ATE334681T1 - Verwendung von pteridinderivaten für die behandlung von erhöhtem hirndruck - Google Patents

Verwendung von pteridinderivaten für die behandlung von erhöhtem hirndruck

Info

Publication number
ATE334681T1
ATE334681T1 AT03788945T AT03788945T ATE334681T1 AT E334681 T1 ATE334681 T1 AT E334681T1 AT 03788945 T AT03788945 T AT 03788945T AT 03788945 T AT03788945 T AT 03788945T AT E334681 T1 ATE334681 T1 AT E334681T1
Authority
AT
Austria
Prior art keywords
increased
treatment
increatic
pressure
pteridine derivatives
Prior art date
Application number
AT03788945T
Other languages
English (en)
Inventor
Robert Doblhofer
Frank Tegtmeier
Original Assignee
Vasopharm Biotech Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vasopharm Biotech Gmbh filed Critical Vasopharm Biotech Gmbh
Application granted granted Critical
Publication of ATE334681T1 publication Critical patent/ATE334681T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT03788945T 2003-03-25 2003-10-08 Verwendung von pteridinderivaten für die behandlung von erhöhtem hirndruck ATE334681T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2003/003096 WO2005037286A1 (en) 2003-03-25 2003-03-25 Use of pteridine derivatives for the treatment of increased intracranial pressure and secondary ischemia

Publications (1)

Publication Number Publication Date
ATE334681T1 true ATE334681T1 (de) 2006-08-15

Family

ID=33040875

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03788945T ATE334681T1 (de) 2003-03-25 2003-10-08 Verwendung von pteridinderivaten für die behandlung von erhöhtem hirndruck

Country Status (14)

Country Link
US (3) US8222238B2 (de)
EP (1) EP1605947B1 (de)
JP (1) JP4630669B2 (de)
KR (1) KR101103888B1 (de)
CN (1) CN1758913B (de)
AT (1) ATE334681T1 (de)
AU (1) AU2003293607B2 (de)
CA (1) CA2519919C (de)
DE (1) DE60307327T2 (de)
ES (1) ES2270151T3 (de)
MX (1) MXPA05009491A (de)
PL (1) PL213123B1 (de)
RU (1) RU2348410C2 (de)
WO (2) WO2005037286A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037286A1 (en) 2003-03-25 2005-04-28 Vasopharm Biotech Gmbh Use of pteridine derivatives for the treatment of increased intracranial pressure and secondary ischemia
WO2009088530A1 (en) * 2008-01-03 2009-07-16 Biomarin Pharmaceutical Inc. Pterin analog for treating bh4 responsive condition
PL2926805T3 (pl) * 2014-03-31 2016-12-30 Stałe kompozycje farmaceutyczne zawierające pochodne biopteryny oraz zastosowania takich kompozycji
US12171766B2 (en) 2021-12-03 2024-12-24 Verinos Operations Gmbh Methods of treating patients suffering from brain injury and methods of increasing the value of the extended Glasgow Outcome Scale of patients suffering from brain injury
EP4440578A1 (de) 2021-12-03 2024-10-09 VeriNOS operations GmbH Verfahren zur behandlung von patienten mit hirnläsion und verfahren zur erhöhung des werts der erweiterten glagow-ergebnisskala von patienten mit hirnläsion
TW202406555A (zh) 2022-05-06 2024-02-16 德商ｖｅｒｉＮＯＳ運營有限公司 治療患有與增加的麩胺酸水平相關的疾病狀況或病症的患者的方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9203323A (es) * 1991-07-11 1994-07-29 Hoechst Ag El empleo de derivados de xantina para el tratamiento de lesiones secundarias de las celulas nerviosas y trastornos funcionales despues de traumas craneo-cerebrales.
US5266594A (en) * 1992-05-12 1993-11-30 Dawson Valina L Inhibitors of nitric oxide synthase and use thereof to prevent glutamate neurotoxicity
JPH08504798A (ja) * 1992-12-18 1996-05-21 ザ ウエルカム ファウンデーション リミテッド 酵素阻害薬としての，ピリミジン，ピリジン，プテリジノンおよびインダゾール誘導体
US5527822A (en) 1993-12-29 1996-06-18 Forest Laboratories, Inc. Method of treatment of traumatic brain injury
DE4418096A1 (de) * 1994-05-24 1995-11-30 Cassella Ag Verwendung von Pteridin-Derivaten als Hemmstoffe der NO-Synthase
DE4418097A1 (de) * 1994-05-24 1995-11-30 Cassella Ag Verwendung von Tetrahydropteridin-Derivaten als Hemmstoffe der NO-Synthase
GB9500691D0 (en) 1995-01-13 1995-03-08 Smithkline Beecham Plc Compounds
GB9509156D0 (en) * 1995-05-05 1995-06-28 Sandoz Ltd Organic compounds
WO1997021711A1 (de) 1995-12-12 1997-06-19 Lonza Ag Verfahren zur herstellung von 4-aminopteridinderivaten
ZA9610741B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
WO1998008516A1 (en) * 1996-08-30 1998-03-05 Suntory Limited Preventives or remedies for diseases induced by hypofunction of nitric oxide synthase (nos)
AU742388B2 (en) 1996-12-24 2002-01-03 Chugai Seiyaku Kabushiki Kaisha Aromatic amine derivatives having nos inhibiting action
EP0966436B1 (de) * 1997-02-21 2002-12-11 Bayer Aktiengesellschaft Arylsulfonamide und analoga und ihre verwendung zur behandlung von neurodegenerativen erkrankungen
DE19740785A1 (de) 1997-02-21 1998-08-27 Bayer Ag Arylsulfonamide und Analoga
US5922713A (en) * 1997-06-26 1999-07-13 Werner; Ernst Inhibition of nitric oxide synthase
DE59703603D1 (de) 1997-10-06 2001-06-28 Ernst Werner Pteridinderivate als NO Synthase-Hemmer
DE19754573A1 (de) 1997-12-09 1999-06-10 Bayer Ag Pharmazeutische Zusammensetzung zur Behandlung von Schlaganfall und Schädel-Hirn-Trauma
DE19801646A1 (de) * 1998-01-17 1999-07-22 Bayer Ag Substituierte alpha,beta-annellierte Butyrolactone
HN1998000027A (es) * 1998-08-19 1999-06-02 Bayer Ip Gmbh Arilsulfonamidas y analagos
WO2000039129A1 (en) 1998-12-28 2000-07-06 K.U. Leuven Research & Development Immunosuppressive effects of pteridine derivatives
US6255280B1 (en) 1999-04-08 2001-07-03 University Of Kentucky Research Foundation Protection against traumatic brain injury
DE19944767A1 (de) * 1999-09-17 2001-03-29 Vasopharm Biotech Gmbh & Co Kg N-substituierte 4-Aminopteridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6589189B2 (en) * 2000-01-07 2003-07-08 Rice Creek Medical, Llc Non-invasive method and apparatus for monitoring intracranial pressure
DE10109866A1 (de) 2001-03-01 2002-09-05 Abbott Gmbh & Co Kg Triazolverbindungen und deren Verwendung zur Prophylaxe und Therapie neurodegenerativer Erkrankungen, Hirntrauma und zerebraler Ischämie
WO2003016910A1 (en) * 2001-08-20 2003-02-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
WO2005037286A1 (en) 2003-03-25 2005-04-28 Vasopharm Biotech Gmbh Use of pteridine derivatives for the treatment of increased intracranial pressure and secondary ischemia

Also Published As

Publication number Publication date
US20130184281A1 (en) 2013-07-18
PL213123B1 (pl) 2013-01-31
EP1605947A1 (de) 2005-12-21
JP4630669B2 (ja) 2011-02-09
RU2348410C2 (ru) 2009-03-10
RU2005128956A (ru) 2006-04-27
KR20060002861A (ko) 2006-01-09
AU2003293607A1 (en) 2004-10-18
MXPA05009491A (es) 2006-02-22
US20130131071A1 (en) 2013-05-23
WO2004084906A1 (en) 2004-10-07
CA2519919C (en) 2009-09-08
PL378633A1 (pl) 2006-05-15
AU2003293607B2 (en) 2009-12-03
WO2005037286A1 (en) 2005-04-28
US20070032498A1 (en) 2007-02-08
CN1758913A (zh) 2006-04-12
ES2270151T3 (es) 2007-04-01
DE60307327D1 (de) 2006-09-14
EP1605947B1 (de) 2006-08-02
US9422289B2 (en) 2016-08-23
DE60307327T2 (de) 2007-10-25
US9382252B2 (en) 2016-07-05
CA2519919A1 (en) 2004-10-07
US8222238B2 (en) 2012-07-17
KR101103888B1 (ko) 2012-01-12
CN1758913B (zh) 2010-04-28
JP2006514965A (ja) 2006-05-18

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