ATE332701T1 - Verfahren zur herstellung von nordamerikanischen ginseng fraktionen, enthaltende produkte, und verwendung als immunmodulatoren - Google Patents
Verfahren zur herstellung von nordamerikanischen ginseng fraktionen, enthaltende produkte, und verwendung als immunmodulatorenInfo
- Publication number
- ATE332701T1 ATE332701T1 AT98963784T AT98963784T ATE332701T1 AT E332701 T1 ATE332701 T1 AT E332701T1 AT 98963784 T AT98963784 T AT 98963784T AT 98963784 T AT98963784 T AT 98963784T AT E332701 T1 ATE332701 T1 AT E332701T1
- Authority
- AT
- Austria
- Prior art keywords
- north american
- american ginseng
- products containing
- fractions
- immune modulators
- Prior art date
Links
- 240000005373 Panax quinquefolius Species 0.000 title abstract 3
- 235000003140 Panax quinquefolius Nutrition 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000001311 chemical methods and process Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 abstract 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 abstract 1
- 201000009240 nasopharyngitis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6953497P | 1997-12-12 | 1997-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE332701T1 true ATE332701T1 (de) | 2006-08-15 |
Family
ID=22089640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98963784T ATE332701T1 (de) | 1997-12-12 | 1998-12-11 | Verfahren zur herstellung von nordamerikanischen ginseng fraktionen, enthaltende produkte, und verwendung als immunmodulatoren |
Country Status (12)
| Country | Link |
|---|---|
| US (7) | US6432454B1 (de) |
| EP (1) | EP1037645B1 (de) |
| JP (2) | JP4458505B2 (de) |
| KR (2) | KR100855409B1 (de) |
| CN (1) | CN1285752B (de) |
| AT (1) | ATE332701T1 (de) |
| AU (1) | AU752702B2 (de) |
| CA (1) | CA2314453C (de) |
| DE (1) | DE69835230T2 (de) |
| DK (1) | DK1037645T3 (de) |
| NZ (1) | NZ504975A (de) |
| WO (1) | WO1999030725A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432454B1 (en) * | 1997-12-12 | 2002-08-13 | C. V. Technologies, Inc. | Processes of making north american ginseng fractions, products containing them, and use as immunomodulators |
| AU3478600A (en) * | 1999-02-25 | 2000-09-14 | Cv Technologies Inc. | Treatment of autoimmune diseases with american ginseng extract |
| TWI222357B (en) * | 2000-01-11 | 2004-10-21 | Medical & Pharm Ind Tech & Dev | Anti-ulcer pharmaceutical composition and the preparation and use thereof |
| GB2364640B (en) * | 2000-07-11 | 2002-12-04 | Pharmaceutical Ind Tech & Dev | Anti-ulcer pharmaceutical composition and the preparation thereof |
| ES2193874B1 (es) * | 2002-04-03 | 2005-03-01 | Puleva Biotech, S.A. | Compuestos naturales y derivados de estos para la prevencion y el tratamiento de enfermedades cardiovasculares, hepaticas, renales y cosmeticas. |
| KR100594353B1 (ko) * | 2002-05-28 | 2006-07-03 | 주식회사 엠디바이오알파 | 신규한 인삼잎 및 줄기 다당체, 그 제조방법 및 그를활성성분으로 함유하는 항암제 및 항암보조제 조성물 |
| WO2004037165A2 (en) * | 2002-08-23 | 2004-05-06 | The Research Foundation Of State University Of New York | Nitric oxide and its biomedical significance |
| AR046078A1 (es) | 2003-08-06 | 2005-11-23 | Senomyx Inc | Nuevos sabores, modificadores de sabores, sustancias gustativas, mejoradores de gusto, sustancias gustativas y/o mejoradoras del gusto umani o dulce y uso de los mismos. |
| US20050079234A1 (en) * | 2003-08-27 | 2005-04-14 | Chiang Yang Chi | Compositions comprising herbs and method for immunomodulation |
| KR101102480B1 (ko) * | 2004-04-27 | 2012-01-05 | 노부유키 하야시 | 가압 열매체를 이용한 추출방법 및 그 장치 |
| KR100456089B1 (ko) * | 2004-07-15 | 2004-11-09 | 박용진 | 항암 활성을 갖는 산삼 추출정제액을 정제하는 방법 및이를 함유하는 조성물 |
| CN100509006C (zh) | 2005-03-25 | 2009-07-08 | 北京欧纳尔生物工程技术有限公司 | 治疗抑郁症的药物组合物及其制法 |
| DE602006017423D1 (de) * | 2005-11-14 | 2010-11-18 | Unilever Nv | Essbares produkt, das ginseng-polysaccharide und gesunde bakterien enthält |
| US20120263806A1 (en) * | 2007-05-16 | 2012-10-18 | Miller Sandra | Uses of North American Ginseng Fractions for Treating Leukemia |
| WO2008139241A1 (en) * | 2007-05-16 | 2008-11-20 | C.V. Technologies, Inc. | Uses of north american ginseng fractions for treating leukemia |
| US20090047405A1 (en) * | 2007-08-16 | 2009-02-19 | Conopco, Inc., D/B/A Unilever | Food composition with therapeutic agents |
| KR101018989B1 (ko) | 2007-10-31 | 2011-03-07 | 내추럴초이스 (주) | 홍삼박을 이용한 홍삼 다당체의 생산방법 |
| WO2009071425A1 (en) * | 2007-12-07 | 2009-06-11 | Unilever Nv | Edible product having an immunostimulating effect |
| MY158195A (en) * | 2008-02-29 | 2016-09-15 | Afexa Life Sciences Inc | Activation of innate and adaptive immune responses by a ginseng extract |
| BRPI0919298A2 (pt) * | 2008-09-30 | 2019-09-24 | Unhwa Corp | composição para a prevenção ou o tratamento da aids que compreende a linhagem de células do tronco da planta derivada do câmbio da panax ginseng incluindo ginseng selvagem ou ginseng como ingrediente ativo. |
| KR101067959B1 (ko) * | 2008-10-29 | 2011-09-26 | 구성학 | 감기 및 독감의 치료와 예방에 효과적인 발효유지 조성물의제조방법 |
| WO2010095911A2 (ko) * | 2009-02-23 | 2010-08-26 | 주식회사 운화 | 산삼 또는 인삼을 포함한 인삼류의 형성층 유래 식물줄기세포주를 유효성분으로 함유하는 면역증강용 조성물 |
| US8574639B2 (en) | 2010-08-17 | 2013-11-05 | ILHWA Co., Ltd. | Fermented ginseng concentrate having IH-901 |
| WO2012148277A1 (en) | 2011-04-29 | 2012-11-01 | Unilever N.V. | Method for isolation of polysaccharides |
| US20140255526A1 (en) * | 2011-10-28 | 2014-09-11 | Afexa Life Sciences Inc. | Use of a ginseng extract to prevent and treat alopecia areata |
| CN103656113A (zh) * | 2012-09-13 | 2014-03-26 | 江中药业股份有限公司 | 一种调节免疫的中药组合物及其制备方法 |
| CN102928373B (zh) * | 2012-11-26 | 2015-05-13 | 广东省农业科学院花卉研究所 | 一种石斛多糖含量的测定方法及其应用 |
| KR102200012B1 (ko) * | 2013-04-02 | 2021-01-08 | (주)아모레퍼시픽 | 인삼열매 추출물을 포함하는 뇌 활성화 조성물 |
| WO2014196817A1 (ko) * | 2013-06-04 | 2014-12-11 | 중앙대학교 산학협력단 | 자일리톨을 유효성분으로 함유하는 인플루엔자 바이러스 감염증 예방 또는 치료용 조성물 |
| US20150044306A1 (en) | 2013-08-12 | 2015-02-12 | Melvin Mitchell | Process for fractionation and extraction of herbal plant material to isolate extractives for pharmaceuticals and nutraceuticals |
| KR102184157B1 (ko) * | 2019-01-08 | 2020-11-30 | 주식회사 바이오에프디엔씨 | 항상성 증가를 통한 피부면역개선, 외부환경에 대한 피부보호 및 피부활력증진을 위한 인삼 유래 테트라펩타이드를 함유하는 화장료 조성물 |
| WO2022126261A1 (en) * | 2020-12-15 | 2022-06-23 | Shan Jacqueline J | American ginseng root fractions, processes of their preparation and uses thereof |
| CN114848695A (zh) * | 2022-03-25 | 2022-08-05 | 潍坊医学院 | 一种人参稀有皂苷与西洋参多糖的组合物及其应用 |
| CN117050207A (zh) * | 2023-09-11 | 2023-11-14 | 湖南省中医药研究院 | 一种西洋参多糖、提取方法与其调节机体抗流感免疫的应用 |
| GB202316295D0 (en) | 2023-10-24 | 2023-12-06 | Amazentis Sa | Composition |
| GB202411739D0 (en) | 2024-08-08 | 2024-09-25 | Amazentis Sa | Compositions |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4912020A (de) * | 1972-05-17 | 1974-02-02 | ||
| DE3070086D1 (en) * | 1979-12-03 | 1985-03-14 | Kitasato Inst | A process for preparing substances having interferon inducing activity |
| JPS6118722A (ja) * | 1984-07-05 | 1986-01-27 | Wakunaga Seiyaku Kk | 生体防御能亢進剤 |
| JPS61109732A (ja) * | 1984-10-31 | 1986-05-28 | Wakunaga Seiyaku Kk | 殺腫瘍性物質誘発剤 |
| US4708949A (en) * | 1985-09-24 | 1987-11-24 | Yaguang Liu | Therapeutic composition from plant extracts |
| US4706949A (en) * | 1985-12-17 | 1987-11-17 | Dossey Robert L | Vise jaw support system and interchangeable vise jaws therefor |
| SU1410322A1 (ru) * | 1986-03-07 | 1996-03-27 | Владивостокский государственный медицинский институт | Способ получения тритерпеновых гликозидов-панаксозидов из корней женьшеня (panax ginseng c.a.mey) |
| JPH0643327B2 (ja) * | 1987-03-27 | 1994-06-08 | 株式会社ツムラ | 免疫賦活剤 |
| US5071839A (en) * | 1987-11-02 | 1991-12-10 | Yaguang Liu | Safe pharmaceutical composition for decreasing side effects of antiviral drugs and increasing the immune function (SDI) II |
| JPH0245499A (ja) * | 1988-08-06 | 1990-02-15 | Wakunaga Pharmaceut Co Ltd | オタネニンジン糖タンパク質およびその用途 |
| JPH0245501A (ja) * | 1988-08-06 | 1990-02-15 | Wakunaga Pharmaceut Co Ltd | 竹節ニンジン多糖およびその用途 |
| JPH05317041A (ja) * | 1991-06-05 | 1993-12-03 | Nippon Oil Co Ltd | 動物細胞増殖促進剤及び無血清培地 |
| JPH0639759A (ja) * | 1992-04-20 | 1994-02-15 | Tokico Ltd | 工業用ロボット装置 |
| JPH069418A (ja) * | 1992-06-29 | 1994-01-18 | Nitto Denko Corp | パナキンケコール化合物、及び制癌剤 |
| CN1088448A (zh) * | 1992-12-25 | 1994-06-29 | 彭德赐 | 西洋参多糖营养液和西洋参多糖胶囊及其制备方法 |
| JPH0782167A (ja) * | 1993-06-29 | 1995-03-28 | Japan Energy Corp | 血清csf活性誘導剤及びその製造方法 |
| US5840309A (en) * | 1994-10-03 | 1998-11-24 | La Prairie Sa | Stimulating fibroblasts and/or keratinocytes |
| KR100192678B1 (ko) * | 1995-06-07 | 1999-06-15 | 손경식 | 약효가 증강된 가공인삼 제품 |
| US6083932A (en) * | 1997-04-18 | 2000-07-04 | Cv Technologies Inc. | Pharmaceutical compositions derived from ginseng and methods of treatment using same |
| KR20010023208A (ko) * | 1997-08-28 | 2001-03-26 | 브루스, 제임스 에이취 | 허브 추출물의 화학 및 약리학적 표준화 |
| US6432454B1 (en) * | 1997-12-12 | 2002-08-13 | C. V. Technologies, Inc. | Processes of making north american ginseng fractions, products containing them, and use as immunomodulators |
| AU3478600A (en) | 1999-02-25 | 2000-09-14 | Cv Technologies Inc. | Treatment of autoimmune diseases with american ginseng extract |
| DE60015734D1 (de) * | 1999-02-26 | 2004-12-16 | Inspire Pharmaceuticals Durham | Verwendung von dinukleotidtriphosphaten, cytidindiphosphaten und adenindiphosphaten zur herstellung einer pharmazeutischen zubereitung zur förderung der schleimauthydratation |
| US6555527B1 (en) * | 1999-08-27 | 2003-04-29 | Korea Atomic Energy Research Institute | Hematopoietic, myeloprotecting, antitumor immune cells generating and radiosensitizing polysaccharide isolated from Panax ginseng |
-
1998
- 1998-11-11 US US09/581,161 patent/US6432454B1/en not_active Expired - Lifetime
- 1998-12-11 CN CN988120690A patent/CN1285752B/zh not_active Expired - Lifetime
- 1998-12-11 CA CA002314453A patent/CA2314453C/en not_active Expired - Lifetime
- 1998-12-11 KR KR1020077020271A patent/KR100855409B1/ko not_active Expired - Lifetime
- 1998-12-11 AT AT98963784T patent/ATE332701T1/de active
- 1998-12-11 NZ NZ504975A patent/NZ504975A/xx not_active IP Right Cessation
- 1998-12-11 DK DK98963784T patent/DK1037645T3/da active
- 1998-12-11 JP JP2000538705A patent/JP4458505B2/ja not_active Expired - Lifetime
- 1998-12-11 EP EP98963784A patent/EP1037645B1/de not_active Expired - Lifetime
- 1998-12-11 KR KR1020007006333A patent/KR100780521B1/ko not_active Expired - Lifetime
- 1998-12-11 WO PCT/US1998/025724 patent/WO1999030725A1/en not_active Ceased
- 1998-12-11 AU AU19034/99A patent/AU752702B2/en not_active Expired
- 1998-12-11 DE DE69835230T patent/DE69835230T2/de not_active Expired - Lifetime
-
2002
- 2002-07-02 US US10/187,289 patent/US7067160B2/en not_active Expired - Lifetime
- 2002-07-02 US US10/186,733 patent/US20030077341A1/en not_active Abandoned
-
2003
- 2003-10-23 US US10/690,628 patent/US7186423B2/en not_active Expired - Lifetime
-
2005
- 2005-04-26 US US11/114,089 patent/US7413756B2/en not_active Expired - Fee Related
-
2008
- 2008-07-16 US US12/173,966 patent/US7763290B2/en not_active Expired - Fee Related
-
2009
- 2009-08-10 JP JP2009186027A patent/JP2009256387A/ja active Pending
-
2010
- 2010-07-19 US US12/839,386 patent/US20100278945A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7067160B2 (en) | 2006-06-27 |
| HK1032358A1 (en) | 2001-07-20 |
| US20080286389A1 (en) | 2008-11-20 |
| US20030124207A1 (en) | 2003-07-03 |
| DK1037645T3 (da) | 2006-11-06 |
| DE69835230T2 (de) | 2007-07-05 |
| KR100855409B1 (ko) | 2008-08-29 |
| EP1037645A4 (de) | 2004-03-03 |
| EP1037645B1 (de) | 2006-07-12 |
| JP2009256387A (ja) | 2009-11-05 |
| DE69835230D1 (de) | 2006-08-24 |
| AU752702B2 (en) | 2002-09-26 |
| CN1285752B (zh) | 2011-05-25 |
| CN1285752A (zh) | 2001-02-28 |
| US20100278945A1 (en) | 2010-11-04 |
| US20050196471A1 (en) | 2005-09-08 |
| CA2314453C (en) | 2009-03-03 |
| JP2002508329A (ja) | 2002-03-19 |
| US7186423B2 (en) | 2007-03-06 |
| US20030077341A1 (en) | 2003-04-24 |
| US6432454B1 (en) | 2002-08-13 |
| NZ504975A (en) | 2004-02-27 |
| AU1903499A (en) | 1999-07-05 |
| EP1037645A1 (de) | 2000-09-27 |
| CA2314453A1 (en) | 1999-06-24 |
| KR20010032984A (ko) | 2001-04-25 |
| KR20070093155A (ko) | 2007-09-17 |
| US7413756B2 (en) | 2008-08-19 |
| US7763290B2 (en) | 2010-07-27 |
| WO1999030725A1 (en) | 1999-06-24 |
| KR100780521B1 (ko) | 2007-11-29 |
| JP4458505B2 (ja) | 2010-04-28 |
| US20040137087A1 (en) | 2004-07-15 |
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