|
2024-03-26 |
2025-10-02 |
Juno Therapeutics, Inc. |
Genetically engineered cells having anti-cd33 / anti-cd123 chimeric antigen receptors, and uses thereof
|
|
WO2025226122A1
(ko)
*
|
2024-04-25 |
2025-10-30 |
(주)셀트리온 |
글루타민 합성효소 유전자를 불활성화시키는 방법 및 이를 이용한 목적 단백질의 생산 방법
|
|
WO2025224715A1
(en)
|
2024-04-26 |
2025-10-30 |
King Abdullah Univeristy Of Science And Technology |
Methods for improving precise genome modification and reducing unwanted mutations by crispr-cas editing
|
|
US20250345431A1
(en)
|
2024-05-10 |
2025-11-13 |
Juno Therapeutics, Inc. |
Genetically engineered t cells expressing a cd19 chimeric antigen receptor (car) and uses thereof for allogeneic cell therapy
|
|
WO2025260068A1
(en)
|
2024-06-14 |
2025-12-18 |
Tune Therapeutics, Inc. |
Lipid nanoparticle formulation for delivery of nucleic acids to cells
|
|
WO2026006832A1
(en)
|
2024-06-28 |
2026-01-02 |
University Of Connecticut |
Gene modulation for treating cancer
|
|
WO2026015647A1
(en)
|
2024-07-09 |
2026-01-15 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for cell differentiation using targeted gene activation of dll4 and/or vcam1
|
|
WO2026064753A1
(en)
|
2024-09-23 |
2026-03-26 |
Tune Therapeutics, Inc. |
Dna methyltransferase-like protein (dnmt3l) or dna methyltransferase 3a (dnmt3a) repressor systems for epigenetic editing
|
|
WO2026122879A1
(en)
|
2024-12-05 |
2026-06-11 |
Massachusetts Institute Of Technology |
Compositions and methods for producing endotoxin-free phage
|
|
WO2026123001A2
(en)
|
2024-12-06 |
2026-06-11 |
Umoja Biopharma, Inc. |
Lineage-loci engineered cell therapy and related methods of producing and using same
|
|
WO2026128588A1
(en)
|
2024-12-10 |
2026-06-18 |
Yale University |
Compositions and methods for treating fibrosis
|
|
WO2026136848A2
(en)
|
2024-12-20 |
2026-06-25 |
Juno Therapeutics, Inc. |
Cd70-targeted cars and engineered cells comprising same and related methods
|
|
WO2026161895A1
(en)
|
2025-01-27 |
2026-07-30 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for epigenetic regulation of lipoprotein a (lpa) gene expression
|