ZA94128B - Process for the preparation of taxane derivatives and betalactam intermediates therefor - Google Patents

Process for the preparation of taxane derivatives and betalactam intermediates therefor

Info

Publication number
ZA94128B
ZA94128B ZA94128A ZA94128A ZA94128B ZA 94128 B ZA94128 B ZA 94128B ZA 94128 A ZA94128 A ZA 94128A ZA 94128 A ZA94128 A ZA 94128A ZA 94128 B ZA94128 B ZA 94128B
Authority
ZA
South Africa
Prior art keywords
taxol
taxotere
analogues
side chain
modified
Prior art date
Application number
ZA94128A
Other languages
English (en)
Inventor
Iwao Ojima
Original Assignee
Univ New York State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found filed Critical Univ New York State Res Found
Publication of ZA94128B publication Critical patent/ZA94128B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA94128A 1993-02-01 1994-01-10 Process for the preparation of taxane derivatives and betalactam intermediates therefor ZA94128B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1192293A 1993-02-01 1993-02-01

Publications (1)

Publication Number Publication Date
ZA94128B true ZA94128B (en) 1994-08-19

Family

ID=21752542

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA94128A ZA94128B (en) 1993-02-01 1994-01-10 Process for the preparation of taxane derivatives and betalactam intermediates therefor

Country Status (17)

Country Link
EP (1) EP0681568B1 (de)
JP (1) JP3492367B2 (de)
KR (1) KR960700226A (de)
AT (1) ATE334115T1 (de)
AU (1) AU687782B2 (de)
CA (1) CA2154071C (de)
CZ (1) CZ192195A3 (de)
DE (1) DE69434801T2 (de)
FI (1) FI953645L (de)
MX (1) MX9400806A (de)
NO (1) NO953011L (de)
NZ (1) NZ261529A (de)
PL (1) PL310075A1 (de)
RU (1) RU95116366A (de)
SK (1) SK90295A3 (de)
WO (1) WO1994018164A1 (de)
ZA (1) ZA94128B (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9345691B2 (en) 2011-09-21 2016-05-24 Stem Cell Medicine Ltd. Beta-lactam compounds for enhancing T cell-mediated immune responses
US9474744B2 (en) 2011-09-21 2016-10-25 Stem Cell Medicine Ltd. Beta-lactam compounds for treating diabetes

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US6040466A (en) * 1996-03-25 2000-03-21 Rhone Poulenc Rorer Sa Taxoids, their preparation and pharmaceutical compositions containing them
FR2732340B1 (fr) * 1995-03-27 1997-04-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US6232477B1 (en) 1996-03-25 2001-05-15 Aventis Pharma S.A. Methods of preparing new taxoids and pharmaceutical compositions containing them
US6593482B2 (en) 1993-02-01 2003-07-15 Aventis Pharma S.A. Methods for preparing new taxoids and pharmaceutical compositions containing them
CA2120221A1 (en) * 1993-04-23 1994-10-24 Allan W. Rey N-substituted 2-azetidinones
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
US5847170A (en) * 1995-03-27 1998-12-08 Rhone-Poulenc Rorer, S.A. Taxoids, their preparation and pharmaceutical compositions containing them
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
KR20000069431A (ko) * 1996-12-13 2000-11-25 피터 지. 스트링거 Ｐｓａ의 효소 활성 억제제
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
AU2006258065A1 (en) 2005-06-10 2006-12-21 Florida State University Research Foundation, Inc. Processes for the production of polycyclic fused ring compounds
US7550608B2 (en) * 2005-06-10 2009-06-23 Florida State University Research Foundation, Inc. Processes for the preparation of docetaxel
AU2010310986A1 (en) 2009-10-29 2012-06-14 Aventis Pharma S.A. Novel antitumoral use of cabazitaxel
CN102408356A (zh) * 2011-09-28 2012-04-11 北京东方协和医药生物技术有限公司 一种多西他赛手性侧链中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
CA2071160A1 (en) * 1991-07-31 1993-02-01 Vittorio Farina Asymmetric synthesis of taxol side chain
HU226369B1 (en) * 1991-09-23 2008-09-29 Univ Florida State Process for preparing substituted isoserine-esters using metal alkoxides and beta-lactams
AU663732B2 (en) * 1991-09-23 1995-10-19 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9345691B2 (en) 2011-09-21 2016-05-24 Stem Cell Medicine Ltd. Beta-lactam compounds for enhancing T cell-mediated immune responses
US9474744B2 (en) 2011-09-21 2016-10-25 Stem Cell Medicine Ltd. Beta-lactam compounds for treating diabetes

Also Published As

Publication number Publication date
ATE334115T1 (de) 2006-08-15
NO953011D0 (no) 1995-07-31
JPH08506339A (ja) 1996-07-09
FI953645A7 (fi) 1995-09-27
CA2154071C (en) 2005-06-28
JP3492367B2 (ja) 2004-02-03
EP0681568A1 (de) 1995-11-15
PL310075A1 (en) 1995-11-27
DE69434801D1 (de) 2006-09-07
AU687782B2 (en) 1998-03-05
RU95116366A (ru) 1997-06-10
WO1994018164A1 (en) 1994-08-18
MX9400806A (es) 1994-08-31
NZ261529A (en) 1997-05-26
KR960700226A (ko) 1996-01-19
FI953645A0 (fi) 1995-07-31
NO953011L (no) 1995-09-21
EP0681568B1 (de) 2006-07-26
FI953645L (fi) 1995-09-27
SK90295A3 (en) 1996-05-08
CA2154071A1 (en) 1994-08-18
CZ192195A3 (en) 1995-12-13
AU6031394A (en) 1994-08-29
DE69434801T2 (de) 2007-08-09

Similar Documents

Publication Publication Date Title
FI953645A0 (fi) Menetelmä taksaanijohdannaisten valmistamiseksi sekä niiden B-laktaaminivälituotteet
FI970271A0 (fi) Puolisynteettiset taksaanit, joilla on kasvaimenvastainen vaikutus
PT674630E (pt) 7-halo- e 7beta,8beta-metano-taxois utilizacao antineoplasica e composicoes farmaceuticas que os contem
TW255890B (de)
AU7308696A (en) Intermediates for the hemisynthesis of taxanes and their processes of preparation
NO953796D0 (no) Antitumor-forbindelser, farmasöytiske blandinger, fremgangsmåter for fremstilling derav og for behandling
Jia et al. Design, synthesis and biological evaluation of “Multi-Site”-binding influenza virus neuraminidase inhibitors
HUT68589A (en) The cyclodextrin cluster complexes of taxol, taxotere, or taxus, process for their production, and use of them
IL185921A0 (en) A process for the preparation of the 14beta-hydroxy-baccatin iii-1, 14-carbonate
NZ325323A (en) Method for selective protection of baccatin derivatives and its application to taxane synthesis
NZ514407A (en) C10 carbamoyloxy substituted taxanes as antitumor agents
PL350024A1 (en) C7 carbamoyloxy substituted taxanes as antitumor agents
IL161443A0 (en) A process for the preparation of the 14beta-hydroxy-baccatin iii-1,14-carbonate
IT1274356B (it) Tassani semisintetici odtati di attivita' antitumorale