ATE334115T1 - Verfahren zur herstellung von taxanderivaten und beta-lactam zwischenprodukte - Google Patents

Verfahren zur herstellung von taxanderivaten und beta-lactam zwischenprodukte

Info

Publication number
ATE334115T1
ATE334115T1 AT94906685T AT94906685T ATE334115T1 AT E334115 T1 ATE334115 T1 AT E334115T1 AT 94906685 T AT94906685 T AT 94906685T AT 94906685 T AT94906685 T AT 94906685T AT E334115 T1 ATE334115 T1 AT E334115T1
Authority
AT
Austria
Prior art keywords
taxol
taxotere
beta
analogues
side chain
Prior art date
Application number
AT94906685T
Other languages
English (en)
Inventor
Iwao Ojima
Original Assignee
Univ New York State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found filed Critical Univ New York State Res Found
Application granted granted Critical
Publication of ATE334115T1 publication Critical patent/ATE334115T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT94906685T 1993-02-01 1994-01-28 Verfahren zur herstellung von taxanderivaten und beta-lactam zwischenprodukte ATE334115T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1192293A 1993-02-01 1993-02-01

Publications (1)

Publication Number Publication Date
ATE334115T1 true ATE334115T1 (de) 2006-08-15

Family

ID=21752542

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94906685T ATE334115T1 (de) 1993-02-01 1994-01-28 Verfahren zur herstellung von taxanderivaten und beta-lactam zwischenprodukte

Country Status (17)

Country Link
EP (1) EP0681568B1 (de)
JP (1) JP3492367B2 (de)
KR (1) KR960700226A (de)
AT (1) ATE334115T1 (de)
AU (1) AU687782B2 (de)
CA (1) CA2154071C (de)
CZ (1) CZ192195A3 (de)
DE (1) DE69434801T2 (de)
FI (1) FI953645L (de)
MX (1) MX9400806A (de)
NO (1) NO953011L (de)
NZ (1) NZ261529A (de)
PL (1) PL310075A1 (de)
RU (1) RU95116366A (de)
SK (1) SK90295A3 (de)
WO (1) WO1994018164A1 (de)
ZA (1) ZA94128B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US6593482B2 (en) 1993-02-01 2003-07-15 Aventis Pharma S.A. Methods for preparing new taxoids and pharmaceutical compositions containing them
US6232477B1 (en) 1996-03-25 2001-05-15 Aventis Pharma S.A. Methods of preparing new taxoids and pharmaceutical compositions containing them
US6040466A (en) * 1996-03-25 2000-03-21 Rhone Poulenc Rorer Sa Taxoids, their preparation and pharmaceutical compositions containing them
FR2732340B1 (fr) * 1995-03-27 1997-04-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
CA2120221A1 (en) * 1993-04-23 1994-10-24 Allan W. Rey N-substituted 2-azetidinones
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
US5847170A (en) * 1995-03-27 1998-12-08 Rhone-Poulenc Rorer, S.A. Taxoids, their preparation and pharmaceutical compositions containing them
MA23823A1 (fr) * 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
EP0944594A4 (de) * 1996-12-13 2000-05-03 Lilly Co Eli Inhibitoren der enzymatischen aktiviät von psa
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
BRPI0611954A2 (pt) 2005-06-10 2009-04-28 Univ Florida State Res Found processos para a produÇço de compostos de anel fundido policÍclico
KR101333438B1 (ko) * 2005-06-10 2013-11-27 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 도세탁셀의 제조 방법
KR101712231B1 (ko) 2009-10-29 2017-03-03 아벤티스 파마 소시에떼아노님 카바지탁셀의 신규한 항종양 용도
HK1201466A1 (en) 2011-09-21 2015-09-04 干细胞医药有限公司 Beta-lactam compounds for treating diabetes
US9345691B2 (en) 2011-09-21 2016-05-24 Stem Cell Medicine Ltd. Beta-lactam compounds for enhancing T cell-mediated immune responses
CN102408356A (zh) * 2011-09-28 2012-04-11 北京东方协和医药生物技术有限公司 一种多西他赛手性侧链中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
CA2071160A1 (en) * 1991-07-31 1993-02-01 Vittorio Farina Asymmetric synthesis of taxol side chain
HU225474B1 (en) * 1991-09-23 2006-12-28 Univ Florida State New 10-desacetoxytaxol derivatives, pharmaceutical derivatives containing them and procedure for preparing them
EP0884314B1 (de) * 1991-09-23 2004-01-21 Florida State University Metallalkoxide
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Also Published As

Publication number Publication date
EP0681568B1 (de) 2006-07-26
AU6031394A (en) 1994-08-29
KR960700226A (ko) 1996-01-19
ZA94128B (en) 1994-08-19
WO1994018164A1 (en) 1994-08-18
NO953011L (no) 1995-09-21
NO953011D0 (no) 1995-07-31
FI953645A0 (fi) 1995-07-31
FI953645A7 (fi) 1995-09-27
PL310075A1 (en) 1995-11-27
SK90295A3 (en) 1996-05-08
JP3492367B2 (ja) 2004-02-03
DE69434801T2 (de) 2007-08-09
DE69434801D1 (de) 2006-09-07
RU95116366A (ru) 1997-06-10
MX9400806A (es) 1994-08-31
FI953645L (fi) 1995-09-27
CA2154071C (en) 2005-06-28
CA2154071A1 (en) 1994-08-18
CZ192195A3 (en) 1995-12-13
EP0681568A1 (de) 1995-11-15
AU687782B2 (en) 1998-03-05
JPH08506339A (ja) 1996-07-09
NZ261529A (en) 1997-05-26

Similar Documents

Publication Publication Date Title
ATE334115T1 (de) Verfahren zur herstellung von taxanderivaten und beta-lactam zwischenprodukte
DK0773938T3 (da) Semi-syntetiske taxaner med anti-tumoraktivitet
EA200000282A1 (ru) Способ введения таксана пациенту, нуждающемуся в лечении таксаном, способ лечения человека таксаном (варианты)
BR9107070A (pt) Processo para a preparação de derivados de quinazolina uteis para melhorar a atividade antitumoral.
EE03126B1 (et) Meetod 10-desatsetüülbakatiin III saamiseks ja 10-desatsetüülbakatiin III kasutamine
RU95114377A (ru) 7-гало- и 7бета, 8бета -метано-таксолы, фармацевтическая композиция, промежуточные соединения, способы получения промежуточных соединений
DK0690856T3 (da) Antitumorforbindelser, farmaceutiske præparater, fremgangsmåder til fremstilling deraf og til behandling
MX9305766A (es) Procedimiento para la preparacion de derivados de taxano y productosobtenidos por medio del mismo.
EE03610B1 (et) Meetod taksaanide külgahela prekursorite valmistamiseks, sellel meetodil saadud ühendid, ning taksaanide valmistamismeetod ja nende derivaadid
HUT68589A (en) The cyclodextrin cluster complexes of taxol, taxotere, or taxus, process for their production, and use of them
ES2166448T3 (es) (2r,3s)-3-fenilisoserina con el hidroxilo en c-2' protegido con un grupo bencilo y el n protegido con un grupo carbamato, y procedimiento de produccion para la misma.
ATE241376T1 (de) Zusammensetzungen, die dolastatin-15-analoge in kombination mit taxane und dessen derivaten enthalten
ATE308533T1 (de) Zwischenprodukt und verfahren zur teilsynthese von paclitaxel und dessen analogen
KR950700684A (ko) 시클릭 항-종양 촉진제 화합물, 그의 조성물, 제조 방법 및 용도(Cyclic Anti-Tumor Promoter Compounds, Compositions and Methods for Production and Use)
NZ325323A (en) Method for selective protection of baccatin derivatives and its application to taxane synthesis
ATE466847T1 (de) Verfahren zur herstellung von 14-beta- hydroxybaccatin-iii-1,14-carbonat
IT1274356B (it) Tassani semisintetici odtati di attivita' antitumorale
IT1278108B1 (it) Secotassani dotati di attivita' antitumorale.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties