ATE324464T1 - Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäuren - Google Patents
Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäurenInfo
- Publication number
- ATE324464T1 ATE324464T1 AT03000499T AT03000499T ATE324464T1 AT E324464 T1 ATE324464 T1 AT E324464T1 AT 03000499 T AT03000499 T AT 03000499T AT 03000499 T AT03000499 T AT 03000499T AT E324464 T1 ATE324464 T1 AT E324464T1
- Authority
- AT
- Austria
- Prior art keywords
- oligonucleotide
- cascade
- nucleic acids
- circular
- reaction
- Prior art date
Links
- 238000006243 chemical reaction Methods 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 5
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108020004638 Circular DNA Proteins 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 108060002716 Exonuclease Proteins 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 238000006073 displacement reaction Methods 0.000 abstract 1
- 102000013165 exonuclease Human genes 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- -1 nucleoside triphosphates Chemical class 0.000 abstract 1
- 239000001226 triphosphate Substances 0.000 abstract 1
- 235000011178 triphosphate Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Ceramic Products (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK137995 | 1995-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE324464T1 true ATE324464T1 (de) | 2006-05-15 |
Family
ID=8104224
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96939821T ATE238434T1 (de) | 1995-12-05 | 1996-12-05 | Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäuren |
| AT03000499T ATE324464T1 (de) | 1995-12-05 | 1996-12-05 | Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäuren |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96939821T ATE238434T1 (de) | 1995-12-05 | 1996-12-05 | Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäuren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6610481B2 (de) |
| EP (2) | EP0868530B1 (de) |
| AT (2) | ATE238434T1 (de) |
| AU (1) | AU704750B2 (de) |
| CA (1) | CA2239287C (de) |
| DE (2) | DE69636080T2 (de) |
| DK (2) | DK1300466T3 (de) |
| ES (1) | ES2262902T3 (de) |
| WO (1) | WO1997020948A1 (de) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7135312B2 (en) | 1993-04-15 | 2006-11-14 | University Of Rochester | Circular DNA vectors for synthesis of RNA and DNA |
| US6077668A (en) * | 1993-04-15 | 2000-06-20 | University Of Rochester | Highly sensitive multimeric nucleic acid probes |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| DK0862656T3 (da) | 1995-11-21 | 2001-04-09 | Univ Yale | Unimolekylær segmentamplifikation og -detektering |
| JP2002525049A (ja) * | 1998-09-15 | 2002-08-13 | イェール ユニバーシティ | ローリングサークル増幅を用いる分子クローニング |
| EP1112385A1 (de) * | 1998-09-15 | 2001-07-04 | Yale University | Künstliche vektoren mit langen wiederholungssequenzen |
| US6986990B1 (en) * | 1999-04-27 | 2006-01-17 | Genox Research, Inc. | Pollen allergy-related gene 513 |
| US6368801B1 (en) | 2000-04-12 | 2002-04-09 | Molecular Staging, Inc. | Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase |
| CA2411794A1 (en) | 2000-06-30 | 2002-01-10 | Molecular Staging, Inc. | Signal amplification with lollipop probes |
| GB0025144D0 (en) * | 2000-10-13 | 2000-11-29 | Medical Res Council | Concatenated nucleic acid sequences |
| US6573051B2 (en) | 2001-03-09 | 2003-06-03 | Molecular Staging, Inc. | Open circle probes with intramolecular stem structures |
| WO2003002761A1 (en) * | 2001-06-29 | 2003-01-09 | Novozymes A/S | Method of multimerization and site-directed mutagenesis |
| GB2378245A (en) | 2001-08-03 | 2003-02-05 | Mats Nilsson | Nucleic acid amplification method |
| GB2382137A (en) | 2001-11-20 | 2003-05-21 | Mats Gullberg | Nucleic acid enrichment |
| US7553619B2 (en) | 2002-02-08 | 2009-06-30 | Qiagen Gmbh | Detection method using dissociated rolling circle amplification |
| US8394944B2 (en) * | 2002-09-20 | 2013-03-12 | Siemens Healthcare Diagnostics Inc. | Dual-purpose primers and probes for providing enhanced hybridization assays by disruption of secondary structure formation |
| WO2004048594A2 (en) | 2002-11-21 | 2004-06-10 | Epicentre Technologies | Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences |
| US9487823B2 (en) | 2002-12-20 | 2016-11-08 | Qiagen Gmbh | Nucleic acid amplification |
| US6977153B2 (en) | 2002-12-31 | 2005-12-20 | Qiagen Gmbh | Rolling circle amplification of RNA |
| WO2006035701A1 (ja) * | 2004-09-27 | 2006-04-06 | The Furukawa Electric Co., Ltd. | 接続部材 |
| BRPI0515777A (pt) * | 2004-12-11 | 2008-08-05 | Cytogenix Inc | biossìntese isenta de células de ácido nucléico de alta qualidade e usos dos mesmos |
| GB0504774D0 (en) * | 2005-03-08 | 2005-04-13 | Lingvitae As | Method |
| EP1871897B1 (de) | 2005-04-12 | 2010-09-29 | Olink AB | Verfahren zur herstellung von oligonukleotiden |
| US7989166B2 (en) | 2005-04-12 | 2011-08-02 | In Situ Rcp A/S | Circle probes and their use in the identification of biomolecules |
| EP3257949A1 (de) | 2005-06-15 | 2017-12-20 | Complete Genomics Inc. | Nukleinsäureanalyse durch zufällige mischungen von nichtüberlappenden fragmenten |
| EP1762627A1 (de) | 2005-09-09 | 2007-03-14 | Qiagen GmbH | Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion |
| CA2624324A1 (en) | 2005-10-06 | 2007-04-19 | Lucigen Corporation | Thermostable viral polymerases and methods of use |
| US7960104B2 (en) * | 2005-10-07 | 2011-06-14 | Callida Genomics, Inc. | Self-assembled single molecule arrays and uses thereof |
| US20070168197A1 (en) * | 2006-01-18 | 2007-07-19 | Nokia Corporation | Audio coding |
| SG170028A1 (en) * | 2006-02-24 | 2011-04-29 | Callida Genomics Inc | High throughput genome sequencing on dna arrays |
| CN101432439B (zh) | 2006-02-24 | 2013-07-24 | 考利达基因组股份有限公司 | Dna阵列上的高通量基因组测序 |
| GB0621361D0 (en) * | 2006-10-26 | 2006-12-06 | Fermentas Uab | Use of DNA polymerases |
| US7910354B2 (en) | 2006-10-27 | 2011-03-22 | Complete Genomics, Inc. | Efficient arrays of amplified polynucleotides |
| US20090111706A1 (en) | 2006-11-09 | 2009-04-30 | Complete Genomics, Inc. | Selection of dna adaptor orientation by amplification |
| US20080221832A1 (en) * | 2006-11-09 | 2008-09-11 | Complete Genomics, Inc. | Methods for computing positional base probabilities using experminentals base value distributions |
| RU2414510C2 (ru) * | 2007-06-14 | 2011-03-20 | Институт биохимии и генетики Уфимского научного центра РАН | Способ амплификации специфичных фрагментов нуклеиновых кислот с помощью рекуррентной цепной реакции |
| US7897344B2 (en) * | 2007-11-06 | 2011-03-01 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs |
| US8415099B2 (en) | 2007-11-05 | 2013-04-09 | Complete Genomics, Inc. | Efficient base determination in sequencing reactions |
| US8518640B2 (en) * | 2007-10-29 | 2013-08-27 | Complete Genomics, Inc. | Nucleic acid sequencing and process |
| US8298768B2 (en) * | 2007-11-29 | 2012-10-30 | Complete Genomics, Inc. | Efficient shotgun sequencing methods |
| WO2009061840A1 (en) * | 2007-11-05 | 2009-05-14 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation |
| US8592150B2 (en) | 2007-12-05 | 2013-11-26 | Complete Genomics, Inc. | Methods and compositions for long fragment read sequencing |
| WO2009094583A1 (en) * | 2008-01-23 | 2009-07-30 | Complete Genomics, Inc. | Methods and compositions for preventing bias in amplification and sequencing reactions |
| WO2009097368A2 (en) * | 2008-01-28 | 2009-08-06 | Complete Genomics, Inc. | Methods and compositions for efficient base calling in sequencing reactions |
| WO2009132028A1 (en) * | 2008-04-21 | 2009-10-29 | Complete Genomics, Inc. | Array structures for nucleic acid detection |
| US9524369B2 (en) | 2009-06-15 | 2016-12-20 | Complete Genomics, Inc. | Processing and analysis of complex nucleic acid sequence data |
| CN103649331A (zh) | 2011-02-15 | 2014-03-19 | 莱卡生物系统纽卡斯尔有限责任公司 | 用于mrna的定位的原位检测的方法 |
| US9556473B2 (en) | 2011-02-15 | 2017-01-31 | Leica Biosystems Newcastle Ltd | Methods for identifying nucleic acid sequences |
| EP2718465B1 (de) | 2011-06-09 | 2022-04-13 | Illumina, Inc. | Verfahren zur vorbereitung eines analyt-arrays |
| EP3305400A3 (de) | 2011-10-28 | 2018-06-06 | Illumina, Inc. | System und verfahren zur herstellung von mikroarrays |
| US20160369321A1 (en) | 2012-11-14 | 2016-12-22 | Olink Ab | RCA Reporter Probes and Their Use in Detecting Nucleic Acid Molecules |
| EP2920324B1 (de) | 2012-11-14 | 2017-12-27 | Olink Bioscience AB | Lokalisiertes rca-basiertes verstärkungsverfahren |
| GB201320145D0 (en) | 2013-11-14 | 2014-01-01 | Olink Ab | Localised RCA-based amplification method using a padlock-probe |
| CA3219413A1 (en) | 2014-05-16 | 2015-11-19 | Illumina, Inc. | Nucleic acid synthesis techniques |
| US10604790B2 (en) * | 2014-12-24 | 2020-03-31 | Abbott Laboratories | Sequence conversion and signal amplifier DNA cascade reactions and detection methods using same |
| GB201614023D0 (en) | 2016-08-16 | 2016-09-28 | Olink Bioscience Ab | Double-stranded circle probes |
| CN118345145A (zh) | 2016-12-09 | 2024-07-16 | 乌尔蒂维尤股份有限公司 | 用于使用标记的核酸成像剂进行多路复用成像的改进方法 |
| EP3601339A4 (de) | 2017-03-31 | 2020-11-04 | Ultivue, Inc. | Dna-antigenaustausch und amplifikation |
| CN116218893B (zh) * | 2023-03-24 | 2025-07-29 | 哈尔滨医科大学 | 一种通过体外扩增重组质粒在其编码基因上生成短片段串联重复序列的方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| AU649066B2 (en) * | 1990-07-25 | 1994-05-12 | Syngene, Inc. | Circular extension for generating multiple nucleic acid complements |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| AU8997991A (en) | 1991-01-31 | 1992-08-06 | Becton Dickinson & Company | Exonuclease mediated strand displacement amplification |
| JP3080178B2 (ja) | 1991-02-18 | 2000-08-21 | 東洋紡績株式会社 | 核酸配列の増幅方法およびそのための試薬キット |
| JP3085409B2 (ja) * | 1991-03-29 | 2000-09-11 | 東洋紡績株式会社 | 標的核酸配列の検出方法およびそのための試薬キット |
| GB9117910D0 (en) * | 1991-08-20 | 1991-10-09 | Nat Res Dev | Oligonucleotides and their use in an assay |
| JPH07500734A (ja) * | 1991-10-31 | 1995-01-26 | ユニヴァーシティ オブ ピッツバーグ | オリゴヌクレオチドプローブのポリマーを用いる核酸配列の検出方法 |
| US5270184A (en) | 1991-11-19 | 1993-12-14 | Becton, Dickinson And Company | Nucleic acid target generation |
| US6180338B1 (en) * | 1992-08-04 | 2001-01-30 | Beckman Coulter, Inc. | Method, reagent and kit for the detection and amplification of nucleic acid sequences |
| EP0717782A1 (de) * | 1994-06-22 | 1996-06-26 | Mount Sinai School Of Medicine Of The City University Of New York | Ligation-abhängige amplifizierung zum nachweis von infektösen pathogenen und anormalen genen |
| US5942391A (en) | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
| US5876924A (en) | 1994-06-22 | 1999-03-02 | Mount Sinai School Of Medicine | Nucleic acid amplification method hybridization signal amplification method (HSAM) |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| DK0862656T3 (da) * | 1995-11-21 | 2001-04-09 | Univ Yale | Unimolekylær segmentamplifikation og -detektering |
-
1996
- 1996-12-05 AT AT96939821T patent/ATE238434T1/de not_active IP Right Cessation
- 1996-12-05 WO PCT/DK1996/000513 patent/WO1997020948A1/en not_active Ceased
- 1996-12-05 EP EP96939821A patent/EP0868530B1/de not_active Expired - Lifetime
- 1996-12-05 ES ES03000499T patent/ES2262902T3/es not_active Expired - Lifetime
- 1996-12-05 DK DK03000499T patent/DK1300466T3/da active
- 1996-12-05 DE DE69636080T patent/DE69636080T2/de not_active Expired - Lifetime
- 1996-12-05 AT AT03000499T patent/ATE324464T1/de not_active IP Right Cessation
- 1996-12-05 EP EP03000499A patent/EP1300466B1/de not_active Expired - Lifetime
- 1996-12-05 AU AU76917/96A patent/AU704750B2/en not_active Ceased
- 1996-12-05 DE DE69627698T patent/DE69627698T2/de not_active Expired - Lifetime
- 1996-12-05 CA CA002239287A patent/CA2239287C/en not_active Expired - Fee Related
- 1996-12-05 DK DK96939821T patent/DK0868530T3/da active
-
1999
- 1999-12-17 US US09/465,589 patent/US6610481B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1300466B1 (de) | 2006-04-26 |
| DE69636080T2 (de) | 2006-11-30 |
| DE69636080D1 (de) | 2006-06-01 |
| WO1997020948A1 (en) | 1997-06-12 |
| EP1300466A3 (de) | 2004-01-02 |
| EP0868530B1 (de) | 2003-04-23 |
| AU7691796A (en) | 1997-06-27 |
| CA2239287A1 (en) | 1997-06-12 |
| AU704750B2 (en) | 1999-05-06 |
| EP1300466A2 (de) | 2003-04-09 |
| DE69627698T2 (de) | 2004-01-15 |
| CA2239287C (en) | 2008-02-26 |
| DK1300466T3 (da) | 2006-08-28 |
| EP0868530A1 (de) | 1998-10-07 |
| DE69627698D1 (de) | 2003-05-28 |
| DK0868530T3 (da) | 2003-07-21 |
| US6610481B2 (en) | 2003-08-26 |
| ATE238434T1 (de) | 2003-05-15 |
| ES2262902T3 (es) | 2006-12-01 |
| US20020031764A1 (en) | 2002-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1300466 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |