ATE442361T1 - Verfahren zur herstellung kristalliner formen von orlistat - Google Patents
Verfahren zur herstellung kristalliner formen von orlistatInfo
- Publication number
- ATE442361T1 ATE442361T1 AT04769349T AT04769349T ATE442361T1 AT E442361 T1 ATE442361 T1 AT E442361T1 AT 04769349 T AT04769349 T AT 04769349T AT 04769349 T AT04769349 T AT 04769349T AT E442361 T1 ATE442361 T1 AT E442361T1
- Authority
- AT
- Austria
- Prior art keywords
- orlistat
- crystalline forms
- producing crystalline
- relates
- processes
- Prior art date
Links
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 title abstract 5
- 229960001243 orlistat Drugs 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- AHLBNYSZXLDEJQ-UHFFFAOYSA-N N-formyl-L-leucylester Natural products CCCCCCCCCCCC(OC(=O)C(CC(C)C)NC=O)CC1OC(=O)C1CCCCCC AHLBNYSZXLDEJQ-UHFFFAOYSA-N 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1144DE2003 | 2003-09-12 | ||
| PCT/IB2004/002957 WO2005026140A1 (en) | 2003-09-12 | 2004-09-13 | Process for the preparation of crystalline forms of orlistat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE442361T1 true ATE442361T1 (de) | 2009-09-15 |
Family
ID=34308043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04769349T ATE442361T1 (de) | 2003-09-12 | 2004-09-13 | Verfahren zur herstellung kristalliner formen von orlistat |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1673359B1 (de) |
| AT (1) | ATE442361T1 (de) |
| DE (1) | DE602004023102D1 (de) |
| ES (1) | ES2329474T3 (de) |
| PT (1) | PT1673359E (de) |
| WO (1) | WO2005026140A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1763021B (zh) * | 2005-09-29 | 2010-08-11 | 杭州华东医药集团生物工程研究所有限公司 | 一种提纯奥利司他的方法 |
| EP1803714A1 (de) * | 2005-12-27 | 2007-07-04 | KRKA, tovarna zdravil, d.d., Novo mesto | Verfahren zur Herstellung kristalliner Formen von Orlistat |
| EP1944025A1 (de) * | 2007-01-09 | 2008-07-16 | Ranbaxy Laboratories Limited | Stabile pharmazeutische Zusammensetzungen mit Orlistat |
| SI2002825T1 (sl) * | 2007-06-14 | 2013-10-30 | Krka | Farmacevtski sestavki, ki obsegajo orlistat |
| EP2141236A1 (de) | 2008-07-03 | 2010-01-06 | KRKA, D.D., Novo Mesto | Verfahren zur Herstellung von Lipstatin und Mikroorganismen dafür |
| US8309107B2 (en) | 2008-10-06 | 2012-11-13 | Banner Pharmacaps, Inc. | Stable solutions of orlistat for pharmaceutical dosage forms |
| WO2010084502A1 (en) * | 2009-01-22 | 2010-07-29 | Biocon Limited | A crystalline form of orlistat and a process thereof |
| EP2413911B1 (de) | 2009-03-31 | 2014-02-19 | KRKA, D.D., Novo Mesto | Progressive emulsionskristallisation |
| CN102993135B (zh) * | 2012-12-31 | 2015-09-09 | 山东新时代药业有限公司 | 一种奥利司他的纯化方法 |
| CN107266395A (zh) * | 2017-08-08 | 2017-10-20 | 中山万远新药研发有限公司 | 一种奥利司他ⅰ晶型的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60000796T2 (de) * | 1999-01-29 | 2003-09-18 | F. Hoffmann-La Roche Ag, Basel | Reinigung von Lipstatin |
| US6730319B2 (en) * | 2001-06-06 | 2004-05-04 | Hoffmann-La Roche Inc. | Pharmaceutical compositions having depressed melting points |
| EP1470116A4 (de) * | 2001-12-04 | 2005-04-06 | Biogal Gyogyszergyar | Zubereitung von orlistat und kristalline orlistatformen |
-
2004
- 2004-09-13 EP EP04769349A patent/EP1673359B1/de not_active Expired - Lifetime
- 2004-09-13 DE DE602004023102T patent/DE602004023102D1/de not_active Expired - Lifetime
- 2004-09-13 ES ES04769349T patent/ES2329474T3/es not_active Expired - Lifetime
- 2004-09-13 WO PCT/IB2004/002957 patent/WO2005026140A1/en not_active Ceased
- 2004-09-13 PT PT04769349T patent/PT1673359E/pt unknown
- 2004-09-13 AT AT04769349T patent/ATE442361T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT1673359E (pt) | 2009-10-06 |
| WO2005026140A1 (en) | 2005-03-24 |
| EP1673359B1 (de) | 2009-09-09 |
| EP1673359A1 (de) | 2006-06-28 |
| DE602004023102D1 (de) | 2009-10-22 |
| ES2329474T3 (es) | 2009-11-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |